Association of CYP2D6 100 C > T and 2850 C > T polymorphisms with generalized tonic clonic seizures among Indians

Journal of Neural Transmission

Volumn 113, Issue 12, 2006, Pages 1873-1876

  Soundararajan, C C ^a   Adhin, A ^a   Tripathi, M ^a   Prasad, H K ^a   Jain, S ^a   Vivekanandhan, S ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

CYP2D6; Epilepsy; Phenytoin toxicity; Tonic clonic seizures

Indexed keywords

CYTOCHROME P450 2D6; PHENYTOIN;

ARTICLE; CONTROLLED STUDY; DRUG ERUPTION; GENE FREQUENCY; GENETIC POLYMORPHISM; GINGIVA HYPERTROPHY; GRAND MAL SEIZURE; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; TONIC CLONIC SEIZURE;

ADULT; ALLELES; ANTICONVULSANTS; CYTOCHROME P-450 CYP2D6; DNA; EPILEPSY, TONIC-CLONIC; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INDIA; MALE; PHENYTOIN; POLYMORPHISM, GENETIC;

EID: 33751020859     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-006-0494-6     Document Type: Article

References (23)

1. BK Abraham C Adithan J Mohanasundaram CH Shashindran K Koumaravelou M Asad 2001 Genetic polymorphism of CYP2D6 in Tamil population Eur J Clin Pharmacol 56 849 850
2. G Alvan P Bechtel L Iselius U Gundert-Remy 1990 Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations Eur J Clin Pharmacol 39 533 537
3. L Bate M Gardiner 1999 Molecular genetics of human epilepsies Expert Rev Mol Med 1 1 22
4. SF Berkovic RA Howell DA Hay JL Hopper 1998 Epilepsies in twins: genetics of the major epilepsy syndromes Ann Neurol 43 435 445
5. JT Borlak V Harsany H Schneble KD Haegele 1994 pNAT and CYP2D6 gene polymorphism in epileptic patients Biochem Pharmacol 48 1717 1720
6. Commission on Classification and Terminology of the International League Against Epilepsy 1989 Proposal for revised classification of epilepsies and epileptic syndromes Epilepsia 30 389 399
7. ML Dahl QY Yue HK Roh I Johansson J Sawe F Sjoqvist L Bertilsson 1995 Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects Pharmacogenetics 5 159 164
8. SL Ho MH Kung LS Li IJ Lauder DB Ramsden 1999 Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease in Chinese and Caucasians Eur J Neurol 6 323 329
9. K Iwahashi H Suwaki Y Matsuo Y Ichikawa K Hosokawa 1994 Correspondence of increased debrisoquine 4-monooxygenase activity with seizure-susceptibility in Mongolian gerbils J Neurol Sci 121 18 21
10. T Komatsu H Yamazaki S Asahi EM Gillam FP Guengerich M Nakajima T Yokoi 2000 Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4 Drug Metab Dispos 28 1361 1368
11. V Lamba JK Lamba JB Dilawari KK Kohli 1998 Genetic polymorphism of CYP2D6 in North Indian subjects Eur J Clin Pharmacol 54 787 791
12. MS Lennard 1993 Genetically determined adverse drug reactions involving metabolism Drug Saf 9 60 77
13. LP Liang M Patel 2004 Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice Free Radic Biol Med 36 542 554
14. D Marez M Legrand N Sabbagh JM Guidice C Spire JJ Lafitte UA Meyer F Broly 1997 Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution Pharmacogenetics 7 193 202
15. UA Meyer UM Zanger 1997 Molecular mechanisms of genetic polymorphisms of drug metabolism Annu Rev Pharmacol Toxicol 37 269 296
16. R Ottman JF Annegers N Risch WA Hauser M Susser 1996 Relations of genetic and environmental factors in the etiology of epilepsy Ann Neurol 39 442 449
17. BK Ray S Bhattacharya TN Kundu SP Saha SK Das 2002 Epidemiology of epilepsy-Indian perspective J Indian Med Assoc 100 322 326
18. HK Roh ML Dahl I Johansson M Ingelman-Sundberg YN Cha L Bertilsson 1996 Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population Pharmacogenetics 6 441 447
19. BB Spear 2001 Pharmacogenetics and antiepileptic drugs Epilepsia 42 [Suppl] 5 31 34
20. R Sridharan BN Murthy 1999 Prevalence and pattern of epilepsy in India Epilepsia 40 631 636
21. Y Tsuneoka Y Matsuo K Iwahashi H Takeuchi Y Ichikawa 1993 A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease J Biochem (Tokyo) 114 263 266
22. GR Wilkinson 2005 Drug metabolism and variability among patients in drug response N Engl J Med 352 2211 2221
23. CR Wolf G Smith 1999 Cytochrome P450 CYP2D6 IARC Sci Publ 148 209 229