Cu-mediated N-arylation of 1,2,3-triazin-4-ones: Synthesis of fused triazinone derivatives as potential inhibitors of chorismate mutase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 1146-1150

  Shiva Kumar, K ^a   Adepu, Raju ^a   Sandra, Sandhya ^a   Rambabu, D ^a   Rama Krishna, G ^b   Malla Reddy, C ^b   Misra, Parimal ^a   Pal, Manojit ^a  

^a INSTITUTE OF LIFE SCIENCES   (India)

^b INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH KOLKATA   (India)

Author keywords

1,2,3 Triazin 4 one; Chorismate mutase; Copper; Coupling

Indexed keywords

1,2 DICHLOROETHANE; 1,2,3 TRIAZIN 4 ONE DERIVATIVE; 3 PHENYLBENZO[D][1,2,3]TRIAZIN 4(3H) ONE; 4 (3,5 DIMETHOXYPHENETHYLAMINO) 3 NITRO 5 SULFAMOYLBENZOIC ACID; BORIC ACID; CHORISMATE MUTASE; COPPER; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; CATALYSIS; CONCENTRATION RESPONSE; CROSS COUPLING REACTION; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; X RAY DIFFRACTION;

CATALYSIS; CHORISMATE MUTASE; COPPER; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 84855645319     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.096     Document Type: Article

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