Magnetic-resonance imaging for kinetic analysis of permeability changes during focused ultrasound-induced blood-brain barrier opening and brain drug delivery

Journal of Controlled Release

Volumn 192, Issue , 2014, Pages 1-9

  Chai, Wen Yen ^a,b   Chu, Po Chun ^a   Tsai, Meng Yen ^a   Lin, Yu Chun ^a,b   Wang, Jiun Jie ^a   Wei, Kuo Chen ^a   Wai, Yau Yau ^b   Liu, Hao Li ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Blood brain barrier; Focused ultrasound; Kinetic analysis; Microbubble; MRI

Indexed keywords

BLOOD; DRUG DELIVERY; MAGNETIC RESONANCE IMAGING; MOLECULES; PLASMAS; RATE CONSTANTS; ULTRASONIC APPLICATIONS;

BLOOD-BRAIN BARRIER; BRAIN DRUG DELIVERIES; DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING; FOCUSED ULTRASOUND; KINETIC ANALYSIS; MICRO-BUBBLE; PHARMACOKINETICS AND PHARMACODYNAMICS; THERAPEUTIC MOLECULES; PERMEABILITY CHANGE;

KINETICS; MAGNETIC RESONANCE IMAGING;

ALBUMIN; EVANS BLUE; ERYTHROMYCIN ETHYLSUCCINATE; COLORING AGENT;

ACCURACY; ADULT; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CONTRAST ENHANCEMENT; DRUG DELIVERY SYSTEM; DRUG EXTRAVASATION; DRUG HALF LIFE; DRUG PENETRATION; EXTRAVASCULAR SPACE; FOCUSED ULTRASOUND; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRESSURE; PRIORITY JOURNAL; RADIATION EXPOSURE; RAT; ULTRASOUND; ANIMAL MODEL; ANIMAL TISSUE; BRAIN DRUG DELIVERY; BRAIN HISTOLOGY; CONTROLLED STUDY; DRUG BRAIN LEVEL; HIGH INTENSITY FOCUSED ULTRASOUND; IN VIVO STUDY; KINETICS; MICROBUBBLE; ANIMAL; BRAIN; METABOLISM; PROCEDURES; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; COLORING AGENTS; DRUG DELIVERY SYSTEMS; EVANS BLUE; MAGNETIC RESONANCE IMAGING; MALE; MICROBUBBLES; RATS, SPRAGUE-DAWLEY; ULTRASONICS;

EID: 84904319430     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.06.023     Document Type: Article

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