Topical drug delivery by a polymeric nanosphere gel: Formulation optimization and in vitro and in vivo skin distribution studies

Journal of Controlled Release

Volumn 149, Issue 2, 2011, Pages 159-167

  Batheja, Priya ^a,b   Sheihet, Larisa ^a   Kohn, Joachim ^a   Singer, Adam J ^c   Michniak Kohn, Bozena ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Amphiphilic triblock copolymers; Azone; Gel; HPMC; Nanospheres; Nile Red; Permeation enhancer; Topical skin delivery

Indexed keywords

AMPHIPHILIC TRIBLOCK COPOLYMERS; AZONE; HPMC; NILE RED; PERMEATION ENHANCER; TOPICAL SKIN DELIVERY;

AMINO ACIDS; BLOCK COPOLYMERS; COPOLYMERIZATION; DISPERSIONS; DRUG DELIVERY; GELS; HYDROPHILICITY; POLYMERS; RHEOLOGY; SKIN; SODIUM;

NANOSPHERES;

CARBOMER; DICLOFENAC; FLUORESCENT DYE; HYDROXYPROPYLMETHYLCELLULOSE; NANOSPHERE; NILE RED; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CYTOTOXICITY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RELEASE; GEL; HUMAN; HUMAN TISSUE; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; SKIN PERMEABILITY; SWINE; TOPICAL DRUG ADMINISTRATION; VISCOSITY;

ADMINISTRATION, CUTANEOUS; ANIMALS; AZEPINES; BUTADIENES; CELL SURVIVAL; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DICLOFENAC; DRUG CARRIERS; FIBROBLASTS; GELS; HUMANS; KERATINOCYTES; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NANOSPHERES; PHARMACEUTICAL PREPARATIONS; POLYGLUTAMIC ACID; POLYMERS; SKIN; SKIN ABSORPTION; SURFACE PROPERTIES; SWINE; TISSUE DISTRIBUTION; VISCOSITY;

EID: 78651378966     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.10.005     Document Type: Article

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