Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: Behavioral effects and consequences on the transcriptional responses and reinforcing properties

Psychopharmacology

Volumn 231, Issue 16, 2014, Pages 3139-3149

  Seleman, Marianne ^a,b,c   Chapy, Hélène ^a,b,c   Cisternino, Salvatore ^a,b,c   Courtin, Cindie ^a,b,c   Smirnova, Maria ^a,b,c   Schlatter, Joël ^d   Chiadmi, Fouad ^d   Scherrmann, Jean Michel ^a,b,c   Noble, Florence ^a,b,c   Marie Claire, Cynthia ^a,b,c  

^a CNRS   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d HÔPITAL JEAN VERDIER   (France)

Author keywords

Gene expression; Heroin; Locomotor activity; Morphine; Nociception; P glycoprotein

Indexed keywords

DIAMORPHINE; MORPHINE; MORPHINE 6 ACETATE; MULTIDRUG RESISTANCE PROTEIN; 6-O-MONOACETYLMORPHINE; CYCLOSPORIN DERIVATIVE; MORPHINE DERIVATIVE; NARCOTIC AGENT; VALSPODAR;

ANALGESIA; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CONTROLLED STUDY; DISSECTION; DRUG UPTAKE; EFFUSION; HOT PLATE TEST; KINETICS; LOCOMOTION; MALE; METABOLITE; MOUSE; NEUROMODULATION; NOCICEPTION; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REINFORCEMENT; RNA EXTRACTION; TRANSCRIPTION REGULATION; TREATMENT DURATION; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEROIN DEPENDENCE; INSTRUMENTAL CONDITIONING; METABOLISM; MOTOR ACTIVITY; PAIN MEASUREMENT; PHYSIOLOGY; PSYCHOLOGY;

ANIMALS; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; CONDITIONING, OPERANT; CYCLOSPORINS; GENE EXPRESSION; HEROIN; HEROIN DEPENDENCE; MALE; MICE; MORPHINE; MORPHINE DERIVATIVES; MOTOR ACTIVITY; NARCOTICS; NOCICEPTION; NUCLEUS ACCUMBENS; P-GLYCOPROTEIN; PAIN MEASUREMENT; TRANSCRIPTION, GENETIC;

EID: 84904987362     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3490-9     Document Type: Article

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