Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue-composition-based model as a mechanistic animal alternative method

Journal of Pharmaceutical Sciences

Volumn 101, Issue 6, 2012, Pages 2250-2261

  Poulin, Patrick ^a   Haddad, Sami ^b  

^a Université de Montréal ^*  (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

ADME; Animal alternative; Disposition; Distribution; First time in human; PBPK; Pharmacokinetics; Protein binding; Unbound fraction; Volume of distribution

Indexed keywords

ACID; AMIODARONE; CHOLESTEROL; ETRETIN; ETRETINATE; EVEROLIMUS; FULVESTRANT; ITRACONAZOLE; LIPOPROTEIN; MIFEPRISTONE; TAMOXIFEN; THIORIDAZINE; TRIACYLGLYCEROL; VINBLASTINE; WATER;

ADIPOSE DERIVED STEM CELL; ARTICLE; BLOOD CELL; BONE; BRAIN; DRUG DISTRIBUTION; DRUG SOLUBILITY; DRUG TISSUE LEVEL; HEART; INTESTINE; IONIZATION; KIDNEY; LIPOPHILICITY; LIVER; LUNG; MODEL; MUSCLE; PLASMA; SKIN; SPLEEN; THYMUS; TISSUE COMPOSITION BASED MODEL;

EID: 84859769115     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23090     Document Type: Article

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