Obesity and sleep-disordered breathing-when two 'bad guys' meet

QJM: An International Journal of Medicine

Volumn 107, Issue 12, 2014, Pages 949-954

  Ryan, S ^a,b   Crinion, S J ^a,b   Mcnicholas, W T ^a,b  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CONGESTIVE HEART FAILURE; DISEASE SEVERITY; FOLLOW UP; HUMAN; INFLAMMATION; MEDICINE; METABOLIC DISORDER; MORBIDITY; MORTALITY; OBESITY; OBESITY HYPOVENTILATION SYNDROME; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; PUBLIC HEALTH; QUALITY OF LIFE; REVIEW; SLEEP DISORDERED BREATHING; SOCIAL INTERACTION; WORKLOAD; CARDIOVASCULAR DISEASES; COMPLICATION; ENERGY METABOLISM; FEMALE; MALE; PHYSIOLOGY; SLEEP APNEA, OBSTRUCTIVE;

CARDIOVASCULAR DISEASES; ENERGY METABOLISM; FEMALE; HUMANS; MALE; OBESITY; OBESITY HYPOVENTILATION SYNDROME; SLEEP APNEA, OBSTRUCTIVE;

EID: 84904365238     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcu029     Document Type: Review

References (42)

1. Preventing Chronic Diseases: A Vital Investment. Geneva: World Health Organisation, 2005.
2. Kopelman PG. Obesity as a medical problem. Nature 2000; 404:635-43.
3. McNicholas WT, Ryan S. Obstructive sleep apnoea syndrome: translating science to clinical practice. Respirology 2006; 11:136-44.
4. McNicholas WT, Bonsignore MR. Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J 2007; 29:156-78.
5. Gordon P, Sanders MH. Sleep.7: positive airway pressure therapy for obstructive sleep apnoea/hypopnoea syndrome. Thorax 2005; 60:68-75.
6. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005; 365:1046-53.
7. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 2013, 177 (9): 1006-14.
8. Schwab RJ, Gupta KB, Gefter WB, Metzger LJ, Hoffman EA, Pack AI. Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls. Am J Respir Crit Care Med 1995; 152 (5 Pt 1):1673-89.
9. Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleepdisordered breathing. JAMA 2000; 284:3015-21.
10. Shelton KE, Woodson H, Gay S, Suratt PM. Pharyngeal fat in obstructive sleep apnea. Am Rev Respir Dis 1993; 148:462-6.
11. Schwartz AR, Patil SP, Squier S, Schneider H, Kirkness JP, Smith PL. Obesity and upper airway control during sleep. J Appl Physiol 2010; 108:430-5.
12. Gifford AH, Leiter JC, Manning HL. Respiratory function in an obese patient with sleep-disordered breathing. Chest 2010; 138:704-15.
13. Campo A, Fruhbeck G, Zulueta JJ, Iriarte J, Seijo LM, Alcaide AB, et al. Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients. Eur Respir J 2007; 30:223-31.
14. Strobel RJ, Rosen RC. Obesity and weight loss in obstructive sleep apnea: a critical review. Sleep 1996; 19:104-15.
15. Sutherland K, Lee RW, Phillips CL, Dungan G, Yee BJ, Magnussen JS, et al. Effect of weight loss on upper airway size and facial fat in men with obstructive sleep apnoea. Thorax 2011; 66:797-803.
16. Greenburg DL, Lettieri CJ, Eliasson AH. Effects of surgical weight loss on measures of obstructive sleep apnea: a meta-analysis. Am J Med 2009; 122:535-42.
17. Kent BD, Ryan S, McNicholas WT. The genetics of obstructive sleep apnoea. Curr Opin Pulm Med 2010; 16:536-42.
18. Nowbar S, Burkart KM, Gonzales R, Fedorowicz A, Gozansky WS, Gaudio JC, et al. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med 2004; 116:1-7.
19. Mokhlesi B, Tulaimat A, Faibussowitsch I, Wang Y, Evans AT. Obesity hypoventilation syndrome: prevalence and predictors in patients with obstructive sleep apnea. Sleep Breath 2007; 11:117-24.
20. Piper AJ, Grunstein RR. Obesity hypoventilation syndrome: mechanisms and management. Am J Respir Crit Care Med 2011; 183:292-8.
21. Resta O, Foschino-Barbaro MP, Bonfitto P, Talamo S, Legari G, De Pergola G, et al. Prevalence and mechanisms of diurnal hypercapnia in a sample of morbidly obese subjects with obstructive sleep apnoea. Respir Med 2000; 94:240-6.
22. De Miguel Diez J, De Lucas Ramos P, Perez Parra JJ, Buendia Garcia MJ, Cubillo Marcos JM, Gonzalez-Moro JM. Analysis of withdrawal from noninvasive mechanical ventilation in patients with obesity-hypoventilation syndrome. Medium term results. Arch Bronconeumol 2003; 39:292-7.
23. Ayappa I, Berger KI, Norman RG, Oppenheimer BW, Rapoport DM, Goldring RM. Hypercapnia and ventilatory periodicity in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2002; 166:1112-5.
24. Tankersley CG, O'Donnell C, Daood MJ, Watchko JF, Mitzner W, Schwartz A, et al. Leptin attenuates respiratory complications associated with the obese phenotype. J Appl Physiol 1998; 85:2261-9.
25. Phipps PR, Starritt E, Caterson I, Grunstein RR. Association of serum leptin with hypoventilation in human obesity. Thorax 2002; 57:75-6.
26. Perez de Llano LA, Golpe R, Ortiz Piquer M, Veres Racamonde A, Vazquez Caruncho M, Caballero Muinelos O, et al. Short-term and long-term effects of nasal intermittent positive pressure ventilation in patients with obesity-hypoventilation syndrome. Chest 2005; 128:587-94.
27. Phillips BG, Hisel TM, Kato M, Pesek CA, Dyken ME, Narkiewicz K, et al. Recent weight gain in patients with newly diagnosed obstructive sleep apnea. J Hypertens 1999; 17:1297-300.
28. Gozal D, Kheirandish-Gozal L. Childhood obesity and sleep: relatives, partners, or both?-a critical perspective on the evidence. Ann N Y Acad Sci 2012; 1264:135-41.
29. Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 2004; 141:846-50.
30. Ong CW, O'Driscoll DM, Truby H, Naughton MT, Hamilton GS. The reciprocal interaction between obesity and obstructive sleep apnoea. Sleep Med Rev 2013; 17:123-31.
31. O'Driscoll DM, Turton AR, Copland JM, Strauss BJ, Hamilton GS. Energy expenditure in obstructive sleep apnea: validation of a multiple physiological sensor for determination of sleep and wake. Sleep Breath 2013; 17:139-46.
32. Harris M, Glozier N, Ratnavadivel R, Grunstein RR. Obstructive sleep apnea and depression. Sleep Med Rev 2009; 13:437-44.
33. West SD, Kohler M, Nicoll DJ, Stradling JR. The effect of continuous positive airway pressure treatment on physical activity in patients with obstructive sleep apnoea: a randomised controlled trial. Sleep Med 2009; 10:1056-8.
34. Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 2005; 112:2660-7.
35. Ryan S, Taylor CT, McNicholas WT. Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax 2009; 64:631-6.
36. Cummins EP, Taylor CT. Hypoxia-responsive transcription factors. Pflugers Arch 2005; 450:363-71.
37. Ryan S, Taylor CT, McNicholas WT. Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2006; 174:824-30.
38. Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001; 60:329-39.
39. Trayhurn P, Wang B, Wood IS. Hypoxia and the endocrine and signalling role of white adipose tissue. Arch Physiol Biochem 2008; 114:267-76.
40. Drager LF, Li J, Reinke C, Bevans-Fonti S, Jun JC, Polotsky VY. Intermittent hypoxia exacerbates metabolic effects of dietinduced obesity. Obesity (Silver Spring) 2011; 19:2167-74.
41. Poulain L, Thomas A, Rieusset J, Casteilla L, Levy P, Arnaud C, et al. Visceral white fat remodeling contributes to intermittent hypoxia-induced atherogenesis. Eur Respir J 2014; 43:513-22.
42. Taylor CT, Kent BD, McNicholas WT, Ryan S. High sensitivity of human adipocytes to intermittent hypoxia promotes activation of pro-inflammatory pathways. Am J Respir Crit Care Med 2013; 187:A2377.