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Volumn 6 E, Issue 2, 2014, Pages 377-386

Genetic polymorphisms associated with antiepileptic metabolism

Author keywords

Alleles; Anticonvulsants; CYP450 genes; DNA polymorphism; Drug metabolism; Epilepsy; Pharmacogenetics; Review

Indexed keywords

ANTICONVULSIVE AGENT; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4;

EID: 84904464389     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e713     Document Type: Review
Times cited : (34)

References (76)
  • 3
    • 13244298981 scopus 로고    scopus 로고
    • Potential role of drug transporters in the pathogenesis of medically intractable epilepsy
    • Kwan P, Brodie MJ. Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 46, 224-35 (2005)
    • (2005) Epilepsia , vol.46 , pp. 224-235
    • Kwan, P.1    Brodie, M.J.2
  • 4
    • 0027137896 scopus 로고
    • Some aspects of prognosis in the epilepsies: A review
    • Sander JW. Some aspects of prognosis in the epilepsies: a review. Epilepsia 34, 1007-16 (1993)
    • (1993) Epilepsia , vol.34 , pp. 1007-1016
    • Sander, J.W.1
  • 5
    • 0032918385 scopus 로고    scopus 로고
    • Clinical aspects and biological bases of drug-resistant epilepsies
    • Regesta G, Tanganelli P. Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res 34, 109-22 (1999)
    • (1999) Epilepsy Res , vol.34 , pp. 109-122
    • Regesta, G.1    Tanganelli, P.2
  • 6
    • 20544475805 scopus 로고    scopus 로고
    • Löscher W. Drug resistance in epilepsy: Putative neurobiologic and clinical mechanisms
    • Schmidt D., Löscher W. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 46 (6), 858-77 (2005)
    • (2005) Epilepsia , vol.46 , Issue.6 , pp. 858-877
    • Schmidt, D.1
  • 7
    • 84880326639 scopus 로고    scopus 로고
    • The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs
    • Rogawski MA. The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs. Epilepsia 54 Suppl 2, 33-40 (2013)
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 2 , pp. 33-40
    • Rogawski, M.A.1
  • 8
    • 0036128985 scopus 로고    scopus 로고
    • Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs
    • Löscher W. Potschka H. Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs. J Pharmacol Exp Ther 301, 7-14 (2002)
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 7-14
    • Löscher, W.1    Potschka, H.2
  • 10
    • 58149231251 scopus 로고    scopus 로고
    • The clinical impact of pharmacogenetics on the treatment of epilepsy
    • DOI: 10.1111/j.1528-1167.2008.01716.x
    • Löscher W, Klotz U, Zimprich F, Schmidt D. The clinical impact of pharmacogenetics on the treatment of epilepsy. Epilepsia 50, 1-23 (2009). DOI: 10.1111/j.1528-1167.2008.01716.x
    • (2009) Epilepsia , vol.50 , pp. 1-23
    • Löscher, W.1    Klotz, U.2    Zimprich, F.3    Schmidt, D.4
  • 11
    • 84857273073 scopus 로고    scopus 로고
    • Cytochrome P450 variations in different ethnic populations
    • McGraw J, Waller D. Cytochrome P450 variations in different ethnic populations. Expert Opin Drug Metab Toxicol 8, 371-82 (2012)
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 371-382
    • McGraw, J.1    Waller, D.2
  • 12
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • Meyer UA. Pharmacogenetics and adverse drug reactions. Lancet 356, 1667-71 (2000)
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 15
    • 33745155394 scopus 로고    scopus 로고
    • ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients
    • Seo T, Ishitsu T, Ueda N, Nakada N, Yurube K, Ueda K, Nakagawa K. ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients. Pharmacogenomics 7 (4), 551-61 (2006)
    • (2006) Pharmacogenomics , vol.7 , Issue.4 , pp. 551-561
    • Seo, T.1    Ishitsu, T.2    Ueda, N.3    Nakada, N.4    Yurube, K.5    Ueda, K.6    Nakagawa, K.7
  • 18
    • 0038196961 scopus 로고    scopus 로고
    • Clinically important drug interactions in epilepsy: General features and interactions between antiepileptic drugs
    • Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs. Lancet Neurol 2, 347-56 (2003)
    • (2003) Lancet Neurol , vol.2 , pp. 347-356
    • Patsalos, P.N.1    Perucca, E.2
  • 19
    • 0031841377 scopus 로고    scopus 로고
    • Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
    • Miners JO, Birkett DJ. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol 45, 525-38 (1998)
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 525-538
    • Miners, J.O.1    Birkett, D.J.2
  • 21
    • 33645050104 scopus 로고    scopus 로고
    • Cytochrome P450s and other enzymes in drug metabolism and toxicity
    • Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J 8, E101-11 (2006)
    • (2006) AAPS J , vol.8
    • Guengerich, F.P.1
  • 22
    • 74149092567 scopus 로고    scopus 로고
    • Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 y CYP2D6 in Han Chinese
    • Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM. Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 y CYP2D6 in Han Chinese. Pharmacogenomics J 9, 380-94 (2009)
    • (2009) Pharmacogenomics J , vol.9 , pp. 380-394
    • Zhou, Q.1    Yu, X.M.2    Lin, H.B.3    Wang, L.4    Yun, Q.Z.5    Hu, S.N.6    Wang, D.M.7
  • 23
    • 77952301353 scopus 로고    scopus 로고
    • Pharmacogenetics biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system
    • Ingelman-Sundberg M, Sim SC. Pharmacogenetics biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system. Biochem Biophys Res Commun 396, 90-94 (2010)
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 90-94
    • Ingelman-Sundberg, M.1    Sim, S.C.2
  • 25
    • 32944460369 scopus 로고    scopus 로고
    • Análisis estadístico de polimorfismos genéticos en estudios epidemiológicos
    • Iniesta R, Guinóa E, Moreno V. Análisis estadístico de polimorfismos genéticos en estudios epidemiológicos. Gac Sanit 19, 333-41 (2005)
    • (2005) Gac Sanit , vol.19 , pp. 333-341
    • Iniesta, R.1    Guinóa, E.2    Moreno, V.3
  • 26
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • Meyer UA. Pharmacogenetics and adverse drug reactions. Lancet 356, 1667-71. (2000)
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 27
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer UA, Zanger UM. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu Rev Pharmacol Toxicol 37, 269-96 (1997)
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 29
    • 0033199227 scopus 로고    scopus 로고
    • Cytochrome P450 and the individuality of species
    • Nelson DR. Cytochrome P450 and the individuality of species. Arch Biochem Biophys 1, 1-10 (1999)
    • (1999) Arch Biochem Biophys , vol.1 , pp. 1-10
    • Nelson, D.R.1
  • 30
    • 54949144309 scopus 로고    scopus 로고
    • Functional pharmacogenetics/genomics of human cytocromes P450 involved in drug biotransformation
    • Zanger U, Turpeinen M, Klein K, Schwab M. Functional pharmacogenetics/ genomics of human cytocromes P450 involved in drug biotransformation. Anal Bioanal Chem 392, 1093-1108 (2008).
    • (2008) Anal Bioanal Chem , vol.392 , pp. 1093-1108
    • Zanger, U.1    Turpeinen, M.2    Klein, K.3    Schwab, M.4
  • 31
    • 33645116164 scopus 로고    scopus 로고
    • Cytochrome P450 pharmacogenetics and cáncer
    • Rodríguez-Antona C, Ingelman-Sunberg M. Cytochrome P450 pharmacogenetics and cáncer. Oncogene 25, 1679-1690 (2006)
    • (2006) Oncogene , vol.25 , pp. 1679-1690
    • Rodríguez-Antona, C.1    Ingelman-Sunberg, M.2
  • 32
    • 0036628637 scopus 로고    scopus 로고
    • Pharmacogenetics and cardiovascular disease: Impact on drug response and applications to disease management
    • Humma LM, Terra SG. Pharmacogenetics and cardiovascular disease: impact on drug response and applications to disease management. Am J Health Syst Pharm. 59, 1241-52 (2002)
    • (2002) Am J Health Syst Pharm , vol.59 , pp. 1241-1252
    • Humma, L.M.1    Terra, S.G.2
  • 33
    • 80054806990 scopus 로고    scopus 로고
    • Biomarkers for antiepileptic drug response
    • Glauser TA. Biomarkers for antiepileptic drug response. Biomark Med 5, 635-41 (2011)
    • (2011) Biomark Med , vol.5 , pp. 635-641
    • Glauser, T.A.1
  • 34
    • 33748787999 scopus 로고    scopus 로고
    • Pharmacogenetics, drugmetabolizing enzymes, and clinical practice
    • Gardiner SJ, Begg EJ. Pharmacogenetics, drugmetabolizing enzymes, and clinical practice. Pharmacol Rev 58, 521-90. (2006)
    • (2006) Pharmacol Rev , vol.58 , pp. 521-590
    • Gardiner, S.J.1    Begg, E.J.2
  • 35
    • 0014128388 scopus 로고
    • Sjöqvist F. Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds
    • Hammer W, Sjöqvist F. Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds. Life Sci 6 (17), 1895-903 (1967)
    • (1967) Life Sci , vol.6 , Issue.17 , pp. 1895-1903
    • Hammer, W.1
  • 36
    • 34248140809 scopus 로고    scopus 로고
    • Enzymes and pharmacogenetics of cardiovascular drugs
    • Siest G, Jeannesson E, Visvikis-Siest S. Enzymes and pharmacogenetics of cardiovascular drugs. Clin Chim Acta 381, 26-31 (2007)
    • (2007) Clin Chim Acta , vol.381 , pp. 26-31
    • Siest, G.1    Jeannesson, E.2    Visvikis-Siest, S.3
  • 37
    • 27944474000 scopus 로고    scopus 로고
    • CYP2D6 genotype and phenotype determination in a Mexican mestizo population
    • López M, Guerrero J, Jung-Cook H, Alonso ME. CYP2D6 genotype and phenotype determination in a Mexican mestizo population. Eur J Clin Pharmacol 61, 749-54 (2005)
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 749-754
    • López, M.1    Guerrero, J.2    Jung-Cook, H.3    Alonso, M.E.4
  • 39
    • 0036124107 scopus 로고    scopus 로고
    • CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    • Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 3, 229-43 (2002)
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
    • Bradford, L.D.1
  • 41
    • 0034469337 scopus 로고    scopus 로고
    • Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population
    • Isaza CA, Henao J, Lopez AM, Cacabelos R. Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population. Methods Find Exp Clin Pharmacol 22, 695-705 (2000)
    • (2000) Methods Find Exp Clin Pharmacol , vol.22 , pp. 695-705
    • Isaza, C.A.1    Henao, J.2    Lopez, A.M.3    Cacabelos, R.4
  • 42
    • 0032810509 scopus 로고    scopus 로고
    • Comparative evolutionary pharmacogenetics of CYP2D6 in Ngawbe and Embera Amerindians of Panama and Colombia: Role of selection versus drift in world populations
    • Jorge LF, Eichelbaum M, Griese EU, Inaba T, Arias TD. Comparative evolutionary pharmacogenetics of CYP2D6 in Ngawbe and Embera Amerindians of Panama and Colombia: role of selection versus drift in world populations. Pharmacogenetics 9, 217-28 (1999).
    • (1999) Pharmacogenetics , vol.9 , pp. 217-228
    • Jorge, L.F.1    Eichelbaum, M.2    Griese, E.U.3    Inaba, T.4    Arias, T.D.5
  • 43
    • 0029028932 scopus 로고
    • Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19
    • Bertilsson L. Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19. Clin Pharmacokinet 29, 192-09 (1995)
    • (1995) Clin Pharmacokinet , vol.29 , pp. 192-209
    • Bertilsson, L.1
  • 44
    • 0037131892 scopus 로고    scopus 로고
    • CYP2C9 allelic variants: Ethnic distribution and functional significance
    • Xie HG, Prasad HC, Kim RB, Stein CM. CYP2C9 allelic variants: ethnic distribution and functional significance. Adv Drug Deliv Rev 54, 1257-70 (2002)
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1257-1270
    • Xie, H.G.1    Prasad, H.C.2    Kim, R.B.3    Stein, C.M.4
  • 45
    • 84891475020 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphisms of Mexican indigenous populations
    • DOI:10.1515/dmdi-2013-0037
    • Sosa-Macías M, Llerena A. Cytochrome P450 genetic polymorphisms of Mexican indigenous populations Drug Metabol Drug Interact 28, 193-208 (2013). DOI:10.1515/dmdi-2013-0037
    • (2013) Drug Metabol Drug Interact , vol.28 , pp. 193-208
    • Sosa-Macías, M.1    Llerena, A.2
  • 46
    • 79952048263 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China
    • Yang ZF, Cui HW, Hasi T, Jia SQ, Gong ML, Su XL. Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China. Genet Mol Res 9,1844-51 (2010)
    • (2010) Genet Mol Res , vol.9 , pp. 1844-1851
    • Yang, Z.F.1    Cui, H.W.2    Hasi, T.3    Jia, S.Q.4    Gong, M.L.5    Su, X.L.6
  • 48
    • 79955754985 scopus 로고    scopus 로고
    • CYP2C9 polymorphism in patients with epilepsy: Genotypic frequency analyzes and phenytoin adverse reactions correlation
    • Twardowschy CA, Werneck LC, Scola RH, De Paola L, Silvado CE. CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation. Arq Neuropsiquiatr 69, 153-8 (2011)
    • (2011) Arq Neuropsiquiatr , vol.69 , pp. 153-158
    • Twardowschy, C.A.1    Werneck, L.C.2    Scola, R.H.3    De Paola, L.4    Silvado, C.E.5
  • 49
    • 0030904031 scopus 로고    scopus 로고
    • Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations
    • Goldstein JA, Ishizaki T, Chiba K, de Morais SM, Bell D, Krahn PM, Evans DA.Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics 7, 59-64 (1997)
    • (1997) Pharmacogenetics , vol.7 , pp. 59-64
    • Goldstein, J.A.1    Ishizaki, T.2    Chiba, K.3    De Morais, S.M.4    Bell, D.5    Krahn, P.M.6    Evans, D.A.7
  • 50
    • 79251470415 scopus 로고    scopus 로고
    • Impac of CYP2C19 polimorphism and smoking on response, to clopidogrel in patients with stable coronary artery disease
    • Liu XL, Wang ZJ, Yang Q, Ge HL, Gao F, Liu YY, Shi DM, Zhao YX, Zhou YJ. Impac of CYP2C19 polimorphism and smoking on response, to clopidogrel in patients with stable coronary artery disease. Chin Med J 123, 3178-83 (2010)
    • (2010) Chin Med J , vol.123 , pp. 3178-3183
    • Liu, X.L.1    Wang, Z.J.2    Yang, Q.3    Ge, H.L.4    Gao, F.5    Liu, Y.Y.6    Shi, D.M.7    Zhao, Y.X.8    Zhou, Y.J.9
  • 51
    • 30344457586 scopus 로고    scopus 로고
    • A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
    • Sim SC, Risinger C, Dahl ML, Aklillu E, Christensen M, Bertilsson L, Ingelman-Sundberg M. A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin Pharmacol Ther 79, 103-13 (2006)
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 103-113
    • Sim, S.C.1    Risinger, C.2    Dahl, M.L.3    Aklillu, E.4    Christensen, M.5    Bertilsson, L.6    Ingelman-Sundberg, M.7
  • 52
  • 53
    • 0036892578 scopus 로고    scopus 로고
    • Pharmacokinetics of midazolam and 1'-hydroxymidazolam in Chinese with different CYP3A5 genotypes
    • Shih PS, Huang JD. Pharmacokinetics of midazolam and 1'-hydroxymidazolam in Chinese with different CYP3A5 genotypes. Drug Metab Dispos 30, 1491-6 (2002)
    • (2002) Drug Metab Dispos , vol.30 , pp. 1491-1496
    • Shih, P.S.1    Huang, J.D.2
  • 54
    • 0021960864 scopus 로고
    • Extent of urinary excretion of phydroxyphenytoin in healthy subjects given phenytoin
    • Dickinson R, Hooper W, Patterson M, Eadia M, Maguire B. Extent of urinary excretion of phydroxyphenytoin in healthy subjects given phenytoin. Ther Drug Monit 7, 283-9 (1985)
    • (1985) Ther Drug Monit , vol.7 , pp. 283-289
    • Dickinson, R.1    Hooper, W.2    Patterson, M.3    Eadia, M.4    Maguire, B.5
  • 55
    • 0028787051 scopus 로고
    • Cytochrome P450 isozymes and antiepileptic drug interactions
    • Levy RH. Cytochrome P450 isozymes and antiepileptic drug interactions. Epilepsia 36, S8-13 (1995)
    • (1995) Epilepsia , vol.36
    • Levy, R.H.1
  • 56
    • 84861045786 scopus 로고    scopus 로고
    • The cytochrome P-450 2C9/2C19 but not the ABCB1 genetic polymorphism may be associated with the liver cytochrome 3A4 induction by phenytoin
    • Chhun S, Verstuyft C, Rizzo-Padoin N, Simoneau G, Becquemont L, Bergmann JF, Mouly S. The cytochrome P-450 2C9/2C19 but not the ABCB1 genetic polymorphism may be associated with the liver cytochrome 3A4 induction by phenytoin. J Clin Psychopharmacol 32, 429-31 (2012)
    • (2012) J Clin Psychopharmacol , vol.32 , pp. 429-431
    • Chhun, S.1    Verstuyft, C.2    Rizzo-Padoin, N.3    Simoneau, G.4    Becquemont, L.5    Bergmann, J.F.6    Mouly, S.7
  • 57
    • 0034978572 scopus 로고    scopus 로고
    • The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement
    • Van Der Weide J, Steijns LS, Van Weelden MJ, De Haan K. The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement. Pharmacogenetics 11, 287-91 (2001)
    • (2001) Pharmacogenetics , vol.11 , pp. 287-291
    • Van Der Weide, J.1    Steijns, L.S.2    Van Weelden, M.J.3    De Haan, K.4
  • 58
    • 0034042132 scopus 로고    scopus 로고
    • Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication
    • Ninomiya H, Mamiya K, Matsuo S, Ieiri I, Higuchi S, Tashiro N. Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication. Ther Drug Monit 22, 230-2 (2000)
    • (2000) Ther Drug Monit , vol.22 , pp. 230-232
    • Ninomiya, H.1    Mamiya, K.2    Matsuo, S.3    Ieiri, I.4    Higuchi, S.5    Tashiro, N.6
  • 60
    • 0034037772 scopus 로고    scopus 로고
    • CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: Analysis by population pharmacokinetics
    • Mamiya K, Hadama A, Yukawa E, Ieiri I, Otsubo K, Ninomiya H, Tashiro N, Higuchi S. CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics. Eur J Clin Pharmacol 55, 821-5 (2000)
    • (2000) Eur J Clin Pharmacol , vol.55 , pp. 821-825
    • Mamiya, K.1    Hadama, A.2    Yukawa, E.3    Ieiri, I.4    Otsubo, K.5    Ninomiya, H.6    Tashiro, N.7    Higuchi, S.8
  • 61
    • 0034792584 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
    • Goldstein JA. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol 52, 349-55 (2001)
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 349-355
    • Goldstein, J.A.1
  • 67
  • 68
    • 70049099656 scopus 로고    scopus 로고
    • Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients
    • Park PW, Seo YH, Ahn JY, Kim KA, Park JY. Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients. Clin Pharm Ther 34, 569-74 (2009)
    • (2009) Clin Pharm Ther , vol.34 , pp. 569-574
    • Park, P.W.1    Seo, Y.H.2    Ahn, J.Y.3    Kim, K.A.4    Park, J.Y.5
  • 70
    • 0029896587 scopus 로고    scopus 로고
    • Drug interaction profile of topiramate
    • Bourgeois BF. Drug interaction profile of topiramate. Epilepsia; 37, S14-7 (1996)
    • (1996) Epilepsia , vol.37
    • Bourgeois, B.F.1
  • 71
    • 0036001227 scopus 로고    scopus 로고
    • Topiramate therapeutic monitoring in patients with epilepsy: Effect of concomitant antiepileptic drugs
    • Contin M, Riva R, Albani F, Avoni P, Baruzzi A. Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. Ther Drug Monit 24, 332-7 (2002)
    • (2002) Ther Drug Monit , vol.24 , pp. 332-337
    • Contin, M.1    Riva, R.2    Albani, F.3    Avoni, P.4    Baruzzi, A.5
  • 72
    • 3342885956 scopus 로고    scopus 로고
    • Levetiracetam therapeutic monitoring in patients with epilepsy: Effect of concomitant antiepileptic drugs
    • Contin M, Albani F, Riva R, Baruzzi A. Levetiracetam therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs . Ther Drug Monit 26, 375-9 (2004)
    • (2004) Ther Drug Monit , vol.26 , pp. 375-379
    • Contin, M.1    Albani, F.2    Riva, R.3    Baruzzi, A.4
  • 73
    • 84864096509 scopus 로고    scopus 로고
    • Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes
    • Walzer M, Bekersky I, Blum RA, Tolbert D. Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy 32, 340-53 (2012)
    • (2012) Pharmacotherapy , vol.32 , pp. 340-353
    • Walzer, M.1    Bekersky, I.2    Blum, R.A.3    Tolbert, D.4
  • 74
    • 33751020859 scopus 로고    scopus 로고
    • Association of CYP2D6 100 C > T and 2850 C > T polymorphisms with generalized tonic clonic seizures among Indians
    • Soundararajan CC, Adhin A, Tripathi M, Prasad HK, Jain S, Vivekanandhan S. Association of CYP2D6 100 C > T and 2850 C > T polymorphisms with generalized tonic clonic seizures among Indians. J Neural Transm 113, 1873-6 (2006)
    • (2006) J Neural Transm , vol.113 , pp. 1873-1876
    • Soundararajan, C.C.1    Adhin, A.2    Tripathi, M.3    Prasad, H.K.4    Jain, S.5    Vivekanandhan, S.6
  • 75
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2C19 genetic polymorphism
    • Desta Z, Zhao X, Shin JG, Flockhart DA. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 41, 913-58 (2002)
    • (2002) Clin Pharmacokinet , vol.41 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.G.3    Flockhart, D.A.4
  • 76
    • 33644909875 scopus 로고    scopus 로고
    • Clinically relevant drug interactions with antiepileptic drugs
    • Perucca E. Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol 61 (3), 246-55 (2006)
    • (2006) Br J Clin Pharmacol , vol.61 , Issue.3 , pp. 246-255
    • Perucca, E.1


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