Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 1945-1948

  Bradbury, Robert H ^a   Acton, David G ^a   Broadbent, Nicola L ^a   Brooks, A Nigel ^a   Carr, Gregory R ^a   Hatter, Glenn ^a   Hayter, Barry R ^a   Hill, Kathryn J ^a   Howe, Nicholas J ^a   Jones, Rhys D O ^a   Jude, David ^a   Lamont, Scott G ^a   Loddick, Sarah A ^a   McFarland, Heather L ^a   Parveen, Zaieda ^a   Rabow, Alfred A ^a   Sharma Singh, Gorkhn ^a   Stratton, Natalie C ^a   Thomason, Andrew G ^a   Trueman, Dawn ^a   Walker, Graeme E ^a   Wells, Stuart L ^a   Wilson, Joanne ^a   Wood, J Matthew ^a   more..

^a ASTRAZENECA   (United Kingdom)

Author keywords

Androgen receptor downregulator; AZD3514; Prostate cancer

Indexed keywords

6 [4 (4 CYANOBENZYL)PIPERAZIN 1 YL] 3 (TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3 B]PYRIDAZINE; ANTINEOPLASTIC AGENT; AZD 3514; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANTINEOPLASTIC ACTIVITY; ARTICLE; CASTRATION RESISTANT PROSTATE CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; NONHUMAN; RAT;

ANIMALS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; PYRIDAZINES; RECEPTORS, ANDROGEN; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875211899     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.056     Document Type: Article

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