Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication

Therapeutic Drug Monitoring

Volumn 22, Issue 2, 2000, Pages 230-232

  Ninomiya, Hideaki ^a   Mamiya, Kohsuke ^b   Matsuo, Shin ichiro ^a   Ieiri, Ichiro ^c   Higuchi, Shun ^b   Tashiro, Nobutada ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

CYP2C subfamily; Genetic polymorphism; Phenytoin

Indexed keywords

CARBAMAZEPINE; CLONAZEPAM; DIAZEPAM; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; SULTIAME; ZONISAMIDE;

ADULT; ARTICLE; CASE REPORT; CENTRAL NERVOUS SYSTEM; CLINICAL FEATURE; DRUG BLOOD LEVEL; DRUG INTOXICATION; DRUG MONITORING; GENE MUTATION; GENETIC POLYMORPHISM; HETEROZYGOSITY; HUMAN; MALE; PATHOGENESIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEIZURE;

ADULT; ANTICONVULSANTS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MALE; PHENYTOIN; POLYMORPHISM, GENETIC;

EID: 0034042132     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200004000-00016     Document Type: Article

References (7)

1. Browne TR, LeDuc B. Phenytoin, Chemistry and Biotransformation. In: Levy RH, Mattson RH, Meldrum BS, eds. Antiepileptic Drugs. New York: Raven Press; 1995:283-98.
2. Kimura M, Ieiri I, Mamiya K, et al. Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population. Ther Drug Monit 1998;20:243-7.
3. Mamiya K, Ieiri I, Shimamoto J, et al. The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy; studies in stereoselective hydroxylation and population pharmacokinetics. Epilepsia 1998;39:1317-23.
4. Odani A, Hashimoto Y, Otsuka Y, et al. Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese. Clin Pharmacol Ther 1997;62:287-92.
5. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. A pharmacokinetic analysis program (multi) for microcomputer. J Pharm Dyn 1981;4:879-85.
6. Sheiner LB, Beal SL. Some suggestions for measuring predictive performance. J Pharmacokinet Biopharm 1981;8:246-56.
7. Donahue SR, Flockhart DA, Abernethy DR, et al. Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Clin Pharmacol Ther 1997;62:572-7.