Mechanism of in vitro percutaneous absorption enhancement of carvedilol by penetration enhancers

Pharmaceutical Development and Technology

Volumn 13, Issue 6, 2008, Pages 533-539

  Amin, Saima ^a   Kohli, Kanchan ^a   Khar, Roop K ^a   Mir, Showkat R ^a   Pillai, Krishna K ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Black cumin oil; Carvedilol; Penetration enhancer (PE); Percutaneous absorption; Stratum corneum (SC)

Indexed keywords

BASIL OIL; BLACK CUMIN OIL; CARVEDILOL; CERAMIDE; CLOVE OIL; ESSENTIAL OIL; EUCALYPTUS OIL; OLEIC ACID; PENETRATION ENHANCING AGENT; POLYSORBATE 80; SKIN LIPID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCULATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; ENHANCEMENT FACTOR; EXTRACTION; FEMALE; FLUIDIZATION; HISTOLOGY; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIPID BILAYER; NONHUMAN; PARAMETER; PERMEABILITY COEFFICIENT; PRIORITY JOURNAL; RAT; SKIN ABSORPTION; SKIN PERMEABILITY; STRATUM CORNEUM; TRANSDERMAL FLUX;

2-PROPANOL; ADJUVANTS, PHARMACEUTIC; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CARBAZOLES; CLOVE OIL; EPIDERMIS; EUCALYPTUS; FEMALE; NIGELLA SATIVA; OLEIC ACID; PLANT OILS; POLYSORBATES; PROPANOLAMINES; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRANSITION TEMPERATURE; VASODILATOR AGENTS;

EID: 54949149900     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450802309646     Document Type: Article

References (32)

1. Langer R. Transdermal drug discovery: past progress, current status, and future prospects. Adv. Drug Deliver. Rev. 2004;56(5):556-557.
2. Blank IH. Penetration of low molecular weight alcohols into skin - the effect of concentration of alcohol and type of vehicle. J. Invest. Dermatol.1964;43:415-420.
3. Hadgraft J. Recent developments in topical and transdermal delivery. Eur. J . Drug Metab. Pharmacokinet. 1996;21:165-173.
4. Hadgraft J. Passive enhancement strategies in topical and transdermal drug delivery. Int. J. Pharm. 1999;184:1-6.
5. Guy RH. Iontophoresis: Recent developments. J. Pharm. Pharmcol. 1998;50(4):371-374.
6. Mitragotri S, Blankschtein D, Langer R. Transdermal drug delivery using low frequency sonophoresis. Pharm. Res. 1996;13(3):411-420.
7. Mollgard M. Synergistic effects in percutaneous enhancement. In: Walters KA, Hadgraft J, eds. Pharmaceutical Skin Penetration Enhancement. New York: Marcel Dekker; 1993:229-242.
8. Sugibayashi K, Nakayama S, Seki T, Hosoyak K, Morimoto Y. Mechanism of skin permeation enhancing effect by laurocapram. J. Pharm. Sci. 1992;81:58-64.
9. Zhao K, Singh J. Mechanism(s) of in-vitro percutaneous absorption enhancement of tamoxifen by enhancers. J. Pharm. Sci., 2000;89(6):771-780.
10. Aungst BJ, Blake JA, Rogers NJ, Husain MA. Transdermal oxymorphone formulation development and methods for evaluating flux, lag times for two skin permeation enhancing vehicles. J. Pharm. Sci. 1990;79:1072-1076.
11. Burdock GA. Encyclopedia of Food and Color Additives. Baco Raton, FL: CRC Press, 1997:230-231;461-462;1051-1054.
12. Goates CY, Knutson K. Enhanced permeation of polar compounds through human epidermis. I. Permeability and membrane structural change in the presence of short chain alcohols. Biochim. Biophys. Acta 1994;1195:169-179.
13. Tanojo H, Bouwstra JA, Junginger HE, Bodd HE. Subzero thermal analysis of human stratum corneum. Pharm. Res. 1994;11:1610-1616.
14. Dreher F, Walde P, Walther P, Wehrli E. Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal port. J. Control. Rel. 1997;45:131-140.
15. Goodman M, Barry BW. Action of penetration enhancer on human stratum corneum as assessed by differential scanning calorimetry. In: Bronaugh RL, Maibach HL, eds. Percutaneous Absorption. New York and Basel: Marcel Dekker; 1989:567-593.
16. Shin SC, Shin EY, Cho CW. Enhancing effects of fatty acids on piroxicam permeation through rat skins. Drug. Dev. Ind. Pharm. 2000;26(5):563-566.
17. Dollery, C. Therapeutic drugs. Vol. 1, Edinburg: Churchill Livingstone: 1999:76-81.
18. Chisty MNA, Bellantone RA, Taft DR, Plakogiannis FM. In-vitro evaluation of the release of albuterol sulfate from polymer gels: effect of fatty acids on drug transport across biological membranes. Drug Dev. Ind. Pharm. 2002;28(10):1221-1229.
19. Chaurasia G, Bhadra D, Bhadra S, Jain NK. UV spectrophotometric determination of carvedilol. Indian J. Pharm. Sci., 2005;67(5):606-608.
20. Vaddi HK, Ho PC, Chan SY. Terpenes in propylene glycol as skin extraction enhancers: permeation and partition of haloperidol, fourier transform infrared spectroscopy and differential scanning calorimetry. J. Pharm. Sci. 2002;91(7):1639-1651.
21. Bergh B, Bouwstra JA, Junginger HE, Wertz PW. Elasticity of vesicles affect hairless mouse skin structure and permeability. J. Control. Rel. 1999;62(3):367-379.
22. Kantarc G, Ozguney I, Karasulu HY, Guneri T, Basdemir G. In-vitro permeation of diclofenac sodium from novel microemulsion formulations through rabbit skin. Drug Dev. Res. 2005;65(1):17-25.
23. Golden GM, Guzek DB, Harris RR, McKie JE, Potts RO. Lipid thermotropic transition in human stratum corneum. J. Invest. Dermatol. 1986;86:255-269.
24. Golden GM, McKie JE, Potts RO. Role of stratum corneum lipid fluidity in transdermal drug flux. J. Pharm. Sci. 1987;76:25-28.
25. Knutson AM, Potts RO, Guzek DB, Golden GM, McKie JE, Lambert WJ, Higuchi WI. Macromolecular physical-chemical considerations in understanding the stratum corneum. J. Control. Rel. 1985;2:67-87.
26. Leopold CS, Lippold BC. An attempt to clarify the mechanism of the penetration enhancing effects of lipophilic vehicles with differential scanning calorimetry (DSC). J. Pharm. Pharmacol. 1995;47:276-281.
27. Bommannan DB, Potts RO, Guy RH. Examination of the effect of ethanol on human stratum corneum in vivo using infrared spectroscopy. J. Control. Rel. 1991;16:299-304.
28. Bhatia K, Singh J. Mechanism of transport enhancement of LHRH through porcine epidermis by terpenes and iontophoresis: permeability and lipid extraction studies. Pharm. Res. 1998;15:1857-1862.
29. Moore DJ, Rerek ME. Insight into the molecular organization of lipids in the skin barrier from infrared spectroscopy studies of SC lipids models. Acta Dermatol. 2000;208:16-22.
30. Moser K, Kriwet K, Naik A, Kalia YN, Guy RH. Passive skin penetration enhancement and its quantification in vitro. Eur. J. Pharm. Biopharm. 2001;52(2):103-112.
31. Yum S, Lee E, Taskovic L, Theeuwes F. Permeation enhancement with ethanol: mechanism of action through skin. In: Hsich DS, ed. Drug Permeation Enhancement. New York: Marcel Dekker; 1994:143-170.
32. Sintov A, Zeevi A, Uzan R, Nyska A. Influence of pharmaceutical gel vehicles containing oleic acid/sodium oleate combinations on hairless mouse skin, a histological evaluation. Eur. J. Pharm. Biopharm. 1999;47(3):299-303.