Complex metastatic niches: Already a target for therapy?

Current Opinion in Cell Biology

Volumn 31, Issue 1, 2014, Pages 29-38

  Ordóñez Morán, Paloma ^a   Huelsken, Joerg ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR MARKER;

CANCER CELL; CANCER DIAGNOSIS; CANCER GROWTH; CANCER THERAPY; CELL SPREADING; CELL SURVIVAL; COEVOLUTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOSURVEILLANCE; METASTASIS; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; REVIEW; SIGNAL TRANSDUCTION; SYSTEMATIC REVIEW; TISSUE SPECIFICITY; TUMOR GROWTH; TUMOR IMMUNITY; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR VOLUME; ANIMAL; DRUG EFFECTS; METABOLISM; NEOPLASM METASTASIS; NEOPLASMS; PATHOLOGY; STROMA CELL; CELL PROLIFERATION; MOLECULAR MECHANICS; NONHUMAN;

ANIMALS; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; STROMAL CELLS; TUMOR MICROENVIRONMENT;

EID: 84904354199     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2014.06.012     Document Type: Review

References (52)

1. Oskarsson T., Acharyya S., Zhang X.H., Vanharanta S., Tavazoie S.F., Morris P.G., Downey R.J., Manova-Todorova K., Brogi E., Massague J. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med 2011, 17:867-874.
2. O'Connell J.T., Sugimoto H., Cooke V.G., MacDonald B.A., Mehta A.I., LeBleu V.S., Dewar R., Rocha R.M., Brentani R.R., Resnick M.B., et al. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A 2011, 108:16002-16007.
3. Malanchi I., Santamaria-Martinez A., Susanto E., Peng H., Lehr H.A., Delaloye J.F., Huelsken J. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 2012, 481:85-89.
4. Ghajar C.M., Peinado H., Mori H., Matei I.R., Evason K.J., Brazier H., Almeida D., Koller A., Hajjar K.A., Stainier D.Y., et al. The perivascular niche regulates breast tumour dormancy. Nat Cell Biol 2013, 15:807-817.
5. Gao D., Joshi N., Choi H., Ryu S., Hahn M., Catena R., Sadik H., Argani P., Wagner P., Vahdat L.T., et al. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer Res 2012, 72:1384-1394.
6. Said N., Sanchez-Carbayo M., Smith S.C., Theodorescu D. RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. J Clin Invest 2012, 122:1503-1518.
7. Eisinger-Mathason T.S., Zhang M., Qiu Q., Skuli N., Nakazawa M.S., Karakasheva T., Mucaj V., Shay J.E., Stangenberg L., Sadri N., et al. Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis. Cancer Discov. 2013, 3:1190-1205.
8. Gilkes D.M., Bajpai S., Wong C.C., Chaturvedi P., Hubbi M.E., Wirtz D., Semenza G.L. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res 2013, 11:456-466.
9. Okuda H., Kobayashi A., Xia B., Watabe M., Pai S.K., Hirota S., Xing F., Liu W., Pandey P.R., Fukuda K., et al. Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. Cancer Res 2012, 72:537-547.
10. Chen Q., Zhang X.H., Massague J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 2011, 20:538-549.
11. Lu X., Mu E., Wei Y., Riethdorf S., Yang Q., Yuan M., Yan J., Hua Y., Tiede B.J., Haffty B.G., et al. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteoclast progenitors. Cancer Cell 2011, 20:701-714.
12. Valiente M., Obenauf A.C., Jin X., Chen Q., Zhang X.H., Lee D.J., Chaft J.E., Kris M.G., Huse J.T., Brogi E., et al. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell 2014, 156:1002-1016.
13. Gao H., Chakraborty G., Lee-Lim A.P., Mo Q., Decker M., Vonica A., Shen R., Brogi E., Brivanlou A.H., Giancotti F.G. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell 2012, 150:764-779.
14. Paolino M., Choidas A., Wallner S., Pranjic B., Uribesalgo I., Loeser S., Jamieson A.M., Langdon W.Y., Ikeda F., Fededa J.P., et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature 2014, 507:508-512.
15. Calon A., Espinet E., Palomo-Ponce S., Tauriello D.V., Iglesias M., Cespedes M.V., Sevillano M., Nadal C., Jung P., Zhang X.H., et al. Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Cancer Cell 2012, 22:571-584.
16. Roy L.D., Curry J.M., Sahraei M., Besmer D.M., Kidiyoor A., Gruber H.E., Mukherjee P. Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling. Breast Cancer Res 2013, 15:R32.
17. Yan L., Cai Q., Xu Y. The ubiquitin-CXCR4 axis plays an important role in acute lung infection-enhanced lung tumor metastasis. Clin Cancer Res 2013, 19:4706-4716.
18. Acharyya S., Oskarsson T., Vanharanta S., Malladi S., Kim J., Morris P.G., Manova-Todorova K., Leversha M., Hogg N., Seshan V.E., et al. A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell 2012, 150:165-178.
19. Monteiro A.C., Leal A.C., Goncalves-Silva T., Mercadante A.C., Kestelman F., Chaves S.B., Azevedo R.B., Monteiro J.P., Bonomo A. T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer. PLoS ONE 2013, 8:e68171.
20. Casazza A., Laoui D., Wenes M., Rizzolio S., Bassani N., Mambretti M., Deschoemaeker S., Van Ginderachter J.A., Tamagnone L., Mazzone M. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell 2013, 24:695-709.
21. Yang P., Li Q.J., Feng Y., Zhang Y., Markowitz G.J., Ning S., Deng Y., Zhao J., Jiang S., Yuan Y., et al. TGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell 2012, 22:291-303.
22. Vadrevu S.K., Chintala N.K., Sharma S.K., Sharma P., Cleveland C., Riediger L., Manne S., Fairlie D.P., Gorczyca W., Almanza O., et al. Complement C5a receptor facilitates cancer metastasis by altering T cell responses in the metastatic niche. Cancer Res 2014, 74(13):3454-3465.
23. Qian B.Z., Li J., Zhang H., Kitamura T., Zhang J., Campion L.R., Kaiser E.A., Snyder L.A., Pollard J.W. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011, 475:222-225.
24. Gil-Bernabe A.M., Ferjancic S., Tlalka M., Zhao L., Allen P.D., Im J.H., Watson K., Hill S.A., Amirkhosravi A., Francis J.L., et al. Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. Blood 2012, 119:3164-3175.
25. Bidwell B.N., Slaney C.Y., Withana N.P., Forster S., Cao Y., Loi S., Andrews D., Mikeska T., Mangan N.E., Samarajiwa S.A., et al. Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape. Nat Med 2012, 18:1224-1231.
26. Ballas Z.K., Buchta C.M., Rosean T.R., Heusel J.W., Shey M.R. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS ONE 2013, 8:e65599.
27. Peinado H., Aleckovic M., Lavotshkin S., Matei I., Costa-Silva B., Moreno-Bueno G., Hergueta-Redondo M., Williams C., Garcia-Santos G., Ghajar C.M., et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012.
28. Zhou W., Fong M.Y., Min Y., Somlo G., Liu L., Palomares M.R., Yu Y., Chow A., O'Connor S.T., Chin A.R., et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell 2014, 25:501-515.
29. Auvinen P., Rilla K., Tumelius R., Tammi M., Sironen R., Soini Y., Kosma V.M., Mannermaa A., Viikari J., Tammi R. Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival. Breast Cancer Res Treat 2014, 143:277-286.
30. Lokeshwar V.B., Lopez L.E., Munoz D., Chi A., Shirodkar S.P., Lokeshwar S.D., Escudero D.O., Dhir N., Altman N. Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells. Cancer Res 2010, 70:2613-2623.
31. Yoshihara S., Kon A., Kudo D., Nakazawa H., Kakizaki I., Sasaki M., Endo M., Takagaki K. A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. FEBS Lett 2005, 579:2722-2726.
32. Chen Q., Massague J. Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis. Clin Cancer Res 2012, 18:5520-5525.
33. Ji J., Liu X., Sundquist K., Sundquist J. Survival of cancer in patients with rheumatoid arthritis: a follow-up study in Sweden of patients hospitalized with rheumatoid arthritis 1 year before diagnosis of cancer. Rheumatology 2011, 50:1513-1518.
34. Chapman R.W., Phillips J.E., Hipkin R.W., Curran A.K., Lundell D., Fine J.S. CXCR2 antagonists for the treatment of pulmonary disease. Pharmacol Therapeut 2009, 121:55-68.
35. Biankin A.V., Waddell N., Kassahn K.S., Gingras M.C., Muthuswamy L.B., Johns A.L., Miller D.K., Wilson P.J., Patch A.M., Wu J., et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012, 491:399-405.
36. Kohl J. Drug evaluation: the C5a receptor antagonist PMX-53. Curr Opin Mol Ther 2006, 8:529-538.
37. Laubli H., Borsig L. Selectins promote tumor metastasis. Semin Cancer Biol 2010, 20:169-177.
38. Nguyen D.X., Bos P.D., Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009, 9:274-284.
39. Lu P., Weaver V.M., Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol 2012, 196:395-406.
40. Sleeman J.P. The metastatic niche and stromal progression. Cancer Metastasis Rev 2012, 31:429-440.
41. Motz G.T., Coukos G. Deciphering and reversing tumor immune suppression. Immunity 2013, 39:61-73.
42. Dudek A.M., Martin S., Garg A.D., Agostinis P. Immature, semi-mature, and fully mature dendritic cells: toward a DC-cancer cells interface that augments anticancer immunity. Front Immunol 2013, 4:438.
43. Yang M., Rui K., Wang S., Lu L. Regulatory B cells in autoimmune diseases. Cell Mol Immunol 2013, 10:122-132.
44. Kim H.J., Verbinnen B., Tang X., Lu L., Cantor H. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature 2010, 467:328-332.
45. Kraman M., Bambrough P.J., Arnold J.N., Roberts E.W., Magiera L., Jones J.O., Gopinathan A., Tuveson D.A., Fearon D.T. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science 2010, 330:827-830.
46. Motz G.T., Santoro S.P., Wang L.P., Garrabrant T., Lastra R.R., Hagemann I.S., Lal P., Feldman M.D., Benencia F., Coukos G. Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat Med 2014, 20(6):607-615.
47. Germain R.N. Maintaining system homeostasis: the third law of Newtonian immunology. Nat Immunol 2012, 13:902-906.
48. Klein C.A. Framework models of tumor dormancy from patient-derived observations. Curr Opin Genet Dev 2011, 21:42-49.
49. Bragado P., Estrada Y., Parikh F., Krause S., Capobianco C., Farina H.G., Schewe D.M., Aguirre-Ghiso J.A. TGF-beta2 dictates disseminated tumour cell fate in target organs through TGF-beta-RIII and p38alpha/beta signalling. Nat Cell Biol 2013, 15:1351-1361.
50. Francia G., Cruz-Munoz W., Man S., Xu P., Kerbel R.S. Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat Rev Cancer 2011, 11:135-141.
51. Serres S., O'Brien E.R., Sibson N.R. Imaging angiogenesis, inflammation, and metastasis in the tumor microenvironment with magnetic resonance imaging. Adv Exp Med Biol 2014, 772:263-283.
52. Serres S., Soto M.S., Hamilton A., McAteer M.A., Carbonell W.S., Robson M.D., Ansorge O., Khrapitchev A., Bristow C., Balathasan L., et al. Molecular MRI enables early and sensitive detection of brain metastases. Proc Natl Acad Sci U S A 2012, 109:6674-6679.