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Volumn 30, Issue 6, 2011, Pages 714-723

GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin

Author keywords

catenin; E cadherin; GLI1; invasion; MUC5AC; pancreatic cancer

Indexed keywords

BETA CATENIN; DOXYCYCLINE; MUCIN 2; MUCIN 5AC; MUCIN 5B; MUCIN 6; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; UVOMORULIN;

EID: 79951512092     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.459     Document Type: Article
Times cited : (102)

References (35)
  • 1
    • 1842839986 scopus 로고    scopus 로고
    • Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site
    • DOI 10.1016/j.gene.2004.01.010, PII S0378111904000368
    • Agren M, Kogerman P, Kleman MI, Wessling M, Toftgard R. (2004). Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene 330: 101-114. (Pubitemid 38490423)
    • (2004) Gene , vol.330 , Issue.1-2 , pp. 101-114
    • Agren, M.1    Kogerman, P.2    Kleman, M.I.3    Wessling, M.4    Toftgard, R.5
  • 2
    • 33745675445 scopus 로고    scopus 로고
    • Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: Gastric foveolar type is associated with aggressive tumour behaviour
    • DOI 10.1111/j.1365-2559.2006.02414.x
    • Aishima S, Kuroda Y, Nishihara Y, Taguchi K, Taketomi A, Maehara Y et al. (2006). Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: gastric foveolar type is associated with aggressive tumour behaviour. Histopathology 49: 35-44. (Pubitemid 43972918)
    • (2006) Histopathology , vol.49 , Issue.1 , pp. 35-44
    • Aishima, S.1    Kuroda, Y.2    Nishihara, Y.3    Taguchi, K.4    Taketomi, A.5    Maehara, Y.6    Tsuneyoshi, M.7
  • 3
    • 1642392438 scopus 로고    scopus 로고
    • Epithelial-Cadherin and β-Catenin Expression Changes in Pancreatic Intraepithelial Neoplasia
    • DOI 10.1158/1078-0432.CCR-03-0087
    • Al-Aynati MM, Radulovich N, Riddell RH, Tsao MS. (2004). Epithelial-cadherin and beta-catenin expression changes in pancreatic intraepithelial neoplasia. Clin Cancer Res 10: 1235-1240. (Pubitemid 38365212)
    • (2004) Clinical Cancer Research , vol.10 , Issue.4 , pp. 1235-1240
    • Al-Aynati, M.M.1    Radulovich, N.2    Riddell, R.H.3    Tsao, M.-S.4
  • 4
    • 77952668655 scopus 로고    scopus 로고
    • Membrane-bound mucins: The mechanistic basis for alterations in the growth and survival of cancer cells
    • Bafna S, Kaur S, Batra SK. (2010). Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene 29: 2893-2904.
    • (2010) Oncogene , vol.29 , pp. 2893-2904
    • Bafna, S.1    Kaur, S.2    Batra, S.K.3
  • 8
    • 33646111185 scopus 로고    scopus 로고
    • Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes
    • Eichberger T, Sander V, Schnidar H, Regl G, Kasper M, Schmid C et al. (2006). Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes. Genomics 87: 616-632.
    • (2006) Genomics , vol.87 , pp. 616-632
    • Eichberger, T.1    Sander, V.2    Schnidar, H.3    Regl, G.4    Kasper, M.5    Schmid, C.6
  • 10
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: Protection and control of the cell surface
    • Hollingsworth MA, Swanson BJ. (2004). Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 4: 45-60. (Pubitemid 38082153)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.1 , pp. 45-60
    • Hollingsworth, M.A.1    Swanson, B.J.2
  • 11
    • 0037168129 scopus 로고    scopus 로고
    • kip, but does not activate mitogen-activated kinase or protein kinase B/Akt pathways
    • DOI 10.1038/sj.onc.1205970
    • Jepson S, Komatsu M, Haq B, Arango ME, Huang D, Carraway CA et al. (2002). Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene 21: 7524-7532. (Pubitemid 35305580)
    • (2002) Oncogene , vol.21 , Issue.49 , pp. 7524-7532
    • Jepson, S.1    Komatsu, M.2    Haq, B.3    Arango, M.E.4    Huang, D.5    Carothers Carraway, C.A.6    Carraway, K.L.7
  • 13
    • 54249162413 scopus 로고    scopus 로고
    • SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell
    • Kasai K, Inaguma S, Yoneyama A, Yoshikawa K, Ikeda H. (2008). SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell. Cancer Res 68: 7723-7729.
    • (2008) Cancer Res , vol.68 , pp. 7723-7729
    • Kasai, K.1    Inaguma, S.2    Yoneyama, A.3    Yoshikawa, K.4    Ikeda, H.5
  • 15
    • 0035883673 scopus 로고    scopus 로고
    • MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: Their roles as prognostic indicators
    • DOI 10.1002/1097-0142(20010915)92:6<1427::AID-CNCR1466>3.0.CO;2-L
    • Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, Kim WH. (2001). MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators. Cancer 92: 1427-1434. (Pubitemid 32947826)
    • (2001) Cancer , vol.92 , Issue.6 , pp. 1427-1434
    • Lee, H.S.1    Lee, H.K.2    Kim, H.S.3    Yang, H.K.4    Kim, Y.I.5    Kim, W.H.6
  • 16
    • 0032549673 scopus 로고    scopus 로고
    • Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts
    • DOI 10.1074/jbc.273.12.6812
    • 0-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. J Biol Chem 273: 6812-6820. (Pubitemid 28160344)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.12 , pp. 6812-6820
    • Li, D.1    Gallup, M.2    Fan, N.3    Szymkowski, D.E.4    Basbaum, C.B.5
  • 17
    • 58149506283 scopus 로고    scopus 로고
    • GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
    • Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernandez-Zapico ME et al. (2009). GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev 23: 24-36.
    • (2009) Genes Dev , vol.23 , pp. 24-36
    • Nolan-Stevaux, O.1    Lau, J.2    Truitt, M.L.3    Chu, G.C.4    Hebrok, M.5    Fernandez-Zapico, M.E.6
  • 18
    • 39649119479 scopus 로고    scopus 로고
    • Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions
    • DOI 10.1002/ijc.23225
    • Park ET, Gum JR, Kakar S, Kwon SW, Deng G, Kim YS. (2008). Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. Int J Cancer 122: 1253-1260. (Pubitemid 351287224)
    • (2008) International Journal of Cancer , vol.122 , Issue.6 , pp. 1253-1260
    • Park, E.T.1    Gum, J.R.2    Kakar, S.3    Kwon, S.W.4    Deng, G.5    Kim, Y.S.6
  • 20
    • 16444378654 scopus 로고    scopus 로고
    • Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells
    • DOI 10.1158/0008-5472.CAN-04-1413
    • Prasad NB, Biankin AV, Fukushima N, Maitra A, Dhara S, Elkahloun AG et al. (2005). Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res 65: 1619-1626. (Pubitemid 40478583)
    • (2005) Cancer Research , vol.65 , Issue.5 , pp. 1619-1626
    • Prasad, N.B.1    Biankin, A.V.2    Fukushima, N.3    Maitra, A.4    Dhara, S.5    Elkahloun, A.G.6    Hruban, R.H.7    Goggins, M.8    Leach, S.D.9
  • 21
    • 33646051846 scopus 로고    scopus 로고
    • Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: Comparison of expression patterns between invasive components and cancerous or non-neoplastic intraductal components
    • Sanada Y, Yoshida K, Ohara M, Oeda M, Konishi K, Tsutani Y. (2006). Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or non-neoplastic intraductal components. Pancreas 32: 164-170.
    • (2006) Pancreas , vol.32 , pp. 164-170
    • Sanada, Y.1    Yoshida, K.2    Ohara, M.3    Oeda, M.4    Konishi, K.5    Tsutani, Y.6
  • 22
    • 0035918199 scopus 로고    scopus 로고
    • Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland
    • Schroeder JA, Thompson MC, Gardner MM, Gendler SJ. (2001). Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem 276: 13057-13064.
    • (2001) J Biol Chem , vol.276 , pp. 13057-13064
    • Schroeder, J.A.1    Thompson, M.C.2    Gardner, M.M.3    Gendler, S.J.4
  • 23
    • 58149291766 scopus 로고    scopus 로고
    • The MUC gene family: Their role in the diagnosis and prognosis of gastric cancer
    • Senapati S, Sharma P, Bafna S, Roy HK, Batra SK. (2008). The MUC gene family: their role in the diagnosis and prognosis of gastric cancer. Histol Histopathol 23: 1541-1552.
    • (2008) Histol Histopathol , vol.23 , pp. 1541-1552
    • Senapati, S.1    Sharma, P.2    Bafna, S.3    Roy, H.K.4    Batra, S.K.5
  • 24
    • 0141919600 scopus 로고    scopus 로고
    • Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the β-catenin/T-cell factor complex
    • Shimokawa T, Furukawa Y, Sakai M, Li M, Miwa N, Lin YM et al. (2003). Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex. Cancer Res 63: 6116-6120. (Pubitemid 37255147)
    • (2003) Cancer Research , vol.63 , Issue.19 , pp. 6116-6120
    • Shimokawa, T.1    Furukawa, Y.2    Sakai, M.3    Li, M.4    Miwa, N.5    Lin, Y.-M.6    Nakamura, Y.7
  • 26
    • 54349122044 scopus 로고    scopus 로고
    • Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer
    • Singh AP, Senapati S, Ponnusamy MP, Jain M, Lele SM, Davis JS et al. (2008). Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer. Lancet Oncol 9: 1076-1085.
    • (2008) Lancet Oncol , vol.9 , pp. 1076-1085
    • Singh, A.P.1    Senapati, S.2    Ponnusamy, M.P.3    Jain, M.4    Lele, S.M.5    Davis, J.S.6
  • 27
    • 66149100988 scopus 로고    scopus 로고
    • Associations between selected biomarkers and prognosis in a population-based pancreatic cancer tissue microarray
    • Takikita M, Altekruse S, Lynch CF, Goodman MT, Hernandez BY, Green M et al. (2009). Associations between selected biomarkers and prognosis in a population-based pancreatic cancer tissue microarray. Cancer Res 69: 2950-2955.
    • (2009) Cancer Res , vol.69 , pp. 2950-2955
    • Takikita, M.1    Altekruse, S.2    Lynch, C.F.3    Goodman, M.T.4    Hernandez, B.Y.5    Green, M.6
  • 29
    • 0345269741 scopus 로고    scopus 로고
    • Requirement of both mucins and proteoglycans in cell-cell dissociation and invasiveness of colon carcinoma HT-29 cells
    • DOI 10.1002/ijc.11011
    • Truant S, Bruyneel E, Gouyer V, De Wever O, Pruvot FR, Mareel M et al. (2003). Requirement of both mucins and proteoglycans in cell-cell dissociation and invasiveness of colon carcinoma HT-29 cells. Int J Cancer 104: 683-694. (Pubitemid 36418504)
    • (2003) International Journal of Cancer , vol.104 , Issue.6 , pp. 683-694
    • Truant, S.1    Bruyneel, E.2    Gouyer, V.3    De Wever, O.4    Pruvot, F.-R.5    Mareel, M.6    Huet, G.7
  • 30
    • 34948824382 scopus 로고    scopus 로고
    • Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells
    • DOI 10.1038/sj.onc.1210479, PII 1210479
    • Vincent A, Perrais M, Desseyn JL, Aubert JP, Pigny P, Van Seuningen I. (2007). Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells. Oncogene 26: 6566-6576. (Pubitemid 47530602)
    • (2007) Oncogene , vol.26 , Issue.45 , pp. 6566-6576
    • Vincent, A.1    Perrais, M.2    Desseyn, J.-L.3    Aubert, J.-P.4    Pigny, P.5    Van Seuningen, I.6
  • 33
    • 0037085379 scopus 로고    scopus 로고
    • Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation
    • DOI 10.1074/jbc.M105708200
    • Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA et al. (2002). Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 277: 5548-5555. (Pubitemid 34968606)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.7 , pp. 5548-5555
    • Yoon, J.W.1    Kita, Y.2    Frank, D.J.3    Majewski, R.R.4    Konicek, B.A.5    Nobrega, M.A.6    Jacob, H.7    Walterhouse, D.8    Iannaccone, P.9
  • 34
    • 0030450545 scopus 로고    scopus 로고
    • Overexpression of MUC5 genes is associated with early postoperative metastasis in non-small-cell lung cancer
    • Yu CJ, Yang PC, Shun CT, Lee YC, Kuo SH, Luh KT. (1996). Overexpression of MUC5 genes is associated with early postoperative metastasis in non-small-cell lung cancer. Int J Cancer 69: 457-465.
    • (1996) Int J Cancer , vol.69 , pp. 457-465
    • Yu, C.J.1    Yang, P.C.2    Shun, C.T.3    Lee, Y.C.4    Kuo, S.H.5    Luh, K.T.6
  • 35
    • 10444233473 scopus 로고    scopus 로고
    • Sialyl Lewis antigens: Association with MUC5AC protein and correlation with post-operative recurrence of non-small cell lung cancer
    • DOI 10.1016/j.lungcan.2004.05.018, PII S0169500204002594
    • Yu CJ, Shih JY, Lee YC, Shun CT, Yuan A, Yang PC. (2005). Sialyl Lewis antigens: association with MUC5AC protein and correlation with post-operative recurrence of non-small cell lung cancer. Lung Cancer 47: 59-67. (Pubitemid 39643242)
    • (2005) Lung Cancer , vol.47 , Issue.1 , pp. 59-67
    • Yu, C.-J.1    Shih, J.-Y.2    Lee, Y.-C.3    Shun, C.-T.4    Yuan, A.5    Yang, P.-C.6


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