2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and congeneus in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition

Archives of Toxicology

Volumn 71, Issue 6, 1997, Pages 383-400

  Kreuzer, P E ^a   Csanady Gy A ^a,d   Baur, C ^b   Kessler, W ^a   Papke O ^c   Greim, H ^a   Filser, J G ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c ERGO Forschungsgesellschaft mBH   (Germany)

^d CTRL RES INSTITUTE FOR CHEMISTRY   (Hungary)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Adipose tissue; Human; Infant; Liver; Polychlorinated dibenzodioxins; Polychlorinated dibenzofuranes; Toxicokinetics

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; POLYCHLORINATED DIBENZODIOXIN;

ADIPOSE TISSUE; ARTICLE; AUTOPSY; BODY BURDEN; BREAST FEEDING; CONTROLLED STUDY; DRUG ACCUMULATION; FETUS; FOOD INTAKE; HUMAN; HUMAN TISSUE; INFANT; LIPID LIVER LEVEL; LIVER; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; STILLBIRTH; SUDDEN INFANT DEATH SYNDROME; TOXICOKINETICS;

ADIPOSE TISSUE; BODY BURDEN; BREAST FEEDING; CHILD, PRESCHOOL; DIGESTIVE SYSTEM; FECES; FEMALE; FETAL DEATH; FOOD CONTAMINATION; HUMANS; INFANT; INFANT, NEWBORN; LIPID METABOLISM; LIVER; MILK, HUMAN; MODELS, BIOLOGICAL; MUSCLES; PESTICIDE RESIDUES; SUDDEN INFANT DEATH; TETRACHLORODIBENZODIOXIN;

EID: 0030977083     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050402     Document Type: Article

References (70)

1. Abraham K, Krowke R, Neubert D (1988) Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Dose-dependent tissue distribution and induction of hepatic ethoxyresorufin O-deethylase in rats following a single injection. Arch Toxicol 62: 359-368
2. Abraham K, Hille A, Ende M, Helge H (1994a) Intake and fecal excretion of PCDDs, PCDFs, HCB and PCBs (138, 153, 180) in a breast-fed and a formula-fed infant. Chemosphere 29: 2279-2286
3. Abraham K, Päpke O, Ball M, Lis A, Helge H (1994b) Concentrations of PCDDs, PCDFs and coplanar PCBs in blood fat of a breast-fed and a formula-fed infant. Organohalogen Comp 21: 163-165
4. Abraham K, Steuerwald U, Päpke O, Ball M, Lis A, Weihe P, Helge H (1995) Concentrations of PCDDs, PCDFs and PCBs in human perinatal samples from Faroe Islands and Berlin. Organohalogen Comp 26: 213-218
5. Acker L, Barke E, Hapke H-J, Heeschen W, Koransky W, Kübler W, Reinhardt D (1984) In: DFG-Deutsche Forschungsgemeinschaft, Rückstände und Verunreinigungen in Frauenmilch, Mitteilung XII der Kommission zur Prüfung von Rückständen in Lebensmitteln. Verlag Chemie, Weinheim
6. Andersen ME, Mills JJ, Gargas ML, Kedderis L, Birnbaum LS, Neubert D, Greenlee WF (1993) Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment. Risk Anal 13: 25-36
7. Ayotte P, Carrier G, Dewailly E (1994) Health risk assessment for newborns exposed to organochlorine compounds through breast feeding. Organohalogen Comp 21: 45-50
8. Beck H (1992) Routes and levels of human exposure. In: Current views on the impact of dioxins and furans on human health and the environment. The Toxicology Forum, Berlin 11/9-11/1992, Germany, pp 36-60
9. Beck H, Eckart K, Mathar W, Wittkowski R (1987) Isomerspezifische Bestimmung von PCDD und PCDF in Human- und Lebensmittelproben. In: Dioxin eine technische, analytische, ökologische und toxikologische Herausforderung: Kolloquium Mannheim. 5/5-7/1987, VDI-Komm.Reinhaltung d. Luft, Düsseldorf, VDI-Verlag, VDI-Berichte 634: 359-382
10. Beck H, Eckart K, Mathar W, Wittkowski R (1989a) PCDD and PCDF body burden from food intake in the Federal Republic of Germany. Chemosphere 18: 417-424
11. Beck H, Eckart K, Mathar W, Wittkowski R (1989b) Dependence of PCDD and PCDF levels in human milk on various parameters in the Federal Republic of Germany. Chemosphere 18: 1063-1066
12. Beck H, Droß A, Kleemann WJ, Mathar W (1990) PCDD and PCDF concentrations in different organs from infants. Chemosphere 20: 903-910
13. Bowman RE, Schantz SL, Weerasinghe NCA, Gross ML, Barsotti DA (1989) Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimate of reproductive toxicity. Chemosphere 18: 243-252
14. Bowman RE, Tong HY, Gross ML, Monson SJ, Weerasinghe NCA (1990) Controlled exposure of female rhesus monkeys to 2,3,7,8-TCDD: concentrations of TCDD in fat of offspring, and its decline over time. Chemosphere 20: 1199-1202
15. Brouwer A, Ahlborg UG, Van den Berg M, Birnbaum LS, Boersma ER, Bosveld B, Denison MS, Earl Gray L, Hagmar L, Holene E, Huisman M, Jacobson SW, Jacobson JL, Koopman-Esseboom C, Koppe JG, Kulig BM, Morse DC, Muckle G, Peterson RE, Sauer PJJ, Seegal RF, Smits-Van Prooije AE, Touwen BCL, Weisglas-Kuperus N, Winneke G (1995) Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants. Eur J Pharmacol Environ Toxicol Pharmacol section 293: 1-40
16. Carrier G, Brunet RC, Brodeur J (1995a) Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. I. Nonlinear distribution of PCDD/PCDF body burden between liver and adipose tissues. Tox Appl Pharmacol 131: 253-266
17. Carrier G, Brunei RC, Brodeur J (1995b) Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. II. Kinetics of absorption and disposition of PCDDs/PCDFs. Tocixol Appl Pharmacol 131: 267-276
18. Documenta Geigy (1975) In: Diem K, Lentner C (eds) Wissenschaftliche Tabellen, 7th edn. Georg Thieme Verlag, Stuttgart
19. Filser JG, Gans G, Kreuzer PE, Wuthe J (1992) Ein auf physiologischen Parametern beruhendes pharmakokinetisches Modell zur Beschreibung der Belastung des Menschen mit 2,3,7.8-Tetrachlordibenzo-p-dioxin (TCDD) über die gesamte Lebenszeit. Verhandlungen der Deutschen Gesellschaft für Arbeitsmedizin e.V., 32. Jahrestagung, Köln 18. 21. 5. 1992. Center Verlag, Stuttgart, pp 617-621
20. Filser JG, Csanády GyA, Gans G, Kreuzer PE (1994) Pharmakokinetik der Dioxin-Belastung von Säuglingen durch Muttermilch - Entwicklung und Validierung eines pharmakokinetischen Lebenszeitmodells für 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Abschlußbericht. Ministerium für Arbeit, Gesundheit und Sozialordnung Baden-Württemberg, Stuttgart, Germany
21. Fürst P, Krüger C, Meemken H-A, Groebel W (1989) PCDD and PCDF levels in human milk dependence on the period of lactation. Cheniosphere 18: 439-444
22. Fürst P, Fürst C, Wilmers K (1994) Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs. Environ Health Perspect 102 (Suppl 1): 187-193
23. Geyer HJ, Scheunert I, Filser JG, Korte F (1986) Bioconcentration potential (BCP) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) in terrestrial organisms including humans. Chemosphere 15: 1495-1502.
24. Greim H (1994) 2,3,7,8-Tetrachlordibenzo-p-dioxin. In: Gesundheitsschädliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten (Maximale Arbeitsplatzkonzentrationen), 20th delivery, VCH Verlagsgesellschaft, Weinheim, Germany
25. Greim H, Deml E, Mangelsdorf I, Sterzl-Eckert H (1993) Untersuchung der Belastung der Bevölkerung in Schwandorf mit polychlorierten Dibenzodioxinen und Dibenzofuranen. Bericht für die Regierung der Oberpfalz, Bayern, Germany
26. Hagenmaier H, Wiesmüller T, Golor G, Krowke R, Helge H, Neubert D (1990) Transfer of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDEs) via placenta and through milk in a marmoset monkey. Arch Toxicol 64: 601-615
27. ICRP (International Commission on Radiological Protection) (1975) No 23 Report of the task group on reference man. Pergamon Press, Oxford New York Toronto Sydney Braunschweig
28. Jensen AA (1989) Background levels in humans. In: Kimbrough RD, Jensen AA (eds), Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products, 2nd edn. Elsevier, Amsterdam New York Oxford, pp 345-380
29. Jödicke B, Ende M, Helge H, Neubert D (1992) Fecal excretion of PCDDs/PCDFs in a 3-month-old breast-fed infant. Chemosphere 25: 1061-1065
30. Kedderis LB, Andersen ME, Birnbaum LS (1993) Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Fundam Appl Toxicol 21: 405-411
31. Kissel JC, Robarge GM (1988) Assessing the elimination of 2,3,7,8-TCDD from humans with a physiologically based pharmacokinetic model. Chemosphere 17: 2017-2027
32. Körner W, Dawidowsky N, Hagenmaier H (1993) Fecal excretion rates of PCDDs and PCDFs in two breast-fed infants. Chemosphere 27: 157-162
33. Kreuzer PE, Kessler W, Päpke O, Baur C, Greim H, Filser JG (1993a) A pharmacokinetic model describing the body burden of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in man over the entire lifetime validated by measured data. Society of Toxicology, 32nd annual meeting, New Orleans, USA, 14-18 March 1993. Toxicologist 13: 196
34. Kreuzer PE, Päpke O, Baur C, Filser JG (1993b) Pharmacokinetic modelling of the body burden of 2,3,7,8-tetrachlorodibenzo-p-dioxin in man over the entire lifetime validated by measured data. Joint meeting of the Deutsche Gesellschaft für Pharmakologie und Toxikologie and of the Association Francaise des Pharmacologistes, University of Lille, France, 6 8 October 1993. Fundam Clinic Pharmacol 7: 368
35. Kreuzer PE, Csanády GyA, Baur C, Filser JG (1995) Influence of breast feeding on the body burden of 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeneres in infants impact on risk assessment. Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie, 36th spring meeting. Mainz, Germany, 14-17 March 1995. Naunyn-Schmiedeberg's Arch Pharmacol Suppl 351, R31
36. Leitsätze zur Säuglingsernährung (1984). In: Schöch G, Manz F (eds) Ernährungsplan für das 1. Lebensjahr. Forschungsinstitut für Kinderernährung, Dortmund, Germany
37. Leung H-W, Ku RH, Paustenbach DJ, Andersen ME (1988) A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. Toxicol Lett 42: 15-28
38. Leung H-W, Paustenbach DJ, Murray FJ, Andersen ME (1990a) A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Toxicol Appl Pharmacol 103: 399-410
39. 125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin in mice: analysis with a physiological modeling approach. Toxicol Appl Pharmacol 103: 411-419
40. McLachlan MS (1993) Digestive tract absorption of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in a nursing infant. Toxicol Appl Pharmacol 123: 68-72
41. Mocarelli P, Needham LL, Marocchi A, Patterson DG, Brambilla P, Gerthoux PM, Meazza L, Carreri V (1991) Serum concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin and test results from selected residents of Seveso, Italy. J Toxicol Environ Health 32: 357-366
42. NATO (1988) Committee on the Challenges of Modern Society: pilot study on international information exchange on dioxins and related compounds. International toxicity equivalency factor (I-TEF). Method of risk assessment for complex mixtures of dioxins and related compounds, Report no. 176
43. Nau H, Bass R (1981) Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the mouse embryo and fetus. Toxicology 20: 299-308
44. Nau H, Baß R, Neubert D (1986) Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) via placenta and milk, and postnatal toxicity in the mouse. Arch Toxicol 59: 36-40
45. Needham LL, Patterson DG, Houk VN (1991) Levels of TCDD in selected human populations and their relevance to human risk assessment. In: Gallo MA, Scheuplein RJ, Van der Heijden KA (eds) Banbury report 35: Biological basis for risk assessment of dioxins and related compounds. Cold Spring Harbor Laboratory, Cold Spring Harbor. New York, pp 229-257
46. Neubert D (1988) Significance of pharmacokinetic variables in reproductive and developmental toxicity. Xenobiotica 18 (Suppl 1): 45-58
47. Olson JR, McGarrigle BP, Gigliotti PJ, Kumar S, McReynolds JH (1994) Hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran. Fundam Appl Toxicol 22: 631-640
48. Päpke O, Ball M, Lis A (1994) PCDD/PCDF in humans, a 1993-update of background data. Chemosphere 29: 2355-2360
49. Poiger H, Schlatter C (1979) Biological degradation of TCDD in rats. Nature 281: 706-707
50. Poiger H, Schlatter C (1986) Pharmacokinetics of 2,3,7,8-TCDD in man. Chemosphere 15: 1489-1494
51. Ramsey JC, Hefner JG, Karbowski RJ, Braun WH, Gehring PJ (1982) The in vivo biotransformation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat. Toxicol Appl Pharmacol 65: 180-184
52. Rappe C (1992) Dioxins in the environment. In: Current views on the impact of dioxins and furans on human health and the environment. The Toxicology Forum, 11/9-11/1992, Germany, pp 21-35
53. Rappe C, Andersson R (1992) Levels of PCDDs and PCDFs in human feces. Organohalogen Comp 9: 195-198
54. Sagunski H, Csicsaky M, Fertmann R, Roller M, Schümann M (1992) Age dependent levels of PCDD and PCDF in human blood samples. Organohalogen Comp 9: 211-214
55. Scheeler A, Päpke O, Ball M (1990) Evidence for transplacental transfer of dioxins from mother to fetus: chlorinated dioxin and dibenzofuran levels in the livers of stillborn infants. Chemosphere 21: 1017-1022
56. Schecter A, Fürst P, Fürst C, Päpke O, Ball M, Ryan JJ, Cau HD, Dai LC, Quynh HT, Cuong HQ, Phuong NTN, Phiet PH, Beim A, Constable J, Startin J, Samedy M, Seng YK (1994) Chlorinated dioxins and dibenzofurans in human tissue from general populations: a selective review. Environ Health Perspect 102 (Suppl 1): 159-171
57. Schlatter C, Poiger H (1989) Chlorierte Dibenzodioxine und Dibenzofurane (PCDDs/PCDFs) - Belastung und gesundheitliche Beurteilung. Z Umweltchem Ökotox 2: 11-17
58. Smith LM, Stalling DL, Johnson JL (1984) Determination of part-per-trillion levels of polychlorinated dibenzofurans and dioxins in environmental samples. Anal Chem 56: 1830-1842
59. Thoma H (1989) Polychlordibenzo-p-Dioxine und Polychlordibenzofurane in Humanproben. Z Umweltchem Okotox 1: 25-26
60. Thoma H, Mücke W, Kretschmer E (1989) Concentrations of PCDD and PCDF in human fat and liver samples. Chemosphere 18:491-498
61. Thoma H, Mücke W, Kauert G (1990) Comparison of the polychlorinated dibenzo-p-dioxin and dibenzofuran in human tissue and human liver. Chemosphere 20: 433-442
62. Van den Berg M, Heeremans C, Veenhoven E, Olie K (1987) Transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans to fetal and neonatal rats. Fundam Appl Toxicol 9: 635-644
63. Van den Berg M, De Jongh J, Poiger H, Olson JR (1994) The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDS) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit Rev Toxicol 24: 1-74
64. Van der Molen GW, Kooijman SALM, Slob W (1996) A generic toxicokinetic model for persistent lipophilic compounds in humans: an application to TCDD. Fundam Appl Toxicol 31: 83-94
65. Van Wijnen J, Van Bavel B, Lindström G, Koppe JG, Olie K (1990) Placental transport of PCDDs and PCDFs in humans. Organohalogen Comp 1: 47-50
66. Weber H, Birnbaum LS (1985) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) in pregnant C57BL/6N mice: distribution to the embryo and excretion. Arch Toxicol 57: 159-162
67. Weber LWD, Ernst SW, Stahl BU, Rozman K (1993) Tissue distribution and toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats after intravenous injection. Fundam Appl Toxicol 21: 523-534
68. 3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin in human feces to ascertain its relative matabolism in man. Anal Chem 62: 796-800
69. Wroblewski VJ, Olson JR (1985) Hepatic matabolism of 2,37,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat and guinea pig. Toxicol Appl Pharmacol 81: 231-240
70. Wuthe J, Link B, Filser J, Kreuzer PE, Piechotowski I, Päpke O (1995) PCDD/PCDF levels in children from southern Germany. Organohalogen Comp 26: 209-212