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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4562-4566

Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors

(8) Wen, Wandong a,b Wu, Wenjun a Romaine, Ian M b Kaufmann, Kristian b Du, Yu b Sulikowski, Gary A b,d Weaver, C David b,d Lindsley, Craig W b,c,d

a NORTHWEST A F UNIVERSITY (China)

b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

c VANDERBILT UNIVERSITY MEDICAL CENTER (United States)

d VANDERBILT UNIVERSITY (United States)

Author keywords

Activators; GIRK Kir3.x; Inhibitors; Thallium flux

Indexed keywords

G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL ACTIVATOR; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL INHIBITOR; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

ACTIVATORS; GIRK; INHIBITORS; K(IR)3.X; THALLIUM FLUX;

BIOTRANSFORMATION; DRUG DISCOVERY; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84880574814 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.06.023 Document Type: Article

Times cited : (24)

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