Increased locomotor activity induced by heroin in mice: Pharmacokinetic demonstration of heroin acting as a prodrug for the mediator 6-monoacetylmorphine in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 331, Issue 1, 2009, Pages 153-161

  Andersen, Jannike Mørch ^a   Ripel, Åse ^a   Boix, Fernando ^a   Normann, Per Trygve ^a   Mørland, Jørg ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

DIAMORPHINE; MORPHINE; MORPHINE 6 ACETATE; NALTREXONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BEHAVIOR CHANGE; BRAIN TISSUE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG MEGADOSE; IN VIVO STUDY; LOCOMOTION; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HEROIN; MALE; MICE; MICE, INBRED C57BL; MORPHINE DERIVATIVES; MOTOR ACTIVITY; PRODRUGS;

EID: 70349316440     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.152462     Document Type: Article

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