The activation of β1-integrin by type I collagen coupling with the hedgehog pathway promotes the epithelial-mesenchymal transition in pancreatic cancer

Current Cancer Drug Targets

Volumn 14, Issue 5, 2014, Pages 446-457

  Duan, Wanxing ^a   Ma, Jiguang ^a   Ma, Qingyong ^a   Xu, Qinhong ^a   Lei, Jianjun ^a   Han, Liang ^a   Li, Xuqi ^a   Wang, Zheng ^a   Wu, Zheng ^a   Lv, Shifang ^a   Ma, Zhenhua ^a   Liu, Mouzhu ^a   Wang, Fengfei ^b   Wu, Erxi ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Desmoplastic reaction; Epithelial mesenchymal transition; Extracellular matrix; Hedgehog pathway; Pancreatic cancer

Indexed keywords

BETA ACTIN; BETA1 INTEGRIN; CD18 ANTIGEN; COLLAGEN TYPE 1; FOCAL ADHESION KINASE; MATRIGEL; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UVOMORULIN; VIMENTIN; GLI1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CANCER GROWTH; CASE REPORT; CELL INVASION; CELL INVASION ASSAY; CELL MIGRATION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; MIDDLE AGED; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; WOUND HEALING; CELL PROLIFERATION; METABOLISM; METASTASIS; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ANTIGENS, CD29; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COLLAGEN TYPE I; EPITHELIAL-MESENCHYMAL TRANSITION; HEDGEHOG PROTEINS; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS; TRANSCRIPTION FACTORS; ZINC FINGER PROTEIN GLI1;

EID: 84904730961     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/1568009614666140402105101     Document Type: Article

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