Caspase-14 expression impairs retinal pigment epithelium barrier function: Potential role in diabetic macular edema

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Beasley, Selina ^a,b   El Sherbiny, Mohamed ^a,b,c   Megyerdi, Sylvia ^a,b   El Shafey, Sally ^b   Choksi, Karishma ^b   Kaddour Djebbar, Ismail ^a   Sheibani, Nader ^d   Hsu, Stephen ^b   Al Shabrawey, Mohamed ^a,b,c  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b AUGUSTA UNIVERSITY   (United States)

^c MANSOURA UNIVERSITY   (Egypt)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CASPASE 14; CASPASE 4; CASPASE 5; CASPASE 8; CASPASE 9; GLUCOSE; INTERLEUKIN 1BETA CONVERTING ENZYME; SMALL INTERFERING RNA; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DIABETIC MACULAR EDEMA; ELECTRIC RESISTANCE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NICK END LABELING; PHAGOCYTOSIS; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; APOPTOSIS; BIOLOGICAL MODEL; CELL LINE; DIABETIC RETINOPATHY; DRUG EFFECTS; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE SILENCING; MACULAR EDEMA; METABOLISM; PATHOLOGY; PERMEABILITY; RETINAL PIGMENT EPITHELIUM;

APOPTOSIS; CASPASE 14; CELL LINE; DEXTRANS; DIABETIC RETINOPATHY; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HUMANS; MACULAR EDEMA; MODELS, BIOLOGICAL; PERMEABILITY; PHAGOCYTOSIS; RETINAL PIGMENT EPITHELIUM;

EID: 84904823385     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/417986     Document Type: Article

References (45)

1. Fong D. S., Aiello L. P., Ferris F. L. III, Klein R., Diabetic retinopathy. Diabetes Care 2004 27 10 2540 2553 10.2337/diacare.27.10.2540 2-s2.0-4644316459 (Pubitemid 39281419)
2. Congdon N. G., Friedman D. S., Lietman T., Important causes of visual impairment in the world today. The Journal of the American Medical Association 2003 290 15 2057 2060 10.1001/jama.290.15.2057 2-s2.0-0142088514 (Pubitemid 37430590)
3. Roth F., Bindewald A., Holz F. G., Keypathophysiologic pathways in age-related macular disease. Graefe's Archive for Clinical and Experimental Ophthalmology 2004 242 8 710 716 10.1007/s00417-004-0976-x 2-s2.0-4544273293 (Pubitemid 39242849)
4. Xu H., Song Z., Fu S., Zhu M., Le Y., RPE barrier breakdown in diabetic retinopathy: Seeing is believing. Journal of Ocular Biology, Diseases, and Informatics 2011 4 1-2 83 92 10.1007/s12177-011-9068-4 2-s2.0-84863982016
5. Vinores S. A., van Niel E., Swerdloff J. L., Campochiaro P. A., Electron microscopic immunocytochemical demonstration of blood-retinal barrier breakdown in human diabetics and its association with aldose reductase in retinal vascular endothelium and retinal pigment epithelium. The Histochemical Journal 1993 25 9 648 663 10.1007/BF00157879 2-s2.0-0027500946 (Pubitemid 23288882)
6. Simó R., Villarroel M., Corraliza L., Hernández C., Garcia-Ramírez M., The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier-implications for the pathogenesis of diabetic retinopathy. Journal of Biomedicine and Biotechnology 2010 2010 15 190724 10.1155/2010/190724 2-s2.0-77953170750
7. Strauss O., The retinal pigment epithelium in visual function. Physiological Reviews 2005 85 3 845 881 10.1152/physrev.00021.2004 2-s2.0-21244451958 (Pubitemid 40885218)
8. Harhaj N. S., Antonetti D. A., Regulation of tight junctions and loss of barrier function in pathophysiology. International Journal of Biochemistry and Cell Biology 2004 36 7 1206 1237 10.1016/j.biocel.2003.08.007 2-s2.0-1942502810 (Pubitemid 38519069)
9. Russ P. K., Davidson M. K., Hoffman L. H., Haselton F. R., Partial characterization of the human retinal endothelial cell tight and adherens junction complexes. Investigative Ophthalmology and Visual Science 1998 39 12 2479 2485 2-s2.0-0031732526 (Pubitemid 28485661)
10. Klaassen I., Hughes J. M., Vogels I. M. C., Schalkwijk C. G., Van Noorden C. J. F., Schlingemann R. O., Altered expression of genes related to blood-retina barrier disruption in streptozotocin-induced diabetes. Experimental Eye Research 2009 89 1 4 15 10.1016/j.exer.2009.01.006 2-s2.0-67349236067
11. Finnemann S. C., Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. The EMBO Journal 2003 22 16 4143 4154 10.1093/emboj/cdg416 2-s2.0-0042466638 (Pubitemid 37021743)
12. Bok D., Retinal photoreceptor-pigment epithelium interactions: Friedenwald lecture. Investigative Ophthalmology and Visual Science 1985 26 12 1659 1694 2-s2.0-0022344155 (Pubitemid 16172107)
13. Campochiaro P. A., Sugg R., Grotendorst G., Hjelmeland L. M., Retinal pigment epithelial cells produce PDGF-like proteins and secrete them into their media. Experimental Eye Research 1989 49 2 217 227 10.1016/0014-4835(89)90092-4 2-s2.0-0024416686 (Pubitemid 19231043)
14. Ogata N., Tombran-Tink J., Nishikawa M., Nishimura T., Mitsuma Y., Sakamoto T., Matsumura M., Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. American Journal of Ophthalmology 2001 132 3 378 382 10.1016/S0002-9394(01) 01008-X 2-s2.0-0034880565 (Pubitemid 32768607)
15. Witmer A. N., Vrensen G. F. J. M., van Noorden C. J. F., Schlingemann R. O., Vascular endothelial growth factors and angiogenesis in eye disease. Progress in Retinal and Eye Research 2003 22 1 1 29 10.1016/S1350-9462(02)00043- 5 2-s2.0-0037277741 (Pubitemid 36207453)
16. Frank R. N., Diabetic retinopathy. The New England Journal of Medicine 2004 350 1 48 58 10.1056/NEJMra021678 2-s2.0-0348048874 (Pubitemid 38032183)
17. Miller J. W., Adamis A. P., Aiello L. P., Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes/Metabolism Reviews 1997 13 1 37 50 (Pubitemid 27213792)
18. Nowak J. Z., Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacological Reports 2006 58 3 353 363 2-s2.0-33746373850 (Pubitemid 44111070)
19. Bhutto I. A., McLeod D. S., Hasegawa T., Kim S. Y., Merges C., Tong P., Lutty G. A., Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Experimental Eye Research 2006 82 1 99 110 10.1016/j.exer.2005.05. 007 2-s2.0-30344447284 (Pubitemid 43063401)
20. An E., Lu X., Flippin J., Devaney J. M., Halligan B., Hoffman E., Csaky K., Hathout Y., Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors. Journal of Proteome Research 2006 5 10 2599 2610 2-s2.0-34248233606 (Pubitemid 44595162)
21. Abe T., Sugano E., Saigo Y., Tamai M., Interleukin-1 β and barrier function of retinal pigment epithelial cells (ARPE-19): aberrant expression of junctional complex molecules. Investigative Ophthalmology and Visual Science 2003 44 9 4097 4104 10.1167/iovs.02-0867 2-s2.0-0042283930 (Pubitemid 37047987)
22. Losso J. N., Truax R. E., Richard G., Trans-resveratrol inhibits hyperglycemia-induced inflammation and connexin downregulation in retinal pigment epithelial cells. Journal of Agricultural and Food Chemistry 2010 58 14 8246 8252 10.1021/jf1012067 2-s2.0-77954878032
23. Thornberry N. A., Lazebnik Y., Caspases: enemies within. Science 1998 281 5381 1312 1316 10.1126/science.281.5381.1312 2-s2.0-0032575750 (Pubitemid 28406817)
24. Nicholson D. W., Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death and Differentiation 1999 6 11 1028 1042 10.1038/sj.cdd.4400598 2-s2.0-0032785021
25. Eckhart L., Ban J., Fischer H., Tschachler E., Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation. Biochemical and Biophysical Research Communications 2000 277 3 655 659 10.1006/bbrc.2000.3698 2-s2.0-0034597671
26. van Loo G., Lippens S., Hahne M., Matthijssens F., Declercq W., Saelens X., Vandenabeele P., A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand. Cytokine 2003 22 3-4 62 70 10.1016/S1043-4666(03)00111-X 2-s2.0-0037708792 (Pubitemid 36808763)
27. Al-Shabrawey M., Ahmad S., Megyerdi S., Othman A., Baban B., Palenski T. L., Shin E. S., Gurel Z., Hsu S., Sheibani N., Caspase-14: a novel caspase in the retina with a potential role in diabetic retinopathy. Molecular Vision 2012 18 197-198 1895 1906 2-s2.0-84865828276
28. Swärd P., Rippe B., Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability. Acta Physiologica 2012 204 3 294 307 10.1111/j.1748-1716.2011.02343.x 2-s2.0-84856514036
29. Murakami T., Felinski E. A., Antonetti D. A., Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. Journal of Biological Chemistry 2009 284 31 21036 21046 10.1074/jbc.M109.016766 2-s2.0-68949129005
30. Roelandt T., Heughebaert C., Verween G., Giddelo C., Verbeken G., Pirnay J., Devos D., Crumrine D., Roseeuw D., Elias P. M., Hachem J., Actin dynamics regulate immediate PAR-2-dependent responses to acute epidermal permeability barrier abrogation. Journal of Dermatological Science 2011 61 2 101 109 10.1016/j.jdermsci.2010.11.016 2-s2.0-78951495393
31. Durham J. T., Herman I. M., Microvascular modifications in diabetic retinopathy. Current Diabetes Reports 2011 11 4 253 264 10.1007/s11892-011-0204- 0 2-s2.0-80051597186
32. Scholl S., Kirchhof J., Augustin A. J., Pathophysiology of macular edema. Ophthalmologica 2010 224 1 8 15 10.1159/000315155 2-s2.0-77955781894
33. Wang W., Matsukura M., Fujii I., Ito K., Zhao J. E., Shinohara M., Wang Y. Q., Zhang X. M., Inhibition of high glucose-induced VEGF and ICAM-1 expression in human retinal pigment epithelium cells by targeting ILK with small interference RNA. Molecular Biology Reports 2012 39 1 613 620 10.1007/s11033-011-0778-2 2-s2.0-84855198209
34. Trudeau K., Roy S., Guo W., Hernández C., Villarroel M., Simó R., Roy S., Fenofibric acid reduces fibronectin and collagen type IV overexpression in human retinal pigment epithelial cells grown in conditions mimicking the diabetic milieu: Functional implications in retinal permeability. Investigative Ophthalmology and Visual Science 2011 52 9 6348 6354 10.1167/iovs.11-7282 2-s2.0-80053513862
35. Zhang N., Beuve A., Townes-Anderson E., The nitric oxide- cGMP signaling pathway differentially regulates presynaptic structural plasticity in cone and rod cells. The Journal of Neuroscience 2005 25 10 2761 2770 10.1523/JNEUROSCI. 3195-04.2005 2-s2.0-14944349039 (Pubitemid 40365187)
36. Hu S., Snipas S. J., Vincenz C., Salvesen G., Dixit V. M., Caspase-14 is a novel developmentally regulated protease. The Journal of Biological Chemistry 1998 273 45 29648 29653 10.1074/jbc.273.45.29648 2-s2.0-0032491577 (Pubitemid 28509974)
37. Bhattacharya S., Chaum E., Johnson D. A., Johnson L. R., Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association. Investigative Ophthalmology & Visual Science 2012 53 13 8350 8366 10.1167/iovs.12-10495 2-s2.0-84873726462
38. Bhattacharya S., Ray R. M., Chaum E., Johnson D. A., Johnson L. R., Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosis. Investigative Ophthalmology and Visual Science 2011 52 6 3368 3380 10.1167/iovs.10-6991 2-s2.0-79960981176
39. Salvesen G. S., Dixit V. M., Caspases: intracellular signaling by proteolysis. Cell 1997 91 4 443 446 10.1016/S0092-8674(00)80430-4 2-s2.0-0030702084 (Pubitemid 27508233)
40. Franchi L., Eigenbrod T., Muñoz-Planillo R., Nuñez G., The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nature Immunology 2009 10 3 241 247 10.1038/ni.1703 2-s2.0-60749104683
41. Lamkanfi M., Dixit V. M., Inflammasomes: guardians of cytosolic sanctity. Immunological Reviews 2009 227 1 95 105 10.1111/j.1600-065X.2008.00730.x 2-s2.0-58049202273
42. Srinivasula S. M., Ahmad M., Fernandes-Alnemri T., Alnemri E. S., Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Molecular Cell 1998 1 7 949 957 10.1016/S1097-2765(00)80095-7 2-s2.0-0032085941 (Pubitemid 128379256)
43. Kalimuthu S., Se-Kwon K., Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds. International Journal of Molecular Sciences 2013 14 2 2334 2354 10.3390/ijms14022334 2-s2.0-84875103424
44. Druškovič M., Šuput D., Milisav I., Overexpression of caspase-9 triggers its activation and apoptosis in vitro. Croatian Medical Journal 2006 47 6 832 840 2-s2.0-33845879865 (Pubitemid 46021235)
45. Cullen S. P., Martin S. J., Caspase activation pathways: some recent progress. Cell Death and Differentiation 2009 16 7 935 938 10.1038/cdd.2009.59 2-s2.0-67549107386