AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice

Diabetologia

Volumn 57, Issue 8, 2014, Pages 1693-1702

  O'Neill, Hayley M ^a,b   Lally, James S ^a   Galic, Sandra ^b   Thomas, Melissa ^a   Azizi, Paymon D ^a   Fullerton, Morgan D ^a   Smith, Brennan K ^a,c   Pulinilkunnil, Thomas ^d   Chen, Zhiping ^b   Samaan, M Constantine ^a   Jorgensen, Sebastian B ^b,e   Dyck, Jason R B ^d   Holloway, Graham P ^c   Hawke, Thomas J ^a   Van Denderen, Bryce J ^b   Kemp, Bruce E ^b   Steinberg, Gregory R ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF GUELPH   (Canada)

^d UNIVERSITY OF ALBERTA   (Canada)

^e NOVO NORDISK A S   (Denmark)

Author keywords

ACC2; AMPK; Fatty acid oxidation; Insulin resistance; Knock in mice; Malonyl CoA; Skeletal muscle

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 2; CERAMIDE; CITRATE SYNTHASE; GLUCOSE TRANSPORTER 4; GLYCOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MALONYL COENZYME A DECARBOXYLASE; PROTEIN KINASE B; SUCCINATE DEHYDROGENASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; ACACB PROTEIN, MOUSE; AICA RIBONUCLEOTIDE; ANTIDIABETIC AGENT; INSULIN; LEPTIN; MALONYL COENZYME A; RIBONUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; EXTENSOR DIGITORUM LONGUS MUSCLE; FATTY ACID OXIDATION; GENE TARGETING; GENOTYPE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLYCOGEN LIVER LEVEL; GLYCOGEN MUSCLE LEVEL; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIPID HOMEOSTASIS; LIPID LIVER LEVEL; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY QUOTIENT; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; LIPID METABOLISM; METABOLISM; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYSIOLOGY; SKELETAL MUSCLE;

ACETYL-COA CARBOXYLASE; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LEPTIN; LIPID METABOLISM; MALONYL COENZYME A; MICE; MUSCLE, SKELETAL; OBESITY; OXIDATION-REDUCTION; PHOSPHORYLATION; RIBONUCLEOTIDES;

EID: 84904764021     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3273-1     Document Type: Article

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