메뉴 건너뛰기




Volumn 33, Issue 2-3, 2014, Pages 567-579

Novel drugs targeting the androgen receptor pathway in prostate cancer

Author keywords

Abiraterone; Androgen receptor; CYP17; Enzalutamide; Prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS;

EID: 84905124852     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/s10555-013-9472-2     Document Type: Review
Times cited : (30)

References (111)
  • 1
    • 0001466821 scopus 로고
    • Surgical removal of the hypertrophied prostate
    • White W. (1893). Surgical removal of the hypertrophied prostate. Annals of Surgery, 18, 152-158.
    • (1893) Annals of Surgery , vol.18 , pp. 152-158
    • White, W.1
  • 2
    • 0004831844 scopus 로고
    • The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic glands in the lumbar region and in the pelvis
    • Adams, J. (1853). The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic glands in the lumbar region and in the pelvis. Lancet, 1, 393.
    • (1853) Lancet , vol.1 , pp. 393
    • Adams, J.1
  • 3
    • 84928580276 scopus 로고
    • The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prosta
    • Huggins, C., & Hodges, C. (1941). The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prosta. Cancer Research, 1, 293-297.
    • (1941) Cancer Research , vol.1 , pp. 293-297
    • Huggins, C.1    Hodges, C.2
  • 4
    • 0017858354 scopus 로고
    • Pituitary gonadotropin inhibition by a highly active analog of luteinizing hormone-releasing hormone
    • Sandow, J., Von Rechenberg, W., Jerzabek, G., & Stoll, W. (1978). Pituitary gonadotropin inhibition by a highly active analog of luteinizing hormone-releasing hormone. Fertility and Sterility, 30, 205-209. (Pubitemid 8383269)
    • (1978) Fertility and Sterility , vol.30 , Issue.2 , pp. 205-209
    • Sandow, J.1    Von Rechenberg, W.2    Jerzabek, G.3    Stoll, W.4
  • 5
    • 0021721387 scopus 로고
    • Leuprolide versus diethylstilbestrol for metastatic prostate cancer
    • The Leuprolide Study Group. The Leuprolide Study Group
    • The Leuprolide Study Group. (1984). Leuprolide versus diethylstilbestrol for metastatic prostate cancer. The Leuprolide Study Group. New England Journal of Medicine, 311, 1281-1286.
    • (1984) New England Journal of Medicine , vol.311 , pp. 1281-1286
  • 6
    • 0014639879 scopus 로고
    • A soluble androgen receptor in the cytoplasm of rat prostate
    • Mainwaring, W. I. (1969). A soluble androgen receptor in the cytoplasm of rat prostate. Journal of Endocrinology, 45, 531-541.
    • (1969) Journal of Endocrinology , vol.45 , pp. 531-541
    • Mainwaring, W.I.1
  • 7
    • 0014424444 scopus 로고
    • Selective retention of dihydrotestosterone by prostatic nuclei
    • 20
    • Anderson, K. M., & Liao, S. (1968). Selective retention of dihydrotestosterone by prostatic nuclei. Nature, 219, 277-279. 20.
    • (1968) Nature , vol.219 , pp. 277-279
    • Anderson, K.M.1    Liao, S.2
  • 8
    • 0014430280 scopus 로고
    • The intranuclear binding of testosterone and 5-alpha-androstan-17-beta- ol-3-one by rat prostate
    • 25
    • Bruchovsky, N., & Wilson, J. D. (1968). The intranuclear binding of testosterone and 5-alpha-androstan-17-beta-ol-3-one by rat prostate. Journal of Biological Chemistry, 243, 5953-5960. 25.
    • (1968) Journal of Biological Chemistry , vol.243 , pp. 5953-5960
    • Bruchovsky, N.1    Wilson, J.D.2
  • 10
    • 10344260143 scopus 로고    scopus 로고
    • A controlled trial of bicalutamide versus flutamide, each in combination with luteinizing hormone-releasing hormone analogue therapy, in patients with advanced prostate carcinoma. Analysis of time to progression
    • CASODEX Combination Study Group. 15
    • Schellhammer, P. F., Sharifi, R., Block, N. L., Soloway, M. S., Venner, P. M., Patterson, A. L., et al. (1996). A controlled trial of bicalutamide versus flutamide, each in combination with luteinizing hormone-releasing hormone analogue therapy, in patients with advanced prostate carcinoma. Analysis of time to progression. CASODEX Combination Study Group. Cancer, 78, 2164-2169. 15.
    • (1996) Cancer , vol.78 , pp. 2164-2169
    • Schellhammer, P.F.1    Sharifi, R.2    Block, N.L.3    Soloway, M.S.4    Venner, P.M.5    Patterson, A.L.6
  • 11
    • 33645690200 scopus 로고    scopus 로고
    • Mechanisms nnderlying the development of androgen-independent prostate cancer
    • 15
    • Pienta, K. J., & Bradley, D. (2006). Mechanisms nnderlying the development of androgen-independent prostate cancer. Clinical Cancer Research, 12, 1665-1671. 15.
    • (2006) Clinical Cancer Research , vol.12 , pp. 1665-1671
    • Pienta, K.J.1    Bradley, D.2
  • 17
    • 84861197052 scopus 로고    scopus 로고
    • Steroid biosynthesis and prostate cancer
    • Sharifi, N., & Auchus, R. J. (2012). Steroid biosynthesis and prostate cancer. Steroids, 77, 719-726.
    • (2012) Steroids , vol.77 , pp. 719-726
    • Sharifi, N.1    Auchus, R.J.2
  • 18
    • 79951665862 scopus 로고    scopus 로고
    • The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
    • Miller, W. L., & Auchus, R. J. (2011). The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocrine Reviews, 32, 81-151.
    • (2011) Endocrine Reviews , vol.32 , pp. 81-151
    • Miller, W.L.1    Auchus, R.J.2
  • 22
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • Pratt, W. B., & Toft, D. O. (1997). Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocrine Reviews, 18, 306-360.
    • (1997) Endocrine Reviews , vol.18 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 24
    • 67349225032 scopus 로고    scopus 로고
    • Coactivator selective regulation of androgen receptor activity
    • Agoulnik, I. U., & Weigel, N. L. (2009). Coactivator selective regulation of androgen receptor activity. Steroids, 74, 669-674.
    • (2009) Steroids , vol.74 , pp. 669-674
    • Agoulnik, I.U.1    Weigel, N.L.2
  • 25
    • 28544432178 scopus 로고    scopus 로고
    • Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer
    • DOI 10.1111/j.1464-410X.2005.05821.x
    • Attard, G., Belldegrun, A. S., & De Bono, J. S. (2005). Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU International, 96, 1241-1246. (Pubitemid 41743917)
    • (2005) BJU International , vol.96 , Issue.9 , pp. 1241-1246
    • Attard, G.1    Belldegrun, A.S.2    De Bono, J.S.3
  • 26
    • 0015657595 scopus 로고
    • Adrenalectomy and hypophysectomy for prostatic cancer
    • Brendler, H. (1973). Adrenalectomy and hypophysectomy for prostatic cancer. Urology, 2, 99-102.
    • (1973) Urology , vol.2 , pp. 99-102
    • Brendler, H.1
  • 27
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • Stanbrough, M., Bubley, G. J., Ross, K., Golub, T. R., Rubin, M. a., Penning, T. M., et al. (2006). Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Research, 66, 2815-2825.
    • (2006) Cancer Research , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3    Golub, T.R.4    Rubin, M.A.5    Penning, T.M.6
  • 28
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • Montgomery, R. B., Mostaghel, E. a., Vessella, R., Hess, D. L., Kalhorn, T. F., Higano, C. S., et al. (2008). Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Research, 68, 4447-4454.
    • (2008) Cancer Research , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5    Higano, C.S.6
  • 29
    • 0019841416 scopus 로고
    • Adaptation versus selection as the mechanism responsible for the relapse of prostatic cancer to androgen ablation therapy as studied in the Dunning R-3327-H adenocarcinoma
    • Isaacs, J. T., & Coffey, D. S. (1981). Adaptation versus selection as the mechanism responsible for the relapse of prostatic cancer to androgen ablation therapy as studied in the Dunning R-3327-H adenocarcinoma. Cancer Research, 41, 5070-5075.
    • (1981) Cancer Research , vol.41 , pp. 5070-5075
    • Isaacs, J.T.1    Coffey, D.S.2
  • 31
    • 76149107169 scopus 로고    scopus 로고
    • Androgen receptor expression is associated with prostate cancer-specific survival in castrate patients with metastatic disease
    • Donovan, M. J., Osman, I., Khan, F. M., Vengrenyuk, Y., Capodieci, P., Koscuiszka, M., et al. (2010). Androgen receptor expression is associated with prostate cancer-specific survival in castrate patients with metastatic disease. BJU International, 105, 462-467.
    • (2010) BJU International , vol.105 , pp. 462-467
    • Donovan, M.J.1    Osman, I.2    Khan, F.M.3    Vengrenyuk, Y.4    Capodieci, P.5    Koscuiszka, M.6
  • 32
    • 0033557839 scopus 로고    scopus 로고
    • Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays
    • 15
    • Bubendorf, L., Kononen, J., Koivisto, P., Schraml, P., Moch, H., Gasser, T. C., et al. (1999). Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays. Cancer Research, 59, 803-806. 15.
    • (1999) Cancer Research , vol.59 , pp. 803-806
    • Bubendorf, L.1    Kononen, J.2    Koivisto, P.3    Schraml, P.4    Moch, H.5    Gasser, T.C.6
  • 34
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm, S. M., Schmidt, L. J., Heemers, H. V., Vessella, R. L., & Tindall, D. J. (2008). Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Research, 68, 5469-5477.
    • (2008) Cancer Research , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 35
    • 70350244512 scopus 로고    scopus 로고
    • Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
    • 15
    • Waltering, K. K., Helenius, M. A., Sahu, B., Manni, V., Linja, M. J., Jänne, O. A., et al. (2009). Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens. Cancer Research, 69, 8141-8149. 15.
    • (2009) Cancer Research , vol.69 , pp. 8141-8149
    • Waltering, K.K.1    Helenius, M.A.2    Sahu, B.3    Manni, V.4    Linja, M.J.5    Jänne, O.A.6
  • 36
    • 0042130389 scopus 로고    scopus 로고
    • Androgen receptor mutations in androgen-independent prostate cancer: Cancer and leukemia group B study 9663
    • 15
    • Taplin, M.-E., Rajeshkumar, B., Halabi, S., Werner, C. P., Woda, B. a., Picus, J., et al. (2003). Androgen receptor mutations in androgen-independent prostate cancer: cancer and leukemia group B study 9663. Journal of Clinical Oncology, 21, 2673-2678. 15.
    • (2003) Journal of Clinical Oncology , vol.21 , pp. 2673-2678
    • Taplin, M.-E.1    Rajeshkumar, B.2    Halabi, S.3    Werner, C.P.4    Woda, B.A.5    Picus, J.6
  • 37
    • 0037187408 scopus 로고    scopus 로고
    • Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer
    • 28
    • Matias, P. M., Carrondo, M. A., Coelho, R., Thomaz, M., Zhao, X.-Y., Wegg, A., et al. (2002). Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer. Journal of Medicinal Chemistry, 45, 1439-1446. 28.
    • (2002) Journal of Medicinal Chemistry , vol.45 , pp. 1439-1446
    • Matias, P.M.1    Carrondo, M.A.2    Coelho, R.3    Thomaz, M.4    Zhao, X.-Y.5    Wegg, A.6
  • 38
    • 0031032651 scopus 로고    scopus 로고
    • The regulation of 17,20 lyase activity
    • DOI 10.1016/S0039-128X(96)00172-9, PII S0039128X96001720
    • Miller, W. L., Auchus, R. J., & Geller, D. H. (1997). The regulation of 17,20 lyase activity. Steroids, 62, 133-142. (Pubitemid 27066997)
    • (1997) Steroids , vol.62 , Issue.1 , pp. 133-142
    • Miller, W.L.1    Auchus, R.J.2    Geller, D.H.3
  • 39
    • 84856774377 scopus 로고    scopus 로고
    • Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer
    • Attard, G., Reid, A. H. M., Auchus, R. J., Hughes, B. A., Cassidy, A. M., Thompson, E., et al. (2012). Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer. Journal of Clinical Endocrinology and Metabolism, 97, 507-516.
    • (2012) Journal of Clinical Endocrinology and Metabolism , vol.97 , pp. 507-516
    • Attard, G.1    Reid, A.H.M.2    Auchus, R.J.3    Hughes, B.A.4    Cassidy, A.M.5    Thompson, E.6
  • 40
    • 84948006407 scopus 로고
    • Ketoconazole blocks testosterone synthesis
    • DOI 10.1001/archinte.142.12.2137
    • Pont, A., Williams, P. L., Azhar, S., Reitz, R. E., Bochra, C., Smith, E. R., et al. (1982). Ketoconazole blocks testosterone synthesis. Archives of Internal Medicine, 142, 2137-2140. (Pubitemid 12007067)
    • (1982) Archives of Internal Medicine , vol.142 , Issue.12 , pp. 2137-2140
    • Pont, A.1    Williams, P.L.2    Azhar, S.3
  • 41
    • 0038062686 scopus 로고    scopus 로고
    • Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo
    • DOI 10.1016/S0960-0760(03)00070-0
    • Haidar, S., Ehmer, P. B., Barassin, S., Batzl-Hartmann, C., & Hartmann, R. W. (2003). Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo. Journal of Steroid Biochemistry and Molecular Biology, 84, 555-562. (Pubitemid 36588809)
    • (2003) Journal of Steroid Biochemistry and Molecular Biology , vol.84 , Issue.5 , pp. 555-562
    • Haidar, S.1    Ehmer, P.B.2    Barassin, S.3    Batzl-Hartmann, C.4    Hartmann, R.W.5
  • 43
  • 44
    • 0029058770 scopus 로고
    • Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): Potential agents for the treatment of prostatic cancer
    • 23
    • Potter, G. A., Barrie, S. E., Jarman, M., & Rowlands, M. G. (1995). Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. Journal of Medicinal Chemistry, 38, 2463-2471. 23.
    • (1995) Journal of Medicinal Chemistry , vol.38 , pp. 2463-2471
    • Potter, G.A.1    Barrie, S.E.2    Jarman, M.3    Rowlands, M.G.4
  • 45
    • 68949094223 scopus 로고    scopus 로고
    • Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer
    • 10
    • Attard, G., Reid, A. H. M., A'Hern, R., Parker, C., Oommen, N. B., Folkerd, E., et al. (2009). Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer. Journal of Clinical Oncology, 27, 3742-3748. 10.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 3742-3748
    • Attard, G.1    Reid, A.H.M.2    A'Hern, R.3    Parker, C.4    Oommen, N.B.5    Folkerd, E.6
  • 46
    • 3042784503 scopus 로고    scopus 로고
    • Hormonal impact of the 17alphahydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer
    • 14
    • O'Donnell, A., Judson, I., Dowsett, M., Raynaud, F., Dearnaley, D., Mason, M., et al. (2004). Hormonal impact of the 17alphahydroxylase/C(17,20)- lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. British Journal of Cancer, 90, 2317-2325. 14.
    • (2004) British Journal of Cancer , vol.90 , pp. 2317-2325
    • O'Donnell, A.1    Judson, I.2    Dowsett, M.3    Raynaud, F.4    Dearnaley, D.5    Mason, M.6
  • 47
    • 77951518711 scopus 로고    scopus 로고
    • Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
    • 20
    • Reid, A. H. M., Attard, G., Danila, D. C., Oommen, N. B., Olmos, D., Fong, P. C., et al. (2010). Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. Journal of Clinical Oncology, 28, 1489-1495. 20.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 1489-1495
    • Reid, A.H.M.1    Attard, G.2    Danila, D.C.3    Oommen, N.B.4    Olmos, D.5    Fong, P.C.6
  • 48
    • 0024237507 scopus 로고
    • Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture
    • DOI 10.1016/0022-4731(88)90295-6
    • Luthy, I. A., Begin, D. J., & Labrie, F. (1988). Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. Journal of Steroid Biochemistry, 31, 845-852. (Pubitemid 19006901)
    • (1988) Journal of Steroid Biochemistry , vol.31 , Issue.5 , pp. 845-852
    • Luthy, I.A.1    Begin, D.J.2    Labrie, F.3
  • 49
    • 70749101076 scopus 로고    scopus 로고
    • Steroid hormone receptors in prostate cancer: A hard habit to break?
    • 8
    • Attard, G., Cooper, C. S.,& De Bono, J. S. (2009). Steroid hormone receptors in prostate cancer: a hard habit to break? Cancer Cell, 16, 458-462. 8.
    • (2009) Cancer Cell , vol.16 , pp. 458-462
    • Attard, G.1    Cooper, C.S.2    De Bono, J.S.3
  • 50
    • 77951523950 scopus 로고    scopus 로고
    • Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
    • 20
    • Ryan, C. J., Smith, M. R., Fong, L., Rosenberg, J. E., Kantoff, P., Raynaud, F., et al. (2010). Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. Journal of Clinical Oncology, 28, 1481-1488. 20.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 1481-1488
    • Ryan, C.J.1    Smith, M.R.2    Fong, L.3    Rosenberg, J.E.4    Kantoff, P.5    Raynaud, F.6
  • 51
    • 77951591066 scopus 로고    scopus 로고
    • Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer
    • 20
    • Danila, D. C., Morris, M. J., De Bono, J. S., Ryan, C. J., Denmeade, S. R., Smith, M. R., et al. (2010). Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer. Journal of Clinical Oncology, 28, 1496-1501. 20.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 1496-1501
    • Danila, D.C.1    Morris, M.J.2    De Bono, J.S.3    Ryan, C.J.4    Denmeade, S.R.5    Smith, M.R.6
  • 52
    • 84870243969 scopus 로고    scopus 로고
    • Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: Exploratory analysis of data from the COU-AA-301 randomised trial
    • Logothetis, C. J., Basch, E., Molina, A., Fizazi, K., North, S. A., Chi, K. N., et al. (2012). Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised trial. Lancet Oncology, 13, 1210-1217.
    • (2012) Lancet Oncology , vol.13 , pp. 1210-1217
    • Logothetis, C.J.1    Basch, E.2    Molina, A.3    Fizazi, K.4    North, S.A.5    Chi, K.N.6
  • 53
    • 3242754330 scopus 로고    scopus 로고
    • 17,20-lyase inhibitors
    • DOI 10.1016/j.bmc.2004.06.016, PII S0968089604004481
    • Matsunaga, N., Kaku, T., Ojida, A., Tanaka, T., Hara, T., Yamaoka, M., et al. (2004). C(17,20)-lyase inhibitors. Part 2: design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C(17,20)-lyase inhibitors. Bioorganic & Medicinal Chemistry, 12, 4313-4336. (Pubitemid 39055637)
    • (2004) Bioorganic and Medicinal Chemistry , vol.12 , Issue.16 , pp. 4313-4336
    • Matsunaga, N.1    Kaku, T.2    Ojida, A.3    Tanaka, T.4    Hara, T.5    Yamaoka, M.6    Kusaka, M.7    Tasaka, A.8
  • 54
    • 84858228703 scopus 로고    scopus 로고
    • Orteronel (TAK-700), a novel nonsteroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys
    • Yamaoka, M., Hara, T., Hitaka, T., Kaku, T., Takeuchi, T., Takahashi, J., et al. (2012). Orteronel (TAK-700), a novel nonsteroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. The Journal of Steroid Biochemistry and Molecular Biology, 129, 115-128.
    • (2012) The Journal of Steroid Biochemistry and Molecular Biology , vol.129 , pp. 115-128
    • Yamaoka, M.1    Hara, T.2    Hitaka, T.3    Kaku, T.4    Takeuchi, T.5    Takahashi, J.6
  • 56
    • 84867615161 scopus 로고    scopus 로고
    • A phase III, randomized, double-blind, multicenter trial comparing the investigational agent orteronel (TAK-700) plus prednisone (P) with placebo plus P in patients with metastatic castration-resistant prostate cancer (mCRPC) that has progressed during or following docetaxel-based chemotherapy
    • [abstract]. 2012 abstr TPS4693
    • Dreicer, R., Agus, D. B., Bellmunt, J., De Bono, J. S., Petrylak, D., Tejura, B., et al. (2012). A phase III, randomized, double-blind, multicenter trial comparing the investigational agent orteronel (TAK-700) plus prednisone (P) with placebo plus P in patients with metastatic castration-resistant prostate cancer (mCRPC) that has progressed during or following docetaxel-based chemotherapy [abstract]. Journal of Clinical Oncology, 30, 2012 (suppl; abstr TPS4693).
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.SUPPL.
    • Dreicer, R.1    Agus, D.B.2    Bellmunt, J.3    De Bono, J.S.4    Petrylak, D.5    Tejura, B.6
  • 57
    • 84860870765 scopus 로고    scopus 로고
    • Safety, efficacy, and pharmacodynamics of the investigational agent orteronel (TAK-700) in metastatic castration-resistant prostate cancer (mCRPC): Updated data from a phase I/II study
    • [abstract]. 30, 2012 abstr 98
    • Agus, D. B., Stadler, W. M., Shevrin, D. H., Hart, L., Macvicar, G. R., Hainsworth, J. D., et al. (2012). Safety, efficacy, and pharmacodynamics of the investigational agent orteronel (TAK-700) in metastatic castration-resistant prostate cancer (mCRPC): updated data from a phase I/II study. [abstract]. Journal of Clinical Oncology, 50, 50-51. 30, 2012 (suppl 5; abstr 98).
    • (2012) Journal of Clinical Oncology , vol.50 , Issue.SUPPL. 5 , pp. 50-51
    • Agus, D.B.1    Stadler, W.M.2    Shevrin, D.H.3    Hart, L.4    Macvicar, G.R.5    Hainsworth, J.D.6
  • 58
    • 20944449560 scopus 로고    scopus 로고
    • Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: Synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model
    • 21
    • Handratta, V. D., Vasaitis, T. S., Njar, V. C. O., Gediya, L. K., Kataria, R., Chopra, P., et al. (2005). Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. Journal of Medicinal Chemistry, 48, 2972-2984. 21.
    • (2005) Journal of Medicinal Chemistry , vol.48 , pp. 2972-2984
    • Handratta, V.D.1    Vasaitis, T.S.2    Njar, V.C.O.3    Gediya, L.K.4    Kataria, R.5    Chopra, P.6
  • 59
    • 53349101498 scopus 로고    scopus 로고
    • Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole- 1-yl)androsta-5,16-diene in prostate cancer
    • Vasaitis, T., Belosay, A., Schayowitz, A., Khandelwal, A., Chopra, P., Gediya, L. K., et al. (2008). Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer. Molecular Cancer Therapeutics, 7, 2348-2357.
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 2348-2357
    • Vasaitis, T.1    Belosay, A.2    Schayowitz, A.3    Khandelwal, A.4    Chopra, P.5    Gediya, L.K.6
  • 60
    • 84856477784 scopus 로고    scopus 로고
    • Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
    • DeVore, N. M., & Scott, E. E. (2012). Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001. Nature, 482(7383), 116-119.
    • (2012) Nature , vol.482 , Issue.7383 , pp. 116-119
    • DeVore, N.M.1    Scott, E.E.2
  • 61
    • 78650809385 scopus 로고    scopus 로고
    • A modeling and simulation framework to support early clinical drug development decisions in oncology
    • Bruno, R., Lu, J.-F., Sun, Y.-N., & Claret, L. (2011). A modeling and simulation framework to support early clinical drug development decisions in oncology. Journal of Clinical Pharmacology, 51, 6-8.
    • (2011) Journal of Clinical Pharmacology , vol.51 , pp. 6-8
    • Bruno, R.1    Lu, J.-F.2    Sun, Y.-N.3    Claret, L.4
  • 62
    • 38349186341 scopus 로고    scopus 로고
    • Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro
    • Schayowitz, A., Sabnis, G., Njar, V. C. O., & Brodie, A. M. H. (2008). Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro. Molecular Cancer Therapeutics, 7, 121-132.
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 121-132
    • Schayowitz, A.1    Sabnis, G.2    Njar, V.C.O.3    Brodie, A.M.H.4
  • 63
    • 84870908111 scopus 로고    scopus 로고
    • Phase I clinical trial of galeterone (TOK-001), a multifunctional antiandrogen and CYP17 inhibitor in castration resistant prostate cancer (CRPC)
    • [abstract]. 2012 abstr 4665. 2012
    • Montgomery, R. B., Eisenberger, M. a., Rettig, M., Chu, F., Pili, R., Stephenson, J., et al. (2012). Phase I clinical trial of galeterone (TOK-001), a multifunctional antiandrogen and CYP17 inhibitor in castration resistant prostate cancer (CRPC). [abstract]. Journal of Clinical Oncology, 30, 2012 (suppl; abstr 4665). 2012.
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.SUPPL.
    • Montgomery, R.B.1    Eisenberger, M.A.2    Rettig, M.3    Chu, F.4    Pili, R.5    Stephenson, J.6
  • 64
    • 84879868368 scopus 로고    scopus 로고
    • Assessment of Steroid Hormones Upstream of P450c17 (CYP17) in Chemically Castrate Male Rhesus Monkeys Following Treatment with the CYP17 Inhibitors VT-464 and Abiraterone Acetate (AA)
    • [abstract]. 2012; (03-MeetingAbstracts): Sat 266
    • Eisner, J. R., Aboott, D., I. M. B, Rafferty, S. W., Schotzinger, R. J. (2012). Assessment of Steroid Hormones Upstream of P450c17 (CYP17) in Chemically Castrate Male Rhesus Monkeys Following Treatment with the CYP17 Inhibitors VT-464 and Abiraterone Acetate (AA) [abstract]. Endocrine Reviews, 2012; Vol 33 (03-MeetingAbstracts): Sat 266.
    • (2012) Endocrine Reviews , vol.33
    • Eisner, J.R.1    Aboott, D.2    B, I.M.3    Rafferty, S.W.4    Schotzinger, R.J.5
  • 65
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran, C., Ouk, S., Clegg, N. J., Chen, Y., Watson, P. A., Wongvipat, J., et al. (2009). Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science, 324, 787-790.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3    Chen, Y.4    Watson, P.A.5    Wongvipat, J.6
  • 66
    • 84879067087 scopus 로고    scopus 로고
    • Overcoming mutation-based resistance to antiandrogens with rational drug design
    • Balbas, M. D., Evans, M. J., Hosfield, D. J., Wongvipat, J., Arora, V. K., Watson, P. a., et al. (2013). Overcoming mutation-based resistance to antiandrogens with rational drug design. eLife, 2, e00499.
    • (2013) eLife , vol.2
    • Balbas, M.D.1    Evans, M.J.2    Hosfield, D.J.3    Wongvipat, J.4    Arora, V.K.5    Watson, P.A.6
  • 67
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour activity of MDV3100 in castration-resistant prostate cancer: A phase 1-2 study
    • Scher, H. I., Beer, T. M., Higano, C. S., Anand, A., Taplin, M.-E., Efstathiou, E., et al. (2010). Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet, 375, 1437-1446.
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1    Beer, T.M.2    Higano, C.S.3    Anand, A.4    Taplin, M.-E.5    Efstathiou, E.6
  • 68
    • 0034865645 scopus 로고    scopus 로고
    • GABAergic mechanisms in epilepsy
    • Treiman, D. M. (2001). GABAergic mechanisms in epilepsy. Epilepsia, 42(Suppl 3), 8-12.
    • (2001) Epilepsia , vol.42 , Issue.SUPPL. 3 , pp. 8-12
    • Treiman, D.M.1
  • 70
    • 84870868470 scopus 로고    scopus 로고
    • A phase I study of the androgen signaling inhibitor ARN-509 in patients with metastatic castration-resistant prostate cancer (mCRPC)
    • [abstract]. 2012 abstr 4548. 2012
    • Rathkopf, D. E., Morris, M. J., Danila, D. C., Slovin, S., Steinbrecher, J., Arauz, G., et al. (2012). A phase I study of the androgen signaling inhibitor ARN-509 in patients with metastatic castration-resistant prostate cancer (mCRPC) [abstract]. Journal of Clinical Oncology, 30, 2012 (suppl; abstr 4548). 2012.
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.SUPPL.
    • Rathkopf, D.E.1    Morris, M.J.2    Danila, D.C.3    Slovin, S.4    Steinbrecher, J.5    Arauz, G.6
  • 71
    • 84873847379 scopus 로고    scopus 로고
    • Arn-509 in men with high risk non-metastatic castration-resistant prostate cancer
    • [abstract]. abst 920
    • Smith, M., Antonarakis, E. S., Ryan, C. J., Berry, W., Shore, N., Liu, G., et al. (2012) Arn-509 in men with high risk non-metastatic castration-resistant prostate cancer [abstract]. Annals of Oncology, 23 (suppl 9) abst 920.
    • (2012) Annals of Oncology , vol.23 , Issue.SUPPL. 9
    • Smith, M.1    Antonarakis, E.S.2    Ryan, C.J.3    Berry, W.4    Shore, N.5    Liu, G.6
  • 72
    • 84873804151 scopus 로고    scopus 로고
    • Arn-509 in men with metastatic castration-resistant prostate cancer (CRPC)
    • [abstract]. abst 964
    • Rathkopf, D. E., Antonarakis, E. S., Shore, N., Tutrone, R., Amlukai, J., Ryan, C. J., et al. (2012). Arn-509 in men with metastatic castration-resistant prostate cancer (CRPC) [abstract]. Annals of Oncology, 23 (suppl 9) abst 964.
    • (2012) Annals of Oncology , vol.23 , Issue.SUPPL. 9
    • Rathkopf, D.E.1    Antonarakis, E.S.2    Shore, N.3    Tutrone, R.4    Amlukai, J.5    Ryan, C.J.6
  • 74
    • 84873877215 scopus 로고    scopus 로고
    • Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer
    • abstract
    • Loddick, S. a., Bradbury, R., Broadbent, N., Campbell, H., Gaughan, L., Growcott, J., et al. (2012). Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer [abstract]. Cancer Research, 72, 3848-3848.
    • (2012) Cancer Research , vol.72 , pp. 3848-3848
    • Loddick, S.A.1    Bradbury, R.2    Broadbent, N.3    Campbell, H.4    Gaughan, L.5    Growcott, J.6
  • 75
    • 84897932032 scopus 로고    scopus 로고
    • A first-in-human study of the oral selective androgen receptor down-regulating drug (SARD) AZD3514 in patients with castration-resistant prostate cancer (CRPC)
    • [abstract]. 2013 abstr 4511
    • Omlin, A., Jones, R. J., vn der Noll, R., Graham, J., Ong, M., Schellens, J. H. M., et al. (2013). A first-in-human study of the oral selective androgen receptor down-regulating drug (SARD) AZD3514 in patients with castration-resistant prostate cancer (CRPC) [abstract]. Journal of Clinical Oncology, 31, 2013 (suppl; abstr 4511).
    • (2013) Journal of Clinical Oncology , vol.31 , Issue.SUPPL.
    • Omlin, A.1    Jones, R.J.2    Vn Der Noll, R.3    Graham, J.4    Ong, M.5    Schellens, J.H.M.6
  • 76
    • 84873839629 scopus 로고    scopus 로고
    • ARADES trial: A first- in-man, openlabel, phase I/II safety, pharmacokinetic, and proof-of-concept study of ODM-201 in patients (pts) with progressive metastatic castration-resistant prostate cancer (mCRPC)
    • [abstract]. abst LBA25
    • Massard, C., James, N., Culine, S., Jones, R., Vuorela, A., Mustonen, M., et al. (2012). ARADES trial: a first- in-man, openlabel, phase I/II safety, pharmacokinetic, and proof-of-concept study of ODM-201 in patients (pts) with progressive metastatic castration-resistant prostate cancer (mCRPC) [abstract]. Annals of Oncology, 23 (suppl 9) abst LBA25.
    • (2012) Annals of Oncology , vol.23 , Issue.SUPPL. 9
    • Massard, C.1    James, N.2    Culine, S.3    Jones, R.4    Vuorela, A.5    Mustonen, M.6
  • 77
    • 69249083981 scopus 로고    scopus 로고
    • Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer
    • Attar, R. M., Jure-Kunkel, M., Balog, A., Cvijic, M. E., Dell-John, J., Rizzo, C. A., et al. (2009). Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer. Cancer Research, 69, 6522-6530.
    • (2009) Cancer Research , vol.69 , pp. 6522-6530
    • Attar, R.M.1    Jure-Kunkel, M.2    Balog, A.3    Cvijic, M.E.4    Dell-John, J.5    Rizzo, C.A.6
  • 78
    • 79951840577 scopus 로고    scopus 로고
    • Phase I dose-escalation study of the novel antiandrogen BMS-641988 in patients with castration-resistant prostate cancer
    • Rathkopf, D., Liu, G., Carducci, M. A., Eisenberger, M. A., Anand, A., Morris, M. J., et al. (2011). Phase I dose-escalation study of the novel antiandrogen BMS-641988 in patients with castration-resistant prostate cancer. Clinical Cancer Research, 17, 880-887.
    • (2011) Clinical Cancer Research , vol.17 , pp. 880-887
    • Rathkopf, D.1    Liu, G.2    Carducci, M.A.3    Eisenberger, M.A.4    Anand, A.5    Morris, M.J.6
  • 79
    • 0036786205 scopus 로고    scopus 로고
    • Mechanism of antiandrogen action: Key role of hsp90 in conformational change and transcriptional activity of the androgen receptor
    • Georget, V., Térouanne, B., Nicolas, J.-C., & Sultan, C. (2002). Mechanism of antiandrogen action: key role of hsp90 in conformational change and transcriptional activity of the androgen receptor. Biochemistry, 41, 11824-11831.
    • (2002) Biochemistry , vol.41 , pp. 11824-11831
    • Georget, V.1    Térouanne, B.2    Nicolas, J.-C.3    Sultan, C.4
  • 80
    • 28844481089 scopus 로고    scopus 로고
    • Molecular chaperones throughout the life cycle of the androgen receptor
    • Prescott, J., & Coetzee, G. A. (2006). Molecular chaperones throughout the life cycle of the androgen receptor. Cancer Letters, 231, 12-19.
    • (2006) Cancer Letters , vol.231 , pp. 12-19
    • Prescott, J.1    Coetzee, G.A.2
  • 81
    • 34047241332 scopus 로고    scopus 로고
    • The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells
    • DOI 10.1002/pros.20541
    • Saporita, A. J., Ai, J., & Wang, Z. (2007). The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells. Prostate, 67, 509-520. (Pubitemid 46536944)
    • (2007) Prostate , vol.67 , Issue.5 , pp. 509-520
    • Saporita, A.J.1    Ai, J.2    Wang, Z.3
  • 82
    • 56249138279 scopus 로고    scopus 로고
    • Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells
    • Tsui, K.-H., Feng, T.-H., Lin, C.-M., Chang, P.-L., Juang, H.-H. (2008). Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells. Journal of Andrology, 29, 661-668.
    • (2008) Journal of Andrology , vol.29 , pp. 661-668
    • Tsui, K.-H.1    Feng, T.-H.2    Lin, C.-M.3    Chang, P.-L.4    Juang, H.-H.5
  • 83
    • 80052330412 scopus 로고    scopus 로고
    • Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer
    • Oh, W. K., Galsky, M. D., Stadler, W. M., Srinivas, S., Chu, F., Bubley, G., et al. (2011). Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer. Urology, 78, 626-630.
    • (2011) Urology , vol.78 , pp. 626-630
    • Oh, W.K.1    Galsky, M.D.2    Stadler, W.M.3    Srinivas, S.4    Chu, F.5    Bubley, G.6
  • 84
    • 35948950583 scopus 로고    scopus 로고
    • Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity
    • DOI 10.1158/0008-5472.CAN-07-2057
    • Zoubeidi, A., Zardan, A., Beraldi, E., Fazli, L., Sowery, R., Rennie, P., et al. (2007). Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity. Cancer Research, 67, 10455-10465. (Pubitemid 350070821)
    • (2007) Cancer Research , vol.67 , Issue.21 , pp. 10455-10465
    • Zoubeidi, A.1    Zardan, A.2    Beraldi, E.3    Fazli, L.4    Sowery, R.5    Rennie, P.6    Nelson, C.7    Gleave, M.E.8
  • 85
    • 28244456529 scopus 로고    scopus 로고
    • Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis
    • DOI 10.1158/0008-5472.CAN-05-1840
    • Rocchi, P., Beraldi, E., Ettinger, S., Fazli, L., Vessella, R. L., Nelson, C., et al. (2005). Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis. Cancer Research, 65, 11083-11093. (Pubitemid 41713379)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 11083-11093
    • Rocchi, P.1    Beraldi, E.2    Ettinger, S.3    Fazli, L.4    Vessella, R.L.5    Nelson, C.6    Gleave, M.7
  • 86
    • 77950518207 scopus 로고    scopus 로고
    • Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E
    • Andrieu, C., Taieb, D., Baylot, V., Ettinger, S., Soubeyran, P., De-Thonel, A., et al. (2010). Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. Oncogene, 29, 1883-1896.
    • (2010) Oncogene , vol.29 , pp. 1883-1896
    • Andrieu, C.1    Taieb, D.2    Baylot, V.3    Ettinger, S.4    Soubeyran, P.5    De-Thonel, A.6
  • 87
    • 84877855030 scopus 로고    scopus 로고
    • Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer
    • Shiota, M., Bishop, J. L., Nip, K. M., Zardan, A., Takeuchi, A., Cordonnier, T., et al. (2013). Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer. Cancer Research, 73, 3109-3119.
    • (2013) Cancer Research , vol.73 , pp. 3109-3119
    • Shiota, M.1    Bishop, J.L.2    Nip, K.M.3    Zardan, A.4    Takeuchi, A.5    Cordonnier, T.6
  • 88
    • 84873742677 scopus 로고    scopus 로고
    • A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC)
    • [abstract]. 2012 abstr 4514. 2012
    • Chi, K. N., Hotte, S. J., Ellard, S. L., Gingerich, J., Joshua, A., Yu, E. Y., et al. (2012). A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC). [abstract]. Journal of Clinical Oncology, 30, 2012 (suppl; abstr 4514). 2012.
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.SUPPL.
    • Chi, K.N.1    Hotte, S.J.2    Ellard, S.L.3    Gingerich, J.4    Joshua, A.5    Yu, E.Y.6
  • 89
    • 77957957234 scopus 로고    scopus 로고
    • Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer
    • Chi, K. N., Hotte, S. J., Yu, E. Y., Tu, D., Eigl, B. J., Tannock, I., et al. (2010). Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer. Journal of Clinical Oncology, 28, 4247-4254.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 4247-4254
    • Chi, K.N.1    Hotte, S.J.2    Yu, E.Y.3    Tu, D.4    Eigl, B.J.5    Tannock, I.6
  • 91
    • 80052808323 scopus 로고    scopus 로고
    • Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
    • Darshan, M. S., Loftus, M. S., Thadani-Mulero, M., Levy, B. P., Escuin, D., Zhou, X. K., et al. (2011). Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer. Cancer Research, 71, 6019-6029.
    • (2011) Cancer Research , vol.71 , pp. 6019-6029
    • Darshan, M.S.1    Loftus, M.S.2    Thadani-Mulero, M.3    Levy, B.P.4    Escuin, D.5    Zhou, X.K.6
  • 92
    • 0032811602 scopus 로고    scopus 로고
    • Making drugs out of oligonucleotides: A brief review and perspective
    • Cook, P. D. (1999). Making drugs out of oligonucleotides: a brief review and perspective. Nucleosides& Nucleotides, 18, 1141-1162.
    • (1999) Nucleosides& Nucleotides , vol.18 , pp. 1141-1162
    • Cook, P.D.1
  • 94
    • 83355163334 scopus 로고    scopus 로고
    • Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer
    • Zhang, Y., Castaneda, S., Dumble, M., Wang, M., Mileski, M., Qu, Z., et al. (2011). Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer. Molecular Cancer Therapeutics, 10, 2309-2319.
    • (2011) Molecular Cancer Therapeutics , vol.10 , pp. 2309-2319
    • Zhang, Y.1    Castaneda, S.2    Dumble, M.3    Wang, M.4    Mileski, M.5    Qu, Z.6
  • 95
    • 84887841103 scopus 로고    scopus 로고
    • First-in-human phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide (LNA-ASO) to androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC)
    • [abstract]. abstr 5052
    • Bianchini, D., Omlin, A., Pezaro, C., Mukherji, D., Lorente Estelles. D., Zivi, A., et al. (2013). First-in-human phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide (LNA-ASO) to androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC) [abstract]. Journal of Clinical Oncology, 31 (suppl; abstr 5052).
    • (2013) Journal of Clinical Oncology , vol.31 , Issue.SUPPL.
    • Bianchini, D.1    Omlin, A.2    Pezaro, C.3    Mukherji, D.4    Lorente Estelles, D.5    Zivi, A.6
  • 96
    • 84860523917 scopus 로고    scopus 로고
    • Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: A rationale for increasing abiraterone exposure or combining with MDV3100
    • Richards, J., Lim, A. C., Hay, C. W., Taylor, A. E., Wingate, A., Nowakowska, K., et al. (2012). Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Research, 72, 2176-2182.
    • (2012) Cancer Research , vol.72 , pp. 2176-2182
    • Richards, J.1    Lim, A.C.2    Hay, C.W.3    Taylor, A.E.4    Wingate, A.5    Nowakowska, K.6
  • 97
    • 84882789820 scopus 로고    scopus 로고
    • Antitumour activity of abiraterone acetate againstmetastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100)
    • Loriot, Y., Bianchini, D., Ileana, E., Sandhu, S., Patrikidou, A., Pezaro, C., et al. (2013). Antitumour activity of abiraterone acetate againstmetastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100). Annals of Oncology, 24(7), 1807-1812.
    • (2013) Annals of Oncology , vol.24 , Issue.7 , pp. 1807-1812
    • Loriot, Y.1    Bianchini, D.2    Ileana, E.3    Sandhu, S.4    Patrikidou, A.5    Pezaro, C.6
  • 98
    • 84882799782 scopus 로고    scopus 로고
    • Clinical activity of abiraterone acetate in patients with metastatic castration-resistant prostate cancer progressing after enzalutamide
    • Noonan, K. L., North, S., Bitting, R. L., Armstrong, a. J., Ellard, S. L., & Chi, K. N. (2013). Clinical activity of abiraterone acetate in patients with metastatic castration-resistant prostate cancer progressing after enzalutamide. Annals of Oncology, 24(7), 1802-1807.
    • (2013) Annals of Oncology , vol.24 , Issue.7 , pp. 1802-1807
    • Noonan, K.L.1    North, S.2    Bitting, R.L.3    Armstrong, A.J.4    Ellard, S.L.5    Chi, K.N.6
  • 99
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning, B. D., & Cantley, L. C. (2007). AKT/PKB signaling: navigating downstream. Cell, 129, 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 100
    • 84872808630 scopus 로고    scopus 로고
    • The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way
    • Mediwala, S. N., Sun, H., Szafran, A. T., Hartig, S. M., Sonpavde, G., Hayes, T. G., et al. (2013). The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way. Prostate, 73, 267-277.
    • (2013) Prostate , vol.73 , pp. 267-277
    • Mediwala, S.N.1    Sun, H.2    Szafran, A.T.3    Hartig, S.M.4    Sonpavde, G.5    Hayes, T.G.6
  • 101
    • 84885614687 scopus 로고    scopus 로고
    • Knockdown of the co-chaperone SGTA results in the suppression of androgen and PI3K/AKT signaling and inhibition of prostate cancer cell proliferation
    • Trotta, A. P., Need, E. F., Selth, L. A., Chopra, S., Pinnock, C. B., Leach, D. A., et al. (2013). Knockdown of the co-chaperone SGTA results in the suppression of androgen and PI3K/AKT signaling and inhibition of prostate cancer cell proliferation. International Journal of Cancer, 133(12), 2812-2823.
    • (2013) International Journal of Cancer , vol.133 , Issue.12 , pp. 2812-2823
    • Trotta, A.P.1    Need, E.F.2    Selth, L.A.3    Chopra, S.4    Pinnock, C.B.5    Leach, D.A.6
  • 102
    • 34548299547 scopus 로고    scopus 로고
    • FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome
    • DOI 10.1038/sj.bjc.6603924, PII 6603924
    • Yoshimoto, M., Cunha, I. W., Coudry, R. A., Fonseca, F. P., Torres, C. H., Soares, F. A., et al. (2007). FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. British Journal of Cancer, 97, 678-685. (Pubitemid 47339893)
    • (2007) British Journal of Cancer , vol.97 , Issue.5 , pp. 678-685
    • Yoshimoto, M.1    Cunha, I.W.2    Coudry, R.A.3    Fonseca, F.P.4    Torres, C.H.5    Soares, F.A.6    Squire, J.A.7
  • 103
    • 33748038440 scopus 로고    scopus 로고
    • Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice
    • DOI 10.1158/0008-5472.CAN-06-1637
    • Gao, H., Ouyang, X., Banach-Petrosky, W. A., Shen, M. M., & Abate-Shen, C. (2006). Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. Cancer Research, 66, 7929-7933. (Pubitemid 44299155)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 7929-7933
    • Gao, H.1    Ouyang, X.2    Banach-Petrosky, W.A.3    Shen, M.M.4    Abate-Shen, C.5
  • 104
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver, B. S., Chapinski, C., Wongvipat, J., Hieronymus, H., Chen, Y., Chandarlapaty, S., et al. (2011). Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell, 19, 575-586.
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1    Chapinski, C.2    Wongvipat, J.3    Hieronymus, H.4    Chen, Y.5    Chandarlapaty, S.6
  • 106
    • 84882805666 scopus 로고    scopus 로고
    • Efficacy and safety of enzalutamide (ENZA) monotherapy in hormone-naive prostate cancer (HNPC)
    • [abstract]. 2013 abstr 5001
    • Smith, M., Borre, M., Rathenborg, P., Werbrouck, P., Van Poppel, H., Heidenreich, A., et al. (2013). Efficacy and safety of enzalutamide (ENZA) monotherapy in hormone-naive prostate cancer (HNPC). [abstract]. Journal of Clinical Oncology, 31, 2013 (suppl; abstr 5001).
    • (2013) Journal of Clinical Oncology , vol.31 , Issue.SUPPL.
    • Smith, M.1    Borre, M.2    Rathenborg, P.3    Werbrouck, P.4    Van Poppel, H.5    Heidenreich, A.6
  • 107
    • 77950133837 scopus 로고    scopus 로고
    • Neo-adjuvant and adjuvant hormone therapy for localised and locally advanced prostate cancer
    • doi: 10.1002/14651858.CD006019.pub2
    • Kumar, S., Shelley, M., Harrison, C., Coles, B., Wilt, T. J., Mason, M. D. (2006). Neo-adjuvant and adjuvant hormone therapy for localised and locally advanced prostate cancer. Cochrane Database Systematic Reviews. doi: 10.1002/14651858.CD006019.pub2
    • (2006) Cochrane Database Systematic Reviews
    • Kumar, S.1    Shelley, M.2    Harrison, C.3    Coles, B.4    Wilt, T.J.5    Mason, M.D.6
  • 110
    • 84871382961 scopus 로고    scopus 로고
    • PSA response to neoadjuvant androgen deprivation therapy is a strong independent predictor of survival in high-risk prostate cancer in the dose-escalated radiation therapy era
    • McGuire, S. E., Lee, A. K., Cerne, J. Z., Munsell, M. F., Levy, L. B., Kudchadker, R. J., et al. (2013). PSA response to neoadjuvant androgen deprivation therapy is a strong independent predictor of survival in high-risk prostate cancer in the dose-escalated radiation therapy era. International Journal of Radiation Oncology Biology and Physics, 85, e39-e46.
    • (2013) International Journal of Radiation Oncology Biology and Physics , vol.85
    • McGuire, S.E.1    Lee, A.K.2    Cerne, J.Z.3    Munsell, M.F.4    Levy, L.B.5    Kudchadker, R.J.6
  • 111
    • 84866909023 scopus 로고    scopus 로고
    • Effect of neoadjuvant abiraterone acetate (AA) plus leuprolide acetate (LHRHa) on PSA, pathological complete response (pCR), and near pCR in localized high-risk prostate cancer (LHRPC): Results of a randomized phase II study
    • [abstract]. 2012 abstr 4521
    • Taplin, M.-E., Montgomery, R. B., Logothetis, C. J., Bubley, G. J., Richie, J. P., Dalkin, B. L., et al. (2012). Effect of neoadjuvant abiraterone acetate (AA) plus leuprolide acetate (LHRHa) on PSA, pathological complete response (pCR), and near pCR in localized high-risk prostate cancer (LHRPC): Results of a randomized phase II study. [abstract]. Journal of Clinical Oncology, 30, 2012 (suppl; abstr 4521).
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.SUPPL.
    • Taplin, M.-E.1    Montgomery, R.B.2    Logothetis, C.J.3    Bubley, G.J.4    Richie, J.P.5    Dalkin, B.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.