Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association.

Investigative ophthalmology & visual science

Volumn 53, Issue 13, 2012, Pages 8350-8366

  Bhattacharya, Sujoy ^a   Chaum, Edward ^b   Johnson, Dianna A ^b   Johnson, Leonard R ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; BENZAMIDE DERIVATIVE; CASP3 PROTEIN, HUMAN; CASPASE 3; IMIDAZOLE DERIVATIVE; MDM2 PROTEIN, HUMAN; NAPHTHOL DERIVATIVE; NUTLIN 3; ONCOPROTEIN; PIPERAZINE DERIVATIVE; PROTEIN MDM2; PROTEIN P53; SIRT1 PROTEIN, HUMAN; SIRT2 PROTEIN, HUMAN; SIRTINOL; SIRTUIN 1; SIRTUIN 2; SMALL INTERFERING RNA;

ACETYLATION; ADULT; AGED; AGING; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; DISEASE PREDISPOSITION; DNA FRAGMENTATION; DRUG ANTAGONISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; METABOLISM; MIDDLE AGED; NICK END LABELING; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PIGMENT EPITHELIUM; WESTERN BLOTTING;

ACETYLATION; ADULT; AGED; AGED, 80 AND OVER; AGING; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZAMIDES; BLOTTING, WESTERN; CASPASE 3; CELL PROLIFERATION; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; DNA FRAGMENTATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMIDAZOLES; IN SITU NICK-END LABELING; MIDDLE AGED; NAPHTHOLS; PHOSPHORYLATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RETINAL PIGMENT EPITHELIUM; RNA, SMALL INTERFERING; SIRTUIN 1; SIRTUIN 2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84873726462     PISSN: None     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10495     Document Type: Article

References (0)