A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

Cytokine

Volumn 22, Issue 3-4, 2003, Pages 62-70

  Van Loo, Geert ^a   Lippens, Saskia ^a   Hahne, Michel ^b   Matthijssens, Filip ^a   Declercq, Wim ^a   Saelens, Xavier ^a   Vandenabeele, Peter ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Apoptosis; Bcl 2; FasL; Hepatitis

Indexed keywords

CASPASE; CELL NUCLEUS DNA; CYTOCHROME C; FAS ANTIBODY; FAS ANTIGEN; FAS LIGAND; FASL PROTEIN; MEMBRANE PROTEIN; PROTEIN BCL 2; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; DNA DEGRADATION; DNA DETERMINATION; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETICS; HEPATITIS; HUMAN; HUMAN CELL; IATROGENIC DISEASE; IN VIVO STUDY; INJECTION; LETHALITY; LEUKEMIA CELL LINE; LIVER CELL; LIVER DISEASE; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; METABOLISM; MITOCHONDRION; MOUSE; MOUSE STRAIN; NONHUMAN; PARAMETER; PATHOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; REGULATORY MECHANISM; SOLUBILITY; TRANSGENE; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE;

MUS MUSCULUS;

EID: 0037708792     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-4666(03)00111-X     Document Type: Article

References (36)

1. Nagata S. Fas ligand-induced apoptosis. Annu Rev Genet. 33:1999;29-55.
2. Kischkel F.C., Hellbardt S., Behrmann I., Germer M., Pawlita M., Krammer P.H., et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14:1995;5579-5588.
3. Chinnaiyan A.M., O'Rourke K., Tewari M., Dixit V.M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 81:1995;505-512.
4. Boldin M.P., Varfolomeev E.E., Pancer Z., Mett I.L., Camonis J.H., Wallach D. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem. 270:1995;7795-7798.
5. Boldin M.P., Goncharov T.M., Goltsev Y.V., Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 85:1996;803-815.
6. Muzio M., Chinnaiyan A.M., Kischkel F.C., O'Rourke K., Shevchenko A., Ni J., et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell. 85:1996;817-827.
7. Medema J.P., Scaffidi C., Kischkel F.C., Shevchenko A., Mann M., Krammer P.H., et al. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 16:1997;2794-2804.
8. Scaffidi C., Fulda S., Srinivasan A., Friesen C., Li F., Tomaselli K.J., et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17:1998;1675-1687.
9. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
10. Li H., Zhu H., Xu C.J., Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 94:1998;491-501.
11. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 94:1998;481-490.
12. Cain K., Bratton S.B., Langlais C., Walker G., Brown D.G., Sun X.M., et al. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. J Biol Chem. 275:2000;6067-6070.
13. Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 275:1997;1132-1136.
14. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 275:1997;1129-1132.
15. L prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem. 274:1999;1156-1163.
16. L. Proc Natl Acad Sci USA. 96:1999;14871-14876.
17. Lacronique V., Mignon A., Fabre M., Viollet B., Rouquet N., Molina T., et al. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med. 2:1996;80-86.
18. Rodriguez I., Matsuura K., Khatib K., Reed J.C., Nagata S., Vassalli P. A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med. 183:1996;1031-1036.
19. Yin X.M., Wang K., Gross A., Zhao Y., Zinkel S., Klocke B., et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature. 400:1999;886-891.
20. Adachi M., Suematsu S., Kondo T., Ogasawara J., Tanaka T., Yoshida N., et al. Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet. 11:1995;294-300.
21. Schneider P., Holler N., Bodmer J.L., Hahne M., Frei K., Fontana A., et al. Conversion of membrane-bound Fas (CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med. 187:1998;1205-1213.
22. Schneider P., Bodmer J.L., Holler N., Mattmann C., Scuderi P., Terskikh A., et al. Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. J Biol Chem. 272:1997;18827-18833.
23. Ogasawara J., Watanabe-Fukunaga R., Adachi M., Matsuzawa A., Kasugai T., Kitamura Y., et al. Lethal effect of the anti-Fas antibody in mice. Nature. 364:1993;806-809.
24. Van Molle W., Denecker G., Rodriguez I., Brouckaert P., Vandenabeele P., Libert C. Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins. J Immunol. 163:1999;5235-5241.
25. Kitanaka C., Kuchino Y. Caspase-independent programmed cell death with necrotic morphology. Cell Death Differ. 6:1999;508-515.
26. Cheng E.H., Kirsch D.G., Clem R.J., Ravi R., Kastan M.B., Bedi A., et al. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science. 278:1997;1966-1968.
27. Roy S., Nicholson D.W. Cross-talk in cell death signaling. J Exp Med. 192:2000;F21-F25.
28. Steemans M., Goossens V., Van de Craen M., Van Herreweghe F., Vancompernolle K., De Vos K., et al. A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism. J Exp Med. 188:1998;2193-2198.
29. Kawahara A., Ohsawa Y., Matsumura H., Uchiyama Y., Nagata S. Caspase-independent cell killing by Fas-associated protein with death domain. J Cell Biol. 143:1998;1353-1360.
30. Matsumura H., Shimizu Y., Ohsawa Y., Kawahara A., Uchiyama Y., Nagata S. Necrotic death pathway in Fas receptor signaling. J Cell Biol. 151:2000;1247-1256.
31. Slee E.A., Keogh S.A., Martin S.J. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell Death Differ. 7:2000;556-565.
32. Krajewski S., Tanaka S., Takayama S., Schibler M.J., Fenton W., Reed J.C. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53:1993;4701-4714.
33. Gotow T., Shibata M., Kanamori S., Tokuno O., Ohsawa Y., Sato N., et al. Selective localization of Bcl-2 to the inner mitochondrial and smooth endoplasmic reticulum membranes in mammalian cells. Cell Death Differ. 7:2000;666-674.
34. Van Loo G., Demol H., van Gurp M., Hoorelbeke B., Schotte P., Beyaert R., et al. A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid. Cell Death Differ. 9:2002;301-308.
35. Van de Craen M., Declercq W., Van den brande I., Fiers W., Vandenabeele P. The proteolytic procaspase activation network: an in vitro analysis. Cell Death Differ. 6:1999;1117-1124.
36. Tada H., Shiho O., Kuroshima K., Koyama M., Tsukamoto K. An improved colorimetric assay for interleukin 2. J Immunol Methods. 93:1986;157-165.