Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk

Critical Reviews in Toxicology

Volumn 44, Issue 7, 2014, Pages 600-617

  Lehmann, Geniece M ^a   Verner, Marc André ^b   Luukinen, Bryan ^c   Henning, Cara ^c   Assimon, Sue Anne ^d   Lakind, Judy S ^e,f,g   Mclanahan, Eva D ^a   Phillips, Linda J ^a   Davis, Matthew H ^a   Powers, Christina M ^a   Hines, Erin P ^a   Haddad, Sami ^h   Longnecker, Matthew P ⁱ   Poulsen, Michael T ^j   Farrer, David G ^k   Marchitti, Satori A ^a   Tan, Yu Mei ^a   Swartout, Jeffrey C ^a   Sagiv, Sharon K ^l   Welsh, Clement ^m   Campbell Jr , Jerry L ⁿ   Foster, Warren G ^o   Yang, Raymond S H ^p   Fenton, Suzanne E ⁱ   Tornero Velez, Rogelio ^a   Francis, Bettina M ^q   Barnett, John B ^r   El Masri, Hisham A ^a   Simmons, Jane Ellen ^a   more..

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ICF INTERNATIONAL   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e LaKind Associates LLC   (United States)

^f UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^g PENN STATE COLLEGE OF MEDICINE   (United States)

^h UNIVERSITÉ DE MONTRÉAL   (Canada)

ⁱ NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^j Oregon Department Environmental Quality   (United States)

^k OREGON HEALTH AUTHORITY   (United States)

^l BOSTON UNIVERSITY   (United States)

^m AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY   (United States)

ⁿ HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^o MCMASTER UNIVERSITY   (Canada)

^p Veterinary Dentistry and Oral Surgery   (United States)

^q UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^r WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Children; Exposure; PBT chemicals; Persistent organic pollutants; POPs; Research needs; Risk assessment; Uncertainty

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; ENVIRONMENTAL CHEMICAL; HEXACHLOROBENZENE; LIPOPHILIC PERSISTENT ENVIRONMENTAL CHEMICAL; METHYLMERCURY; MOXIDECTIN; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID; POLYCHLORINATED BIPHENYL; UNCLASSIFIED DRUG; POLLUTANT;

BODY BURDEN; BODY FAT; BREAST FEEDING; BREAST MILK; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); ENVIRONMENTAL EXPOSURE; EXPERIMENTAL ANIMAL; GESTATIONAL AGE; HALF LIFE TIME; HEALTH HAZARD; HUMAN; LACTATION; MATHEMATICAL MODEL; METABOLIC RATE; MONTE CARLO METHOD; NONHUMAN; PREDICTION; PRENATAL EXPOSURE; REVIEW; RISK ASSESSMENT; ANALYSIS; ANIMAL; CHEMISTRY; DOSE RESPONSE; FEMALE; METHODOLOGY; POLLUTANT; PREGNANCY; RAT; THEORETICAL MODEL;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; MATERNAL EXPOSURE; MILK, HUMAN; MODELS, THEORETICAL; MONTE CARLO METHOD; PREGNANCY; RATS; RESEARCH DESIGN; RISK ASSESSMENT;

EID: 84905003158     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2014.926306     Document Type: Review

References (82)

1. AAP. (2012). Breastfeeding and the use of human milk. Pediatrics, 129, e827-41
2. Adams J, Barone S Jr, Lamantia A, Philen R, Rice DC, Spear L, Susser E. (2000). Workshop to identify critical windows of exposure for children's health: Neurobehavioral Work Group summary. Environ Health Perspect, 108, 535-44
3. Arcus-Arth A, Krowech G, Zeise L. (2005). Breast milk and lipid intake distributions for assessing cumulative exposure and risk. J Expo Anal Environ Epidemiol, 15, 357-65
4. Baker JL, Gamborg M, Heitmann BL, Lissner L, Soørensen TI, Rasmussen KM. (2008). Breastfeeding reduces postpartum weight retention. Am J Clin Nutr, 88, 1543-51
5. Berlin CM, Lakind JS, Fenton SE, Wang RY, Bates MN, Brent RL, et al. (2005). Conclusions and recommendations of the expert panel: Technical workshop on human milk surveillance and biomonitoring for environmental chemicals in the United States. J Toxicol Environ Health A, 68, 1825-31
6. Berlin CM, Lakind JS, Sonawane BR, Kacew S, Borgert CJ, Bates MN, et al. (2002). Conclusions, research needs, and recommendations of the expert panel: Technical workshop on human milk surveillance and research for environmental chemicals in the United States. J Toxicol Environ Health A, 65, 1929-35
7. Bogen KT, Cullen AC, Frey HC, Price PS. (2009). Probabilistic exposure analysis for chemical risk characterization. Toxicol Sci, 109, 4-17
8. Borrud LG, Flegal KM, Looker AC, Everhart JE, Harris TB, Shepherd JA. (2010). Body composition Data for individuals 8 years of age and older: US population, 1999-2004. National Center for Health Statistics. Vital Health Stat 11, (250), 1-87
9. Butte NF, Hopkinson JM, Wong WW, Smith EO, Ellis KJ. (2000). Body composition During the first 2 years of life: An updated reference. Pediatr Res, 47, 578-85
10. Byczkowski JZ, Lipscomb JC. (2001). Physiologically based pharmacokinetic modeling of the lactational transfer of methylmercury. Risk Anal, 21, 869-82
11. Clewell RA, Gearhart JM. (2002). Pharmacokinetics of toxic chemicals in breast milk: Use of PBPK models to predict infant exposure. Environ Health Perspect, 110, A333-7
12. Cohen Hubal EA, Moya J, Selevan SG. (2008). A lifestage approach to assessing children's exposure. Birth Defects Res B Dev Reprod Toxicol, 83, 522-9
13. Dekant W. (2009). The role of biotransformation and bioactivation in toxicity. EXS, 99, 57-86
14. Desaulniers D, Cooke GM, Leingartner K, Soumano K, Cole J, Yang J, et al. (2005). Effects of postnatal exposure to a mixture of polychlorinated biphenyls, p,p'-dichlorodiphenyltrichloroethane, and p-p'- dichlorodiphenyldichloroethene in prepubertal and adult female Sprague-Dawley rats. Int J Toxicol, 24, 111-27
15. Dórea JG, Fenton SE, LaKind JS, Berlin CM Jr. (2012). Researching chemicals in human milk can be conducted without discouraging breastfeeding. Bosn J Basic Med Sci, 12, 137-8
16. Eidelman AI. (2012). Breastfeeding and the use of human milk: An analysis of the American Academy of Pediatrics 2012 Breastfeeding Policy Statement. Breastfeed Med, 7, 323-4
17. Enzi G, Zanardo V, Caretta F, Inelmen EM, Rubaltelli F. (1981). Intrauterine growth and adipose tissue development. Am J Clin Nutr, 34, 1785-90
18. Fenton SE, Condon M, Ettinger AS, Lakind JS, Mason A, McDiarmid M, et al. (2005). Collection and use of exposure data from human milk biomonitoring in the United States. J Toxicol Environ Health A, 68, 1691-712
19. Fiorotto ML, Burrin DG, Perez M, Reeds PJ. (1991). Intake and use of milk nutrients by rat pups suckled in small, medium, or large litters. Am J Physiol, 260, R1104-13
20. Fisher J, Mahle D, Bankston L, Greene R, Gearhart J. (1997). Lactational transfer of volatile chemicals in breast milk. Am Ind Hyg Assoc J, 58, 425-31
21. Fisher JW, Whittaker TA, Taylor DH, Clewell HJ III, Andersen ME. (1990). Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. Toxicol Appl Pharmacol, 102, 497-513
22. Frank JW, Newman J. (1993). Breast-feeding in a polluted world-uncertain risks, clear benefits. Can Med Assoc J, 149, 33-7
23. Geraghty SR, Khoury JC, Morrow AL, Lanphear BP. (2008). Reporting individual test results of environmental chemicals in breastmilk: Potential for premature weaning. Breastfeed Med, 3, 207-13
24. GetData Graph Digitizer. (2008). Available at: Http://www.getdata- graphdigitizer. com/index.php. Version, 2.24. Accessed on June 16, 2014
25. Haddad S, Poulin P, Krishnan K. (2000). Relative lipid content as the sole mechanistic determinant of the adipose tissue: Blood partition coefficients of highly lipophilic organic chemicals. Chemosphere, 40, 839-43
26. HHS. (2011). Executive Summary: The Surgeon General's Call to Action to Support Breastfeeding. Washington DC: US Department of Health and Human Services, Office of the Surgeon General. Available at: Http://www. surgeongeneral.gov/library/calls/breastfeeding/executive summary.pdf. Accessed on June 16 2014
27. Hines RN. (2008). The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharmacol Ther, 118, 250-67
28. Hines RN, McCarver DG. (2002). The ontogeny of human Drugmetabolizing enzymes: Phase I oxidative enzymes. J Pharmacol Exp Ther, 300, 355-60
29. Holladay SD, Smialowicz RJ. (2000). Development of the murine and human immune system: Differential effects of immunotoxicants depend on time of exposure. Environ Health Perspect, 108, 463-73
30. ICF International. (2013). Improving the risk assessment of persistent, bioaccumulative, and toxic (PBT) chemicals in breast milk: Workshop summary report. Washington, DC: US Environmental Protection Agency. Available at: Http://www.cfpub.epa.gov/ncea/risk/recordisplay. cfm?deid?262210. Accessed on June 16, 2014
31. Kerger BD, Leung HW, Scott P, Paustenbach DJ, Needham LL, Patterson DG Jr, et al. (2006). Age-And concentration-dependent elimination half-life of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Seveso children. Environ Health Perspect, 114, 1596-602
32. Knight CH, Docherty AH, Peaker M. (1984). Milk yield in rats in relation to activity and size of the mammary secretory cell population. J Dairy Res, 51, 29-35
33. Korth-Bradley JM, Parks V, Chalon S, Gourley I, Matschke K, Gossart S, et al. (2011). Excretion of moxidectin into breast milk and pharmacokinetics in healthy lactating women. Antimicrob Agents Chemother, 55, 5200-4
34. Koss G, Koransky W. (1975). Studies on the toxicology of hexachlorobenzene: I pharmacokinetics. Arch Toxicol, 34, 203-12
35. Kreuzer PE, Csanady GA, Baur C, Kessler W, Papke O, Greim H, Filser JG. (1997). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition. Arch Toxicol, 71, 383-400
36. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, et al. (2002). 2000 CDC growth charts for the United States: Methods and development. National Center for Health Statistics. Vital Health Stat 11, (246), 36
37. LaKind JS, Amina Wilkins A, Berlin CM. (2004). Environmental chemicals in human milk: A review of levels, infant exposures and health, and guidance for future research. Toxicol Appl Pharmacol, 198, 184-208
38. LaKind JS, Berlin CM, Mattison DR. (2008). The heart of the matter on breastmilk and environmental chemicals: Essential points for healthcare providers and new parents. Breastfeed Med, 3, 251-9
39. LaKind JS, Berlin CM, Sjödin A, Turner W, Wang RY, Needham LL, et al. (2009). Do human milk concentrations of persistent organic chemicals really decline during lactation?. Chemical concentrations during lactation and milk/serum partitioning. Environ Health Perspect, 117, 1625-31
40. LaKind JS, Brent RL, Dourson ML, Kacew S, Koren G, Sonawane B, et al. (2005). Human milk biomonitoring data: Interpretation and risk assessment issues. J Toxicol Environ Health A, 68, 1713-69
41. LaKind JS, Fenton SE, Dorea JG. (2009). Human milk biomonitoring of phthalates: Expanding our understanding of infant exposure is compatible with supporting breastfeeding. Environ Int, 35, 994-5
42. Landrigan PJ, Sonawane B, Mattison D, McCally M, Garg A. (2002). Chemical contaminants in breast milk and their impacts on children's health: An overview. Environ Health Perspect, 110, A313-5
43. Lloyd-Smith M, Sheffield-Brotherton B. (2008). Children's environmental health: Intergenerational equity in action-A civil society perspective. Ann N Y Acad Sci, 1140, 190-200
44. Loccisano AE, Longnecker MP, Campbell JL Jr, Andersen ME, Clewell HJ III. (2013). Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages. J Toxicol Environ Health A, 76, 25-57
45. Lorber M, Phillips L. (2002). Infant exposure to dioxin-like compounds in breast milk. Environ Health Perspect, 110, A325-32
46. Makris SL, Thompson CM, Euling SY, Selevan SG, Sonawane B. (2008). A lifestage-specific approach to hazard and dose-response characterization for children's health risk assessment. Birth Defects Res B Dev Reprod Toxicol, 83, 530-46
47. Martin J, Hamilton B, Ventura S, Osterman M, Wilson E, Mathews T. (2012). Births: Final data for 2010. National Vital Statistics Reports; vol 61 no 1. Hyattsville, MD: National Center for Health Statistics. Available at: Http://www.cdc.gov/nchs/data/nvsr/nvsr61/nvsr61-01. pdf. Accessed on June 16, 2014
48. Matthews HB, Dedrick RL. (1984). Pharmacokinetics of PCBs. Annu Rev Pharmacol Toxicol, 24, 85-103
49. McDowell MA, Fryar CD, Ogden CL, Flegal KM. (2008). Anthropometric reference data for children and adults: United States, 2003-2006
50. National Health Statistics Reports: No 10. Hyattsville, MD: National Center for Health Statistics. Available at: Http://www.cdc.gov/nchs/ data/nhsr/nhsr010.pdf. Accessed on June 16, 2014
51. Mead MN. (2008). Contaminants in human milk: Weighing the risks against the benefits of breastfeeding. Environ Health Perspect, 116, A427-34
52. Milbrath MO, Wenger Y, Chang CW, Emond C, Garabrant D, Gillespie BW, Jolliet O. (2009). Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding. Environ Health Perspect, 117, 417-25
53. Morales E, Sunyer J, Castro-Giner F, Estivill X, Julvez J, Ribas-Fitó N, et al. (2008). Influence of glutathione s-Transferase polymorphisms on cognitive functioning effects induced by p,p'-DDT among preschoolers. Environ Health Perspect, 116, 1581-5
54. National Research Council. 1993). Pesticides in the Diets of Infants and Children. Washington, DC: National Academies Press. Available at: Http://www.nap.edu/catalog.php?record-id?2126. Accessed on June 16 2014
55. Needham LL, Barr DB, Calafat AM. (2005). Characterizing children's exposures: Beyond NHANES. Neurotoxicology, 26, 547-53
56. NTP. (2011). Specifications for the conduct of studies to evaluate the reproductive and developmental toxicity of chemical, biological and physical agents in laboratory animals. Research Triangle Park, NC: National Toxicology Program. Available at: Http://www.ntp.niehs.nih. gov/ntp/test-info/finalntp- reprospecsmay2011-508.pdf. Accessed on June 16, 2014
57. OECD. (2011). Test No. 443: Extended one-generation reproductive toxicity study, OECD guidelines for the testing of chemicals, Section 4. Paris, France: OECD Publishing. Available at: Http://dx.doi. org/10.1787/9789264122550-en. Accessed on June 16, 2014.
58. Oken E, Rifas-Shiman SL, Field AE, Frazier AL, Gillman MW. (2008). Maternal gestational weight gain and offspring weight in adolescence. Obstet Gynecol, 112, 999-1006
59. Oregon DEQ. (2010). Human health risk assessment guidance. Portland, OR: Oregon Department of Environmental Quality. Available at: Http://www.deq.state. or.us/lq/pubs/docs/cu/Human HealthRiskAssessmentGuidance.pdf. Accessed on June 16, 2014
60. Parham FM, Kohn MC, Matthews HB, DeRosa C, Portier CJ. (1997). Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls. Toxicol Appl Pharmacol, 144, 340-7
61. Peyret T, Poulin P, Krishnan K. (2010). A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals. Toxicol Appl Pharmacol, 249, 197-207
62. Poiger H, Schlatter C. (1986). Pharmacokinetics of 2,3,7,8-TCDD in man. Chemosphere, 15, 1489-94
63. Poulin P, Haddad S. (2012). Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue-composition-based model as a mechanistic animal alternative method. J Pharm Sci, 101, 2250-61
64. Redding LE, Sohn MD, McKone TE, Chen JW, Wang SL, Hsieh DP, Yang RS. (2008). Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results. Environ Health Perspect, 116, 1629-35
65. Rogan WJ, Ragan NB. (1994). Chemical contaminants, pharmacokinetics, and the lactating mother. Environ Health Perspect, 102, 89-95
66. Selevan SG, Kimmel CA, Mendola P. (2000). Identifying critical windows of exposure for children's health. Environ Health Perspect, 1083, 451-5
67. Skalsky HL, Guthrie FE. (1978). Binding of insecticides to human serum proteins. Toxicol Appl Pharmacol, 43, 229-35
68. Spindler-Vomachka M, Vodicnik MJ, Lech JJ. (1984). Transport of 2,4,5,2¢,4¢,5¢-hexachlorobiphenyl by lipoproteins in vivo. Toxicol Appl Pharmacol, 74, 70-7
69. Thompson CM, Sonawane B, Barton HA, DeWoskin RS, Lipscomb JC, Schlosser P, et al. (2008). Approaches for applications of physiologically based pharmacokinetic models in risk assessment. J Toxicol Environ Health B Crit Rev, 11, 519-47
70. To-Figueras J, Barrot C, Sala M, Otero R, Silva M, Ozalla MD, et al. (2000). Excretion of hexachlorobenzene and metabolites in feces in a highly exposed human population. Environ Health Perspect, 108, 595-8
71. US EPA. (2011). Exposure factors handbook 2011 edition (final). Washington, DC: US Environmental Protection Agency. Available at: Http://www.cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid?236252. Accessed on June 16, 2014
72. US EPA. (1998). Methodology for assessing health risks associated with multiple pathways of exposure to combustor emissions. Washington, DC: US Environmental Protection Agency. Available at: Http://www. cfpub.epa.gov/ncea/ CFM/recordisplay.cfm?deid?55525. Accessed on June 16, 2014
73. US EPA. (2013). Persistent Bioaccumulative and Toxic (PBT) Chemical Program. EPA Website [Online]. Available at: Http://www.epa.gov/pbt/ index.htm. Updated on March 27, 2013. Accessed on January 10, 2014
74. US EPA. (2002). A review of the reference dose and reference concentration processes. Washington, DC: US Environmental Protection Agency. Available at: Http://www.cfpub.epa.gov/ncea/cfm/ recordisplay.cfm?deid?51717. Accessed on June 16, 2014
75. US EPA. (2000). Supplementary guidance for conducting health risk assessment of chemical mixtures. Washington, DC: US Environmental Protection Agency. Available at: Http://www.cfpub.epa.gov/ncea/cfm/ recordisplay.cfm?deid? 20533. Accessed on June 16, 2014
76. Verner MA, Ayotte P, Muckle G, Charbonneau M, Haddad S. (2009). A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies. Environ Health Perspect, 117, 481-7
77. Verner MA, Plusquellec P, Muckle G, Ayotte P, Dewailly E, Jacobson SW, et al. (2010). Alteration of infant attention and activity by polychlorinated biphenyls: Unravelling critical windows of susceptibility using physiologically based pharmacokinetic modeling. Neurotoxicology, 31, 424-31
78. Verner MA, Sonneborn D, Lancz K, Muckle G, Ayotte P, Dewailly É, et al. (2013). Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies. Environ Health Perspect, 121, 131-7
79. Welch RM, Findlay JW. (1981). Excretion of drugs in human breast milk. Drug Metab Rev, 12, 261-77
80. WHO. (2003). Global strategy for infant and young child feeding. Geneva, Switzerland: World Health Organization. Available at: Http:// www.who.int/nutrition/publications/infantfeeding/9241562218/en/ index.html. Accessed on June 16, 2014
81. Yesair DW, Feder PI, Chin AE, Naber SJ, Kuiper-Goodman T, Siegel Scott C, Robinson PE. (1986). Development, evaluation and use of a pharmacokinetic model for hexachlorobenzene. In: Morris CR, Cabral JRP, Eds. Hexachlorobenzene: Proceedings of an international symposium. Lyon, France: International Agency for Research on Cancer, pp. 297-318
82. Yoon M, Schroeter JD, Nong A, Taylor MD, Dorman DC, Andersen ME, Clewell HJ III. (2011). Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: Describing manganese homeostasis during development. Toxicol Sci, 122, 297-316.