Basic 3-hydroxypyridin-4-ones: Potential antimalarial agents

European Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2008, Pages 1035-1047

  Dehkordi, Lotfollah S ^a   Liu, Zu D ^b   Hider, Robert C ^b  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Hydroxypyridinones; Iron chelators; Lysosomotrophic; Malaria

Indexed keywords

1 ETHYL 2 (1' HYDROXYETHYL) 3 HYDROXYPYRIDIN 4 ONE; 3 HYDROXY 4 PYRIDONE DERIVATIVE; ANTIMALARIAL AGENT; NITROGEN;

ACIDITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IRON BINDING CAPACITY; LYSOSOME; MALE; NONHUMAN; PKA; PLASMODIUM FALCIPARUM; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS; WISTAR RAT;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; IRON; IRON CHELATING AGENTS; IRON OVERLOAD; MALE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PYRIDONES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42949110248     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.07.011     Document Type: Article

References (36)

1. Practical Chemotherapy of Malaria. World Health Organisation Technical Report Series vol. 805 (1990), World Health Organization
2. Mabeza G.F., Biemba G., and Gordeuk V.C. Acta Haematol. 95 (1996) 78-86
3. Peters W. Recent Prog. Med. 81 (1990) 749-753
4. Clyde D.F. Epidemiol. Rev. 9 (1987) 219-243
5. Hider R.C. Exp. Opin. Ther. Patents 4 (1994) 931-940
6. Peto T.E.A., and Thompson J.L. Br. J. Haematol. 63 (1986) 273-280
7. Hershko C., and Peto T.E.A. J. Exp. Med. 168 (1988) 375-387
8. Raventos-Suarez C., Pollack S., and Nagel R.L. Am. J. Trop. Med. Hyg. 31 (1982) 919-929
9. Yinnon A.M., Theanacho E.N., Grady R.W., Spira D.T., and Hershko C. Blood 74 (1989) 2166-2171
10. Dobbin P.S., Hider R.C., Hall A.D., Taylor P.D., Sarpong P., Porter J.B., Xiao G., and van der Helm D. J. Med. Chem. 36 (1993) 2448-2458
11. Hershko C., Theanacho E.N., Spira D.T., Peter H.H., Dobbin P., and Hider R.C. Blood 77 (1991) 637-643
12. Hershko C., Gordeuk V.R., Thuma P.E., Theanacho E.N., Spira D.T., Hider R.C., Peto T.E.A., and Brittenham G.M. J. Inorg. Biochem. 47 (1992) 267-277
13. Hider R.C., and Liu Z.D. J. Pharm. Pharmacol. 49 Suppl. 2 (1997) 59-64
14. de Duve C., de Barsy T., Pool B., Trouet A., Tulkens P., and van Hoof F. Biochem. Pharmacol. 23 (1974) 2495-2531
15. Krogstad D.J., and Schlesinger P.H. Biochem. Pharmacol. 35 (1986) 547-552
16. Harris R.L.N. Aust. J. Chem. 29 (1976) 1329-1334
17. Stunzi H., Harris R.L.N., Perrin D.D., and Teitei T. Aust. J. Chem. 33 (1980) 2207-2220
18. Armit J.W., and Nolan T.J. J. Chem. Soc. (1932) 3023-3031
19. Bickel A.F. J. Am. Chem. Soc. 69 (1947) 1801-1803
20. Spenser I.D., and Notation A.D. Can. J. Chem. 40 (1962) 1374-1379
21. Yasue M., Kawamua N., and Sakakibara J. Yakugaku Zasshi 90 (1970) 1222-1225
22. Mintas M., Orhanovic Z., Jakopcic K., Koller H., Stuhler G., and Mannschreck A. Tetrahedron 41 (1985) 229-233
23. P. Sarpong, The Design of Pyridinone Iron(III) Chelators. Ph.D. Thesis, King's College, London, 1992.
24. Brody F., and Ruby P. In: Klinsburg E. (Ed). The Chemistry of Heterocyclic Compounds (1960), Interscience, New York
25. In: Katritzky A.R., and Rees C.W. (Eds). Comprehensive Heterocyclic Chemistry vol. 3 (1984), Pergamon, Oxford
26. Imafuku K., Takahashi K., and Matsumura H. Bull. Chem. Soc. Jpn. 52 (1979) 111-113
27. B.L. Rai. Design and Synthesis of Iron(III) Chelators for Clinical Use. Ph.D. Thesis, King's College, London, 1996.
28. Rai B.L., Dekhordi L.S., Khodr H., Jin Y., Liu Z.D., and Hider R.C. J. Med. Chem. 41 (1998) 3347-3359
29. Liu Z.D., Khodr H., Liu D.Y., Lu S.L., and Hider R.C. J. Med. Chem. 42 (1999) 4814-4823
30. Taylor P.D., Morrison I.E.G., and Hider R.C. Talanta 35 (1988) 507-512
31. Liu Z.D., Lu S.L., and Hider R.C. Biochem. Pharmacol. 57 (1999) 559-566
32. Pippard M.J., Johnson D.K., and Finch C.A. Blood 58 (1981) 685-692
33. B.E. Tate, R.L. Miller. U.S.A. Patent 3,130,204, 1964.
34. P.D. Taylor. TITRFIT, STABOPT, University of Essex, Colchester, UK.
35. Lambros C., and Vanderberg J.P. J. Parasitol. 65 (1979) 418-420
36. Webster H.K., Boudreau E.F., Pavanand K., Yongvanitchit K., and Pang L.W. Am. J. Trop. Med. Hyg. 34 (1985) 228-235