Visceral white fat remodelling contributes to intermittent hypoxia-induced atherogenesis

European Respiratory Journal

Volumn 43, Issue 2, 2014, Pages 513-522

  Poulain, Laureline ^a   Thomas, Amandine ^a   Rieusset, Jennifer ^b   Casteilla, Louis ^c   Levy, Patrick ^a,d   Arnaud, Claire ^a   Dematteis, Maurice ^a,d  

^a UNIV GRENOBLE ALPES   (France)

^b CarMeN   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d HÔPITAL MICHALLON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE, WHITE; ANIMALS; ANOXIA; AORTA; ATHEROSCLEROSIS; CHEMOKINE CCL2; GLUCOSE TOLERANCE TEST; INFLAMMATION; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; ION CHANNELS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS;

EID: 84893487153     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00019913     Document Type: Article

References (34)

1. Somers VK, White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association/ American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. Circulation 2008; 118: 1080-1111.
2. Dematteis M, Godin-Ribuot D, Arnaud C, et al. Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease. ILAR J 2009; 50: 262-281.
3. Baguet JP, Hammer L, Lévy P, et al. The severity of oxygen desaturation is predictive of carotid wall thickening and plaque occurrence. Chest 2005; 128: 3407-3412.
4. Drager LF, Bortolotto LA, Lorenzi MC, et al. Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 2005; 172: 613-618.
5. Dematteis M, Julien C, Guillermet C, et al. Intermittent hypoxia induces early functional cardiovascular remodeling in mice. Am J Respir Crit Care Med 2008; 177: 227-235.
6. Arnaud C, Beguin PC, Lantuejoul S, et al. The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES/CCL5 inhibition. Am J Respir Crit Care Med 2011; 184: 724-731.
7. Savransky V, Nanayakkara A, Li J, et al. Chronic intermittent hypoxia induces atherosclerosis. Am J Respir Crit Care Med 2007; 175: 1290-1297.
8. Jun J, Reinke C, Bedja D, et al. Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 2010; 209: 381-386.
9. Arnaud C, Poulain L, Lévy P, et al. Inflammation contributes to the atherogenic role of intermittent hypoxia in apolipoprotein-E knock out mice. Atherosclerosis 2011; 219: 425-431.
10. Li J, Thorne LN, Punjabi NM, et al. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 2005; 97: 698-706.
11. Li J, Nanayakkara A, Jun J, et al. Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia. Physiol Genomics 2007; 31: 273-280.
12. Bonsignore MR, McNicholas WT, Montserrat JM, et al. The adipose tissue in obesity and obstructive sleep apnoea. Eur Respir J 2012; 39: 746-767.
13. Bigaard J, Frederiksen K, Tjønneland A, et al. Waist circumference and body composition in relation to all-cause mortality in middle-aged men and women. Int J Obes (Lond) 2005; 29: 778-784.
14. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010; 72: 219-246.
15. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006; 116: 1793-1801.
16. Ohman MK, Shen Y, Obimba CI, et al. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 2008; 117: 798-805.
17. Poulain L, Rieusset J, Levy PA, et al. Intermittent hypoxia induces dyslipidemia and atherogenesis through visceral white adipose tissue inflammation. Am J Respir Crit Care Med 2012; 185: A3867.
18. Council of Europe. European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes. European Treaties ETS 123. Strasbourg, March 18, 1986.
19. National Research Council. Guide for the Care and Use of Laboratory Animals. Washington, National Academies Press, 1996.
20. Trayhurn P, Wang B, Wood IS. Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 2008; 100: 227-235.
21. Prabhakar NR, Kumar GK, Peng YJ. Sympatho-adrenal activation by chronic intermittent hypoxia. J Appl Physiol 2012; 113: 1304-1310.
22. Wang YY, Lin SY, Chuang YH, et al. Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model. Am J Physiol Endocrinol Metab 2010; 300: E155-E163.
23. Kanda H, Tateya S, Tamori Y, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006; 116: 1494-1505.
24. Smorlesi A, Frontini A, Giordano A, et al. The adipose organ: white-brown adipocyte plasticity and metabolic inflammation. Obes Rev 2012; 13: Suppl. 2, 83-96.
25. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352: 1685-1695.
26. Jun J, Polotsky VY. Metabolic consequences of sleep-disordered breathing. ILAR J 2009; 50: 289-306.
27. Bays H, Mandarino L, DeFronzo RA. Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 2004; 89: 463-478.
28. Jensen MD. Is visceral fat involved in the pathogenesis of the metabolic syndrome? Human model. Obesity (Silver Spring) 2006; 14: Suppl. 1, 20S-24S.
29. Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J Appl Physiol 2009; 106: 1538-1544.
30. Iiyori N, Alonso LC, Li J, et al. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med 2007; 175: 851-857.
31. Drager LF, Yao Q, Hernandez KL, et al. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. Am J Respir Crit Care Med 2013; 188: 240-248.
32. Klein S. The case of visceral fat: argument for the defense. J Clin Invest 2004; 113: 1530-1532.
33. Gabriely I, Ma XH, Yang XM, et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 2002; 51: 2951-2958.
34. McKnight SL. WAT-free mice: diabetes without obesity. Genes Dev 1998; 12: 3145-3148.