Microemulsion based vaginal gel of fluconazole: Formulation, in vitro and in vivo evaluation

International Journal of Pharmaceutics

Volumn 365, Issue 1-2, 2009, Pages 175-179

  Bachhav, Yogeshwar G ^a   Patravale, Vandana B ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Fluconazole; Microemulsion; Microemulsion based vaginal gel; Vaginal delivery

Indexed keywords

CANDID V; CARBOMER; CLOTRIMAZOLE; FLUCONAZOLE; GELLING AGENT; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG SOLUBILITY; FEMALE; HUMAN; MICROEMULSION; MICROEMULSION BASED VAGINAL GEL FORMULATION; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TOXICITY TESTING; VAGINA CANDIDIASIS;

ADHESIVENESS; ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIFUNGAL AGENTS; CANDIDIASIS, VULVOVAGINAL; CLOTRIMAZOLE; DOUBLE-BLIND METHOD; EMULSIONS; FEMALE; FLUCONAZOLE; GELS; HUMANS; OILS; PARTICLE SIZE; PILOT PROJECTS; RABBITS; SOLUBILITY; SURFACE-ACTIVE AGENTS; TOXICITY TESTS;

EID: 57049181340     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.08.021     Document Type: Article

References (18)

1. Baloglu E., Özyazi{dotless}c M., Hi{dotless}zarci{dotless}oglu S.Y., and Karavana H.A. An in vitro investigation for vaginal bioadhesive formulations: bioadhesive properties and swelling states of polymer mixtures. Il Farmaco 58 (2003) 391-396
2. Champman R.L. Prevention and treatment of candida infections in neonates. Semin. Perinatol. 31 (2007) 39-46
3. Corswant C.V., Engstrom S., and Söderman O. Microemulsions based on soybean phosphotidylcholine and triglycerides. Phase behavior and microstructure. Langmuir 13 (1997) 5061-5070
4. Date A.A., and Nagarsenker M.S. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int. J. Pharm. 329 (2007) 166-172
5. Date A.A., and Patravale V.B. Microemulsions: applications in transdermal and dermal delivery. Crit. Rev. Ther. Drug Carrier Syst. 24 (2007) 547-596
6. Francois M., Snoeckx E., Putteman P., Wouters F., Proost E.D., Delat U., Peeters J., and Brewser M.E. A mucoadhesive, cyclodextrin-based vaginal cream formulation of itraconazole. AAPS Pharm. Sci. 5 (2003) Article 5
7. Horowitz B.J., Giaquinta D., and Ito S. Evolving pathogens in vulvovaginal candidiasis: implication for patient care. J. Clin. Pharmacol. 32 (1992) 248-255
8. Lawrence M.J., and Rees G.D. Microemulsion-based media as novel drug delivery systems. Adv. Drug Del. Rev. 45 (2000) 89-121
9. Meis J., Petrou M., Bille J., Ellis D., and Gibbs D. A global evaluation of the susceptibility of Candida species to fluconazole by disk diffusion. Ugeskr. Laeger. 162 (2000) 1907-1908
10. Moosa M.Y.S., Sobel J.D., Elhalis H., Du W., and Akins R.A. Fungicidal activity of fluconazole against Candida albicans in a synthetic vagina-simulative medium. Antimicrob. Agents Chemother. 48 (2004) 161-167
11. Nakamura F., Ohta R., Machida Y., and Nagai T. In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. Int. J. Pharm. 134 (1996) 173-181
12. Repka M.A., and Mcginity J.W. Bioadhesive properties of hydroxypropylcellulose topical films produced by hot-melt extrusion. J. Cont. Rel. 70 (2001) pp. 341-151
13. Seidman L., and Skokos C. An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal Candidiasis. Inf. Dis. Obst. Gyn. 13 (2005) 197-206
14. Sharma G., Jain S., Tiwary K., and Kaur G. Once daily bioadhesive vaginal clotrimazole tablets: design and evaluation. Acta Pharm. 56 (2006) 337-345
15. Sobel J.D. Candidal vulvovaginitis. Clin. Obstet. Gynecol. 36 (1993) 153-165
16. Sobel J.D. Vaginitis. N. Engl. J. Med. 337 (1997) 1896-1903
17. Tenjarla S. Microemulsions: an overview and pharmaceutical applications. Crit. Rev. Ther. Drug Carrier Syst. 16 (1999) 461-521
18. Wang Y., and Lee C.H. Characterization of a female controlled drug delivery system for microbicides. Contraception 66 (2002) 281-287