Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia

Journal of Neuroimmunology

Volumn 260, Issue 1-2, 2013, Pages 121-125

  Shi, Fushan ^a   Yang, Yang ^a   Kouadir, Mohammed ^a   Fu, Yongyao ^a   Yang, Lifeng ^a   Zhou, Xiangmei ^a   Yin, Xiaomin ^a   Zhao, Deming ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

IL 1 ; NALP3 inflammasome; Prion diseases; PrP106 126

Indexed keywords

BAFILOMYCIN A1; CRYOPYRIN; CYTOCHALASIN D; INDUCIBLE NITRIC OXIDE SYNTHASE; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PRION PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; LYSOSOME; MICROGLIA; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; CARRIER PROTEINS; CELL LINE, TRANSFORMED; CYTOCHALASIN D; ENZYME INHIBITORS; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; LYSOSOMES; MACROLIDES; MICE; MICROGLIA; NUCLEIC ACID SYNTHESIS INHIBITORS; PEPTIDE FRAGMENTS; PHAGOCYTOSIS; PRIMARY CELL CULTURE; PRIONS;

EID: 84878648941     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2013.04.016     Document Type: Article

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