Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 52, 2012, Pages 21492-21497

  Wydeven, Nicole ^a   Young, Daniele ^a   Mirkovic, Kelsey ^a   Wickman, Kevin ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Baclofen; Electrophysiology; Ion channel; Mutagenesis

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; G PROTEIN GATED INWARDLY RECTIFYING POTASSIUM CHANNEL 1; G PROTEIN GATED INWARDLY RECTIFYING POTASSIUM CHANNEL 2; GUANINE NUCLEOTIDE BINDING PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CHANNEL GATING; CRYSTAL STRUCTURE; HIPPOCAMPUS; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MOUSE; NERVE CELL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DOMAIN; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BACLOFEN; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GLUTAMINE; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MICE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-B; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 84871836589     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212019110     Document Type: Article

References (30)

1. Lüscher C, Slesinger PA (2010) Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci 11(5):301-315.
2. + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron 19(3):687-695.
3. + channel mRNAs are differentially expressed in the adult rat brain. J Neurosci 16(11):3559-3570.
4. Signorini S, Liao YJ, Duncan SA, Jan LY, Stoffel M (1997) Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. Proc Natl Acad Sci USA 94(3):923-927. (Pubitemid 27074423)
5. Koyrakh L, et al. (2005) Molecular and cellular diversity of neuronal G-protein-gated potassium channels. J Neurosci 25(49):11468- 11478.
6. + channels. J Biol Chem 270(48):28660-28667.
7. Inanobe A, et al. (1999)Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. J Physiol 521(Pt 1):19-30.
8. KACh is a hetero-multimer of two inwardly rectifying K(+)-channel proteins. Nature 374(6518):135-141.
9. + channels are activated by G beta gamma subunits and function as heteromultimers. Proc Natl Acad Sci USA 92(14):6542-6546.
10. + channel activity of neuronal and cardiac G-protein-activated inward rectifiers. Biochem Biophys Res Commun 212(2):657-663.
11. Fowler CE, Aryal P, Suen KF, Slesinger PA (2007) Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. J Physiol 580(Pt 1):51-65. (Pubitemid 46470644)
12. Wiser O, et al. (2006) Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN. Neuron 50(4):561-573.
13. Huang CL, Jan YN, Jan LY (1997) Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. FEBS Lett 405(3):291-298. (Pubitemid 27138494)
14. Stevens EB, Woodward R, Ho IH, Murrell-Lagnado R (1997) Identification of regions that regulate the expression and activity of G protein-gated inward rectifier K+ channels in Xenopus oocytes. J Physiol 503(Pt 3):547-562. (Pubitemid 27496667)
15. Slesinger PA, Reuveny E, Jan YN, Jan LY (1995) Identification of structural elements involved in G protein gating of the GIRK1 potassium channel. Neuron 15(5):1145-1156.
16. Chan KW, Sui JL, Vivaudou M, Logothetis DE (1997) Specific regions of heteromeric subunits involved in enhancement of G protein-gated K+ channel activity. J Biol Chem 272(10):6548-6555. (Pubitemid 27118136)
17. Kunkel MT, Peralta EG (1995) Identification of domains conferring G protein regulation on inward rectifier potassium channels. Cell 83(3):443-449.
18. Nishida M, MacKinnon R (2002) Structural basis of inward rectification: Cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution. Cell 111(7):957-965. (Pubitemid 36044688)
19. Chan KW, Sui JL, Vivaudou M, Logothetis DE (1996) Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit. Proc Natl Acad Sci USA 93(24):14193-14198. (Pubitemid 26424268)
20. Rogalski SL, Appleyard SM, Pattillo A, Terman GW, Chavkin C (2000) TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel. J Biol Chem 275(33):25082-25088.
21. Ma D, et al. (2002) Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. Neuron 33(5):715-729. (Pubitemid 34219243)
22. + channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes. J Physiol 581(Pt 1):17-32.
23. + channels in dendrites of hippocampal CA1 pyramidal neurons. J Neurosci 25(15):3787-3792.
24. 2, and sodium. Cell 147(1):199-208.
25. Thomas AM, Brown SG, Leaney JL, Tinker A (2006) Differential phosphoinositide binding to components of the G protein-gated K+ channel. J Membr Biol 211(1):43-53. (Pubitemid 44477359)
26. Ho IH, Murrell-Lagnado RD (1999) Molecular determinants for sodium-dependent activation of G protein-gated K+ channels. J Biol Chem 274(13):8639-8648. (Pubitemid 29164658)
27. Bettahi I, Marker CL, Roman MI, Wickman K (2002) Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh. J Biol Chem 277(50):48282-48288. (Pubitemid 35470781)
28. Xie K, et al. (2010) Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nat Neurosci 13(6):661-663.
29. + signaling in dopamine neurons of the ventral tegmental area. J Neurosci 31(34):12251-12257.
30. Mirkovic K, Wickman K (2011) Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene. Neuroscience 194:11-18.