Identification and structure-activity relationship study of carvacrol derivatives as Mycobacterium tuberculosis chorismate mutase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 29, Issue 4, 2014, Pages 547-554

  Alokam, Reshma ^a   Jeankumar, Variam Ullas ^a   Sridevi, Jonnalagadda Padma ^a   Matikonda, Siddharth Sai ^a   Peddi, Santosh ^a   Alvala, Mallika ^a   Yogeeswari, Perumal ^a   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Carvacrol; Chorismate mutase; Mycobacterium tuberculosis

Indexed keywords

1 ISOPROPYL 2 METHOXY 4 METHYLBENZENE; 2 AMINO BENZOCHROMENE; 2 ISOPROPYL 5 METHYLPHENYL ACETATE; 4 3,4 DIMETHOXYPHENETHYLAMINO) 3 NITRO 5 SULFAMOYLBENZOICACID; 4 BROMO 2 ISOPROPYL 5 METHYLPHENOL; 4 BROMO 5 SOPROPYL 2 METHYLPHENOL; 4 CHLORO 2 ISOPROPYL 5 METHYLPHENOL; 4 CHLORO 5 ISOPROPYL 2 METHYLPHENOL; 4 ISOPROPYL 2 METHOXY 1 METHYLBENZENE; 4 NITRO 2 ISOPROPYL 5 METHYLPHENOL; 4 NITRO 5 ISOPROPYL 2 METHYLPHENOL; 5 ISOPROPYL 2 METHYLPHENYL ACETATE; 5 NAPHTHYL 7 PROPYL 3H PYRAZOLO[4,3 D][1,2,3]TRIAZIN 4(5H)ONE; CARVACROL; CHORISMATE MUTASE; CHORISMIC ACID; ENZYME INHIBITOR; MOXISYLYTE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; TERPENE;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CYTOTOXICITY; DATA BASE; DRUG SCREENING; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CHORISMATE MUTASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOTERPENES; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904302969     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2013.823958     Document Type: Article

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