Respiratory function in an obese patient with sleep-disordered breathing

Chest

Volumn 138, Issue 3, 2010, Pages 704-715

  Gifford, Alex H ^a   Leiter, James C ^a   Manning, Harold L ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE;

ADULT; ANATOMY; APNEA; AROUSAL; ARTHRITIS; ARTICLE; BICARBONATE BLOOD LEVEL; CASE REPORT; DAYTIME SOMNOLENCE; ECHOCARDIOGRAPHY; EXERCISE; HUMAN; HYPOVENTILATION; HYPOXEMIA; KNOWLEDGE; LUNG FUNCTION TEST; LUNG VOLUME; MALE; MUSCLE FUNCTION; NEUROMUSCULAR BLOCKING; OBESITY; PHYSIOLOGY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RESPIRATORY FAILURE; RESPIRATORY FUNCTION; SLEEP APNEA SYNDROME; SLEEP DISORDERED BREATHING; SNORING; SYSTOLIC BLOOD PRESSURE; TOTAL KNEE REPLACEMENT; UPPER RESPIRATORY TRACT; WEIGHT REDUCTION; COMPLICATION; LUNG VENTILATION; MIDDLE AGED; OBESITY HYPOVENTILATION SYNDROME; PATHOPHYSIOLOGY;

HUMANS; LUNG VOLUME MEASUREMENTS; MALE; MIDDLE AGED; OBESITY HYPOVENTILATION SYNDROME; PULMONARY VENTILATION;

EID: 77956867092     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.09-3030     Document Type: Article

References (36)

1. World Health Organization. Obesity and overweight. http://www. who.int/mediacentre/factsheets/fs311/en/. Accessed April 26, 2010.
2. Biring MS, Lewis MI, Liu JT, Mohsenifar Z. Pulmonary physiologic changes of morbid obesity. Am J Med Sci. 1999; 318(5):293-297.
3. Ray CS, Sue DY, Bray GA, Hansen JE, Wasserman K. Effects of obesity on respiratory function. Am Rev Respir Dis. 1983; 128(3):501-506.
4. Vaughan RW, Cork RC, Hollander D. The effect of massive weight loss on arterial oxygenation and pulmonary function tests. Anesthesiology. 1981;54(4):325-328. (Pubitemid 11147394)
5. Jones RL, Nzekwu M-MU. The effects of body mass index on lung volumes. Chest. 2006;130(3):827-833.
6. Rubinstein I, Zamel N, DuBarry L, Hoffstein V. Airflow limitation in morbidly obese, nonsmoking men. Ann Intern Med. 1990;112(11):828-832.
7. Naimark A, Cherniak RM. Compliance of the respiratory system and its components in health and obesity. J Appl Physiol. 1960;15(3):377-382.
8. Suratt PM, Wilhoit SC, Hsiao HS, Atkinson RL, Rochester DF. Compliance of chest wall in obese subjects. J Appl Physiol. 1984;57(2):403-407.
9. Sharp JT, Henry JP, Sweany SK, Meadows WR, Pietras RJ. The total work of breathing in normal and obese men. J Clin Invest. 1964;43:728-739.
10. Sin DD, Jones RL, Man SF. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch Intern Med. 2002; 162(13):1477-1481.
11. Schwartz AR, Smith PL, Wise RA, Gold AR, Permutt S. Induction of upper airway occlusion in sleeping individuals with subatmospheric nasal pressure. J Appl Physiol. 1988;64(2):535-542. (Pubitemid 18069903)
12. Schwartz AR, Gold AR, Schubert N, et al. Effect of weight loss on upper airway collapsibility in obstructive sleep apnea. Am Rev Respir Dis. 1991;144(3 Pt 1):494-498.
13. Kirkness JP, Schwartz AR, Schneider H, et al. Contribution of male sex, age, and obesity to mechanical instability of the upper airway during sleep. J Appl Physiol. 2008;104(6):1618-1624.
14. Barkdull GC, Kohl CA, Patel M, Davidson TM. Computed tomography imaging of patients with obstructive sleep apnea. Laryngoscope. 2008;118(8):1486-1492.
15. Schwab RJ, Gupta KB, Gefter WB, Metzger LJ, Hoffman EA, Pack AI. Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls. Am J Respir Crit Care Med. 1995;152(5 Part 1):1673-1689.
16. Horner RL, Mohiaddin RH, Lowell DG, et al. Sites and sizes of fat deposits around the pharynx in obese patients with obstructive sleep apnoea and weight matched controls. Eur Respir J. 1989;2(7):613-622.
17. Lahav Y, Rosenzweig E, Heyman Z, Doljansky J, Green A, Dagan Y. Tongue base ultrasound: a diagnostic tool for predicting obstructive sleep apnea. Ann Otol Rhinol Laryngol. 2009;118(3):179-184.
18. Wijga AH, Scholtens S, Wieringa MH, et al. Adenotonsillectomy and the development of overweight. Pediatrics. 2009;123(4):1095-1101.
19. Remmers JE, deGroot WJ, Sauerland EK, Anch AM. Pathogenesis of upper airway occlusion during sleep. J Appl Physiol. 1978;44(6):931-938.
20. Mezzanotte WS, Tangel DJ, White DP. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J Clin Invest. 1992;89(5):1571-1579.
21. Akay M, Leiter JC, Daubenspeck JA. Reduced respiratory-related evoked activity in subjects with obstructive sleep apnea syndrome. J Appl Physiol. 2003;94(2):429-438.
22. Ellen RL, Marshall SC, Palayew M, Molnar FJ, Wilson KG, Man-Son-Hing M. Systematic review of motor vehicle crash risk in persons with sleep apnea. J Clin Sleep Med. 2006;2(2):193-200. (Pubitemid 43893272)
23. Gupta RM, Parvizi J, Hanssen AD, Gay PC. Postoperative complications in patients with obstructive sleep apnea syndrome undergoing hip or knee replacement: a case-control study. Mayo Clin Proc. 2001;76(9):897-905.
24. Nowbar S, Burkart KM, Gonzales R, et al. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med. 2004;116(1):1-7. (Pubitemid 38050019)
25. Mokhlesi B, Kryger MH, Grunstein RR. Assessment and management of patients with obesity hypoventilation syndrome. Proc Am Thorac Soc. 2008;5(2):218-225. (Pubitemid 351237881)
26. Milic-Emili J, Tyler JM. Relation between work output of respiratory muscles and end-tidal CO 2 tension. J Appl Physiol. 1963;18(3):497-504.
27. Sharp JT, Henry JP, Sweany SK, Meadows WR, Pietras RJ. Effects of mass loading the respiratory system in man. J Appl Physiol. 1964;19:959-966.
28. Manning H, McCool FD, Scharf SM, Garshick E, Brown R. Oxygen cost of resistive-loaded breathing in quadriplegia. J Appl Physiol. 1992;73(3):825-831.
29. Mokhlesi B, Tulaimat A. Recent advances in obesity hypoventilation syndrome. Chest. 2007;132(4):1322-1336. (Pubitemid 47621010)
30. Khoo MC, Kronauer RE, Strohl KP, Slutsky AS. Factors inducing periodic breathing in humans: a general model. J Appl Physiol. 1982;53(3):644-659.
31. Khoo MC, Gottschalk A, Pack AI. Sleep-induced periodic breathing and apnea: a theoretical study. J Appl Physiol. 1991;70(5):2014-2024.
32. Wellman A, Jordan AS, Malhotra A, et al. Ventilatory control and airway anatomy in obstructive sleep apnea. Am J Respir Crit Care Med. 2004;170(11):1225-1232.
33. Watson RA, Pride NB. Postural changes in lung volumes and respiratory resistance in subjects with obesity. J Appl Physiol. 2005;98(2):512-517.
34. Vaughan RW, Wise L. Intraoperative arterial oxygenation in obese patients. Ann Surg. 1976;184(1):35-42.
35. Feihl F, Broccard AF. Interactions between respiration and systemic hemodynamics. Part I: basic concepts. Intensive Care Med. 2009;35(1):45-54.
36. Kessler R, Chaouat A, Weitzenblum E, et al. Pulmonary hypertension in the obstructive sleep apnoea syndrome: prevalence, causes and therapeutic consequences. Eur Respir J. 1996;9(4):787-794.