Design and synthesis of hydrolytically stable multivalent ligands bearing thiodigalactoside analogues for peanut lectin and human galectin-3 binding

Journal of Organic Chemistry

Volumn 79, Issue 14, 2014, Pages 6456-6467

  Cagnoni, Alejandro J ^a,b   Kovensky, José ^b   Uhrig, María Laura ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Université de Picardie Jules Verne   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BIOACTIVITY; ESCHERICHIA COLI; PROTEINS; SCAFFOLDS;

AMINO ACID RESIDUES; BINDING AFFINITIES; COPPER(I) CATALYZED AZIDE ALKYNE CYCLOADDITION (CUAAC); ISOTHERMAL TITRATION CALORIMETRY; MICROWAVE ACTIVATION; MULTIVALENT EFFECT; MULTIVALENT LIGANDS; RECOGNITION ELEMENT;

LIGANDS;

ALKYNE; ASCORBIC ACID; AZIDE; BETA GALACTOSIDE; BROMINE DERIVATIVE; COPPER SULFATE; CUPROUS ION; GALACTOSIDE; GALECTIN 3; LIGAND; OLIGOSACCHARIDE; PEANUT AGGLUTININ; TRIPHENYLPHOSPHINE; GALECTIN-3, HUMAN; GLYCOCONJUGATE; LECTIN; THIODIGALACTOSIDE; THIOGLYCOSIDE;

ACETYLATION; ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLOADDITION; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; GLYCOSYLATION; HUMAN; HYDROGEN BOND; HYDROLYSIS; ISOTHERMAL TITRATION CALORIMETRY; MICROWAVE IRRADIATION; MOLECULAR DOCKING; MOLECULAR WEIGHT; NONHUMAN; NUCLEOPHILICITY; PEANUT; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; STOICHIOMETRY; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; CARBOHYDRATE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; MOLECULAR GENETICS;

ARACHIS HYPOGAEA; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; GALECTIN 3; GLYCOCONJUGATES; HUMANS; HYDROLYSIS; LECTINS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; THIOGALACTOSIDES;

EID: 84904537827     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo500883v     Document Type: Article

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