Insulin inhibits β-adrenergic action in ischemic/reperfused heart: A novel mechanism of insulin in cardioprotection

Apoptosis

Volumn 13, Issue 2, 2008, Pages 305-317

  Yu, Qiu Jun ^a   Si, Rui ^a   Zhou, Ning ^a   Zhang, Hai Feng ^a   Guo, Wen Yi ^a   Wang, Hai Chang ^a   Gao, Feng ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Adrenoceptor; Apoptosis; Insulin; Ischemia and reperfusion injury; PKA

Indexed keywords

INSULIN; ISOPRENALINE; LACTATE DEHYDROGENASE; PHOSPHOLAMBAN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; HEART CONTRACTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RATE; INOTROPISM; MALE; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION; SYSTOLIC BLOOD PRESSURE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; APOPTOSIS; CALCIUM; CALCIUM-BINDING PROTEINS; CARDIOTONIC AGENTS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; INSULIN; ISOPROTERENOL; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PHOSPHORYLATION; RATS; RECEPTORS, ADRENERGIC, BETA; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

RATTUS;

EID: 38649084713     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0169-2     Document Type: Article

References (40)

1. Mak KH, Topol EJ (2000) Emerging concepts in the management of acute myocardial infarction in patients with diabetes mellitus. J Am Col Cardiol 35:563-568
2. Vadlamudi RV, McNeill JH (1984) Effect of experimental diabetes on isolated rat heart responsiveness to isoproterenol. Can J Physiol Pharmacol 62:124-131
3. Heyliger CE, Pierce GN, Singal PK, Beamish RE, Dhalla NS (1982) Cardiac α- and β-adrenergic receptor alterations in diabetic cardiomyopathy. Basic Res Cardiol 77:610-618
4. Nishio Y, Kashiwagi A, Kida Y et al (1988) Deficiency of cardiac β-adrenergic receptor in streptozotocin-induced diabetic rats. Diabetes 37:1181-1187
5. Wichelhaus A, Russ M, Petersen S, Eckel J (1994) G-protein expression and adenylate cyclase regulation in ventricular cardiomyocytes from STZ-diabetic rats. Am J Physiol 267:H548-H555
6. Fein FS (1990) Diabetic cardiomyopathy. Diabetes Care 13:1169-1179
7. Pfaffman MA (1980) The effects of streptozotocin-induced diabetes and insulin-treatment on the cardiovascular system of the rat. Res Commun Chem Pathol Pharmacol 28:27-41
8. Schömig A, Dart AM, Dietz R, Mayer E, Kubler W (1984) Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: locally mediated release. Circ Res 55:689-701
9. Lameris TW, de Zeeuw S, Alberts G et al (2000) Time course and mechanism of myocardial catecholamine release during transient ischemia in vivo. Circulation 101:2645-2650
10. Lubbe WF, Podzuweit T, Opie LH (1992) Potential arrhythmogenic role of cyclic adenosine monophosphate (AMP) and cytosolic calcium overload: implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors. J Am Coll Cardiol 19:1622-1633
11. Gao F, Gao E, Yue TL et al (2002) Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 105:1497-1502
12. Ma H, Zhang HF, Yu L et al (2006) Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: role of Akt-stimulated NO production. Cardiovasc Res 69:57-65
13. Zhang HF, Fan Q, Qian XX et al (2004) Role of insulin in the anti-apoptotic effect of glucoseinsulin-potassium in rabbits with acute myocardial ischemia and reperfusion. Apoptosis 9:777-783
14. Mattiazzi A, Mundiña-Weilenmann C, Guoxiang C, Vittone L, Kranias E (2005) Role of phospholamban phosphorylation on Thr17 in cardiac physiological and pathological conditions. Cardiovasc Res 68:366-375
15. Temsah RM, Dyck C, Netticadan T, Chapman D, Elimban V, Dhalla NS (2000) Effect of beta-adrenoceptor blockers on sarcoplasmic reticular function and gene expression in the ischemic-reperfused heart. J Pharmacol Exp Ther 293:15-23
16. Sande JB, Sjaastad I, Hoen IB et al (2002) Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity. Cardiovasc Res 53:382-391
17. Zucchi R, Ronca-Testoni S, Di Napoli P et al (1996) Sarcoplasmic reticulum calcium uptake in human myocardium subjected to ischemia and reperfusion during cardiac surgery. J Mol Cell Cardiol 28:1693-1701
18. Krause SM, Jacobus WE, Becker LC (1989) Alterations in cardiac sarcoplasmic reticulum calcium transport in the postischemic "stunned" myocardium. Circ Res 65:526-530
19. Temsah RM, Netticadan T, Chapman D, Takeda S, Mochizuki S, Dhalla NS (1999) Alterations in sarcoplasmic reticulum function and gene expression in ischemic-reperfused rat heart. Am J Physiol 277:H584-594
20. Zhang B, Zhang HF, Fan Q, Ma XL, Gao F (2003) Insulin improves cardiac myocytes contractile function recovery in simulated ischemia-reperfusion: key role of Akt. Chin Sci Bull 48:1364-1369
21. Yu J, Zhang HF, Wu F et al (2006) Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/reperfusion. Acta Pharmacol Sin 27:919-926
22. Ma XL, Kumar S, Gao F et al (1999) Inhibition of p38 mitogenactivated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation 99:1685-1691
23. Zhang QJ, Li QX, Zhang HF et al (2007) Swim training sensitizes myocardial response to insulin: role of akt-dependent eNOS activation. Cardiovasc Res 75:369-380
24. Hopkins TA, Dyck JR, Lopaschuk GD (2003) AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart. Biochem Soc Trans 31:207-212
25. McCormack J, Barr R, Wolff A, Lopaschuk G (1996) Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 93:135-142
26. Remondino A, Kwon SH, Communal C et al (2003) Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res 92:136-138
27. Hu A, Jiao X, Gao E et al (2006) Chronic beta-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress. J Pharmacol Exp Ther 318(2):469-475
28. Engfeldt P, Hellmér J, Wahrenberg H, Arner P (1988) Effects of insulin on adrenoceptor binding and the rate of catecholamine-induced lipolysis in isolated human fat cells. J Biol Chem 263(30):15553-15560
29. Karoor V, Baltensperger K, Paul H, Czech MP, Malbon CC (1995) Phosphorylation of tyrosyl residues 350/354 of the beta-adrenergic receptor is obligatory for counterregulatory effects of insulin. J Biol Chem 270:25305-25308
30. Lee JC, Downing SE (1976) Effects of insulin on cardiac muscle contraction and responsiveness to norepinephrine. Am J Physiol 230:1360-1365
31. Austin C, Chess-Williams R (1994) The in-vitro effects of insulin and the effects of acute fasting on cardiac beta-adrenoceptor responses in the short-term streptozotocin-diabetic rat. J Pharm Pharmacol 46:326-331
32. Ferrara N, Abete P, Corbi G, Paolisso G (2005) Insulin-induced changes in β-adrenergic response: an experimental study in the isolated rat papillary muscle. Am J Hypertension 18:348-353
33. Ren J, Walsh MF, Hamaty M, Sowers JR, Brown RA (1999) Augmentation of the inotropic response to insulin in diabetic rat hearts. Life Sci 65:369-380
34. Lohse MJ (1993) Molecular mechanisms of membrane receptor desensitization. Biochem Biophys Acta 1179:171-188
35. Strasser RH, Marquetant R, Kübler W (1990) Independent sensitization of beta-adrenoceptors and adenylate cyclase in acute myocardial ischaemia. Br J Clin Pharmacol 30(Suppl 1):27S-35S
36. Sichelschmidt OJ, Hahnefeld C, Hohlfeld T, Herberg FW, Schrör K (2003) Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity. Cardiovasc Res 58:602-610
37. Singh RB, Chohan PK, Dhalla NS, Netticadan T (2004) The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart. J Mol Cell Cardiol 37(1):101-110
38. Gavi S, Yin D, Shumay E, Wang HY, Malbon CC (2007) Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptors. Endocrinology 148(6):2653-2662
39. Braz JC, Gregory K, Pathak A et al (2004) PKC-α regulates cardiac contractility and propensity toward heart failure. Nat Med 10:248-254
40. Vittone L, Mundiña-Weilenmann C, Said M, Mattiazzi A (1998) Mechanisms involved in the acidosis enhancement of the isoproterenol-induced phosphorylation of phospholamban in the intact heart. J Biol Chem 273:9804-9811