Enhanced isoprene biosynthesis in Saccharomyces cerevisiae by engineering of the native acetyl-CoA and mevalonic acid pathways with a push-pull-restrain strategy

Journal of Biotechnology

Volumn 186, Issue , 2014, Pages 128-136

  Lv, Xiaomei ^a   Xie, Wenping ^a   Lu, Wenqiang ^a   Guo, Fei ^a   Gu, Jiali ^a   Yu, Hongwei ^a   Ye, Lidan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Acetyl CoA supply; Isoprene; Mevalonic acid pathway; Push pull restrain strategy; Saccharomyces cerevisiae

Indexed keywords

BIOCHEMISTRY; CARBOXYLIC ACIDS; ISOPRENE; METABOLIC ENGINEERING; YEAST;

ACETYL-COA; AEROBIC CONDITION; ENGINEERED STRAINS; MEVALONIC ACID PATHWAY; PARENTAL STRAINS; PRECURSOR SUPPLY; PUSH PULL; REGULATORY NETWORK; PUSH-PULL-RESTRAIN STRATEGY;

YEAST; ISOPRENE;

ACETIC ACID; ACETYL COENZYME A; GALACTOSE; GLYCEROL; ISOPRENE; MEVALONIC ACID; SQUALENE; SUCROSE; 1,3 BUTADIENE DERIVATIVE; HEMITERPENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; OXYGEN; PENTANE;

ARTICLE; BATCH FERMENTATION; BIOSYNTHESIS; CARBON SOURCE; DOWN REGULATION; FUNGUS GROWTH; GENE DISRUPTION; MARKER GENE; METABOLIC ENGINEERING; MOLECULAR CLONING; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; UPREGULATION; WILD TYPE; AEROBIC METABOLISM; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; ENZYMOLOGY; GENETICS; METABOLISM; PROCEDURES;

ACETYL COENZYME A; BUTADIENES; GALACTOSE; HEMITERPENES; HYDROXYMETHYLGLUTARYL COA REDUCTASES; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; MEVALONIC ACID; OXYGEN; PENTANES; SACCHAROMYCES CEREVISIAE;

EID: 84904873611     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2014.06.024     Document Type: Article

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