Effective glycaemic control critically determines insulin cardioprotection against ischaemia/reperfusion injury in anaesthetized dogs

Cardiovascular Research

Volumn 103, Issue 2, 2014, Pages 238-247

  Yu, Qiujun ^a   Zhou, Ning ^b   Nan, Ying ^c   Zhang, Lihua ^d   Li, Yan ^a   Hao, Xiaoke ^a   Xiong, Lize ^c   Lau, Wayne Bond ^e   Ma, Xin L ^e   Wang, Haichang ^a   Gao, Feng ^a,c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Department of Cardiology Hospital of Shaanxi Provincial Corps of Chinese People's Armed Police Forces   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Cardioprotection; Dog; Hyperglycaemia; Insulin; Myocardial ischaemia reperfusion

Indexed keywords

6 DIAZO 5 OXONORLEUCINE; GLUCOSE; HEXOSAMINE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MALONALDEHYDE; MYELOPEROXIDASE; PROTEIN KINASE B; GLUCOSE BLOOD LEVEL;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLYCEMIC CONTROL; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HYPERGLYCEMIA; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN INFUSION; MALE; MONGREL DOG; NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; RAT; REOXYGENATION; REPERFUSION INJURY; ANIMAL; CELL PROTECTION; DISEASE MODEL; DOG; DRUG EFFECTS; HEART MUSCLE; HEART MUSCLE CELL; METABOLISM; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD GLUCOSE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOGS; HYPERGLYCEMIA; INSULIN; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY;

EID: 84904323024     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu132     Document Type: Article

References (36)

1. Tune JD, Mallet RT, Downey HF. Insulin improves cardiac contractile function and oxygen utilization efficiency during moderate ischemia without compromising myocardial energetics. J Mol Cell Cardiol 1998;30:2025-2035 (Pubitemid 28495328)
2. Yu QJ, Si R, Zhou N, Zhang HF, Guo WY, Wang HC, Gao F. Insulin inhibits beta-adrenergic action in ischemic/reperfused heart: a novel mechanism of insulin in cardioprotection. Apoptosis 2008;13:305-317
3. Li J, Wu F, Zhang H, Fu F, Ji L, Dong L, Li Q, LiuW, Zhang Y, Lv A,Wang H, Ren J, Gao F. Insulin inhibits leukocyte-endothelium adherence via an Akt-NO-dependent mechanism in myocardial ischemia/reperfusion. J Mol Cell Cardiol 2009;47:512-519
4. Quinn DW, Pagano D, Bonser RS, Rooney SJ, Graham TR, Wilson IC, Keogh BE, Townend JN, Lewis ME, Nightingale P. Improved myocardial protection during coronary artery surgery with glucose-insulin-potassium: a randomized controlled trial. J Thorac Cardiovasc Surg 2006;131:34-42
5. Howell NJ, Ashrafian H, Drury NE, Ranasinghe AM, Contractor H, Isackson H, Calvert M, Williams LK, Freemantle N, Quinn DW, Green D, Frenneaux M, Bonser RS, Mascaro JG, Graham TR, Rooney SJ, Wilson IC, Pagano D. Glucose-insulin- potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation 2011;123:170-177
6. Chaudhuri A, Janicke D, Wilson MF, Tripathy D, Garg R, Bandyopadhyay A, Calieri J, Hoffmeyer D, Syed T, Ghanim H, Aljada A, Dandona P. Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation 2004;109:849-854 (Pubitemid 38252736)
7. Kloner RA, NestoRW. Glucose-insulin-potassium for acute myocardial infarction: continuing controversy over cardioprotection. Circulation 2008;117:2523-2533 (Pubitemid 351670460)
8. Jonassen AK, Sack MN, Mjos OD, Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 2001;89:1191-1198 (Pubitemid 34627878)
9. Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA,Ma XL. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 2002; 105:1497-1502 (Pubitemid 34263284)
10. Sack MN, Yellon DM. Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulation. J Am Coll Cardiol 2003;41:1404-1407 (Pubitemid 36439004)
11. Fulop N, Marchase RB, Chatham JC. Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system. Cardiovasc Res 2007; 73:288-297 (Pubitemid 44937687)
12. Park SY, Ryu J, LeeW. O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes. Exp Mol Med 2005;37:220-229 (Pubitemid 40992738)
13. Ma H, Zhang HF, Yu L, Zhang QJ, Li J, Huo JH, Li X, Guo WY,Wang HC, Gao F. Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: role of Aktstimulated NO production. Cardiovasc Res 2006;69:57-65 (Pubitemid 41814811)
14. Zhang HX, Zang YM, Huo JH, Liang SJ, Zhang HF,Wang YM, Fan Q, GuoWY,Wang HC, Gao F. Physiologically tolerable insulin reduces myocardial injury and improves cardiac functional recovery in myocardial ischemic/reperfused dogs. J Cardiovasc Pharmacol 2006;48:306-313 (Pubitemid 46066836)
15. Deedwania P, Kosiborod M, Barrett E, Ceriello A, IsleyW, Mazzone T, Raskin P. Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2008;117:1610-1619 (Pubitemid 351440650)
16. Dandona P, Chaudhuri A, Ghanim H. Acute myocardial infarction, hyperglycemia, and insulin. J Am Coll Cardiol 2009;53:1437-1439
17. Gao F, Yue TL, ShiDW, Christopher TA, Lopez BL, Ohlstein EH, Barone FC, Ma XL. p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade ofPMNaccumulation. Cardiovasc Res 2002;53: 414-422 (Pubitemid 34117692)
18. Li J, Zhang H,WuF, Nan Y, Ma H, GuoW,Wang H, Ren J, Das UN, Gao F. Insulin inhibits tumor necrosis factor-alpha induction in myocardial ischemia/reperfusion: role of Akt and endothelial nitric oxide synthase phosphorylation. Crit Care Med 2008;36:1551-1558 (Pubitemid 351620675)
19. Muniyappa R, Montagnani M, Koh KK, Quon MJ. Cardiovascular actions of insulin. Endocr Rev 2007;28:463-491 (Pubitemid 47236334)
20. Opie LH. Metabolic management of acute myocardial infarction comes to the fore and extends beyond control of hyperglycemia. Circulation 2008;117:2172-2177
21. Malmberg K, Ryden L, Efendic S, Herlitz J, Nicol P,Waldenstrom A,Wedel H,Welin L. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction(DIGAMI study): effectson mortality at 1 year. J Am Coll Cardiol 1995;26:57-65
22. Mellbin LG, Malmberg K, Norhammar A,Wedel H, Ryden L. The impact of glucose lowering treatment on long-term prognosis in patients with type 2 diabetes and myocardial infarction: a report from the DIGAMI 2 trial. Eur Heart J 2008;29:166-176
23. Mehta SR, Yusuf S, Diaz R, Zhu J, Pais P, Xavier D, Paolasso E, Ahmed R, Xie C, Kazmi K, Tai J, Orlandini A, Pogue J, Liu L. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA 2005;293:437-446
24. SelkerHP, Beshansky JR, Sheehan PR, Massaro JM, Griffith JL, D'Agostino RB, Ruthazer R, Atkins JM, Sayah AJ, Levy MK, Richards ME, Aufderheide TP, Braude DA, Pirrallo RG, Doyle DD, Frascone RJ, Kosiak DJ, Leaming JM, Van Gelder CM, Walter GP, WayneMA,Woolard RH, Opie LH, Rackley CE, Apstein CS, Udelson JE. Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial. JAMA 2012;307: 1925-1933
25. Goyal A, Mehta SR, Diaz R, Gerstein HC, Afzal R, Xavier D, Liu L, Pais P, Yusuf S. Differential clinical outcomes associated with hypoglycemia and hyperglycemia in acute myocardial infarction. Circulation 2009;120:2429-2437
26. Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P. Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 2003;31:359-366 (Pubitemid 36232926)
27. Su H, Sun X, Ma H, Zhang HF, Yu QJ, Huang C,Wang XM, Luan RH, Jia GL,Wang HC, Gao F. Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK. Am J Physiol Endocrinol Metab 2007;293: E629-E635 (Pubitemid 47358973)
28. Yu Q, Gao F, Ma XL. Insulin says NO to cardiovascular disease. Cardiovasc Res 2011;89: 516-524
29. Webster KA. Stress hyperglycemia and enhanced sensitivity to myocardial infarction. Curr Hypertens Rep 2008;10:78-84 (Pubitemid 351255957)
30. Smit JWA, Romijn JA. Acute insulin resistance in myocardial ischemia: causes and consequences. Semin Cardiothorac Vasc Anesth 2006;10:215-219 (Pubitemid 44221889)
31. Morisco C, Marrone C, TrimarcoV, Crispo S, Monti MG,Sadoshima J, Trimarco B. Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression. Cardiovasc Res 2007;76:453-464 (Pubitemid 350007455)
32. D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G. Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells. FASEB J 2004;18:959-961 (Pubitemid 39561491)
33. Liu J, Marchase RB, Chatham JC. Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis. Am J Physiol Heart Circ Physiol 2007;293:H1391-H1399 (Pubitemid 47367181)
34. SchaperW, FlamengW, Winkler B, Wusten B, TurschmannW, Neugebauer G, Carl M, Pasyk S. Quantification of collateral resistance in acute and chronic experimental coronary occlusion in the dog. Circ Res 1976;39:371-377
35. Wang F,Wang Y, Kim MS, Puthanveetil P, Ghosh S, Luciani DS, Johnson JD, Abrahani A, Rodrigues B. Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization. Cardiovasc Res 2010;87:127-136
36. Luan R, Liu S, Yin T, Lau WB,Wang Q, GuoW,Wang H, Tao L. High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation. Cardiovasc Res 2009;83:294-302