-
1
-
-
0041856595
-
Epidemiology of neurodegeneration
-
Mayeux R. Epidemiology of neurodegeneration. Annu Rev Neurosci 2003; 26: 81-104.
-
(2003)
Annu Rev Neurosci
, vol.26
, pp. 81-104
-
-
Mayeux, R.1
-
2
-
-
51349156675
-
Amyloid Plaque and Neurofibrillary Tangle Pathology in a Regulatable Mouse Model of Alzheimer's Disease
-
Jennifer BP, Martin R, Colleen F, et al. Amyloid Plaque and Neurofibrillary Tangle Pathology in a Regulatable Mouse Model of Alzheimer's Disease. Am J Pathol 2008; 173: 762-72.
-
(2008)
Am J Pathol
, vol.173
, pp. 762-772
-
-
Jennifer, B.P.1
Martin, R.2
Colleen, F.3
-
3
-
-
4744370969
-
Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: Insight from transgenic mouse and tissue-culture models
-
Götz J, Schild A, Hoerndli F, Pennanen L. Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models. Int J Dev Neurosci 2004; 22: 453-65.
-
(2004)
Int J Dev Neurosci
, vol.22
, pp. 453-465
-
-
Götz, J.1
Schild, A.2
Hoerndli, F.3
Pennanen, L.4
-
4
-
-
84940272787
-
An Investigation of volumetric and corpus callosum dimension to detect brain disorders
-
Prabakar S, Porkumaran K. An Investigation of volumetric and corpus callosum dimension to detect brain disorders. J Biomed Sci Engin 2012; 5: 369-77.
-
(2012)
J Biomed Sci Engin
, vol.5
, pp. 369-377
-
-
Prabakar, S.1
Porkumaran, K.2
-
5
-
-
33846049659
-
Insulin and Insulin Resistance
-
Wilcox G. Insulin and Insulin Resistance. Clin Biochem Rev 2005; 26: 19-39.
-
(2005)
Clin Biochem Rev
, vol.26
, pp. 19-39
-
-
Wilcox, G.1
-
6
-
-
0032191856
-
Insulin action and insulin resistance: Diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system
-
Hunter SJ, Garvey WT. Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system. Am J Med 1998; 105: 331-45.
-
(1998)
Am J Med
, vol.105
, pp. 331-345
-
-
Hunter, S.J.1
Garvey, W.T.2
-
7
-
-
84862277598
-
Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20
-
Cao P, Tu LH, Abedini A, et al. Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20. J Mol Biol 2012; 421: 282-95.
-
(2012)
J Mol Biol
, vol.421
, pp. 282-295
-
-
Cao, P.1
Tu, L.H.2
Abedini, A.3
-
8
-
-
0043127453
-
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
-
Schubert M, Brazil DP, Burks DJ, et al. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003; 23: 7084-92.
-
(2003)
J Neurosci
, vol.23
, pp. 7084-7092
-
-
Schubert, M.1
Brazil, D.P.2
Burks, D.J.3
-
9
-
-
0018090354
-
Insulin receptors are widely distributed in the central nervous system of the rat
-
Havrankova J, Jesse R, Michael B. Insulin receptors are widely distributed in the central nervous system of the rat. Nature 1978; 272: 827-9.
-
(1978)
Nature
, vol.272
, pp. 827-829
-
-
Havrankova, J.1
Jesse, R.2
Michael, B.3
-
10
-
-
77949465525
-
Insulin receptor signalling in the development of neuronal structure and function
-
Shu-Ling C, Hollis TC. Insulin receptor signalling in the development of neuronal structure and function. Neural Develop 2010; 5: 7-11.
-
(2010)
Neural Develop
, vol.5
, pp. 7-11
-
-
Shu-Ling, C.1
Hollis, T.C.2
-
11
-
-
0031050268
-
Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study
-
Leibson CL, Rocca WA, Hanson VA, et al. Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study. Am J Epidemiol 1997; 145(4): 301-8.
-
(1997)
Am J Epidemiol
, vol.145
, Issue.4
, pp. 301-308
-
-
Leibson, C.L.1
Rocca, W.A.2
Hanson, V.A.3
-
12
-
-
0036227542
-
Type 2 Diabetes, APOE gene, and the risk for dementia and related pathologies
-
Peila R, Rodriguez BL, Launer LJ. Type 2 Diabetes, APOE gene, and the risk for dementia and related pathologies. Diabetes 2002; 51: 1256-62.
-
(2002)
Diabetes
, vol.51
, pp. 1256-1262
-
-
Peila, R.1
Rodriguez, B.L.2
Launer, L.J.3
-
13
-
-
33750987305
-
Diabetes mellitus and risk of developing Alzheimer disease: Results from the Framingham Study
-
Akomolafe A, Beiser A, Meigs JB, et al. Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Arch Neurol 2006; 63: 1551-5.
-
(2006)
Arch Neurol
, vol.63
, pp. 1551-1555
-
-
Akomolafe, A.1
Beiser, A.2
Meigs, J.B.3
-
14
-
-
15244351255
-
Impaired insulin and insulinlike growth factor expression and signalling mechanisms in Alzheimer's disease-is this type 3 diabetes?
-
Steen E, Terry BM, Rivera EJ, et al. Impaired insulin and insulinlike growth factor expression and signalling mechanisms in Alzheimer's disease-is this type 3 diabetes? J Alzheimers Dis 2005; 7: 63-80.
-
(2005)
J Alzheimers Dis
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
-
16
-
-
1842734659
-
A The source of cerebral insulin
-
Banks W. A The source of cerebral insulin. Eur J Pharmacol 2004; 490: 5-12.
-
(2004)
Eur J Pharmacol
, vol.490
, pp. 5-12
-
-
Banks, W.1
-
17
-
-
79960555700
-
Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis
-
Bosco D, Fava A, Plastino M, Montalcini T, Pujia A. Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis. J Cell Mol Med 2011; 15: 1807-21.
-
(2011)
J Cell Mol Med
, vol.15
, pp. 1807-1821
-
-
Bosco, D.1
Fava, A.2
Plastino, M.3
Montalcini, T.4
Pujia, A.5
-
18
-
-
77951058598
-
Linking type 2 diabetes and Alzheimer's disease
-
Weiping H, Cai Li. Linking type 2 diabetes and Alzheimer's disease, Proc Nat Acad Sci USA 2010; 107: 6557-8.
-
(2010)
Proc Nat Acad Sci USA
, vol.107
, pp. 6557-6558
-
-
Weiping, H.1
Li, C.2
-
19
-
-
0031907459
-
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E Genotype
-
Craft S, Peskind E, Schwartz MW, et al. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology 1998; 50: 164-8.
-
(1998)
Neurology
, vol.50
, pp. 164-168
-
-
Craft, S.1
Peskind, E.2
Schwartz, M.W.3
-
20
-
-
0024160877
-
M Role of insulin resistance in human disease
-
Reaven G. M Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607.
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.1
-
21
-
-
0034037083
-
Metabolic factors that affect beta-cell function and survival
-
Purello F, Rabuazzo AM. Metabolic factors that affect beta-cell function and survival. Diabetes Nutr Metab 2000; 13: 84-91.
-
(2000)
Diabetes Nutr Metab
, vol.13
, pp. 84-91
-
-
Purello, F.1
Rabuazzo, A.M.2
-
22
-
-
0021189287
-
Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain
-
Clarke DW, Boyd FT, Kappy MS, Raizada MK. Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain. J Biol Chem 1984; 259: 11672-5.
-
(1984)
J Biol Chem
, vol.259
, pp. 11672-11675
-
-
Clarke, D.W.1
Boyd, F.T.2
Kappy, M.S.3
Raizada, M.K.4
-
23
-
-
0026513876
-
Glucose, insulin, and insulin-like growth factor I regulate the glycogen content of astroglia-rich primary cultures
-
Dringen R, Hamprecht B. Glucose, insulin, and insulin-like growth factor I regulate the glycogen content of astroglia-rich primary cultures. J Neurochem 1992; 58: 511-7.
-
(1992)
J Neurochem
, vol.58
, pp. 511-517
-
-
Dringen, R.1
Hamprecht, B.2
-
24
-
-
0032841571
-
Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E Genotype and Gender
-
Craft S, Asthana S, Schellenberg G. Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender. Neuroendocrinol 1999; 70: 146-52.
-
(1999)
Neuroendocrinol
, vol.70
, pp. 146-152
-
-
Craft, S.1
Asthana, S.2
Schellenberg, G.3
-
25
-
-
0024403620
-
Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells
-
Werner H, Raizada MK, Mudd LM. Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells. Endocrinology 1989; 125: 314-20.
-
(1989)
Endocrinology
, vol.125
, pp. 314-320
-
-
Werner, H.1
Raizada, M.K.2
Mudd, L.M.3
-
26
-
-
33644591150
-
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine
-
Rivera EJ, Goldin A, Fulmer N, et al. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005; 8: 247-68.
-
(2005)
J Alzheimers Dis
, vol.8
, pp. 247-268
-
-
Rivera, E.J.1
Goldin, A.2
Fulmer, N.3
-
27
-
-
79956359796
-
A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: Evidence from animal models
-
Park SA. A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: evidence from animal models. J Clin Neurol 2011; 7: 10-8.
-
(2011)
J Clin Neurol
, vol.7
, pp. 10-18
-
-
Park, S.A.1
-
28
-
-
38049110692
-
Amyloid beta oligomers induce impairment of neuronal insulin receptors
-
Zhao WQ, De Felice FG, Fernandez S, et al. Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J 2008; 22: 246-60.
-
(2008)
FASEB J
, vol.22
, pp. 246-260
-
-
Zhao, W.Q.1
de Felice, F.G.2
Fernandez, S.3
-
29
-
-
0035871641
-
Stimulation of betaamyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
-
Gasparini L, Gouras GK, Wang R, et al. Stimulation of betaamyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 2001; 21: 2561-70.
-
(2001)
J Neurosci
, vol.21
, pp. 2561-2570
-
-
Gasparini, L.1
Gouras, G.K.2
Wang, R.3
-
30
-
-
0037221379
-
The role of insulin resistance in the pathogenesis of Alzheimer's disease: Implications for treatment
-
Watson GS, Craft S. The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment. CNS Drugs 2003; 17: 27-45.
-
(2003)
CNS Drugs
, vol.17
, pp. 27-45
-
-
Watson, G.S.1
Craft, S.2
-
31
-
-
0034855391
-
Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in non-diabetic elderly: The Rotterdam study
-
Hak AE, Pols HA, Stehouwer CD, et al. Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in non-diabetic elderly: the Rotterdam study. J Clin Endocrinol Metab 2001; 86: 4398-405.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4398-4405
-
-
Hak, A.E.1
Pols, H.A.2
Stehouwer, C.D.3
-
32
-
-
0037212882
-
Strong decrease of high sensitivity C-reactive protein with highdose atorvastatin in patients with type 2 diabetes mellitus
-
Van de Ree MA, Huisman MV, Princen HM, Meinders AE, Kluft C. Strong decrease of high sensitivity C-reactive protein with highdose atorvastatin in patients with type 2 diabetes mellitus. Atherosclerosis 2003; 166: 129-35.
-
(2003)
Atherosclerosis
, vol.166
, pp. 129-135
-
-
Van de Ree, M.A.1
Huisman, M.V.2
Princen, H.M.3
Meinders, A.E.4
Kluft, C.5
-
34
-
-
79251623365
-
Diabetes mellitus and Alzheimer's disease: Shared pathology and treatment?
-
Akter K, Lanza EA, Martin SA, et al. Diabetes mellitus and Alzheimer's disease: shared pathology and treatment? Br J Clin Pharmacol 2011; 71: 365-76.
-
(2011)
Br J Clin Pharmacol
, vol.71
, pp. 365-376
-
-
Akter, K.1
Lanza, E.A.2
Martin, S.A.3
-
35
-
-
0036321773
-
Early inflammation and dementia: A 25-year follow-up of the Honolulu-Asia Aging Study
-
Schmidt R, Schmidt H, Curb JD, et al. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol 2002; 52: 168-74.
-
(2002)
Ann Neurol
, vol.52
, pp. 168-174
-
-
Schmidt, R.1
Schmidt, H.2
Curb, J.D.3
-
36
-
-
2442533101
-
Inflammatory proteins in plasma and the risk of dementia: The Rotterdam study
-
Engelhart MJ, Geerlings MI, Meijer J, et al. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study. Arch Neurol 2004; 61: 668-72.
-
(2004)
Arch Neurol
, vol.61
, pp. 668-672
-
-
Engelhart, M.J.1
Geerlings, M.I.2
Meijer, J.3
-
37
-
-
77951028451
-
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes
-
Takeda S, Sato N, Uchio-Yamada K, et al. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci USA 2010; 107: 7036-41.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7036-7041
-
-
Takeda, S.1
Sato, N.2
Uchio-Yamada, K.3
-
38
-
-
0034643832
-
Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: The Cache County study
-
Anthony JC, Breitner JC, Zandi PP, et al. Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study. Neurology 2000; 54: 2066-71.
-
(2000)
Neurology
, vol.54
, pp. 2066-2071
-
-
Anthony, J.C.1
Breitner, J.C.2
Zandi, P.P.3
-
39
-
-
0033751840
-
Anti-inflammatory drugs protect against Alzheimer disease at low doses
-
Broe GA, Grayson DA, Creasey HM, et al. Anti-inflammatory drugs protect against Alzheimer disease at low doses. Arch Neurol 2000; 57: 1586-91.
-
(2000)
Arch Neurol
, vol.57
, pp. 1586-1591
-
-
Broe, G.A.1
Grayson, D.A.2
Creasey, H.M.3
-
40
-
-
74049099554
-
The relationship between Alzheimer's disease and diabetes: Type 3 diabetes?
-
Kroner Z. The relationship between Alzheimer's disease and diabetes: type 3 diabetes? Altern Med Rev 2009; 14: 373-9.
-
(2009)
Altern Med Rev
, vol.14
, pp. 373-379
-
-
Kroner, Z.1
-
41
-
-
33751405241
-
Alzheimers disease and type 2 diabetes mellitus: Cholinesterase connection?
-
Sreedhar G, Thota H, Alam AR, et al. Alzheimers disease and type 2 diabetes mellitus: cholinesterase connection? Lipids Health Dis 2006; 5: 28-33.
-
(2006)
Lipids Health Dis
, vol.5
, pp. 28-33
-
-
Sreedhar, G.1
Thota, H.2
Alam, A.R.3
-
42
-
-
0017225601
-
Acetylcholinesterase and butrylcholinesterase of developing human brain
-
Kaplay SS. Acetylcholinesterase and butrylcholinesterase of developing human brain. Biol Neonate 1976; 28: 65-73.
-
(1976)
Biol Neonate
, vol.28
, pp. 65-73
-
-
Kaplay, S.S.1
-
43
-
-
0034713266
-
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
-
Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405: 458-62.
-
(2000)
Nature
, vol.405
, pp. 458-462
-
-
Borovikova, L.V.1
Ivanova, S.2
Zhang, M.3
-
44
-
-
0037253073
-
Diabetes, oxidative stress, and antioxidants: A review
-
Martim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003; 17: 24-38.
-
(2003)
J Biochem Mol Toxicol
, vol.17
, pp. 24-38
-
-
Martim, A.C.1
Sanders, R.A.2
Watkins, J.B.3
-
45
-
-
57049143140
-
Mitochondria in neuroplasticity and neurological disorders
-
Mattson MP, Gleichmann M, Cheng A. Mitochondria in neuroplasticity and neurological disorders. Neuron 2008; 60: 748-66.
-
(2008)
Neuron
, vol.60
, pp. 748-766
-
-
Mattson, M.P.1
Gleichmann, M.2
Cheng, A.3
-
46
-
-
69049113059
-
Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: Binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease
-
Jiang D, Li X, Williams R, et al. Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease. Biochemistry 2009; 48: 7939-47.
-
(2009)
Biochemistry
, vol.48
, pp. 7939-7947
-
-
Jiang, D.1
Li, X.2
Williams, R.3
-
47
-
-
0030915855
-
Oxidative stress hypothesis in Alzheimer's Disease
-
Markesbery WR. Oxidative stress hypothesis in Alzheimer's Disease. Free Radic Biol Med 1997; 23: 134-47.
-
(1997)
Free Radic Biol Med
, vol.23
, pp. 134-147
-
-
Markesbery, W.R.1
-
48
-
-
0028363366
-
Advanced glycation end products contribute to amyloidosis in Alzheimer's disease
-
Vitek MP, Bhattacharya K, Glendening JM, et al. Advanced glycation end products contribute to amyloidosis in Alzheimer's disease. Proc Natl Acad Sci USA 1994; 91: 4766-70.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4766-4770
-
-
Vitek, M.P.1
Bhattacharya, K.2
Glendening, J.M.3
-
49
-
-
67649687039
-
An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease
-
Moreira PI, Duarte AI, Santos MS, Rego AC, Oliveira CR. An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease. J Alzheimers Dis 2009; 16: 741-61.
-
(2009)
J Alzheimers Dis
, vol.16
, pp. 741-761
-
-
Moreira, P.I.1
Duarte, A.I.2
Santos, M.S.3
Rego, A.C.4
Oliveira, C.R.5
-
50
-
-
77951096150
-
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
-
Chen H, Chan DC. Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum Mol Genet 2009; 18: R169-76.
-
(2009)
Hum Mol Genet
, vol.18
-
-
Chen, H.1
Chan, D.C.2
-
51
-
-
70449469039
-
Reactive species and diabetes: Counteracting oxidative stress to improve health
-
Perez-Matute P, Zulet MA, Martinez JA. Reactive species and diabetes: counteracting oxidative stress to improve health. Curr Opin Pharmacol 2009; 9: 771-9.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 771-779
-
-
Perez-Matute, P.1
Zulet, M.A.2
Martinez, J.A.3
-
52
-
-
0023895734
-
Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced
-
Novelli A, Reilly JA, Lysko PG, Henneberry RC. Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res 1988; 451: 205-12.
-
(1988)
Brain Res
, vol.451
, pp. 205-212
-
-
Novelli, A.1
Reilly, J.A.2
Lysko, P.G.3
Henneberry, R.C.4
-
53
-
-
44449179863
-
Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease
-
Takeuchi M, Yamagishi S. Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease. Curr Pharm Des 2008; 14: 973-8.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 973-978
-
-
Takeuchi, M.1
Yamagishi, S.2
-
54
-
-
3342948649
-
Alternative routes for the formation of glyceraldehyde-derived AGEs (TAGE) in vivo
-
Takeuchi M, Yamagishi S. Alternative routes for the formation of glyceraldehyde-derived AGEs (TAGE) in vivo. Med Hypotheses 2004; 63: 453-5.
-
(2004)
Med Hypotheses
, vol.63
, pp. 453-455
-
-
Takeuchi, M.1
Yamagishi, S.2
-
55
-
-
3042637228
-
Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy
-
Yamagishi S, Takeuchi M, Inagaki Y, Nakamura K, Imaizumi T. Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy. Int J Clin Pharmacol Res 2003; 23: 129-34.
-
(2003)
Int J Clin Pharmacol Res
, vol.23
, pp. 129-134
-
-
Yamagishi, S.1
Takeuchi, M.2
Inagaki, Y.3
Nakamura, K.4
Imaizumi, T.5
-
56
-
-
0030885482
-
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
-
Smith MA, Harris PL, Sayre LM, Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci USA 1997; 94: 9866-8.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9866-9868
-
-
Smith, M.A.1
Harris, P.L.2
Sayre, L.M.3
Perry, G.4
-
57
-
-
0042611250
-
Alzheimer's disease - synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts
-
Munch G, Schinzel R, Loske C, et al. Alzheimer's disease - synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neural Transm 1998; 105: 439-61.
-
(1998)
J Neural Transm
, vol.105
, pp. 439-461
-
-
Munch, G.1
Schinzel, R.2
Loske, C.3
-
58
-
-
70449732132
-
Immuno-histochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
-
Valente T, Gella A, Fernandez-Busquets X, Unzeta M, Durany N. Immuno-histochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. Neurobiol Dis 2010; 37: 67-76.
-
(2010)
Neurobiol Dis
, vol.37
, pp. 67-76
-
-
Valente, T.1
Gella, A.2
Fernandez-Busquets, X.3
Unzeta, M.4
Durany, N.5
-
60
-
-
84940253627
-
A review of biochemical markers for early diagnosis of Alzheimer's disease
-
Meha FA, Rizwana SW. A review of biochemical markers for early diagnosis of Alzheimer's disease, Am J Neurosci 2012; 3: 54-62.
-
(2012)
Am J Neurosci
, vol.3
, pp. 54-62
-
-
Meha, F.A.1
Rizwana, S.W.2
-
61
-
-
79955051063
-
Linking lipids to Alzheimer's disease: Cholesterol and beyond
-
Di Paolo G, Kim TW. Linking lipids to Alzheimer's disease: cholesterol and beyond. Nat Rev Neurosci 2011; 12: 284-96.
-
(2011)
Nat Rev Neurosci
, vol.12
, pp. 284-296
-
-
Di Paolo, G.1
Kim, T.W.2
-
62
-
-
0036581966
-
Diabetic dyslipidemia
-
Taskinen MR. Diabetic dyslipidemia. Atherosclerosis 2002; 3: 47-51.
-
(2002)
Atherosclerosis
, vol.3
, pp. 47-51
-
-
Taskinen, M.R.1
-
64
-
-
79953769393
-
Lipid metabolism and glial lipoproteins in the central nervous system
-
Hayashi H. Lipid metabolism and glial lipoproteins in the central nervous system. Biol Pharm Bull 2011; 34: 453-61.
-
(2011)
Biol Pharm Bull
, vol.34
, pp. 453-461
-
-
Hayashi, H.1
-
65
-
-
4644371176
-
Lipoproteins, glycoxidation and diabetic angiopathy
-
Jenkins AJ, Best, JD, Klein RL, Lyons TJ. Lipoproteins, glycoxidation and diabetic angiopathy. Diabetes Metabol Res Rev 2004; 20: 349-68.
-
(2004)
Diabetes Metabol Res Rev
, vol.20
, pp. 349-368
-
-
Jenkins, A.J.1
Best, J.D.2
Klein, R.L.3
Lyons, T.J.4
-
66
-
-
33745756094
-
Cholesterol metabolism in the brain: Importance of 24S-hydroxylation
-
Lutjohann D. Cholesterol metabolism in the brain: importance of 24S-hydroxylation. Acta Neurol Scand 2006; 185: 33-42.
-
(2006)
Acta Neurol Scand
, vol.185
, pp. 33-42
-
-
Lutjohann, D.1
-
67
-
-
0037900150
-
In vitro inhibition of insulindegrading enzyme by long-chain fatty acids and their coenzyme A thioesters
-
Hamel FG, Upward JL, Bennett RG. In vitro inhibition of insulindegrading enzyme by long-chain fatty acids and their coenzyme A thioesters. Endocrinology 2003; 144: 2404-8.
-
(2003)
Endocrinology
, vol.144
, pp. 2404-2408
-
-
Hamel, F.G.1
Upward, J.L.2
Bennett, R.G.3
-
68
-
-
0023788829
-
Role of arachidonic acid and other free fatty acids in mitochondrial dysfunction in brain ischemia
-
Hillered L, Chan PH. Role of arachidonic acid and other free fatty acids in mitochondrial dysfunction in brain ischemia. J Neurosci Res 1988; 20: 451-6.
-
(1988)
J Neurosci Res
, vol.20
, pp. 451-456
-
-
Hillered, L.1
Chan, P.H.2
-
69
-
-
77952800717
-
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
-
Zhang JH, Wen-Jun S, Salman A. Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr Metab 2010; 7, 47-52.
-
(2010)
Nutr Metab
, vol.7
, pp. 47-52
-
-
Zhang, J.H.1
Wen-Jun, S.2
Salman, A.3
-
70
-
-
33749073795
-
Cholesterol Sensing, Trafficking, and Esterification
-
Ta-Yuan C, Catherine CY, Chang NO, Yoshio Y. Cholesterol Sensing, Trafficking, and Esterification. Annu Rev Cell Dev Biol 2006; 22: 129-57.
-
(2006)
Annu Rev Cell Dev Biol
, vol.22
, pp. 129-157
-
-
Ta-Yuan, C.1
Catherine, C.Y.2
Chang, N.O.3
Yoshio, Y.4
-
71
-
-
33746932145
-
Aminoterminal domain stability mediates apolipoprotein E Aggregation Into Neurotoxic Fibrils
-
Hatters DM, Zhong N, Rutenber E, Weisgraber KH. Aminoterminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils. J Mol Biol 2006; 361: 932-44.
-
(2006)
J Mol Biol
, vol.361
, pp. 932-944
-
-
Hatters, D.M.1
Zhong, N.2
Rutenber, E.3
Weisgraber, K.H.4
-
72
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Abeta
-
Jiang Q, Lee CY, Mandrekar S, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron 2008; 58: 681-93.
-
(2008)
Neuron
, vol.58
, pp. 681-693
-
-
Jiang, Q.1
Lee, C.Y.2
Mandrekar, S.3
-
73
-
-
12144290271
-
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice
-
Brecht WJ, Harris FM, Chang S, et al. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci Off J Soc Neurosci 2004; 24: 2527-34.
-
(2004)
J Neurosci Off J Soc Neurosci
, vol.24
, pp. 2527-2534
-
-
Brecht, W.J.1
Harris, F.M.2
Chang, S.3
-
74
-
-
0041877634
-
Proteomics as a tool for discovery: Proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets
-
Nicolls MR, D'Antonio JM, Hutton JC, et al. Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. J Proteome Res 2003; 2: 199-205.
-
(2003)
J Proteome Res
, vol.2
, pp. 199-205
-
-
Nicolls, M.R.1
D'Antonio, J.M.2
Hutton, J.C.3
-
75
-
-
33846019607
-
Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes
-
David DC, Ittner LM, Gehrig P, et al. Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics 2006; 6: 6566-77.
-
(2006)
Proteomics
, vol.6
, pp. 6566-6577
-
-
David, D.C.1
Ittner, L.M.2
Gehrig, P.3
-
76
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 2001; 81: 741-66.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
77
-
-
33745140951
-
Tau phosphorylation and aggregation in Alzheimer's disease pathology
-
Avial J. Tau phosphorylation and aggregation in Alzheimer's disease pathology. FEBS Lett 2006; 580: 2922-7.
-
(2006)
FEBS Lett
, vol.580
, pp. 2922-2927
-
-
Avial, J.1
-
78
-
-
0034632806
-
Islets amyloid and type 2 diabetes mellitus
-
Hoppener JW, Ahren B, Lips CJ. Islets amyloid and type 2 diabetes mellitus. N Eng J Med 2000; 343: 411-9.
-
(2000)
N Eng J Med
, vol.343
, pp. 411-419
-
-
Hoppener, J.W.1
Ahren, B.2
Lips, C.J.3
-
79
-
-
33644834054
-
Role of Islets amyloid in type 2 diabetes mellitus
-
Hoppener JW, Lips CJ. Role of Islets amyloid in type 2 diabetes mellitus. Int J Biochem Cell Biol 2006; 38: 726-36.
-
(2006)
Int J Biochem Cell Biol
, vol.38
, pp. 726-736
-
-
Hoppener, J.W.1
Lips, C.J.2
-
80
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-32.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
-
81
-
-
36549076414
-
Leptin regulation of neuronal excitability and cognitive function
-
Harvey J. Leptin regulation of neuronal excitability and cognitive function. Curr Opin Pharmacol 2007; 7: 643-7.
-
(2007)
Curr Opin Pharmacol
, vol.7
, pp. 643-647
-
-
Harvey, J.1
-
82
-
-
64249132485
-
Leptin signalling in brain: A link between nutrition and cognition?
-
Morrison CD. Leptin signalling in brain: A link between nutrition and cognition? Biochem Biophys Acta 2009; 1792: 401-8.
-
(2009)
Biochem Biophys Acta
, vol.1792
, pp. 401-408
-
-
Morrison, C.D.1
-
83
-
-
44649198605
-
Insulin receptor signalling regulates synapse number, dendriticplaticity and circuit function in vivo
-
Chiu SL, Chen CM, Cline HT. Insulin receptor signalling regulates synapse number, dendriticplaticity and circuit function in vivo. Neuron 2008; 58: 708-19.
-
(2008)
Neuron
, vol.58
, pp. 708-719
-
-
Chiu, S.L.1
Chen, C.M.2
Cline, H.T.3
-
84
-
-
27844442718
-
Abeta-degrading enzymes: Modulators of Alzheimer's disease athogenesis and targets for therapeutic intervention
-
Eckmann EA, Ecman CB. Abeta-degrading enzymes: Modulators of Alzheimer's disease athogenesis and targets for therapeutic intervention. Biochem Soc Trans 2005; 33: 1101-5.
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 1101-1105
-
-
Eckmann, E.A.1
Ecman, C.B.2
-
85
-
-
10044238914
-
Obesity related leptin regulates Alzheimers Abeta
-
Fewlass DC. Obesity related leptin regulates Alzheimers Abeta. FASEB J 2004; 18: 1870-8.
-
(2004)
FASEB J
, vol.18
, pp. 1870-1878
-
-
Fewlass, D.C.1
-
86
-
-
0038187674
-
GSK-3alpha regulates production of Alzheimers diseases amyloid beta peptides
-
Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimers diseases amyloid beta peptides. Nature 2003; 423: 435-9.
-
(2003)
Nature
, vol.423
, pp. 435-439
-
-
Phiel, C.J.1
Wilson, C.A.2
Lee, V.M.3
Klein, P.S.4
-
87
-
-
79951787601
-
Telomerase deficiency impairs glucose metabolism and insulin secretion
-
Kuhlow D, Florian S, von Figura G, et al. Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging 2010; 2(10): 650-8.
-
(2010)
Aging
, vol.2
, Issue.10
, pp. 650-658
-
-
Kuhlow, D.1
Florian, S.2
von Figura, G.3
-
88
-
-
79954539970
-
Is shortening of telomeres the missing link between ageing and type 2 diabetes epidemic
-
Mulder H. Is shortening of telomeres the missing link between ageing and type 2 diabetes epidemic. Aging 2010; 2: 634-6.
-
(2010)
Aging
, vol.2
, pp. 634-636
-
-
Mulder, H.1
-
89
-
-
25644434756
-
The central nervous system in animal models of hyperhomocysteinemia
-
Troen AM. The central nervous system in animal models of hyperhomocysteinemia. Progr Neuropsychopharmacol Biol Psychiatry 2005; 29: 1140-51.
-
(2005)
Progr Neuropsychopharmacol Biol Psychiatry
, vol.29
, pp. 1140-1151
-
-
Troen, A.M.1
-
90
-
-
0037075257
-
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
-
Seshadri SMD, Beiser A, Selhub J, et al. Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease. New Engl J Med 2002; 346: 476-83.
-
(2002)
New Engl J Med
, vol.346
, pp. 476-483
-
-
Seshadri, S.M.D.1
Beiser, A.2
Selhub, J.3
-
91
-
-
68549115326
-
Plasma Leptin in Insulin-Resistant and Insulin-Nonresistant Coronary Artery Disease and Its Association with Cardio-Metabolic Risk Factors among Asian Indians
-
Sainani GS, Karatela RA. Plasma Leptin in Insulin-Resistant and Insulin-Nonresistant Coronary Artery Disease and Its Association with Cardio-Metabolic Risk Factors among Asian Indians. Metab Syndr Relat Disord 2009; 7: 335-40.
-
(2009)
Metab Syndr Relat Disord
, vol.7
, pp. 335-340
-
-
Sainani, G.S.1
Karatela, R.A.2
-
92
-
-
0033859798
-
Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents
-
Gallistl S, Wolfgang E, Karl S, Martin B, Harald M. Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents. Diabetes Care 2000; 23: 1348-52.
-
(2000)
Diabetes Care
, vol.23
, pp. 1348-1352
-
-
Gallistl, S.1
Wolfgang, E.2
Karl, S.3
Martin, B.4
Harald, M.5
-
93
-
-
62349110317
-
Effects of Insulin and Glucose on Cellular Metabolic Fluxes in Homocysteine Transsulfuration, Remethylation, S-Adenosylmethionine Synthesis, and Global Deoxyribonucleic Acid Methylation
-
Chiang EP, Wang YC, Chen WW, Tang FY. Effects of Insulin and Glucose on Cellular Metabolic Fluxes in Homocysteine Transsulfuration, Remethylation, S-Adenosylmethionine Synthesis, and Global Deoxyribonucleic Acid Methylation. J Clin Endocrinol Metab 2009; 94: 1017-25.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1017-1025
-
-
Chiang, E.P.1
Wang, Y.C.2
Chen, W.W.3
Tang, F.Y.4
-
94
-
-
33847698158
-
Rosiglitazone induces mitochondrial biogenesis in mouse brain
-
Strum JC, Shehee R, Virley D, et al. Rosiglitazone induces mitochondrial biogenesis in mouse brain. J Alzheimers Dis 2007; 11: 45-51.
-
(2007)
J Alzheimers Dis
, vol.11
, pp. 45-51
-
-
Strum, J.C.1
Shehee, R.2
Virley, D.3
-
96
-
-
79961166873
-
Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer's disease
-
Sodhi RK, Singh N, Jaggi AS. Neuroprotective mechanisms of peroxisome proliferator-activated receptor agonists in Alzheimer's disease. Naunyn Schmiedeberg's Arch Pharmacol 2011; 384: 115-24.
-
(2011)
Naunyn Schmiedeberg's Arch Pharmacol
, vol.384
, pp. 115-124
-
-
Sodhi, R.K.1
Singh, N.2
Jaggi, A.S.3
-
97
-
-
84862946286
-
Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: Elucidation in type 2 diabetes db/db mice
-
Zhao Q, Matsumoto K, Tsuneyama K, et al. Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice. J Pharmacol Sci 2011; 117: 230-42.
-
(2011)
J Pharmacol Sci
, vol.117
, pp. 230-242
-
-
Zhao, Q.1
Matsumoto, K.2
Tsuneyama, K.3
-
98
-
-
78650117774
-
Modeling human diseases in Caenorhabditis elegans
-
Markaki M, Tavernarakis N. Modeling human diseases in Caenorhabditis elegans. Biotechnol J 2010; 5: 1261-76.
-
(2010)
Biotechnol J
, vol.5
, pp. 1261-1276
-
-
Markaki, M.1
Tavernarakis, N.2
-
99
-
-
34547665167
-
Chromosome dosage as a life span determinant in Caenorhabiditis elegans
-
Hartman PS, Naoaki I. Chromosome dosage as a life span determinant in Caenorhabiditis elegans. Mech Ageing Dev 2007; 28: 437-43.
-
(2007)
Mech Ageing Dev
, vol.28
, pp. 437-443
-
-
Hartman, P.S.1
Naoaki, I.2
-
100
-
-
70350365865
-
C elegans as Model for the Study of High Glucose-Mediated Life Span Reduction
-
Andreas S, Georgi K, Farastuk B, et al. C elegans as Model for the Study of High Glucose-Mediated Life Span Reduction. Diabetes 2009; 58: 2450-6.
-
(2009)
Diabetes
, vol.58
, pp. 2450-2456
-
-
Andreas, S.1
Georgi, K.2
Farastuk, B.3
-
101
-
-
77954855717
-
The role of insulin/IGF-like signaling in C elegans longevity and aging
-
Rachel K, Coleen TM. The role of insulin/IGF-like signaling in C elegans longevity and aging. Dis Models Mech 2010; 3: 1-5.
-
(2010)
Dis Models Mech
, vol.3
, pp. 1-5
-
-
Rachel, K.1
Coleen, T.M.2
-
102
-
-
67649690124
-
The model Caenorhabditis elegans in diabetes mellitus and Alzheimer's disease
-
Morcos M, Hutter H. The model Caenorhabditis elegans in diabetes mellitus and Alzheimer's disease. J Alzheimers Dis 2009; 16: 897-908.
-
(2009)
J Alzheimers Dis
, vol.16
, pp. 897-908
-
-
Morcos, M.1
Hutter, H.2
-
103
-
-
79955749452
-
The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease
-
Paula LM, Parthsarathy P, Emilie F, Christian H. The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease. J Neurosci 2011; 31: 6587-94.
-
(2011)
J Neurosci
, vol.31
, pp. 6587-6594
-
-
Paula, L.M.1
Parthsarathy, P.2
Emilie, F.3
Christian, H.4
-
104
-
-
0036725918
-
Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans
-
Wu Z, Smith JV, Paramasivam V, et al. Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell Mol Biol 2002; 48: 725-31.
-
(2002)
Cell Mol Biol
, vol.48
, pp. 725-731
-
-
Wu, Z.1
Smith, J.V.2
Paramasivam, V.3
-
105
-
-
80055117409
-
Assaying beta-amyloid toxicity using a transgenic C elegans model
-
Dostal V, Link CD. Assaying beta-amyloid toxicity using a transgenic C elegans model. J Vis Exp 2010; 44: 11-6.
-
(2010)
J Vis Exp
, vol.44
, pp. 11-16
-
-
Dostal, V.1
Link, C.D.2
|