메뉴 건너뛰기




Volumn 392, Issue 1-2, 2014, Pages 213-227

Combined treatment with quercetin and imperatorin as a potent strategy for killing HeLa and Hep-2 cells

Author keywords

Cancer; Cell death; Imperatorin; Quercetin

Indexed keywords

BECLIN 1; CASPASE 3; CASPASE 8; CASPASE 9; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 72; PENTOSALEN; QUERCETIN; SMALL INTERFERING RNA; FUROCOUMARIN DERIVATIVE;

EID: 84905172002     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2032-4     Document Type: Article
Times cited : (44)

References (65)
  • 1
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495-516
    • (2007) Toxicol Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 2
    • 0035676977 scopus 로고    scopus 로고
    • The machinery of programmed cell death
    • DOI 10.1016/S0163-7258(01)00159-0, PII S0163725801001590
    • Zimmermann KC, Bonzon C, Green DR (2001) The machinery of programmed cell death. Pharmacol Ther 92:57-70 (Pubitemid 34032022)
    • (2001) Pharmacology and Therapeutics , vol.92 , Issue.1 , pp. 57-70
    • Zimmermann, K.C.1    Bonzon, C.2    Green, D.R.3
  • 3
    • 0036205587 scopus 로고    scopus 로고
    • Mechanisms of caspase activation and inhibition during apoptosis
    • Shi Y (2002) Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9:459-470
    • (2002) Mol Cell , vol.9 , pp. 459-470
    • Shi, Y.1
  • 5
    • 70350057568 scopus 로고    scopus 로고
    • Apoptosis in cancer: Key molecular signaling pathways and therapy targets
    • Burz C, Berindan-Neagoe I, Balacescu O, Irimie A (2009) Apoptosis in cancer: key molecular signaling pathways and therapy targets. Acta Oncol 48:811-821
    • (2009) Acta Oncol , vol.48 , pp. 811-821
    • Burz, C.1    Berindan-Neagoe, I.2    Balacescu, O.3    Irimie, A.4
  • 7
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima N (2007) Autophagy: process and function. Genes Dev 21:2861-2873
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 8
    • 78149475088 scopus 로고    scopus 로고
    • Regulation of mammalian autophagy in physiology and pathophysiology
    • Ravekumar B, Sarkar S, Davies JE, Futter M (2010) Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 90:1383-1435
    • (2010) Physiol Rev , vol.90 , pp. 1383-1435
    • Ravekumar, B.1    Sarkar, S.2    Davies, J.E.3    Futter, M.4
  • 9
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • DOI 10.1172/JCI26390
    • Levine B, Yuan J (2005) Autophagy in cell death: an innocent convict? J Clin Invest 115:2679-2688 (Pubitemid 41434392)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.10 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 12
    • 0037007283 scopus 로고    scopus 로고
    • Molecular chaperones-cellular machines for protein folding
    • Walter S, Buchner J (2002) Molecular chaperones-cellular machines for protein folding. Angew Chem Int Ed Engl 41:1098-1113
    • (2002) Angew Chem Int Ed Engl , vol.41 , pp. 1098-1113
    • Walter, S.1    Buchner, J.2
  • 13
    • 21744445069 scopus 로고    scopus 로고
    • Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications
    • DOI 10.1379/CSC-99r.1, csac. 2005.CSC-99r
    • Ciocca DR, Calderwood SK (2005) Heat shock proteins in cancer: diagnostics, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86-103 (Pubitemid 40942470)
    • (2005) Cell Stress and Chaperones , vol.10 , Issue.2 , pp. 86-103
    • Ciocca, D.R.1    Calderwood, S.K.2
  • 14
  • 15
    • 33751203833 scopus 로고    scopus 로고
    • Heat shock proteins 27 and 70: Anti-apoptotic proteins with tumorigenic properties
    • Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G (2006) Heat shock proteins 27 and 70. Anti-apoptotic proteins with tumorigenic properties. Cell Cycle 5:2592-2601 (Pubitemid 44785803)
    • (2006) Cell Cycle , vol.5 , Issue.22 , pp. 2592-2601
    • Garrido, C.1    Brunet, M.2    Didelot, C.3    Zermati, Y.4    Schmitt, E.5    Kroemer, G.6
  • 16
    • 10044246299 scopus 로고    scopus 로고
    • Review of the flavonoids quercetin, hespertin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology
    • Erlund I (2004) Review of the flavonoids quercetin, hespertin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res 24:851-874
    • (2004) Nutr Res , vol.24 , pp. 851-874
    • Erlund, I.1
  • 17
    • 34249882770 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
    • Ramos S (2007) Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 18:427-442
    • (2007) J Nutr Biochem , vol.18 , pp. 427-442
    • Ramos, S.1
  • 18
    • 51349127271 scopus 로고    scopus 로고
    • Multitargeted cancer prevention by quercetin
    • Murakami A, Ashida H, Terao J (2008) Multitargeted cancer prevention by quercetin. Cancer Lett 269:315-325
    • (2008) Cancer Lett , vol.269 , pp. 315-325
    • Murakami, A.1    Ashida, H.2    Terao, J.3
  • 22
    • 77956634425 scopus 로고    scopus 로고
    • Hormesis and synergy: Pathways and mechanisms of quercetin in cancer prevention and management
    • Vargas AJ, Burd R (2010) Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. Nutr Rev 68:418-428
    • (2010) Nutr Rev , vol.68 , pp. 418-428
    • Vargas, A.J.1    Burd, R.2
  • 26
    • 35348821821 scopus 로고    scopus 로고
    • Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice
    • DOI 10.1016/j.ejphar.2007.07.008, PII S0014299907007844
    • Łuszczki J, Głowniak K, Czuczwar SJ (2007) Imperatorin enhances the protective activity of conventional antiepileptic drug against maximal electroshock-induced seizures in mice. Eur J Pharmacol 574:133-139 (Pubitemid 47575522)
    • (2007) European Journal of Pharmacology , vol.574 , Issue.2-3 , pp. 133-139
    • Luszczki, J.J.1    Glowniak, K.2    Czuczwar, S.J.3
  • 27
    • 33947607438 scopus 로고    scopus 로고
    • Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines
    • Kim YK, Kim YS, Ryu SY (2007) Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines. Phytother Res 21:288-290
    • (2007) Phytother Res , vol.21 , pp. 288-290
    • Kim, Y.K.1    Kim, Y.S.2    Ryu, S.Y.3
  • 28
    • 81855213100 scopus 로고    scopus 로고
    • An in vitro and in silico approach to cholinesterase inhibitory and antioxidant effects of the methanol extract, furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits
    • Sezer-Senol F, Skalicka-Woźniak K, Khan MTH, Orhan IE, Sener B, Głowniak K (2011) An in vitro and in silico approach to cholinesterase inhibitory and antioxidant effects of the methanol extract, furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits. Phytochem Lett 4:462-467
    • (2011) Phytochem Lett , vol.4 , pp. 462-467
    • Sezer-Senol, F.1    Skalicka-Woźniak, K.2    Khan, M.T.H.3    Orhan, I.E.4    Sener, B.5    Głowniak, K.6
  • 30
    • 17144427728 scopus 로고    scopus 로고
    • Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
    • Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB, Kondo S (2005) Synergistic augumentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res 65:3336-3346 (Pubitemid 40524618)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3336-3346
    • Takeuchi, H.1    Kondo, Y.2    Fujiwara, K.3    Kanzawa, T.4    Aoki, H.5    Mills, G.B.6    Kondo, S.7
  • 31
    • 0017184389 scopus 로고
    • A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MN (1976) A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.N.1
  • 32
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 33
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hannah D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hannah, D.1    Weinberg, R.A.2
  • 34
    • 35448994282 scopus 로고    scopus 로고
    • The heat shock response and chaperones/heat shock proteins in brain tumors: Surface expression, release, and possible immune consequences
    • DOI 10.1523/JNEUROSCI.3588-07.2007
    • Garner MW, Cumming RI, Bigner DD (2007) The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequence. J Neurosci 27:11214-11227 (Pubitemid 47621325)
    • (2007) Journal of Neuroscience , vol.27 , Issue.42 , pp. 11214-11227
    • Graner, M.W.1    Cumming, R.I.2    Bigner, D.D.3
  • 36
    • 79960420834 scopus 로고    scopus 로고
    • Quercetin-mediated apoptosis via activation of the mitochondrial- dependent pathway in MG-63 osteosarcoma cells
    • Liang W, Li X, Li C, Liao L, Gao B, Gan H, Yang Z, Liao L, Chen X (2011) Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. Mol Med Rep 4:1017-1023
    • (2011) Mol Med Rep , vol.4 , pp. 1017-1023
    • Liang, W.1    Li, X.2    Li, C.3    Liao, L.4    Gao, B.5    Gan, H.6    Yang, Z.7    Liao, L.8    Chen, X.9
  • 37
    • 84862777378 scopus 로고    scopus 로고
    • Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines
    • Zhang H, Zhang M, Yu L, Zhao Y, He N, Yang X (2012) Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines. Food Chem Toxicol 50(5):1589-1599
    • (2012) Food Chem Toxicol , vol.50 , Issue.5 , pp. 1589-1599
    • Zhang, H.1    Zhang, M.2    Yu, L.3    Zhao, Y.4    He, N.5    Yang, X.6
  • 38
    • 33746341468 scopus 로고    scopus 로고
    • Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells
    • DOI 10.1016/j.canlet.2005.09.013, PII S0304383505008669
    • Lee TJ, Kim OH, Kim YH, Lim JH, Kim S, Park JW, Kwon TK (2006) Quercetin arrest G2/M phase and induces caspase-dependent cell death in U937 cells. Cancer Lett 240:234-242 (Pubitemid 44109922)
    • (2006) Cancer Letters , vol.240 , Issue.2 , pp. 234-242
    • Lee, T.-J.1    Kim, O.H.2    Kim, Y.H.3    Lim, J.H.4    Kim, S.5    Park, J.-W.6    Kwon, T.K.7
  • 39
    • 77957319672 scopus 로고    scopus 로고
    • Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells
    • Chou CC, Yang SY, Lu HF, Ip SW, Lo C, Wu CC, Lin JP, Tang NY, Chung JG, Chou MJ, Teng YH, Chen DR (2010) Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. Arch Pharm Res 33(8):1181-1191
    • (2010) Arch Pharm Res , vol.33 , Issue.8 , pp. 1181-1191
    • Chou, C.C.1    Yang, S.Y.2    Lu, H.F.3    Ip, S.W.4    Lo, C.5    Wu, C.C.6    Lin, J.P.7    Tang, N.Y.8    Chung, J.G.9    Chou, M.J.10    Teng, Y.H.11    Chen, D.R.12
  • 40
    • 84903759132 scopus 로고    scopus 로고
    • Quercetin and Sorafenib as a novel and effective couple in programmed cell death induction in human gliomas
    • doi:10.1007/s12640-013-9452-x
    • Jakubowicz-Gil J, Langner E, Ba̧dziul D, Wertel I, Rzeski W (2013) Quercetin and Sorafenib as a novel and effective couple in programmed cell death induction in human gliomas. Neurotox Res 1-14. doi:10.1007/s12640-013-9452-x
    • (2013) Neurotox Res , pp. 1-14
    • Jakubowicz-Gil, J.1    Langner, E.2    Ba̧dziul, D.3    Wertel, I.4    Rzeski, W.5
  • 41
    • 84881475167 scopus 로고    scopus 로고
    • Apoptosis induction in human glioblastoma multiforme T98G cells upon temozolomide and quercetin treatment
    • Jakubowicz-Gil J, Langner E, Ba̧dziul D, Wertel I, Rzeski W (2013) Apoptosis induction in human glioblastoma multiforme T98G cells upon temozolomide and quercetin treatment. Tumor Biol 34(4):2367-2378
    • (2013) Tumor Biol , vol.34 , Issue.4 , pp. 2367-2378
    • Jakubowicz-Gil, J.1    Langner, E.2    Ba̧dziul, D.3    Wertel, I.4    Rzeski, W.5
  • 42
    • 84899643764 scopus 로고    scopus 로고
    • The effect of quercetin and imperatorin on the programmed cell death induction in T98G cells in vitro
    • doi:10.1016/j.pharep.2013.10.003
    • Ba̧dziul D, Jakubowicz-Gil J, Langner E, Rzeski W, Głowniak K, Gawron A (2014) The effect of quercetin and imperatorin on the programmed cell death induction in T98G cells in vitro. Pharmacol Rep. doi:10.1016/j. pharep.2013.10.003
    • (2014) Pharmacol Rep
    • Ba̧dziul, D.1    Jakubowicz-Gil, J.2    Langner, E.3    Rzeski, W.4    Głowniak, K.5    Gawron, A.6
  • 45
    • 0344873282 scopus 로고    scopus 로고
    • The antioxidant, rather than prooxidant, activities of quercetin on normal cells: Quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis
    • DOI 10.1016/S0014-4827(03)00410-5
    • Lee JC, Kim J, Park JK, Chung GH, Jang YS (2003) The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis. Exp Cell Res 291(2):386-397 (Pubitemid 37485726)
    • (2003) Experimental Cell Research , vol.291 , Issue.2 , pp. 386-397
    • Lee, J.-C.1    Kim, J.2    Park, J.-K.3    Chung, G.-H.4    Jang, Y.-S.5
  • 47
    • 5044239935 scopus 로고    scopus 로고
    • Selective effects of quercetin on the cell growth and antioxidant defense system in normal versus transformed mouse hepatic cell lines
    • Son YO, Lee KY, Kook SH, Lee JC, Kim JG, Jeon YM, Jang YS (2004) Selective effects of quercetin on the cell growth and antioxidant defense system in normal versus transformed mouse hepatic cell lines. Eur J Pharmacol 502(2):195-204
    • (2004) Eur J Pharmacol , vol.502 , Issue.2 , pp. 195-204
    • Son, Y.O.1    Lee, K.Y.2    Kook, S.H.3    Lee, J.C.4    Kim, J.G.5    Jeon, Y.M.6    Jang, Y.S.7
  • 49
    • 0036365656 scopus 로고    scopus 로고
    • The cytotoxicity of some organic solvents on isolated hepatocytes in monolayer culture
    • Zapór L, Skowroń J, Gołofit-Szymczak M (2002) The cytotoxicity of some organic solvents on isolated hepatocytes in monolayer culture. Int J Occup Saf Ergon 8(1):121-129
    • (2002) Int J Occup Saf Ergon , vol.8 , Issue.1 , pp. 121-129
    • Zapór, L.1    Skowroń, J.2    Gołofit-Szymczak, M.3
  • 50
    • 84874306420 scopus 로고    scopus 로고
    • In-vitro cytotoxicity evaluation of novel N-substituted bis-benzimidazole derivatives for anti-lung and anti-breast cancer activity
    • Sukhramani PS, Sukhramani PS, Desasi SA, Suthar MP (2011) In-vitro cytotoxicity evaluation of novel N-substituted bis-benzimidazole derivatives for anti-lung and anti-breast cancer activity. Ann Biol Res 2(1):51-59
    • (2011) Ann Biol Res , vol.2 , Issue.1 , pp. 51-59
    • Sukhramani, P.S.1    Sukhramani, P.S.2    Desasi, S.A.3    Suthar, M.P.4
  • 51
    • 0025134198 scopus 로고
    • A simple in vito cytotoxicity test using the MTT (3-(4,5)- dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) colorimetric assay: Analysis of eugenol toxicity on dental pulp cells (RPC-C2A)
    • Kasugai S, Hasegawa N, Ogura H (1990) A simple in vivo cytotoxicity test using the MTT (3-(4,5)-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) colometric assay: analysis of eugenol toxicity on dental pulp cells (RPC-C2A). Jpn J Pharmacol 52:95-100 (Pubitemid 20023693)
    • (1990) Japanese Journal of Pharmacology , vol.52 , Issue.1 , pp. 95-100
    • Kasugai, S.1    Hasegawa, N.2    Ogura, H.3
  • 52
    • 84878719760 scopus 로고    scopus 로고
    • In vitro morphological assessment of apoptosis induced by antiproliferative constituents from the rhizomes of Curcuma zedoaria
    • doi:10.1155/2013/257108
    • Rahman SNSA, Wahab NA, Malek SNA (2013) In vitro morphological assessment of apoptosis induced by antiproliferative constituents from the rhizomes of Curcuma zedoaria. Evid Based Complement Altern Med. doi:10.1155/2013/257108
    • (2013) Evid Based Complement Altern Med
    • Rahman, S.N.S.A.1    Wahab, N.A.2    Malek, S.N.A.3
  • 53
    • 0031106041 scopus 로고    scopus 로고
    • Oligonucleotides tethering Hoechst 33258 derivatives: Effect of the conjugation site on duplex stabilization and fluorescence properties
    • DOI 10.1021/bc960086e
    • Wiederholt K, Rajur SB, McLaughlin W (1997) Oligonucleotides tethering Hoechst 333258 derivatives: effects of the conjugation site on duplex stabilization and fluorescence properties. Bioconj Chem 8:119-126 (Pubitemid 27153284)
    • (1997) Bioconjugate Chemistry , vol.8 , Issue.2 , pp. 119-126
    • Wiederholt, K.1    Rajur, S.B.2    McLaughlin, L.W.3
  • 55
    • 83755182761 scopus 로고    scopus 로고
    • Anticancer effects of imperatorin isolated from Angelica dahurica: Induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways
    • Luo KW, Sun JG, Chan JY, Yang L, Wu SH, Fung KP, Liu FY (2011) Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways. Chemotherapy 57:449-459
    • (2011) Chemotherapy , vol.57 , pp. 449-459
    • Luo, K.W.1    Sun, J.G.2    Chan, J.Y.3    Yang, L.4    Wu, S.H.5    Fung, K.P.6    Liu, F.Y.7
  • 56
    • 84869843046 scopus 로고    scopus 로고
    • Imperatorin-pharmacological effects and possible implication in pharmacotherapy
    • Ulazka B, Głowniak K, Sieniawska E (2012) Imperatorin- pharmacological effects and possible implication in pharmacotherapy. Curr Issues Pharm Med Sci 25(1):80-87
    • (2012) Curr Issues Pharm Med Sci , vol.25 , Issue.1 , pp. 80-87
    • Ulazka, B.1    Głowniak, K.2    Sieniawska, E.3
  • 57
    • 78149497094 scopus 로고    scopus 로고
    • Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention
    • Neergheen V, Bahorun T, Taylor E, Jen L, Aruoma O (2009) Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention. Toxicology 278:229-241
    • (2009) Toxicology , vol.278 , pp. 229-241
    • Neergheen, V.1    Bahorun, T.2    Taylor, E.3    Jen, L.4    Aruoma, O.5
  • 59
    • 34248176724 scopus 로고    scopus 로고
    • Heat shock genes - Integrating cell survival and death
    • DOI 10.1007/s12038-007-0059-3
    • Arya R, Mallik M, Lakhotia SC (2007) Heat shock genes-integrating cell survival and death. J Biosci 32:595-610 (Pubitemid 46708710)
    • (2007) Journal of Biosciences , vol.32 , Issue.3 , pp. 595-610
    • Arya, R.1    Mallik, M.2    Lakhotia, S.C.3
  • 61
    • 0034605446 scopus 로고    scopus 로고
    • Role of heat shock response and molecular chaperones in oncogenesis and cell death
    • Jolly C, Morimoto RI (2000) Role of heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst 92:1564-1572
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1564-1572
    • Jolly, C.1    Morimoto, R.I.2
  • 62
    • 2342651518 scopus 로고    scopus 로고
    • Molecular chaperones and the stress of oncogenesis
    • DOI 10.1038/sj.onc.1207529
    • Mosser DD, Morimoto RI (2004) Molecular chaperones and the stress of oncogenesis. Oncogene 23:2907-2918 (Pubitemid 38638852)
    • (2004) Oncogene , vol.23 , Issue.16 REV. ISS. 2 , pp. 2907-2918
    • Mosser, D.D.1    Morimoto, R.I.2
  • 63
    • 33749554554 scopus 로고    scopus 로고
    • Small interference RNA targeting heat-shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro
    • DOI 10.1111/j.1464-410X.2006.06425.x
    • Rocchi P, Jugpal P, So A, Sinneman S, Ettinger S, Fazil L, Nelson C, Gleave M (2006) Small interference RNA targeting heats shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro. BJU Int 98:1082-1089 (Pubitemid 44536463)
    • (2006) BJU International , vol.98 , Issue.5 , pp. 1082-1089
    • Rocchi, P.1    Jugpal, P.2    So, A.3    Sinneman, S.4    Ettinger, S.5    Fazli, L.6    Nelson, C.7    Gleave, M.8
  • 65
    • 68149132397 scopus 로고    scopus 로고
    • Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells
    • Zhu Q, Xu YM, Wang LF, Zhang Y, Wang F, Zhao J, Jia LT, Zhang WG, Yang AG (2009) Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells. Cancer Biol Ther 8:792-798
    • (2009) Cancer Biol Ther , vol.8 , pp. 792-798
    • Zhu, Q.1    Xu, Y.M.2    Wang, L.F.3    Zhang, Y.4    Wang, F.5    Zhao, J.6    Jia, L.T.7    Zhang, W.G.8    Yang, A.G.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.