Leptin promotes wound healing in the oral mucosa

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Umeki, Hirochika ^a   Tokuyama, Reiko ^a   Ide, Shinji ^a   Okubo, Mitsuru ^a   Tadokoro, Susumu ^a   Tezuka, Mitsuki ^a   Tatehara, Seiko ^a   Satomura, Kazuhito ^a  

^a TSURUMI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOKERATIN 10; CYTOKERATIN 4; EPIDERMAL GROWTH FACTOR; GLUCOSE; KERATINOCYTE GROWTH FACTOR; LEPTIN; LEPTIN RECEPTOR; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; FGF7 PROTEIN, HUMAN;

ADULT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GINGIVA; GLUCOSE BLOOD LEVEL; GRANULAR CELL; HISTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUTH LESION; MOUTH ULCER; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; WEIGHT CHANGE; WOUND HEALING; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL MOTION; DRUG EFFECTS; ENDOTHELIUM CELL; EPITHELIUM CELL; MOUTH MUCOSA; PHYSIOLOGY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADULT; ANIMALS; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; ENDOTHELIAL CELLS; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; FIBROBLAST GROWTH FACTOR 7; HUMANS; LEPTIN; MALE; MOUTH MUCOSA; RABBITS; RECEPTORS, LEPTIN; WOUND HEALING;

EID: 84904480133     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101984     Document Type: Article

References (45)

1. Ten Cate AR (1994) Oral histology, 4th edn. St. Louis: Mosby.
2. Squier A, Kremer MJ (2001) Biology of oral mucosa and esophagus. J Natl Cancer Inst Monogr. (29): 7-15.
3. Hatton MN, Levine MJ, Mergarone JE, Aguirre A (1987) Lubrication and viscosity features of human saliva and commercially available saliva substitutes. J Oral Maxillofac Surg. 45: 496-499. (Pubitemid 17108084)
4. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432. (Pubitemid 24365442)
5. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, et al. (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3: 1029-1033. (Pubitemid 27391961)
6. Bado A, Levasseur S, Attuoub A, Kermorgant S, Laigneau JP, et al. (1998) The stomach is a source of leptin. Nature 394: 790-793. (Pubitemid 28391644)
7. Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L (1998) A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393: 684-688. (Pubitemid 28289657)
8. Jin L, Burguera BG, Couse ME, Scheithauer BW, Lamsan J, et al. (1999) Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab. 84: 2903-2911. (Pubitemid 30642029)
9. Morash B, Li A, Murphy PR, Wilkinson M, Ur E (1999) Leptin gene expression in the brain and pituitary gland. Endocrinology. 140: 5995-5998. (Pubitemid 30645391)
10. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770. (Pubitemid 28485436)
11. Bryson JM, Phuyal JL, SwanV, Caterson AD (1999) Leptin has acute effects on glucose and lipid metabolism in both lean and gold thioglucose-obese mice. Am J Physiol. 277: E417-E422. (Pubitemid 29458200)
12. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, et al. (1996) Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl AcadSci U S A. 93: 14564-14568. (Pubitemid 26419007)
13. Hwa JJ, Ghiboudi L, Compton D, Fawzu AB, Strader CD (1996) Intracerebroventricular injection of leptin increases thermogenesis and mobilizes fat metabolism in ob/ob mice. Horm Metab Res. 8: 659-663. (Pubitemid 27057911)
14. Spicer LJ, Francisco CC (1997) The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology. 138: 3374-3379. (Pubitemid 27345691)
15. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, et al. (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100: 197-207. (Pubitemid 30064908)
16. Kume K, Satomura K, Nishishou S, Kitaoka E, Yamanouchi K, et al. (2002) Potential role of leptin in endochondral ossification. J HistochemCytochem. 50: 159-169. (Pubitemid 34106755)
17. Bouloumié A, Drexler HC, Lafontan M, Busse R (1998) Leptin, the product of Ob gene, promotes angiogenesis. Circ Res. 83: 1059-1066. (Pubitemid 28520935)
18. Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, et al. (1998) Biological action of leptin as an angiogenic factor. Science. 281: 1683-1686. (Pubitemid 28435586)
19. Frank S, Stallmeyer B, Kampfer H, Kolb N, Pfeilscifter J (2000) Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest. 106: 501-509. (Pubitemid 30666383)
20. Murad A, Nath AK, Cha ST, Demir E, Flores-Riveros J, et al. (2003) Leptin is an autocrine/paracrine regulator of wound healing. FASEB J. 17: 1895-1897.
21. Stallmeyer B, Kampfer H, Podda M, Kaufmann R, Pfeilschifter J, et al. (2001) A novel keratinocyte mitogen: regulation of leptin and its functional receptor in skin repair. J Invest Dermatol. 117: 98-105. (Pubitemid 32652445)
22. Fei H, Okano HJ, Li C, Lee G, Zhao C, et al. (1997) Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl AcadSci U S A. 94: 7001-7005. (Pubitemid 27281980)
23. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, et al. (1996) Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387: 113-116.
24. De Matteis R, Dashtipour K, Ognibene A, Cinti S (1998) Localization of leptin receptor splice variants in mouse peripheral tissues by immunohistochemistry. Proc Nutr Soc. 57: 441-448. (Pubitemid 128736354)
25. Guerra B, Santana A, Fuentes T, Delgado-Guerra S, Cabrera-Socorro, et al. (2007) Leptin receptors in human skeletal muscle. J Appl Physiol. 102: 1786-1792. (Pubitemid 46701945)
26. Cohen P, Yang G, Yu X, Soukas AA, Wolfish CS, et al. (2005) Induction of leptin receptor expression in the liver by leptin and food deprivation. J Biol Chem. 280: 10034-10039. (Pubitemid 40395854)
27. Groschl M, Rauh M, Wagner R, Neuhuber W, Metzler M, et al. (2001) Identification of leptin in human saliva. J Clin Endocrinol Metab. 86: 5234-5239. (Pubitemid 33070241)
28. Aydin S, Halifeoglu I, Ozercan IH, Erman F, Kilic N, et al. (2005) A comparison of leptin and ghrelin levels in plasma and saliva of young healthy subjects. Peptides. 26: 647-652. (Pubitemid 40326883)
29. Ohta K, Shigeishi H, Taki M, Nishi H, Higashikawa K, et al. (2008) Regulation of CXCL9/10/11 in oral keratinocytes and fibroblasts. J Dent Res. 87: 1160-1165.
30. Fedarko NS, D'Avis P, Frazier CR, Burril MJ, Fergusson V, et al. (1995) Cell proliferation of human fibroblasts and osteoblasts in osteogenesis imperfecta: influence of age. J Bone Miner Res. 10: 1705-1712.
31. Nauta A, Gurtner G, Longaker MT (2011) Wound healing and regenerative strategies. Oral Dis. 17: 541-549.
32. Guo S, Dipietro LA (2010) Factors affecting wound healing. J Dent Res. 89: 219-229.
33. Tsuchiya T, Shimizu H, Horie T, Mori M (1999) Expression of leptin receptor in lung: leptin as a growth factor. Eur J Pharmacol. 365: 273-279. (Pubitemid 29070774)
34. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C. et al. (1996) Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA. 93: 14564-14568. (Pubitemid 26419007)
35. Tanabe K, Okuya S, Tanizawa Y, Matsutani A, Oka Y (1997) Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase. Biochem Biophys Res Commun. 241: 765-768. (Pubitemid 28036732)
36. Islam MS, Morton NM, Hansson A, Emilsson V (1997) Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response. Biochem Biophys Res Commun. 238: 851-855. (Pubitemid 27472665)
37. Santos-Alvarez J, Goberna R, Sánchez-Margalet V (1999) Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol. 194: 6-11. (Pubitemid 29283971)
38. Brown LF, Yeo KT, Berse B, Yeo T, Senger DR, et al. (1992) Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med. 176: 1375-1379.
39. Keswani SG, Balaji S, Le DL, Leung A, Parvadia JK, et al. (2013) Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing. Wound Repair Regen. 21: 554-562.
40. Greenhalgh DG, Sprugel KH, Murray MJ, Ross R (1990) PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol. 136: 1235-1246. (Pubitemid 20210322)
41. Gibran NS, Isik FF, Heimbach DM, Gordon D (1994) Basic fibroblast growth factor in the early human burn wound. J Surg Res. 56: 226-234. (Pubitemid 24100432)
42. Roberts AB, Frplik CA, Anzano MA, Sporn MB (1983) Transforming growth factors from neoplastic and nonneoplastic tissues. Fed Proc. 42: 2621-2626. (Pubitemid 13040978)
43. Martin P, Dikson MC, Millan FA, Akhurst RJ (1993) Rapid induction and clearance of TGF beta 1 is an early response to wounding in the mouse embryo. Dev Genet. 14: 225-238. (Pubitemid 23219921)
44. Le M, Naridze R, Morrison J, Biggs LC, Rhea L, et al. (2012) Transforming growth factor Beta 3 is required for excisional wound repair in vivo. PLoS One. 7: e48040.
45. Groschl M, Topf HG, Kratzsch J, Dotsch J, Rascher W, et al. (2005) Salivary leptin induces increased expression of growth factors in oral keratinocytes. J Mol Endocrinol. 34: 353-366. (Pubitemid 40585187)