Relationships between serum adipocyte hormones (adiponectin, leptin, resistin), bone mineral density and bone metabolic markers in osteoporosis patients

Journal of Bone and Mineral Metabolism

Volumn 32, Issue 4, 2014, Pages 400-404

  Mohiti Ardekani, J ^a   Soleymani Salehabadi, H ^a   Owlia, M B ^a   Mohiti, A ^a  

^a Shahid Sadougdi University of Medical Science   (Iran)

Author keywords

Adiponectin; BMD; Leptin; Osteoporosis; Resistin

Indexed keywords

ADIPONECTIN; BIOCHEMICAL MARKER; GLUCOSE; LEPTIN; RESISTIN;

ADIPOCYTE; ADULT; AGED; ARTICLE; BLOOD CHEMISTRY; BLOOD SAMPLING; BODY MASS; BONE DENSITY; BONE METABOLISM; CONTROLLED STUDY; CORRELATIONAL STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIET RESTRICTION; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEMUR NECK; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OSTEOPOROSIS; PLASMA; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SERUM; BLOOD; LUMBAR VERTEBRA; PHYSIOLOGY; RADIOGRAPHY;

ADIPONECTIN; ADULT; BONE DENSITY; FASTING; FEMALE; FEMUR NECK; HUMANS; LEPTIN; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OSTEOPOROSIS; RESISTIN;

EID: 84904561100     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-013-0511-4     Document Type: Article

References (41)

1. Lim S, Joung H, Shin CS, Lee HK, Kim KS, Shin EK, Kim HY, Lim MK, Cho SI (2004) Body composition changes with age have gender-specific impacts on bone mineral density. Bone 35:792-798 (Pubitemid 39141882)
2. Felson DT, Zhang Y, Hannan MT, Anderson J (1993) Effects of weight and body mass index on bone mineral density in men and women. J Bone Miner Res 8:567-573 (Pubitemid 23127916)
3. Glauber HS, Vollmer WM, Nevitt MC, Ensrud KE, Orwoll ES (1995) Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density. J Clin Endocrinol Metab 80:1118-1123
4. Lenchik L, Register TC, Lohman K, Hsu F-C, Nicklas BJ, Freedman BI, Langefeld CD, Carr JJ, Bowden DW (2003) Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone 33:646-651 (Pubitemid 37222391)
5. won Muhlen D, Safii S, Jassal SK, Svartberg J, Barrett-Connor E (2007) Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int 18:1337-1344
6. Maeda K, Okubo K, Shimomura I, Mizuno K, Matsuzawa Y, Matsubara K (1997) Analysis of an expression profile of genes in the human adipose tissue. Gene 190:227-235 (Pubitemid 27220127)
7. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura Nakamura T et al (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83 (Pubitemid 29299050)
8. Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L (2001) Endogenous glucose production is inhibited by the adiposederived protein Acrp30. J Clin Invest 108:1875-1881 (Pubitemid 34015133)
9. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953 (Pubitemid 32756433)
10. Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Yamamoto M, Sugimoto T (2007) Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biol 8:51-62
11. Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE (2004) Adiponectin and its receptors are expressed in bone-forming cells. Bone 35:842-849 (Pubitemid 39349215)
12. Williams GA, Wang Y, Callon KE, Watson M, Lam JB, Lin JM, Janice BB, Costa JL, Orpe A, Broom N, Naot D, Reid IR, Cornish J (2009) In vitro and in vivo effects of adiponectin on bone. Endocrinology 150:3603-3610
13. Brennan AM, Mantzoros CS (2006) Drug insight: the role of leptin in human physiology and pathophysiology-emerging clinica applications. Nat Rev Endocrinol 2:318-327 (Pubitemid 43885911)
14. Thomas T, Burguera B, Melton LJ, Atkinson E, Riggs BL, Khosla S (2004) Relationship of serum leptin levels with body composition, sex steroid, and insulin levels in women and men. Metabolism 9:1278-1284
15. Burguera B, Hofbau L, Thomas L, Gori F, Lamsam J et al (2001) Leptin reduces ovariectomy-induced bone loss. Endocrinology 142:3546-3553 (Pubitemid 32681763)
16. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF et al (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100:197-207 (Pubitemid 30064908)
17. Jürimäe J, Jürimäe T, Leppik A, Kums T (2008) The influence of ghrelin, adiponectin, and leptin on bone mineral density in healthy postmenopausal women. J Bone Miner Metab 26:618-623
18. OdabaI E, Ozata M, Turan M, Bingo N, Yonem A, Cakir B, Kutlu M, Ozdemir IC (2000) Plasma leptin concentrations in postmenopausal women with osteoporosis. Eur J Endocrinol 142:170-173 (Pubitemid 30121031)
19. Gonnelli S, Caffarelli C, Del Santo K, Cadirni A, Guerriero C, Lucani B, Franci B, Nuti R (2008) The relationship of ghrelin and adiponectin with bone mineral density and bone turnover markers in elderly men. Calcif Tissue Int 83:55-60
20. Ozkurt B, Ozkurt ZN, Altay M, Aktekin CN, Caolayan O, Tabak Y (2009) The relationship between serum adiponectin level and anthropometry bone mass osteoporotic fracture skin postmenopausal women. Eklem Hastalik Cerrahisi 20:78-84
21. Canhao H, Fonseca JE, Caetano-Lopes J, Saldanha C, Queiroz MV (2008) Assessment of laboratory measurements and -308 TNF gene promoter polymorphisms in normal bone mineral density. Clin Rheumatol 27:301-307
22. Kontogianni MD, Dafni UG, Routsias G, Skopouli FN (2004) Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res 19:546-551 (Pubitemid 41071213)
23. Pang XD, Xian H, Zhao Q, Wu XP, Sun ZQ, Liao EY (2008) Relationships between serum adiponectin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in Chinese men. Clin Chim Acta 387:31-35 (Pubitemid 350050925)
24. Jürimäe J, Jürimäe T (2007) Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women. Osteoporos Int 18:1253-1259
25. Jurima J, Rembel K, Jurimae T, Rehand M (2005) Adiponectin is associated with bone mineral density in perimenopausal women. Horm Metab Res 37:297-302 (Pubitemid 40896213)
26. Ealey KN, Kaludjerovic J, Archer MC, Ward WE (2008) Adiponectin is a negative regulator of bone mineral and bone strength in growing mice. Exp Biol Med (Maywood) 233:1546-1553
27. Richards JB, Valdes AM, Burling K, Perks UC, Spector TD (2007) Serum adiponectin and bone mineral density in women. ICEM 92:1517-1523 (Pubitemid 46556433)
28. Sato M, Takeda N, Sarui H, Takami R, Takami K, Hayashi M et al (2001) Association between serum leptin concentrations and bone mineral density, and biochemical markers of bone turnover in adult men. JCEM 86:5273-5276 (Pubitemid 33070248)
29. Zhong N, Wu XP, Xu ZR, Wang AH, Luo XH, Cao XZ, Xie H, Shan PF, Liao EY (2005) Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta 351:161-168 (Pubitemid 39563571)
30. Parm AL, Jürimäe J, Saar M, Pärna K, Tillmann V, Maasalu K, Neissaar I, Jürimäe T (2011) Plasma adipocytokine and ghrelin levels in relation to bone mineral density in prepubertal rhythmic gymnasts. J Bone Miner Metab 9:717-724
31. Tamura T, Yoneda M, Yamane K, Nakanishi S, Nakashima R, Okubo M, Kohno N (2007) Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. Metabolism 56:623-628 (Pubitemid 46574724)
32. Oshima K, Nampei AM, Iwaki M, Fukuhara A, Hashimoto J, Yoshikawa H, Shimomura I (2005) Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 331:520-526 (Pubitemid 40602668)
33. Luo XH, Guo LJ, Xie H, Yuan LQ, Wu XP, Zhou HD, Liao EY (2006) Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res 21:1648-1656 (Pubitemid 44484610)
34. Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, Depinho RA, Guo EX, Mann JJ, Karsenty G (2013) Adiponectin regulates bone mass via opposite central and peripheral mechanism through FoxO1. Cell Metab 17:901-915
35. Shinoda Y, Yamaguchi M, Ogata N (2006) Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 99:196-208 (Pubitemid 44297964)
36. Atalay A, Elic H, Kayadibi N, Nurettin A (2012) Diagnostic utility of osteocalcin, under carboxylated osteocalcin and alkaline phosphatase for osteoporosis in premenopausal and postmenopausal women. Ann Lab Med 32:23-30
37. Ochoa S, Arantazu F, Diego R, Rebeca M, Raya M, Manuel M (2012) Adiponectin and leptin serum levels in osteoporotic postmenopausal women treated with reloxifene or alendronate. Menopause 19:172-177
38. Biver E, Salliot C, Combescure C, Gossec L, Hardouin P, Legroux- Gerot I, Cortet B (2011) Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis. J Clin Endocrinol Metab 21:56-61
39. Chanprasertyothin S, Piaseu N, Chailurkit L, Rajatanavin R, Ongphiphadhanakul B (2005) Association of circulating leptin with bone mineral density in males and females. J Med Assoc Thai 88:655-659 (Pubitemid 41073262)
40. Martini G, Valenti R, Giovani S, Franci B, Campagna S, Nuti R (2001) Influence of insulin- like growth factor-1 and leptin on bone mass in healthy postmenopausal women. Bone 28:113-117 (Pubitemid 32114090)
41. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T et al (2002) Genetic variation in the gene encoding adiponectin in associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51:536-540 (Pubitemid 34764814)