Permeability dependence study of the focused ultrasound-induced blood-brain barrier opening at distinct pressures and microbubble diameters using DCE-MRI

Magnetic Resonance in Medicine

Volumn 66, Issue 3, 2011, Pages 821-830

  Vlachos, Fotios ^a   Tung, Yao Sheng ^a   Konofagou, Elisa ^a,b  

^a Fu Foundation School of Engineering and Applied Science   (United States)

^b Howard Hughes Medical Institute   (United States)

Author keywords

blood brain barrier; DCE MRI; focused ultrasound; permeability

Indexed keywords

DRUG DELIVERY; IMAGE SEGMENTATION; MAGNETIC RESONANCE IMAGING; MAMMALS; MECHANICAL PERMEABILITY; ULTRASONIC APPLICATIONS;

ACOUSTIC PRESSURES; BLOOD-BRAIN BARRIER; BRAIN DRUG DELIVERIES; DCE-MRI; DYNAMIC CONTRAST ENHANCED MRI; FOCUSED ULTRASOUND; HISTOLOGICAL EXAMINATION; PERMEABILITY PROPERTIES;

BLOOD;

GADOLINIUM PENTETATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN REGION; CLINICAL EFFECTIVENESS; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC VALUE; DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; IMAGE RECONSTRUCTION; IN VIVO STUDY; MALE; MEMBRANE PERMEABILITY; MICROBUBBLE; MOUSE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING;

EID: 80051704697     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22848     Document Type: Article

References (35)

1. Abbott NJ, Rönnbäck L, Hansson E,. Astrocyte-endothelial interactions at the blood-brain barrier. Neuroscience 2006; 7: 41-53. (Pubitemid 41828930)
2. Fortin D,. Altering the properties of the blood-brain barrier: disruption and permeabilization. Prog Drug Res 2003; 61: 125-154. (Pubitemid 37187405)
3. Pardridge WM,. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2005; 2: 3-14. (Pubitemid 40128022)
4. Rapoport SI Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. J Cell Mol Neurobiol 2000; 20: 217-230.
5. Doolittle ND, Miner ME, Hall WA, Siegal T, Jerome E, Osztie E, McAllister LD, Bubalo JS, Kraemer DF, Fortin D, Nixon R, Muldoon LL, Neuwelt EA,. Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors. Cancer 2000; 88: 637-647. (Pubitemid 30056941)
6. Kroll RA, Neuwelt EA,. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 1998; 42: 1083-1099.
7. Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA,. Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology 2001; 220: 640-646. (Pubitemid 32799969)
8. Choi JJ, Pernot M, Small SA, Konofagou EE,. Non-invasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice. Ultrasound Med Biol 2007; 33: 95-104. (Pubitemid 44959316)
9. Choi JJ, Feshitan JA, Baseri B, Wang S, Tung YS, Borden MA, Konofagou EE,. Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo. IEEE Trans Biomed Eng 2010; 57: 145-154.
10. Choi JJ, Wang S, Tung YS, Morisson III B, Konofagou EE,. Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. Ultrasound Med Biol 2010; 36: 58-67.
11. Sheikov N, McDannold N, Vykhodtseva N, Jolesz F, Hynynen K,. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol 2004; 30: 979-989. (Pubitemid 39094314)
12. Sheikov N, McDannold N, Sharma S, Hynynen K,. Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium Ultrasound Med Biol 2008; 34: 1093-1104. (Pubitemid 351893156)
13. Tung YS, Choi JJ, Baseri B, Konofagou EE,. Identifying the inertial cavitation threshold and skull effects in a vessel phantom using focused ultrasound and microbubbles. Ultrasound Med Biol 2010; 36: 840-852.
14. Tung YS, Vlachos F, Choi JJ, Deffieux T, Selert K, Konofagou EE,. In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in mice. Phys Med Biol 2010; 55: 6141-6155.
15. Baseri B, Choi JJ, Tung YS, Konofagou EE,. Multi-modality safety assessment of blood-brain barrier opening using focused ultrasound and definity microbubbles: a short-term study. Ultrasound Med Biol 2010; 36: 1445-1459.
16. Hynynen K, McDannold N, Martin H, Jolesz F, Vykhodtseva N,. The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison). Ultrasound Med Biol 2003; 29: 473-481. (Pubitemid 36434336)
17. Liu HL, Wai YY, Chen WS, Chen JC, Hsu PH, Wu XY, Huang WC, Yen TC, Wang JJ,. Hemorrhage detection during focused-ultrasound induced blood-brain barrier opening by using susceptibility-weighted magnetic resonance imaging. Ultrasound Med Biol 2008; 34: 598-606.
18. Vlachos F, Tung YS, Konofagou EE,. Permeability assessment of the focused ultrasound-induced blood-brain barrier opening using dynamic contrast-enhanced MRI. Phys Med Biol 2010; 55: 5451-5466.
19. Tofts PS, Kermode AG,. Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging, part 1. Fundamental concepts. Magn Reson Med 1991; 17: 357-367.
20. Feshitan JA, Chen CC, Kwan JJ, Borden MA,. Microbubble size isolation by differential centrifugation. J Colloid Interface Sci 2009; 329: 316-324.
21. Choi JJ, Selert K, Gao Z, Samiotaki G, Baseri B, Konofagou EE,. Noninvasive and localized blood-brain barrier disruption using focused ultrasound can be achieved at short pulse lengths and low pulse repetition frequencies. J Cereb Blood Flow Metab 2011; 31: 725-737.
22. Howles GP, Bing KF, Qi Y, Rosenzweig SJ, Nightingale KR, Johnson GA,. Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound. Magn Reson Med 2010; 64: 995-1004.
23. 1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999; 10: 223-232. (Pubitemid 29463104)
24. McGrath DM, Bradley DP, Tessier JL, Lacey T, Taylor CJ, Parker GJ,. Comparison of model-based arterial input functions for dynamic contrast-enhanced MRI in tumor bearing rats. Magn Reson Med 2009; 61: 1173-1184.
25. Parker GJM, Buckley DL,. Tracer kinetic modeling for T1-weighted DCE-MRI. In:, Jackson A, Buckley DL, Parker GJM, editors. Dynamic contrast-enhanced magnetic resonance imaging in oncology. Medical radiology diagnostic imaging. Berlin: Springer; 2005. pp 81-92.
26. Thomas DL, Lythgoe MF, Gadian DG, Ordidge RJ,. In vivo measurement of the longitudinal relaxation time of arterial blood (T1a) in the mouse using a pulsed arterial spin labeling approach. Magn Reson Med 2006; 55: 943-947.
27. Bilgen M, Dogan B, Narayana PA,. In vivo assessment of blood-spinal cord barrier permeability: serial dynamic contrast enhanced MRI of spinal cord injury. Magn Reson Imaging 2002; 20: 337-341.
28. Pellerin M, Yankeelov TE, Lepage M,. Incorporating contrast agent diffusion into the analysis of DCE-MRI data. Magn Reson Med 2007; 58: 1124-1134. (Pubitemid 350234199)
29. 2 relaxometry. Magn Reson Med 2005; 53: 1202-1206. (Pubitemid 40627800)
30. Parker GJ, Roberts C, Macdonald A, Buonaccorsi GA, Cheung S, Buckley DL, Jackson A, Watson Y, Davies K, Jayson GC,. Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. Magn Reson Med 2006; 56: 993-1000. (Pubitemid 44691341)
31. Yankeelov TE, Luci JJ, Lepage M, Li R, Debusk L, Lin PC, Price RR, Gore JC,. Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model. Magn Reson Med 2005; 23: 519-529. (Pubitemid 40779238)
32. Taylor JS, Toft PS, Port R, Evelhoch JL, Knopp M, Reddick WE, Runge VM, Mayr N,. MR Imaging of tumor microvasculature: promise of the new millenium. J Magn Reson Imaging 1999; 10: 903-907.
33. Bilgen M, Narayana PA,. A pharmacokinetic model for quantitative evaluation of spinal cord injury with dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Med 2001; 46: 1099-1106. (Pubitemid 33104298)
34. Blanchette M, Pellerin M, Tremblay L, Lepage M, Fortin D,. Real-time monitoring of gadolinium diethylenetriamine penta-acetic acid during osmotic blood-brain barrier disruption using magnetic resonance imaging in normal Wistar rats. Neurosurgery 2009; 65: 344-351.
35. Yankeelov TE, Luci JJ, Debusk LM, Lin PC, Gore JC,. Incorporating the effects of transcytolemmal water exchange in a reference region model for DCE-MRI analysis: theory, simulations, and experimental results. Magn Reson Med 2008; 59: 326-335. (Pubitemid 351220096)