-
1
-
-
79953695530
-
-
Chapter 14 P441, Developmental genetics and birth defects. Genetics in Medicine. 7th edn. Saunders, Philadelphia PA
-
Developmental genetics and birth defects. (2007) Chapter 14, P441. Genetics in Medicine. 7th edn. Saunders, Philadelphia, PA.
-
(2007)
-
-
-
3
-
-
77953722426
-
Abstract A55: a first-in-human, phase I study of an oral hedgehog pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors
-
doi:10.1158/1535-7163.TARG-09-A55
-
Siu, L.L. (2008) Abstract A55: a first-in-human, phase I study of an oral hedgehog pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors. Mol. Cancer Ther., 8, A55 doi:10.1158/1535-7163.TARG-09-A55.
-
(2008)
Mol. Cancer Ther.
, vol.8
-
-
Siu, L.L.1
-
4
-
-
4544285754
-
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
-
Romer, J.T. et al. (2004) Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell, 3, 229-240.
-
(2004)
Cancer Cell
, vol.3
, pp. 229-240
-
-
Romer, J.T.1
-
5
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
Berman, D.M. et al. (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 425, 846-851.
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
-
6
-
-
33750686955
-
The hedgehog signaling pathway in cancer
-
Evangelista, M. et al. (2006) The hedgehog signaling pathway in cancer. Clin. Cancer Res., 12, p5924-p5928.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5924-5928
-
-
Evangelista, M.1
-
7
-
-
77953693899
-
Targeting hedgehog-a cancer stem cell pathway
-
Review article
-
Merchant, A.A. et al. (2010) Targeting hedgehog-a cancer stem cell pathway. Clin. Cancer Res., 16, p3130-p3150 Review article.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 3130-3150
-
-
Merchant, A.A.1
-
8
-
-
34347253037
-
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
-
Ji, Z. et al. (2007) Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J. Biol. Chem., 282, 14048-14055.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14048-14055
-
-
Ji, Z.1
-
9
-
-
40149091426
-
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
-
Kimura, H. et al. (2008) Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell, 13, 249-260.
-
(2008)
Cancer Cell
, vol.13
, pp. 249-260
-
-
Kimura, H.1
-
10
-
-
50649118068
-
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
-
Dierks, C. et al. (2008) Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell, 14, 238-249.
-
(2008)
Cancer Cell
, vol.14
, pp. 238-249
-
-
Dierks, C.1
-
11
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff, D.D. et al. (2008) Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N. Engl. J. Med., 361, 1164-1172.
-
(2008)
N. Engl. J. Med.
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
-
12
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin, C.M. et al. (2009) Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med., 361, 1173-1178.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
-
13
-
-
33748342931
-
The hedgehog pathway and neurological disorders
-
Dellovade, T. et al. (2006) The hedgehog pathway and neurological disorders. Annu. Rev. Neurosci., 29, 539-563.
-
(2006)
Annu. Rev. Neurosci.
, vol.29
, pp. 539-563
-
-
Dellovade, T.1
-
14
-
-
33751549095
-
Targeting the hedgehog pathway in cancer
-
Review
-
Rubin, L.L. et al. (2006) Targeting the hedgehog pathway in cancer. Nat. Rev. Drug Discov., 12, 1026-1033 Review.
-
(2006)
Nat. Rev. Drug Discov.
, vol.12
, pp. 1026-1033
-
-
Rubin, L.L.1
-
15
-
-
71149116390
-
Basal cell nevus syndrome: clinical and genetic diagnosis
-
García de Marcos, J.A. et al. (2009) Basal cell nevus syndrome: clinical and genetic diagnosis. Oral Maxillofac. Surg., 4, 225-230.
-
(2009)
Oral Maxillofac. Surg.
, vol.4
, pp. 225-230
-
-
García de Marcos, J.A.1
-
16
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
Yauch, R.L. et al. (2009) Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science, 326, 572-574.
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
-
17
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia Chromosome-Positive Leukemias
-
Talpaz, M. (2006) Dasatinib in imatinib-resistant Philadelphia Chromosome-Positive Leukemias. N. Engl. J. Med., 354, 2531-2541.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
-
18
-
-
78049426513
-
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
Choi, Y.L. et al. (2010) EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N. Engl. J. Med., 363, 1734-1739.
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1734-1739
-
-
Choi, Y.L.1
-
19
-
-
34249867843
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
-
Lauth, M. et al. (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl Acad. Sci. USA, 104, 8455-8460.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 8455-8460
-
-
Lauth, M.1
-
20
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer, S.P. et al. (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 425, 851-856.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
-
21
-
-
58149143021
-
Sonic hedgehog promotes desmoplasia in pancreatic cancer
-
Bailey, J.M. et al. (2008) Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin. Cancer Res., 14, 5995-6600.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5995-6600
-
-
Bailey, J.M.1
-
22
-
-
67149143399
-
Inhibition of Hedgehog signalling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K.P. et al. (2009) Inhibition of Hedgehog signalling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science, 324, 1457-1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
-
23
-
-
52649169761
-
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer
-
Feldmann, G. et al. (2008) Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut, 57, 1420-1430.
-
(2008)
Gut
, vol.57
, pp. 1420-1430
-
-
Feldmann, G.1
-
24
-
-
33847052127
-
Identification of pancreatic cancer stem cells
-
Li, C. et al. (2007) Identification of pancreatic cancer stem cells. Cancer Res., 67, 1030-1037.
-
(2007)
Cancer Res
, vol.67
, pp. 1030-1037
-
-
Li, C.1
-
25
-
-
34548455927
-
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
-
Hermann, P.C. et al. (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell, 1, 313-323.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 313-323
-
-
Hermann, P.C.1
-
26
-
-
0033988823
-
A multispeciality approach to approach to the diagnosis and management of pancreatic cancer
-
Hawes, R.H. et al. (2000) A multispeciality approach to approach to the diagnosis and management of pancreatic cancer. Am. J. Gastroenterol., 95, 17-31.
-
(2000)
Am. J. Gastroenterol.
, vol.95
, pp. 17-31
-
-
Hawes, R.H.1
-
27
-
-
52149123619
-
Core signalling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones, S. et al. (2008) Core signalling pathways in human pancreatic cancers revealed by global genomic analyses. Science, 321, 1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
-
28
-
-
70349974840
-
Sonic hedgehog paracrine signalling regulates metastasis and lymphangiogenesis in pancreatic cancer
-
Bailey, J.M. et al. (2009) Sonic hedgehog paracrine signalling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene, 28, 3513-3525.
-
(2009)
Oncogene
, vol.28
, pp. 3513-3525
-
-
Bailey, J.M.1
-
29
-
-
34247646461
-
Sonic hedgehog acts at multiple stages during pancreatic tumourigenesis
-
Morton, J.P. et al. (2007) Sonic hedgehog acts at multiple stages during pancreatic tumourigenesis. Proc. Natl Acad. Sci. USA, 104, 5103-5108.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 5103-5108
-
-
Morton, J.P.1
-
30
-
-
63149124772
-
Hedgehog signalling is restricted to the stromal compartment during pancreatic carcinogenesis
-
Tian, H. et al. (2009) Hedgehog signalling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc. Natl Acad. Sci. USA, 106, 4254-4259.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4254-4259
-
-
Tian, H.1
-
31
-
-
33846405332
-
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial
-
Oettle, H. et al. (2007) Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA, 297, 267-277.
-
(2007)
JAMA
, vol.297
, pp. 267-277
-
-
Oettle, H.1
-
32
-
-
33947254016
-
Blockade of hedgehog signalling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
-
Feldmann, G. et al. (2007) Blockade of hedgehog signalling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res., 67, 2187-2196.
-
(2007)
Cancer Res
, vol.67
, pp. 2187-2196
-
-
Feldmann, G.1
-
33
-
-
22844445593
-
Review article
-
Willett, C.G. et al. (2005) Review article. J. Clin. Oncol., 23, 4538-4544.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 4538-4544
-
-
Willett, C.G.1
-
34
-
-
0142121292
-
Treatment of locally advanced pancreatic cancer in the Real World: population-based practices and effectiveness
-
Krzyanowska, M.K. et al. (2003) Treatment of locally advanced pancreatic cancer in the Real World: population-based practices and effectiveness. J. Clin. Oncol., 21, 3409-3414.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 3409-3414
-
-
Krzyanowska, M.K.1
-
35
-
-
61549102790
-
Arterial and venous resection for pancreatic adenocarcinoma: operative and long-term outcomes
-
Martin, R.C. 2nd et al. (2009) Arterial and venous resection for pancreatic adenocarcinoma: operative and long-term outcomes. Arch. Surg., 144, 154-159.
-
(2009)
Arch. Surg.
, vol.144
, pp. 154-159
-
-
Martin R.C., 2nd.1
-
36
-
-
77950554464
-
Stromal depletion goes on trial in pancreatic cancer
-
Garber, K. (2010) Stromal depletion goes on trial in pancreatic cancer. J. Natl Cancer Inst., 102, 448-450.
-
(2010)
J. Natl Cancer Inst.
, vol.102
, pp. 448-450
-
-
Garber, K.1
-
37
-
-
77949719411
-
Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts
-
Walter, K. et al. (2010) Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Clin. Cancer Res., 16, 1781-1789.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1781-1789
-
-
Walter, K.1
-
38
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore, M.J. et al. (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol., 25, 1960.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1960
-
-
Moore, M.J.1
-
39
-
-
31544458968
-
Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signalling inhibitors, in prostate cancer cells
-
Mimeault, M. et al. (2006) Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signalling inhibitors, in prostate cancer cells. Int. J. Cancer, 118, 1022-1031.
-
(2006)
Int. J. Cancer
, vol.118
, pp. 1022-1031
-
-
Mimeault, M.1
-
40
-
-
70349638289
-
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
-
Zhou, B.B. et al. (2009) Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat. Rev. Drug Discov., 8, 806-823.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 806-823
-
-
Zhou, B.B.1
-
41
-
-
33645220566
-
Phosphoinositide 3-kinase and Akt are essential for sonic hedgehog signalling
-
Riobó, N.A. et al. (2006) Phosphoinositide 3-kinase and Akt are essential for sonic hedgehog signalling. Proc. Natl Acad. Sci. USA, 103, 4505-4510.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 4505-4510
-
-
Riobó, N.A.1
-
42
-
-
34347253037
-
Oncogenic KRAS activates hedgehog signalling pathway in pancreatic cancer cells
-
Ji, Z. et al. (2007) Oncogenic KRAS activates hedgehog signalling pathway in pancreatic cancer cells. J. Biol. Chem., 282, 14048-14055.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14048-14055
-
-
Ji, Z.1
-
43
-
-
77953284901
-
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS
-
Lauth, M. et al. (2010) DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat. Struct. Mol. Biol., 17, 718-725.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 718-725
-
-
Lauth, M.1
-
44
-
-
52149119128
-
A paracrine requirement for hedgehog signalling in cancer
-
Yauch, R.L. et al. (2008) A paracrine requirement for hedgehog signalling in cancer. Nature, 455, 406-410.
-
(2008)
Nature
, vol.455
, pp. 406-410
-
-
Yauch, R.L.1
-
45
-
-
77749249596
-
Hedgehog promotes neovascularisation in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells
-
Nakamura, K. et al. (2010) Hedgehog promotes neovascularisation in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One, 5, e8824.
-
(2010)
PLoS One
, vol.5
-
-
Nakamura, K.1
-
46
-
-
70349974840
-
Sonic hedgehog paracrine signalling regulates metastasis and lymphangiogenesis in pancreatic cancer
-
Bailey, J.M. et al. (2009) Sonic hedgehog paracrine signalling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene, 28, 3513-3525.
-
(2009)
Oncogene
, vol.28
, pp. 3513-3525
-
-
Bailey, J.M.1
-
47
-
-
63149124772
-
Hedgehog signalling is restricted to the stromal compartment during pancreatic carcinogenesis
-
Tian, H. et al. (2009) Hedgehog signalling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc. Natl Acad. Sci. USA, 106, 4254-4259.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4254-4259
-
-
Tian, H.1
|