Overexpression of BAT3 Alleviates Prion Protein Fragment PrP106-126-Induced Neuronal Apoptosis

CNS Neuroscience and Therapeutics

Volumn 20, Issue 8, 2014, Pages 737-747

  Song, Zhi Qi ^a   Yang, Li Feng ^a   Wang, Yun Sheng ^a   Zhu, Ting ^a   Zhou, Xiang Mei ^a   Yin, Xiao Min ^a   Yao, Hong Qiang ^b,c   Zhao, De Ming ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b INNER MONGOLIA AGRICULTURAL UNIVERSITY   (China)

^c AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

Author keywords

BAT3; Neurodegenerative diseases; Neuronal apoptosis; Prion diseases; PrP106 126

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; CYTOCHROME C; HLA B ANTIGEN; HUMAN LEUKOCYTE ANTIGEN B ASSOCIATED TRANSCRIPT 3; PRION PROTEIN; PRION PROTEIN 106 126; PROTEIN BCL 2; UNCLASSIFIED DRUG; BAG6 PROTEIN, RAT; GREEN FLUORESCENT PROTEIN; PEPTIDE FRAGMENT; PROTEIN;

APOPTOSIS; ARTICLE; CELL VIABILITY; CYTOPLASM; CYTOTOXICITY; DEGENERATIVE DISEASE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NERVE CELL NECROSIS; NICK END LABELING; PRION DISEASE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REGULATORY MECHANISM; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULAR GENETICS; NERVE CELL; NEUROBLASTOMA; PATHOLOGY; PROTEIN TRANSPORT; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYTOCHROMES C; GREEN FLUORESCENT PROTEINS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; NEURONS; PEPTIDE FRAGMENTS; PROTEIN TRANSPORT; PROTEINS; PRPC PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SINCALIDE;

EID: 84904597895     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12243     Document Type: Article

References (51)

1. Soto C, Satani N. The intricate mechanisms of neurodegeneration in prion diseases. Trends Mol Med 2011;17:14-24.
2. Song Z, Zhao D, Yang L. Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies. Acta Biochim Biophys Sin (Shanghai) 2013;45:452-464.
3. Morales R, Moreno-Gonzalez I, Soto C. Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases. PLoS Pathog 2013;9:e1003537.
4. Pan KM, Baldwin M, Nguyen J, et al. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci USA 1993;90:10962-10966.
5. Linden R, Martins VR, Prado MA, et al. Physiology of the prion protein. Physiol Rev 2008;88:673-728.
6. Forloni G, Angeretti N, Chiesa R, et al. Neurotoxicity of a prion protein fragment. Nature 1993;362:543-546.
7. Selvaggini C, De Gioia L, Cantu L, et al. Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein. Biochem Biophys Res Commun 1993;194:1380-1386.
8. Henriques ST, Pattenden LK, Aguilar MI, Castanho MA. PrP(106-126) does not interact with membranes under physiological conditions. Biophys J 2008;95:1877-1889.
9. Hessa T, Sharma A, Mariappan M, et al. Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature 2011;475:394-397.
10. Banerji J, Sands J, Strominger JL, Spies T. A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain. Proc Natl Acad Sci USA 1990;87:2374-2378.
11. Thress K, Henzel W, Shillinglaw W, Kornbluth S. Scythe: a novel reaper-binding apoptotic regulator. EMBO J 1998;17:6135-6143.
12. Thress K, Evans EK, Kornbluth S. Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity. EMBO J 1999;18:5486-5493.
13. Desmots F, Russell HR, Lee Y, Boyd K, McKinnon PJ. The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol Cell Biol 2005;25:10329-10337.
14. Desmots F, Russell HR, Michel D, McKinnon PJ. Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis. J Biol Chem 2008;283:3264-3271.
15. Grover A, Izzo AA. BAT3 regulates Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis of macrophages. PLoS ONE 2012;7:e40836.
16. Minami R, Shimada M, Yokosawa H, Kawahara H. Scythe regulates apoptosis through modulating ubiquitin-mediated proteolysis of the Xenopus elongation factor XEF1AO. Biochem J 2007;405:495-501.
17. Shi F, Yang L, Kouadir M, et al. The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation. J Neuroinflammation 2012;9:73.
18. Shi F, Yang Y, Kouadir M, et al. Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia. J Neuroimmunol 2013;260:121-125.
19. Kamper N, Kessler J, Temme S, et al. A novel BAT3 sequence generated by alternative RNA splicing of exon 11B displays cell type-specific expression and impacts on subcellular localization. PLoS ONE 2012;7:e35972.
20. Wang Q, Liu Y, Soetandyo N, et al. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Mol Cell 2011;42:758-770.
21. Minami R, Hayakawa A, Kagawa H, et al. BAG-6 is essential for selective elimination of defective proteasomal substrates. J Cell Biol 2010;190:637-650.
22. O'Donovan CN, Tobin D, Cotter TG. Prion protein fragment PrP-(106-126) induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells. J Biol Chem 2001;276:43516-43523.
23. Wu W, Song W, Li S, et al. Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability. J Cell Sci 2012;125:4219-4229.
24. Brown DR, Schmidt B, Kretzschmar HA. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 1996;380:345-347.
25. Seo JS, Moon MH, Jeong JK, et al. SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death. Neurobiol Aging 2012;33:1110-1120.
26. Wu YH, Shih SF, Lin JY. Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3. J Biol Chem 2004;279:19264-19275.
27. Kretzschmar HA. Neuropathology of human prion diseases (spongiform encephalopathies). Dev Biol Stand 1993;80:71-90.
28. Asante EA, Gowland I, Linehan JM, Mahal SP, Collinge J. Expression pattern of a mini human PrP gene promoter in transgenic mice. Neurobiol Dis 2002;10:1-7.
29. Sasaki T, Marcon E, McQuire T, et al. Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis. J Cell Biol 2008;182:449-458.
30. Kikukawa Y, Minami R, Shimada M, et al. Unique proteasome subunit Xrpn10c is a specific receptor for the antiapoptotic ubiquitin-like protein Scythe. FEBS J 2005;272:6373-6386.
31. Chiarini LB, Freitas AR, Zanata SM, et al. Cellular prion protein transduces neuroprotective signals. EMBO J 2002;21:3317-3326.
32. Kuwahara C, Takeuchi AM, Nishimura T, et al. Prions prevent neuronal cell-line death. Nature 1999;400:225-226.
33. Birbach A, Gold P, Binder BR, et al. Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus. J Biol Chem 2002;277:10842-10851.
34. Wang SC, Hung MC. Cytoplasmic/nuclear shuttling and tumor progression. Ann N Y Acad Sci 2005;1059:11-15.
35. Chu CT, Plowey ED, Wang Y, Patel V, Jordan-Sciutto KL. Location, location, location: altered transcription factor trafficking in neurodegeneration. J Neuropathol Exp Neurol 2007;66:873-883.
36. Patel VP, Chu CT. Nuclear transport, oxidative stress, and neurodegeneration. Int J Clin Exp Pathol 2011;4:215-229.
37. Hung MC, Link W. Protein localization in disease and therapy. J Cell Sci 2011;124:3381-3392.
38. Tsukahara T, Kimura S, Ichimiya S, et al. Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. Cancer Sci 2009;100:47-53.
39. Manchen ST, Hubberstey AV. Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis. Biochem Biophys Res Commun 2001;287:1075-1082.
40. Xu Y, Cai M, Yang Y, Huang L, Ye Y. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Cell Rep 2012;2:1633-1644.
41. Virador VM, Davidson B, Czechowicz J, et al. The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome. PLoS ONE 2009;4:e5136.
42. Preta G, Fadeel B. Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis. FEBS Lett 2012;586:747-752.
43. Kurschner C, Morgan JI. The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system. Brain Res Mol Brain Res 1995;30:165-168.
44. Kurschner C, Morgan JI. Analysis of interaction sites in homo- and heteromeric complexes containing Bcl-2 family members and the cellular prion protein. Brain Res Mol Brain Res 1996;37:249-258.
45. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997;275:1132-1136.
46. Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997;275:1129-1132.
47. Takayama S, Sato T, Krajewski S, et al. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 1995;80:279-284.
48. Lee JH, Takahashi T, Yasuhara N, et al. Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 1999;18:6183-6190.
49. Antoku K, Maser RS, Scully WJ, Delach SM, Johnson DE. Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem Biophys Res Commun 2001;286:1003-1010.
50. Lee JG, Ye Y. Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation. BioEssays 2013;35:377-385.
51. Kawahara H, Minami R, Yokota N. BAG6/BAT3: emerging roles in quality control for nascent polypeptides. J Biochem 2013;153:147-160.