Inhibition of high glucose-induced VEGF and ICAM-1 expression in human retinal pigment epithelium cells by targeting ILK with small interference RNA

Molecular Biology Reports

Volumn 39, Issue 1, 2012, Pages 613-620

  Wang, Wei ^a,b   Matsukura, Makoto ^b   Fujii, Isao ^b   Ito, Kaori ^b   Zhao, Ji En ^c   Shinohara, Makoto ^c   Wang, Ye Qing ^a   Zhang, Xiao Mei ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b SOJO UNIVERSITY   (Japan)

^c Ashikita Institution for Developmental Disabilities   (Japan)

Author keywords

High glucose; Integrin linked kinase; Intercellular adhesion molecule 1; Retinal pigment epithelium; Vascular endothelial growth factor

Indexed keywords

GLUCOSE; INTEGRIN LINKED KINASE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; SMALL INTERFERING RNA; VASCULOTROPIN;

ARTICLE; CELL STRESS; CONTROLLED STUDY; DIABETIC RETINOPATHY; GENE; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INTEGRIN LINKED KINASE GENE; INTERCELLULAR ADHESION MOLECULE 1 GENE; LONG TERM EXPOSURE; MOLECULAR PATHOLOGY; PIGMENT EPITHELIUM; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR GENE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELLS, CULTURED; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; GLUCOSE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; PROTEIN-SERINE-THREONINE KINASES; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84855198209     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-0778-2     Document Type: Article

References (25)

1. A Yoshida S Ishiko M Kojima H Ogasawara 1993 Permeability of the blood-ocular barrier in adolescent and adult diabetic patients Br J Ophthalmol 77 158 161 10.1136/bjo.77.3.158 8457507 10.1136/bjo.77.3.158 1:STN:280:DyaK3s3gvVSntg%3D%3D (Pubitemid 23092502)
2. C Wu S Dedhar 2001 Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes J Cell Biol 155 505 510 10.1083/jcb.200108077 11696562 10.1083/jcb.200108077 1:CAS:528:DC%2BD3MXosVKitb0%3D (Pubitemid 34289309)
3. G Hannigan AA Troussard S Dedhar 2005 Integrin-linked kinase: a cancer therapeutic target unique among its ILK Nat Rev Cancer 5 51 63 10.1038/nrc1524 15630415 10.1038/nrc1524 1:CAS:528:DC%2BD2MXlvVeh (Pubitemid 40052325)
4. D Koul R Shen S Bergh Y Lu JF de Groot TJ Liu GB Mills WK Yung 2005 Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma Mol Cancer Ther 4 1681 1688 10.1158/1535-7163.MCT-05-0258 16275989 10.1158/1535-7163.MCT-05-0258 1:CAS:528:DC%2BD2MXhtFyrtLvK (Pubitemid 41685302)
5. MN Younes OG Yigitbasi YD Yazici SA Jasser CD Bucana AK El-Naggar GB Mills JN Myers 2007 Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck Arch Otolaryngol Head Neck Surg 133 15 23 10.1001/archotol.133.1.15 17224516 10.1001/archotol.133.1.15 (Pubitemid 46129500)
6. YJ Li YN Hui F Yan ZJ Du 2007 Up-regulation of integrin-linked kinase in the streptozotocin-induced diabetic rat retina Graefes Arch Clin Exp Ophthalmol 245 1523 1532 10.1007/s00417-007-0616-3 17653754 10.1007/s00417-007-0616-3 1:CAS:528:DC%2BD2sXhtVajs7rM (Pubitemid 47423335)
7. K Miyamoto S Khosrof SE Bursell Y Moromizato LP Aiello Y Ogura AP Adamis 2000 Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1) Am J Pathol 156 1733 1739 10793084 10.1016/S0002-9440(10)65044-4 1:CAS:528: DC%2BD3cXjslKksr0%3D (Pubitemid 30646710)
8. MG Petrovic J Osredkar M Saraga-Babić D Petrovic 2008 K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes Clin Exp Ophthalmol 36 468 472 10.1111/j.1442-9071.2008.01785.x 10.1111/j.1442-9071.2008. 01785.x
9. K Wang Y Wang L Gao X Li M Li J Guo 2008 Dexamethasone inhibits leukocyte accumulation and vascular permeability in retina of streptozotocin-induced diabetic rats via reducing vascular endothelial growth factor and intercellular adhesion molecule-1 expression Biol Pharm Bull 31 1541 1546 10.1248/bpb.31.1541 18670086 10.1248/bpb.31.1541 1:CAS:528:DC%2BD1cXht1SgurrP
10. PC McDonald A Oloumi J Mills I Dobreva M Maidan V Gray ED Wederell MB Bally LJ Foster S Dedhar 2008 Rictor and integrinlinked kinase interact and regulate Akt phosphorylation and cancer cell survival Cancer Res 68 1618 1624 10.1158/0008-5472.CAN-07-5869 18339839 10.1158/0008-5472.CAN-07-5869 1:CAS:528:DC%2BD1cXjtFOhsr0%3D (Pubitemid 351416544)
11. LA Edwards J Woo LA Huxham M Verreault WH Dragowska G Chiu A Rajput AH Kyle J Kalra D Yapp H Yan AI Minchinton D Huntsman T Daynard DN Waterhouse B Thiessen S Dedhar MB Bally 2008 Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK) Mol Cancer Ther 7 59 70 10.1158/1535-7163.MCT-07-0329 18202010 10.1158/1535-7163.MCT-07-0329 1:CAS:528:DC%2BD1cXmsVyguw%3D%3D
12. C Tan S Cruet-Hennequart A Troussard L Fazli P Costello K Sutton J Wheeler M Gleave J Sanghera S Dedhar 2004 Regulation of tumor angiogenesis by integrin-linked kinase (ILK) Cancer Cell 5 79 90 10.1016/S1535-6108(03)00281-2 14749128 10.1016/S1535-6108(03)00281-2 1:CAS:528:DC%2BD2cXhtFGrsb8%3D (Pubitemid 38121598)
13. SP Lee SW Youn HJ Cho L Li TY Kim HS Yook JW Chung J Hur CH Yoon KW Park BH Oh YB Park HS Kim 2006 Integrin-linked kinase, a hypoxia-responsive molecule, controls postnatal vasculogenesis by recruitment of endothelial progenitor cells to ischemic tissue Circulation 114 150 159 10.1161/CIRCULATIONAHA.105. 595918 16818815 10.1161/CIRCULATIONAHA.105.595918 1:CAS:528:DC%2BD28XmsVGjsLk%3D (Pubitemid 44420747)
14. L Guo W Yu X Li G Zhao J Liang P He K Wang P Zhou Y Jiang M Zhao 2008 Targeting of integrin-linked kinase with a small interfering RNA suppresses progression of experimental proliferative vitreoretinopathy Exp Eye Res 87 551 560 10.1016/j.exer.2008.09.008 18926819 10.1016/j.exer.2008.09.008 1:CAS:528:DC%2BD1cXhsVaisrfI
15. YQ Wang XM Zhang XD Wang BJ Wang W Wang 2010 17-AAG, a Hsp90 inhibitor, attenuates the hypoxia-induced expression of SDF-1alpha and ILK in mouse RPE cells Mol Biol Rep 37 1203 1209 10.1007/s11033-009-9490-x 19266313 10.1007/s11033-009-9490-x 1:CAS:528:DC%2BC3cXhtlWqu7c%3D
16. MD Williams JL Nadler 2007 Inflammatory mechanisms of diabetic complications Curr Diab Rep 7 242 248 10.1007/s11892-007-0038-y 17547842 10.1007/s11892-007-0038-y 1:CAS:528:DC%2BD2sXhtVentbvO (Pubitemid 46951922)
17. S Ishida T Usui K Yamashiro Y Kaji E Ahmed KG Carrasquillo S Amano T Hida Y Oguchi AP Adamis 2003 VEGF164 is proinflammatory in the diabetic retina Invest Ophthalmol Vis Sci 44 2155 2162 10.1167/iovs.02-0807 12714656 10.1167/iovs.02-0807 (Pubitemid 36520312)
18. H Mu XM Zhang JJ Liu L Dong ZL Feng 2009 Effect of high glucose concentration on VEGF and PEDF expression in cultured retinal Müller cells Mol Biol Rep 36 2147 2151 10.1007/s11033-008-9428-8 19107574 10.1007/s11033-008-9428-8 1:CAS:528:DC%2BD1MXht1yrsL7M
19. DS McLeod DJ Lefer C Merges GA Lutty 1995 Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid Am J Pathol 147 642 653 7545873 1:CAS:528:DyaK2MXoslKjsbw%3D
20. N Ogata S Nomura A Shouzu M Imaizumi M Arichi M Matsumura 2006 Elevation of monocyte-derived microparticles in patients with diabetic retinopathy Diabetes Res Clin Pract 73 241 248 10.1016/j.diabres.2006.01.014 16584800 10.1016/j.diabres.2006.01.014 1:CAS:528:DC%2BD28Xns1Slt78%3D (Pubitemid 44107585)
21. S Persad S Attwell V Gray N Mawji JT Deng D Leung J Yan J Sanghera MP Walsh S Dedhar 2001 Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343 J Biol Chem 276 27462 27469 10.1074/jbc.M102940200 11313365 10.1074/jbc.M102940200 1:CAS:528: DC%2BD3MXlsV2is7Y%3D
22. HJ Cho SW Youn SI Cheon TY Kim J Hur SY Zhang SP Lee KW Park MM Lee YS Choi YB Park HS Kim 2005 Regulation of endothelial cell and endothelial progenitor cell survival and vasculogenesis by integrin-linked kinase Arterioscler Thromb Vasc Biol 25 1154 1160 10.1161/01.ATV.0000164312.20008.93 15802621 10.1161/01.ATV.0000164312.20008.93 1:CAS:528:DC%2BD2MXksVWqt7g%3D (Pubitemid 40776602)
23. DE White RD Cardiff S Dedhar WJ Muller 2001 Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice Oncogene 20 7064 7072 10.1038/sj.onc.1204910 11704830 10.1038/sj.onc.1204910 1:CAS:528: DC%2BD3MXotlCgurg%3D (Pubitemid 33052198)
24. K Makino CP Day SC Wang YM Li MC Hung 2004 Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway Oncogene 23 3883 3887 10.1038/sj.onc.1207485 15021910 10.1038/sj.onc.1207485 1:CAS:528:DC%2BD2cXjs1yltrY%3D (Pubitemid 38725701)
25. C Tan A Mui S Dedhar 2002 Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner J Biol Chem 277 3109 3116 10.1074/jbc.M108673200 11724787 10.1074/jbc.M108673200 1:CAS:528:DC%2BD38XhtVaksrs%3D (Pubitemid 34953171)