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Volumn 39, Issue 7, 2012, Pages 7785-7793

Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt

Author keywords

Apoptosis; Leukemia; Quercetin

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE 2; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; QUERCETIN;

EID: 84864284249     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1621-0     Document Type: Article
Times cited : (60)

References (40)
  • 1
    • 0242662773 scopus 로고    scopus 로고
    • Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells
    • DOI 10.1016/j.fct.2003.08.014
    • Li YC et al (2004) Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells. Food Chem Toxicol 42(1):37-43 (Pubitemid 37421324)
    • (2004) Food and Chemical Toxicology , vol.42 , Issue.1 , pp. 37-43
    • Li, Y.C.1    Tyan, Y.S.2    Kuo, H.M.3    Chang, W.C.4    Hsia, T.C.5    Chung, J.G.6
  • 2
    • 0028067658 scopus 로고
    • Quercetin in our diet: From potent mutagen to probable anticarcinogen
    • Stavric B (1994) Quercetin in our diet: from potent mutagen to probable anticarcinogen. Clin Biochem 27:248
    • (1994) Clin Biochem , vol.27 , pp. 248
    • Stavric, B.1
  • 3
    • 0030775750 scopus 로고    scopus 로고
    • Relative bioavailability of the anti-oxidant flavonoid quercetin from various foods in man
    • Hollman PCH et al (1997) Relative bioavailability of the anti-oxidant flavonoid quercetin from various foods in man. FEBS Lett 418(1):156
    • (1997) FEBS Lett , vol.418 , Issue.1 , pp. 156
    • Hollman, P.C.H.1
  • 4
    • 55149124980 scopus 로고    scopus 로고
    • Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer mda-mb-453 cells
    • Choi EJ, Bae SM, Ahn WS (2008) Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells. Arch Pharmacol Res 31(10):1281-1285
    • (2008) Arch Pharmacol Res , vol.31 , Issue.10 , pp. 1281-1285
    • Choi, E.J.1    Bae, S.M.2    Ahn, W.S.3
  • 5
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C et al (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81(1 Suppl):230S-242S
    • (2005) Am J Clin Nutr , vol.81 , Issue.1 SUPPL.
    • Manach, C.1
  • 6
    • 34047109223 scopus 로고    scopus 로고
    • The epidemiology of childhood leukemia with a focus on birth weight and diet
    • DOI 10.1080/10408360601147536, PII 776296428
    • Tower RL, Spector LG (2007) The epidemiology of childhood leukemia with a focus on birth weight and diet. Crit Rev Clin Lab Sci 44(3):203-242 (Pubitemid 46525177)
    • (2007) Critical Reviews in Clinical Laboratory Sciences , vol.44 , Issue.3 , pp. 203-242
    • Tower, R.L.1    Spector, L.G.2
  • 7
    • 33746341468 scopus 로고    scopus 로고
    • Quercetin arrests g2/m phase and induces caspase-dependent cell death in u937 cells
    • Lee TJ et al (2006) Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells. Cancer Lett 240(2): 234-242
    • (2006) Cancer Lett , vol.240 , Issue.2 , pp. 234-242
    • Lee, T.J.1
  • 8
    • 0041709308 scopus 로고    scopus 로고
    • Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells
    • Mertens-Talcott SU, Talcott ST, Percival SS (2003) Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 133(8):2669-2674 (Pubitemid 36935989)
    • (2003) Journal of Nutrition , vol.133 , Issue.8 , pp. 2669-2674
    • Mertens-Talcott, S.U.1    Talcott, S.T.2    Percival, S.S.3
  • 11
    • 4644226020 scopus 로고    scopus 로고
    • Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in bad and hypophosphorylated retinoblastoma expressions
    • Ong CS et al (2004) Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in bad and hypophosphorylated retinoblastoma expressions. Oncol Rep 11(3):727-733
    • (2004) Oncol Rep , vol.11 , Issue.3 , pp. 727-733
    • Ong, C.S.1
  • 13
    • 73149092535 scopus 로고    scopus 로고
    • Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells
    • de Frias M et al (2009) Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Haematologica 94(12):1698-1707
    • (2009) Haematologica , vol.94 , Issue.12 , pp. 1698-1707
    • De Frias, M.1
  • 14
    • 0026726483 scopus 로고
    • The inhibition of phosphatidylinositol 3-Kinase by quercetin and analogs
    • Matter WF, Brown RF, Vlahos CJ (1992) The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem Biophys Res Commun 186(2):624-631
    • (1992) Biochem Biophys Res Commun , vol.186 , Issue.2 , pp. 624-631
    • Matter, W.F.1    Brown, R.F.2    Vlahos, C.J.3
  • 15
    • 0033634827 scopus 로고    scopus 로고
    • Structural determinants of phosphoino-sitide 3-Kinase inhibition by wortmannin, ly294002, quercetin, myricetin, and staurosporine
    • Walker EH et al (2000) Structural determinants of phosphoino-sitide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 6(4):909-919
    • (2000) Mol Cell , vol.6 , Issue.4 , pp. 909-919
    • Walker, E.H.1
  • 16
    • 0036708098 scopus 로고    scopus 로고
    • In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from eurycoma longifolia, a medicinal plant in southeast asia
    • Jiwajinda S et al (2002) In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol 82(1):55-58
    • (2002) J Ethnopharmacol , vol.82 , Issue.1 , pp. 55-58
    • Jiwajinda, S.1
  • 17
    • 0033601275 scopus 로고    scopus 로고
    • Connective tissue growth factor induces apoptosis in human breast cancer cell line mcf-7
    • Hishikawa K et al (1999) Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7. J Biol Chem 274(52):37461-37466
    • (1999) J Biol Chem , vol.274 , Issue.52 , pp. 37461-37466
    • Hishikawa, K.1
  • 18
    • 0035504914 scopus 로고    scopus 로고
    • Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: Cycloox-ygenases and lipoxygenases
    • Chi YS et al (2001) Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cycloox-ygenases and lipoxygenases. Biochem Pharmacol 62:1191
    • (2001) Biochem Pharmacol , vol.62 , pp. 1191
    • Chi, Y.S.1
  • 19
    • 33751082422 scopus 로고    scopus 로고
    • Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2)
    • Granado-Serrano AB et al (2006) Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr 136(11):2715-2721 (Pubitemid 44771763)
    • (2006) Journal of Nutrition , vol.136 , Issue.11 , pp. 2715-2721
    • Granado-Serrano, A.B.1    Martin, M.A.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 20
    • 33645836334 scopus 로고    scopus 로고
    • The antiproliferative effect of quercetin in cancer cells is mediated via inhibition of the pi3k-akt/pkb pathway
    • Gulati N et al (2006) The antiproliferative effect of quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. Anticancer Res 26:1181
    • (2006) Anticancer Res , vol.26 , pp. 1181
    • Gulati, N.1
  • 21
    • 2442623486 scopus 로고    scopus 로고
    • The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in a549 lung cancer cells
    • Nguyen T et al (2004) The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 25(5):647
    • (2004) Carcinogenesis , vol.25 , Issue.5 , pp. 647
    • Nguyen, T.1
  • 22
    • 0042268046 scopus 로고    scopus 로고
    • Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic hl-60 cells by alternative activation of the caspase 3 cascade
    • Shen SC et al (2003) Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. J Cell Biochem 89(5):1044-1055
    • (2003) J Cell Biochem , vol.89 , Issue.5 , pp. 1044-1055
    • Shen, S.C.1
  • 24
    • 33749249943 scopus 로고    scopus 로고
    • The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man
    • DOI 10.1080/10715760600771400, PII Q763861571422100, Polyphenols and Health
    • Jaganath IB et al (2006) The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radic Res 40(10):1035-1046 (Pubitemid 44480544)
    • (2006) Free Radical Research , vol.40 , Issue.10 , pp. 1035-1046
    • Jaganath, I.B.1    Mullen, W.2    Edwards, C.A.3    Crozier, A.4
  • 25
    • 33746698897 scopus 로고    scopus 로고
    • Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
    • DOI 10.1079/BJN20061809
    • Mullen W, Edwards CA, Crozier A (2006) Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl-and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Br J Nutr 96(1):107-116 (Pubitemid 44160903)
    • (2006) British Journal of Nutrition , vol.96 , Issue.1 , pp. 107-116
    • Mullen, W.1    Edwards, C.A.2    Crozier, A.3
  • 26
    • 77956106562 scopus 로고    scopus 로고
    • Alpha-oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans
    • Murota K et al (2010) Alpha-oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans. Arch Biochem Biophys 501(1):91-97
    • (2010) Arch Biochem Biophys , vol.501 , Issue.1 , pp. 91-97
    • Murota, K.1
  • 27
    • 77955284662 scopus 로고    scopus 로고
    • Oral bioavailability of quercetin from different quercetin glycosides in dogs
    • Reinboth M et al (2010) Oral bioavailability of quercetin from different quercetin glycosides in dogs. Br J Nutr 104(2):198-203
    • (2010) Br J Nutr , vol.104 , Issue.2 , pp. 198-203
    • Reinboth, M.1
  • 30
    • 0036172927 scopus 로고    scopus 로고
    • Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in bcl-2 expressing renal epithelial cells
    • DOI 10.1023/A:1013517013069
    • Carbott DE, Duan L, Davis MA (2002) Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. Apoptosis 7(1):69-76 (Pubitemid 34145393)
    • (2002) Apoptosis , vol.7 , Issue.1 , pp. 69-76
    • Carbott, D.E.1    Duan, L.2    Davis, M.A.3
  • 31
    • 44249109955 scopus 로고    scopus 로고
    • Role of bax in quercetin-induced apoptosis in human prostate cancer cells
    • Lee DH, Szczepanski M, Lee YJ (2008) Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Biochem Pharmacol 75(12):2345-2355
    • (2008) Biochem Pharmacol , vol.75 , Issue.12 , pp. 2345-2355
    • Lee, D.H.1    Szczepanski, M.2    Lee, Y.J.3
  • 32
    • 61349114196 scopus 로고    scopus 로고
    • Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells
    • Natsume Y et al (2009) Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells. Toxicology 258(2-3):164-175
    • (2009) Toxicology , vol.258 , Issue.2-3 , pp. 164-175
    • Natsume, Y.1
  • 34
    • 73949119120 scopus 로고    scopus 로고
    • Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: The therapeutic potential of akt inhibition
    • Zhuang J et al (2009) Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica 95(1):118
    • (2009) Haematologica , vol.95 , Issue.1 , pp. 118
    • Zhuang, J.1
  • 35
    • 23044500473 scopus 로고    scopus 로고
    • Flavonoid quercetin, but not apigenin or luteolin, induced apoptosis in human myeloid leukemia cells and their resistant variants
    • Duraj J et al (2005) Flavonoid quercetin, but not apigenin or luteolin, induced apoptosis in human myeloid leukemia cells and their resistant variants. Neoplasma 52(4):279
    • (2005) Neoplasma , vol.52 , Issue.4 , pp. 279
    • Duraj, J.1
  • 36
    • 77957319672 scopus 로고    scopus 로고
    • Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer mcf-7 cells
    • Chou CC et al (2010) Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. Arch Pharmacol Res 33(8):1181-1191
    • (2010) Arch Pharmacol Res , vol.33 , Issue.8 , pp. 1181-1191
    • Chou, C.C.1
  • 37
    • 0037181478 scopus 로고    scopus 로고
    • Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6
    • DOI 10.1016/S0014-5793(02)02440-7, PII S0014579302024407
    • McGee MM et al (2002) Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1, 5-benzoxazepine, PBOX-6. FEBS Lett 515(1-3):66-70 (Pubitemid 34273899)
    • (2002) FEBS Letters , vol.515 , Issue.1-3 , pp. 66-70
    • Mc Gee, M.M.1    Hyland, E.2    Campiani, G.3    Ramunno, A.4    Nacci, V.5    Zisterer, D.M.6
  • 38
    • 70349680622 scopus 로고    scopus 로고
    • Quercetin-induced apoptosis acts through mitochondrial-and caspase-3-dependent pathways in human breast cancer mda-mb-231 cells
    • Chien SY et al (2009) Quercetin-induced apoptosis acts through mitochondrial-and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Hum Exp Toxicol 28(8):493
    • (2009) Hum Exp Toxicol , vol.28 , Issue.8 , pp. 493
    • Chien, S.Y.1
  • 39
    • 80054040531 scopus 로고    scopus 로고
    • Apoptosis-inducing effect of quercetin and kaempferol on human hl-60 cells and its mechanism
    • Ren HJ et al (2010) Apoptosis-inducing effect of quercetin and kaempferol on human HL-60 cells and its mechanism. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(3):629-633
    • (2010) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.18 , Issue.3 , pp. 629-633
    • Ren, H.J.1
  • 40
    • 67649946192 scopus 로고    scopus 로고
    • Quercetin inhibit human sw480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through wnt/beta-catenin signaling pathway
    • Shan BE, Wang MX, Li RQ (2009) Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Investig 6(27):612
    • (2009) Cancer Investig , vol.6 , Issue.27 , pp. 612
    • Shan, B.E.1    Wang, M.X.2    Li, R.Q.3


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