Identification of potent and selective inhibitors of the plasmodium falciparum M18 aspartyl aminopeptidase (PfM18AAP) of human malaria via high-throughput screening

Journal of Biomolecular Screening

Volumn 19, Issue 7, 2014, Pages 1107-1115

  Spicer, Timothy ^a   Fernandez Vega, Virneliz ^a   Chase, Peter ^a   Scampavia, Louis ^a   To, Joyce ^b   Dalton, John P ^b,c   Da Silva, Fabio L ^d   Skinner Adams, Tina S ^d   Gardiner, Donald L ^d   Trenholme, Katharine R ^d   Brown, Christopher L ^e   Ghosh, Partha ^f   Porubsky, Patrick ^f   Wang, Jenna L ^f   Whipple, David A ^f   Schoenen, Frank J ^f   Hodder, Peter ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^c MCGILL UNIVERSITY   (Canada)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^e GRIFFITH UNIVERSITY   (Australia)

^f UNIVERSITY OF KANSAS   (United States)

Author keywords

1536 well; aspartyl aminopeptidase; exopeptidase; malaria; parasite; PfM18AAP; Plasmodium falciparum; QFRET

Indexed keywords

ASPARTYL AMINOPEPTIDASE; CATHEPSIN L; CATHEPSIN L1; CID 23724194; CID 6852389; UNCLASSIFIED DRUG; AMINOPEPTIDASE; ANTIMALARIAL AGENT; GLUTAMYL AMINOPEPTIDASE; MOLECULAR LIBRARY; PEPTIDE; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; MALARIA; PARASITE IDENTIFICATION; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CLUSTER ANALYSIS; DRUG DESIGN; DRUG EFFECTS; ENZYME SPECIFICITY; ENZYMOLOGY; ERYTHROCYTE; FASCIOLA HEPATICA; IC50; KINETICS; MALARIA, FALCIPARUM; METABOLISM; MOLECULAR LIBRARY; PARASITOLOGY; SOFTWARE; SPECTROFLUOROMETRY;

AMINOPEPTIDASES; ANIMALS; ANTIMALARIALS; CATHEPSIN L; CLUSTER ANALYSIS; DRUG DESIGN; ERYTHROCYTES; FASCIOLA HEPATICA; GLUTAMYL AMINOPEPTIDASE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MALARIA, FALCIPARUM; PEPTIDES; PLASMODIUM FALCIPARUM; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; SOFTWARE; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY;

EID: 84904624070     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114525852     Document Type: Article

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