메뉴 건너뛰기




Volumn 10, Issue 8, 2014, Pages 1119-1130

Pharmacogenetics of antiretroviral therapy

Author keywords

Abacavir; Antiretrovirals; HIV; Pharmacogenetics; Pharmacogenomics; Tenofovir

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ATAZANAVIR; BILIRUBIN; CHOLINESTERASE; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DARUNAVIR; DOLUTEGRAVIR; EFAVIRENZ; ELVITEGRAVIR; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 2B7; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; INDINAVIR; MARAVIROC; METHYLTRANSFERASE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN; NUCLEOSIDE ANALOG; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PREGNANE X RECEPTOR; RALTEGRAVIR; RITONAVIR; SAQUINAVIR;

EID: 84904289319     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2014.930128     Document Type: Review
Times cited : (14)

References (145)
  • 1
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • Meyer U. Pharmacogenetics and adverse drug reactions. Lancet 2000;356:1667-71
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.1
  • 2
    • 0001221024 scopus 로고
    • Some statistical data on atypical cholinesterase of human serum
    • Kalow W, Gunn D. Some statistical data on atypical cholinesterase of human serum. Ann Hum Genet 1959;23:239-50
    • (1959) Ann Hum Genet , vol.23 , pp. 239-250
    • Kalow, W.1    Gunn, D.2
  • 3
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - drug disposition, drug targets, and side effects
    • Evans W, McLeod H. Pharmacogenomics - drug disposition, drug targets, and side effects. N Engl J Med 2003;348:538-49
    • (2003) N Engl J Med , vol.348 , pp. 538-549
    • Evans, W.1    McLeod, H.2
  • 4
    • 26444539817 scopus 로고
    • Genetic control of isoniazid metabolism in man
    • Evans D, Manley K, McKusick V. Genetic control of isoniazid metabolism in man. Br Med J 1960;2:485-91
    • (1960) Br Med J , vol.2 , pp. 485-491
    • Evans, D.1    Manley, K.2    McKusick, V.3
  • 5
    • 0024523831 scopus 로고
    • Pharmacogenetic perspectives gained from twin and family studies
    • Vesell E. Pharmacogenetic perspectives gained from twin and family studies. Pharmacol Ther 1989;41:535-52
    • (1989) Pharmacol Ther , vol.41 , pp. 535-552
    • Vesell, E.1
  • 6
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the MDR1 (P-glycoprotein) gene from multidrugresistant human cells
    • Chen C, Chin J, Ueda K, et al. Internal duplication and homology with bacterial transport proteins in the MDR1 (P-glycoprotein) gene from multidrugresistant human cells. Cell 1986;47:381-9
    • (1986) Cell , vol.47 , pp. 381-389
    • Chen, C.1    Chin, J.2    Ueda, K.3
  • 8
    • 0033980182 scopus 로고    scopus 로고
    • P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs
    • Fromm M. P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. Int J Clin Pharmacol Ther 2000;38:69-74
    • (2000) Int J Clin Pharmacol Ther , vol.38 , pp. 69-74
    • Fromm, M.1
  • 9
    • 0023447098 scopus 로고
    • Cellular localization of the multidrugresistance gene product P-glycoprotein in normal human tissues
    • Thiebaut F, Tsuruo T, Hamada H, et al. Cellular localization of the multidrugresistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 1987;84:7735-8
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7735-7738
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 10
    • 0023153149 scopus 로고
    • The human multidrug resistance (MDR1) gene: CDNA cloning and transcription initiation
    • Ueda K, Clark D, Chen C, et al. The human multidrug resistance (MDR1) gene: cDNA cloning and transcription initiation. J Biol Chem 1987;262:505-8
    • (1987) J Biol Chem , vol.262 , pp. 505-508
    • Ueda, K.1    Clark, D.2    Chen, C.3
  • 11
    • 0031808785 scopus 로고    scopus 로고
    • Zidovudine azidoreductase in human liver microsomes: Activation by ethacrynic acid, dipyridamole, and indomethacin by HIV protease inhibitors
    • Fayz S, Inaba T. Zidovudine azidoreductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin by HIV protease inhibitors. Antimicrob Agents Chemother 1998;42:1654-8
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1654-1658
    • Fayz, S.1    Inaba, T.2
  • 12
    • 43649102537 scopus 로고    scopus 로고
    • A review of the pharmacokinetics of abacavir
    • Yuen G, Weller S, Pakes G. A review of the pharmacokinetics of abacavir. Clin Pharmacokinet 2008;47:351-71
    • (2008) Clin Pharmacokinet , vol.47 , pp. 351-371
    • Yuen, G.1    Weller, S.2    Pakes, G.3
  • 13
    • 33745929357 scopus 로고    scopus 로고
    • Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: A pilot study
    • Anderson P, Lamba J, Aquilante C, et al. Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. J Acquir Immune Defic Syndr 2006;42:441-9
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 441-449
    • Anderson, P.1    Lamba, J.2    Aquilante, C.3
  • 14
    • 0036811774 scopus 로고    scopus 로고
    • The abacavir hypersensitivity reaction: A review
    • Clay P. The abacavir hypersensitivity reaction: a review. Clin Ther 2002;24:1502-14
    • (2002) Clin Ther , vol.24 , pp. 1502-1514
    • Clay, P.1
  • 15
    • 0032840959 scopus 로고    scopus 로고
    • Abacavir rechallenge has to be avoided in case of hypersensitivity reaction
    • Escaut L, Liotier J, Albengres E, et al. Abacavir rechallenge has to be avoided in case of hypersensitivity reaction. AIDS 1999;13:1419-20
    • (1999) AIDS , vol.13 , pp. 1419-1420
    • Escaut, L.1    Liotier, J.2    Albengres, E.3
  • 16
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLAB*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse transcriptase inhibitor abacavir
    • Mallal S, Nolan D, Witt C, et al. Association between presence of HLAB*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse transcriptase inhibitor abacavir. Lancet 2002;359:727-32
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1    Nolan, D.2    Witt, C.3
  • 17
    • 38949196447 scopus 로고    scopus 로고
    • PREDICT-1 Study Team. HLA-B*5701 screening for hypersensitivity to abacavir
    • Mallal S, Phillips E, Carosi G, et al. PREDICT-1 Study Team. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med 2008;358:568-79
    • (2008) N Engl J Med , vol.358 , pp. 568-579
    • Mallal, S.1    Phillips, E.2    Carosi, G.3
  • 18
    • 42549131532 scopus 로고    scopus 로고
    • High sensitivity of human leukocyte antigen- B*5701 as a marker for immunogenetically confirmed abacavir hypersensitivity in white and black patients
    • Saag M, Balu R, Phillips E, et al. High sensitivity of human leukocyte antigen- B*5701 as a marker for immunogenetically confirmed abacavir hypersensitivity in white and black patients. Clin Infect Dis 2008;46:1111-18
    • (2008) Clin Infect Dis , vol.46 , pp. 1111-1118
    • Saag, M.1    Balu, R.2    Phillips, E.3
  • 19
    • 33745295856 scopus 로고    scopus 로고
    • Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study
    • Rauch A, Nolan D, Martin A, et al. Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study. Clin Infect Dis 2006;43:99-102
    • (2006) Clin Infect Dis , vol.43 , pp. 99-102
    • Rauch, A.1    Nolan, D.2    Martin, A.3
  • 20
    • 34247636623 scopus 로고    scopus 로고
    • Prospective genetic screening for human leukocyte antigen-B*5701 avoid abacavir hypersensitivity in the ethnically mixed French HIV population
    • Zucman D, Truchis P, Majerholc C, et al. Prospective genetic screening for human leukocyte antigen-B*5701 avoid abacavir hypersensitivity in the ethnically mixed French HIV population. J Acquir Immune Defic Syndr 2007;45:1-3
    • (2007) J Acquir Immune Defic Syndr , vol.45 , pp. 1-3
    • Zucman, D.1    Truchis, P.2    Majerholc, C.3
  • 21
    • 72649086454 scopus 로고    scopus 로고
    • Successful implementation of a national HLA-B*5701 genetic testing service in Canada
    • Lalonde R, Thomas R, Rachlis A, et al. Successful implementation of a national HLA-B*5701 genetic testing service in Canada. Tissue Antigens 2009;75:12-18
    • (2009) Tissue Antigens , vol.75 , pp. 12-18
    • Lalonde, R.1    Thomas, R.2    Rachlis, A.3
  • 22
    • 36349024340 scopus 로고    scopus 로고
    • Prospective HLA-B*5701 screening and abacavir hypersensitivity: A single centre experience
    • Waters L, Mandalia S, Gazzard B, et al. Prospective HLA-B*5701 screening and abacavir hypersensitivity: a single centre experience. AIDS 2007;21:2533-4
    • (2007) AIDS , vol.21 , pp. 2533-2534
    • Waters, L.1    Mandalia, S.2    Gazzard, B.3
  • 23
    • 77954745358 scopus 로고    scopus 로고
    • Use of the HCP5 single nucleotide polymorphism to predict hypersensitivity reactions to abacavir: Correlation with HLA-B*5701
    • Rodriguez-Novoa S, Cuenca L, Morello J, et al Use of the HCP5 single nucleotide polymorphism to predict hypersensitivity reactions to abacavir: correlation with HLA-B*5701. J Antimicrob Chemother 2010 65 1567-9
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1567-1569
    • Rodriguez-Novoa, S.1    Cuenca, L.2    Morello, J.3
  • 24
    • 34249984379 scopus 로고    scopus 로고
    • The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: The first 4 years
    • Nelson M, Katlama C, Montaner J, et al. The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years. AIDS 2007;21:1273-81
    • (2007) AIDS , vol.21 , pp. 1273-1281
    • Nelson, M.1    Katlama, C.2    Montaner, J.3
  • 25
    • 10744221111 scopus 로고    scopus 로고
    • Renal tubular dysfunction associated with tenofovir therapy: Report of 7 cases
    • Peyriere H, Reynes J, Rouanet I, et al. Renal tubular dysfunction associated with tenofovir therapy: report of 7 cases. J Acquir Immune Defic Syndr 2004;35:269-73
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 269-273
    • Peyriere, H.1    Reynes, J.2    Rouanet, I.3
  • 26
    • 0036895460 scopus 로고    scopus 로고
    • Fanconi syndrome and renal failure induced by tenofovir: A first case report
    • Verhelst D, Monge M, Meynard J, et al. Fanconi syndrome and renal failure induced by tenofovir: a first case report. Am J Kidney Dis 2002;40:1331-3
    • (2002) Am J Kidney Dis , vol.40 , pp. 1331-1333
    • Verhelst, D.1    Monge, M.2    Meynard, J.3
  • 27
    • 64549084582 scopus 로고    scopus 로고
    • Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir
    • Labarga P, Barreiro P, Martin-Carbonero L, et al. Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir. AIDS 2009;23:689-96
    • (2009) AIDS , vol.23 , pp. 689-696
    • Labarga, P.1    Barreiro, P.2    Martin-Carbonero, L.3
  • 28
    • 39349112711 scopus 로고    scopus 로고
    • Greater tenofovir-associated renal function decline with protease inhibitorbased versus non-nucleoside reversetranscriptase inhibitor based therapy
    • Goicoechea M, Liu S, Best B, et al. Greater tenofovir-associated renal function decline with protease inhibitorbased versus non-nucleoside reversetranscriptase inhibitor based therapy. J Infect Dis 2008;197:102-8
    • (2008) J Infect Dis , vol.197 , pp. 102-108
    • Goicoechea, M.1    Liu, S.2    Best, B.3
  • 29
    • 84886487823 scopus 로고    scopus 로고
    • Bone mineral density effects of randomized regimen and nucleoside reverse transcriptase inhibitor selection from ACTG A5142
    • Huang J, Hughes M, Riddler S, et al. Bone mineral density effects of randomized regimen and nucleoside reverse transcriptase inhibitor selection from ACTG A5142. HIV Clin Trials 2013;14:224-34
    • (2013) HIV Clin Trials , vol.14 , pp. 224-234
    • Huang, J.1    Hughes, M.2    Riddler, S.3
  • 30
    • 33749531758 scopus 로고    scopus 로고
    • Mechanism of active renal tubular efflux of tenofovir
    • Ray A, Cihlar T, Robinson K, et al. Mechanism of active renal tubular efflux of tenofovir. Antimicrob Agents Chemother 2006;50:3297-304
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3297-3304
    • Ray, A.1    Cihlar, T.2    Robinson, K.3
  • 31
    • 0034852408 scopus 로고    scopus 로고
    • Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs
    • Cihlar T, Ho E, Lin D, Mulato A. Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids 2001;20:641-8
    • (2001) Nucleosides Nucleotides Nucleic Acids , vol.20 , pp. 641-648
    • Cihlar, T.1    Ho, E.2    Lin, D.3    Mulato, A.4
  • 32
    • 12144257103 scopus 로고    scopus 로고
    • Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    • van Aubel R, Smeets P, van den Heuvel P, et al. Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am J Physiol Renal Physiol 2005;288:F327-33
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Van Aubel, R.1    Smeets, P.2    Van Den Heuvel, P.3
  • 33
    • 30344432397 scopus 로고    scopus 로고
    • Multidrug resistanceassociated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites
    • Mallants R, van Oosterwyck K, Van Vaeck L, et al. Multidrug resistanceassociated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites. Xenobiotica 2005;35:1055-66
    • (2005) Xenobiotica , vol.35 , pp. 1055-1066
    • Mallants, R.1    Van Oosterwyck, K.2    Van Vaeck, L.3
  • 34
    • 0034765470 scopus 로고    scopus 로고
    • Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule
    • Miller D. Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule. J Pharmacol Exp Ther 2001;299:567-74
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 567-574
    • Miller, D.1
  • 35
    • 33846420624 scopus 로고    scopus 로고
    • Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir
    • Imaoka T, Kusuhara H, Adachi M, et al. Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol 2007;71:619-27
    • (2007) Mol Pharmacol , vol.71 , pp. 619-627
    • Imaoka, T.1    Kusuhara, H.2    Adachi, M.3
  • 36
    • 0036186107 scopus 로고    scopus 로고
    • The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: Putative efflux pump for urinary cAMP and cGMP
    • van Aubel R, Smeets P, Peters J, et al. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol 2002;13:595-603
    • (2002) J Am Soc Nephrol , vol.13 , pp. 595-603
    • Van Aubel, R.1    Smeets, P.2    Peters, J.3
  • 37
    • 66949119640 scopus 로고    scopus 로고
    • Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: A pharmacogenetic study
    • Rodriguez-Novoa S, Labarga P, Soriano V, et al Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study. Clin Infect Dis 2009 48 108-16
    • (2009) Clin Infect Dis , vol.48 , pp. 108-116
    • Rodriguez-Novoa, S.1    Labarga, P.2    Soriano, V.3
  • 38
    • 33845226137 scopus 로고    scopus 로고
    • Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy
    • Izzedine H, Hulot J, Villard E, et al. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. J Infect Dis 2006;194:1481-91
    • (2006) J Infect Dis , vol.194 , pp. 1481-1491
    • Izzedine, H.1    Hulot, J.2    Villard, E.3
  • 39
    • 79957933957 scopus 로고    scopus 로고
    • Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction
    • Pushpakom S, Liptrott N, Rodriguez-Novoa S, et al. Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction. J Infect Dis 2011;204:145-53
    • (2011) J Infect Dis , vol.204 , pp. 145-153
    • Pushpakom, S.1    Liptrott, N.2    Rodriguez-Novoa, S.3
  • 40
    • 33745114091 scopus 로고    scopus 로고
    • Severe liver disease associated with prolonged exposure to antiretroviral rugs
    • Maida I, Nunez M, Rios MJ, et al. Severe liver disease associated with prolonged exposure to antiretroviral rugs. J Acquir Immune Defic Syndr 2006;42:177-82
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 177-182
    • Maida, I.1    Nunez, M.2    Rios, M.J.3
  • 41
    • 33845945366 scopus 로고    scopus 로고
    • Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIVinfected patients
    • Mallet V, Blanchard P, Verkarre V, et al. Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIVinfected patients. AIDS 2007;21:187-92
    • (2007) AIDS , vol.21 , pp. 187-192
    • Mallet, V.1    Blanchard, P.2    Verkarre, V.3
  • 42
    • 67651086987 scopus 로고    scopus 로고
    • Association of non-cirrhotic portal hypertension in HIV-infected persons and antiretroviral therapy with didanosine: A nested case-control study
    • Kovari H, Ledergerber B, Peter U, et al. Association of non-cirrhotic portal hypertension in HIV-infected persons and antiretroviral therapy with didanosine: a nested case-control study. Clin Infect Dis 2009;49:626-35
    • (2009) Clin Infect Dis , vol.49 , pp. 626-635
    • Kovari, H.1    Ledergerber, B.2    Peter, U.3
  • 43
    • 84875645759 scopus 로고    scopus 로고
    • Genetic determinants of idiopathic noncirrhotic portal hypertension in HIVinfected individuals
    • Vispo E, Cevik M, Rockstroh J, et al. Genetic determinants of idiopathic noncirrhotic portal hypertension in HIVinfected individuals. Clin Infect Dis 2013;56:1117-22
    • (2013) Clin Infect Dis , vol.56 , pp. 1117-1122
    • Vispo, E.1    Cevik, M.2    Rockstroh, J.3
  • 44
    • 0032727054 scopus 로고    scopus 로고
    • Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450
    • Erickson D, Mather G, Trager W, et al. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos 1999;27:1488-95
    • (1999) Drug Metab Dispos , vol.27 , pp. 1488-1495
    • Erickson, D.1    Mather, G.2    Trager, W.3
  • 45
    • 16544365185 scopus 로고    scopus 로고
    • Genetics of the variable expression of CYP3A in humans
    • Wojnowski L. Genetics of the variable expression of CYP3A in humans. Ther Drug Monit 2004;26:192-9
    • (2004) Ther Drug Monit , vol.26 , pp. 192-199
    • Wojnowski, L.1
  • 46
    • 0033632228 scopus 로고    scopus 로고
    • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity
    • Sata F, Sapone A, Elizondo G, et al. CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. Clin Pharmacol Ther 2000;67:48-56
    • (2000) Clin Pharmacol Ther , vol.67 , pp. 48-56
    • Sata, F.1    Sapone, A.2    Elizondo, G.3
  • 47
    • 0000783041 scopus 로고    scopus 로고
    • Evaluation of the genetic component of variability in CYP3A4 activity: A repeated drug administration method
    • Ozdemir V, Kalowa W, Tang B, et al. Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method. Pharmacogenetics 2000;10:373-88
    • (2000) Pharmacogenetics , vol.10 , pp. 373-388
    • Ozdemir, V.1    Kalowa, W.2    Tang, B.3
  • 48
    • 20244364148 scopus 로고    scopus 로고
    • Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
    • Rotger M, Colombo S, Furrer H, et al. Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. Pharmacogenet Genomics 2005;15:1-5
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 1-5
    • Rotger, M.1    Colombo, S.2    Furrer, H.3
  • 49
    • 0037349981 scopus 로고    scopus 로고
    • Interactions between nevirapine plasma levels, chronic hepatitis C, and the development of liver toxicity in HIV-infected patients
    • Nunez M, Gonzalez de Requena D, Gonzalez-Lahoz J, et al. Interactions between nevirapine plasma levels, chronic hepatitis C, and the development of liver toxicity in HIV-infected patients. AIDS Res Hum Retroviruses 2003;19:187-8
    • (2003) AIDS Res Hum Retroviruses , vol.19 , pp. 187-188
    • Nunez, M.1    Gonzalez De Requena, D.2    Gonzalez-Lahoz, J.3
  • 50
    • 21744442255 scopus 로고    scopus 로고
    • Changes in nevirapine plasma concentrations over time and its relationship with liver enzyme elevations
    • Gonzalez de Requena D, Jimenez-Nacher I, Soriano V. Changes in nevirapine plasma concentrations over time and its relationship with liver enzyme elevations. AIDS Res Hum Retroviruses 2005;21:555-9
    • (2005) AIDS Res Hum Retroviruses , vol.21 , pp. 555-559
    • Gonzalez De Requena, D.1    Jimenez-Nacher, I.2    Soriano, V.3
  • 51
    • 65649091303 scopus 로고    scopus 로고
    • Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African Americans
    • Haas D, Gebretsadik T, Mayo G, et al. Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African Americans. J Infect Dis 2009;199:872-80
    • (2009) J Infect Dis , vol.199 , pp. 872-880
    • Haas, D.1    Gebretsadik, T.2    Mayo, G.3
  • 52
    • 77957287517 scopus 로고    scopus 로고
    • CYP2B6 polymorphism and nonnucleoside reverse transcriptase inhibitor plasma concentrations in Chinese HIV-infected patients
    • Chen J, Sun J, Ma Q, et al. CYP2B6 polymorphism and nonnucleoside reverse transcriptase inhibitor plasma concentrations in Chinese HIV-infected patients. Ther Drug Monit 2010;32:573-8
    • (2010) Ther Drug Monit , vol.32 , pp. 573-578
    • Chen, J.1    Sun, J.2    Ma, Q.3
  • 53
    • 73549123640 scopus 로고    scopus 로고
    • Nevirapine-induced hepatotoxicity and pharmacogenetics: A retrospective study in a population from Mozambique
    • Ciccacci C, Borgiani P, Ceffa S, et al. Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique. Pharmacogenomics 2010;11:23-31
    • (2010) Pharmacogenomics , vol.11 , pp. 23-31
    • Ciccacci, C.1    Borgiani, P.2    Ceffa, S.3
  • 54
    • 33748288115 scopus 로고    scopus 로고
    • Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity
    • Ritchie M, Haas D, Motsinger A, et al. Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Clin Infect Dis 2006;43:779-82
    • (2006) Clin Infect Dis , vol.43 , pp. 779-782
    • Ritchie, M.1    Haas, D.2    Motsinger, A.3
  • 55
    • 37349034567 scopus 로고    scopus 로고
    • CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    • Saitoh A, Sarles E, Capparelli E, et al. CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children. AIDS 2007;21:2191-9
    • (2007) AIDS , vol.21 , pp. 2191-2199
    • Saitoh, A.1    Sarles, E.2    Capparelli, E.3
  • 56
    • 33847793822 scopus 로고    scopus 로고
    • Cytochrome P450 2B6 (CYP2B6) G516T influences nevirapine plasma concentrations in HIV-infected patients in Uganda
    • Penzak S, Kabuye G, Mugyenyi P, et al. Cytochrome P450 2B6 (CYP2B6) G516T influences nevirapine plasma concentrations in HIV-infected patients in Uganda. HIV Med 2007;8:86-91
    • (2007) HIV Med , vol.8 , pp. 86-91
    • Penzak, S.1    Kabuye, G.2    Mugyenyi, P.3
  • 57
    • 65449118348 scopus 로고    scopus 로고
    • Cytochrome P450 2B6 516G>T is associated with plasma concentrations of nevirapine at both 200 mg twice daily and 400 mg once daily in an ethnically diverse population
    • Mahungu T, Smith C, Turner F, et al. Cytochrome P450 2B6 516G>T is associated with plasma concentrations of nevirapine at both 200 mg twice daily and 400 mg once daily in an ethnically diverse population. HIV Med 2009;10:310-17
    • (2009) HIV Med , vol.10 , pp. 310-317
    • Mahungu, T.1    Smith, C.2    Turner, F.3
  • 58
    • 69449103829 scopus 로고    scopus 로고
    • Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing antiretroviral therapy
    • Kesselring A, Wit F, Sabin C, et al. Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing antiretroviral therapy. AIDS 2009;23:1689-99
    • (2009) AIDS , vol.23 , pp. 1689-1699
    • Kesselring, A.1    Wit, F.2    Sabin, C.3
  • 59
    • 41549092794 scopus 로고    scopus 로고
    • Hepatotoxicity of nevirapine in virologically suppressed patients according to gender and CD4 cell counts
    • De Lazzari E, Leon A, Arnaiz J, et al. Hepatotoxicity of nevirapine in virologically suppressed patients according to gender and CD4 cell counts. HIV Med 2008;9:221-6
    • (2008) HIV Med , vol.9 , pp. 221-226
    • De Lazzari, E.1    Leon, A.2    Arnaiz, J.3
  • 60
    • 39849105346 scopus 로고    scopus 로고
    • HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz
    • Vitezica Z, Milpied B, Lonjou C, et al. HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz. AIDS 2008;22:540-1
    • (2008) AIDS , vol.22 , pp. 540-541
    • Vitezica, Z.1    Milpied, B.2    Lonjou, C.3
  • 61
    • 85027929582 scopus 로고    scopus 로고
    • Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian and European descent
    • Yuan J, Guo S, Hall D, et al. Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian and European descent. AIDS 2011;25:1271-80
    • (2011) AIDS , vol.25 , pp. 1271-1280
    • Yuan, J.1    Guo, S.2    Hall, D.3
  • 62
    • 33746767604 scopus 로고    scopus 로고
    • HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients
    • Littera R, Carcassi C, Masala A, et al. HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients. AIDS 2006;20:1621-6
    • (2006) AIDS , vol.20 , pp. 1621-1626
    • Littera, R.1    Carcassi, C.2    Masala, A.3
  • 63
    • 33845945094 scopus 로고    scopus 로고
    • HLA-Cw8 primarily associated with hypersensitivity to nevirapine
    • Gatanaga H, Yazaki H, Tanuma J, et al. HLA-Cw8 primarily associated with hypersensitivity to nevirapine. AIDS 2007;21:264-5
    • (2007) AIDS , vol.21 , pp. 264-265
    • Gatanaga, H.1    Yazaki, H.2    Tanuma, J.3
  • 64
    • 84872833727 scopus 로고    scopus 로고
    • Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa
    • Phillips E, Bartlett J, Sanne I, et al. Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa. J Acquir Immune Defic Syndr 2013;62:55-7
    • (2013) J Acquir Immune Defic Syndr , vol.62 , pp. 55-57
    • Phillips, E.1    Bartlett, J.2    Sanne, I.3
  • 65
    • 79952121425 scopus 로고    scopus 로고
    • HLA-B*35 is associated with nevirapine hypersensitivity in the contemporary Western Australian HIV cohort study
    • Phillips E, Lucas M, Keane N, et al. HLA-B*35 is associated with nevirapine hypersensitivity in the contemporary Western Australian HIV cohort study. Eur Ann Allergy Clin Immunol 2010;42:48
    • (2010) Eur Ann Allergy Clin Immunol , vol.42 , pp. 48
    • Phillips, E.1    Lucas, M.2    Keane, N.3
  • 66
    • 59549096348 scopus 로고    scopus 로고
    • HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients
    • Chantarangsu S, Mushiroda T, Mahasirimongkol S, et al. HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients. Pharmacogenet Genomics 2009;19:139-46
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 139-146
    • Chantarangsu, S.1    Mushiroda, T.2    Mahasirimongkol, S.3
  • 67
    • 0035808574 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • Marzolini C, Telenti A, Decosterd L, et al. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS 2001;15:71-5
    • (2001) AIDS , vol.15 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.3
  • 68
    • 1042300270 scopus 로고    scopus 로고
    • Analyzing sleep abnormalities in HIVinfected patients treated with efavirenz
    • Gallego L, Barreiro P, del Rio R, et al. Analyzing sleep abnormalities in HIVinfected patients treated with efavirenz. Clin Infect Dis 2004;38:430-2
    • (2004) Clin Infect Dis , vol.38 , pp. 430-432
    • Gallego, L.1    Barreiro, P.2    Del Rio, R.3
  • 69
    • 0038002981 scopus 로고    scopus 로고
    • The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
    • Ward B, Gorski J, Jones D, et al. The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther 2003;306:287-300
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 287-300
    • Ward, B.1    Gorski, J.2    Jones, D.3
  • 70
    • 0034948077 scopus 로고    scopus 로고
    • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver
    • Lang T, Klein K, Fischer J, et al. Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 2001;11:399-415
    • (2001) Pharmacogenetics , vol.11 , pp. 399-415
    • Lang, T.1    Klein, K.2    Fischer, J.3
  • 71
    • 0032589627 scopus 로고    scopus 로고
    • Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: Species differences in the metabolism of efavirenz
    • Mutlib A, Chen H, Nemeth G, et al. Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz. Drug Metab Dispos 1999;27:13-33
    • (1999) Drug Metab Dispos , vol.27 , pp. 13-33
    • Mutlib, A.1    Chen, H.2    Nemeth, G.3
  • 72
    • 70349108450 scopus 로고    scopus 로고
    • Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine
    • Belanger A, Caron P, Harvey M, et al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos 2009;37:1793-6
    • (2009) Drug Metab Dispos , vol.37 , pp. 1793-1796
    • Belanger, A.1    Caron, P.2    Harvey, M.3
  • 73
    • 10744221053 scopus 로고    scopus 로고
    • Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression
    • Lamba V, Lamba J, Yasuda K, et al. Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 2003;307:906-22
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 906-922
    • Lamba, V.1    Lamba, J.2    Yasuda, K.3
  • 74
    • 4644349582 scopus 로고    scopus 로고
    • Multiple novel non-synonymous CYP2B6 gene polymorphisms in Caucasians: Demonstration of phenotypic null alleles
    • Lang T, Klein K, Richter T, et al. Multiple novel non-synonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles. J Pharmacol Exp Ther 2004;311:34-43
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 34-43
    • Lang, T.1    Klein, K.2    Richter, T.3
  • 75
    • 17844375918 scopus 로고    scopus 로고
    • A natural CYP2B6 TATA box polymorphism (-82T>C) leading to enhanced transcription and relocation of the transcriptional start site
    • Zukunft J, Lang T, Richter T, et al. A natural CYP2B6 TATA box polymorphism (-82T>C) leading to enhanced transcription and relocation of the transcriptional start site. Mol Pharmacol 2005;67:1772-82
    • (2005) Mol Pharmacol , Issue.67 , pp. 1772-1782
    • Zukunft, J.1    Lang, T.2    Richter, T.3
  • 76
    • 40049092364 scopus 로고    scopus 로고
    • High prevalence of the CYP2B6 516G>T (*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe
    • Nyakutira C, Roshammar D, Chigutsa E, et al. High prevalence of the CYP2B6 516G>T (*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe. Eur J Clin Pharmacol 2008;64:357-65
    • (2008) Eur J Clin Pharmacol , Issue.64 , pp. 357-365
    • Nyakutira, C.1    Roshammar, D.2    Chigutsa, E.3
  • 77
    • 34548033928 scopus 로고    scopus 로고
    • CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: Implications for HIV/AIDS treatment
    • Mehlotra R, Bockarie M, Zimmerman P. CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: implications for HIV/AIDS treatment. Br J Clin Pharmacol 2007;64:391-5
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 391-395
    • Mehlotra, R.1    Bockarie, M.2    Zimmerman, P.3
  • 78
    • 2942551228 scopus 로고    scopus 로고
    • Homozygous CYP2B6*6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz containing regimens
    • Tsuchiya K, Gatanaga H, Tachikawa N, et al. Homozygous CYP2B6*6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz containing regimens. Biochem Biophys Res Commun 2004;319:1322-6
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 1322-1326
    • Tsuchiya, K.1    Gatanaga, H.2    Tachikawa, N.3
  • 79
    • 77952322356 scopus 로고    scopus 로고
    • CYP2B6, CYP2A6 and UGT2B7 polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients
    • Kwara A, Lartey M, Sagoe K, et al. CYP2B6, CYP2A6 and UGT2B7 polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients. AIDS 2009;23:2101-6
    • (2009) AIDS , vol.23 , pp. 2101-2106
    • Kwara, A.1    Lartey, M.2    Sagoe, K.3
  • 80
    • 80052143211 scopus 로고    scopus 로고
    • Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: A chargereversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome P450 reductase complex
    • Zhang H, Sridar C, Kenaan C, et al. Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a chargereversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome P450 reductase complex. J Pharmacol Exp Ther 2001;338:803-9
    • (2001) J Pharmacol Exp Ther , vol.338 , pp. 803-809
    • Zhang, H.1    Sridar, C.2    Kenaan, C.3
  • 81
    • 33947382259 scopus 로고    scopus 로고
    • Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals
    • Rotger M, Tegude H, Colombo S, et al. Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals. Clin Pharmacol Ther 2007;81:557-66
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 557-566
    • Rotger, M.1    Tegude, H.2    Colombo, S.3
  • 82
    • 17644414659 scopus 로고    scopus 로고
    • Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects
    • Rodriguez-Novoa S, Barreiro P, Rendon A, et al Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects. Clin Infect Dis 2005 40 1358-61
    • (2005) Clin Infect Dis , vol.40 , pp. 1358-1361
    • Rodriguez-Novoa, S.1    Barreiro, P.2    Rendon, A.3
  • 84
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous system side effects: An adult ACTG study
    • Haas D, Ribaudo H, Kim R, et al. Pharmacogenetics of efavirenz and central nervous system side effects: an adult ACTG study. AIDS 2004;18:2391-400
    • (2004) AIDS , vol.18 , pp. 2391-2400
    • Haas, D.1    Ribaudo, H.2    Kim, R.3
  • 85
    • 31044456584 scopus 로고    scopus 로고
    • Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: An adult ACTG study
    • Ribaudo H, Haas D, Tierney C, et al. Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an adult ACTG study. Clin Infect Dis 2006;42:401-7
    • (2006) Clin Infect Dis , vol.42 , pp. 401-407
    • Ribaudo, H.1    Haas, D.2    Tierney, C.3
  • 86
    • 34250764311 scopus 로고    scopus 로고
    • Impact of CYP2B6 polymorphisms on hepatic efavirenz metabolism in vitro
    • Desta Z, Saussele T, Ward B, et al. Impact of CYP2B6 polymorphisms on hepatic efavirenz metabolism in vitro. Pharmacogenomics 2007;8:547-58
    • (2007) Pharmacogenomics , vol.8 , pp. 547-558
    • Desta, Z.1    Saussele, T.2    Ward, B.3
  • 87
    • 84858674524 scopus 로고    scopus 로고
    • Associations between ABCB1, CYP2A6, CYP2B6, CYP2D6, and CYP3A5 alleles in relation to efavirenz and nevirapine pharmacokinetics in HIV-infected individuals
    • Heil S, van der Ende M, Schenk P, et al. Associations between ABCB1, CYP2A6, CYP2B6, CYP2D6, and CYP3A5 alleles in relation to efavirenz and nevirapine pharmacokinetics in HIV-infected individuals. Ther Drug Monit 2012;34:153-9
    • (2012) Ther Drug Monit , vol.34 , pp. 153-159
    • Heil, S.1    Van Der Ende, M.2    Schenk, P.3
  • 88
    • 35348923463 scopus 로고    scopus 로고
    • Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6*6 and*26
    • Gatanaga H, Hayashida T, Tsuchiya K, et al. Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6*6 and*26. Clin Infect Dis 2007;45:1230-7
    • (2007) Clin Infect Dis , vol.45 , pp. 1230-1237
    • Gatanaga, H.1    Hayashida, T.2    Tsuchiya, K.3
  • 89
    • 47149109976 scopus 로고    scopus 로고
    • Successful use of reduced-dose efavirenz in a patient with HIV infection: Case report and review of the literature
    • Torno M, Witt M, Saitoh A, Fletcher C. Successful use of reduced-dose efavirenz in a patient with HIV infection: case report and review of the literature. Pharmacotherapy 2008;28:782-7
    • (2008) Pharmacotherapy , vol.28 , pp. 782-787
    • Torno, M.1    Witt, M.2    Saitoh, A.3    Fletcher, C.4
  • 90
    • 70449334327 scopus 로고    scopus 로고
    • A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
    • Mukonzo J, Roshammar D, Waako P, et al. A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans. Br J Clin Pharmacol 2009;68:690-9
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 690-699
    • Mukonzo, J.1    Roshammar, D.2    Waako, P.3
  • 91
    • 34648837873 scopus 로고    scopus 로고
    • Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7
    • Rotger M, Saumoy M, Zhang K, et al. Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7. Pharmacogenet Genomics 2007;17:885-90
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 885-890
    • Rotger, M.1    Saumoy, M.2    Zhang, K.3
  • 92
    • 77955674979 scopus 로고    scopus 로고
    • Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort
    • Carr D, la Porte C, Pirmohamed M, et al. Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. J Antimicrob Chemother 2010;65:1889-93
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1889-1893
    • Carr, D.1    La Porte, C.2    Pirmohamed, M.3
  • 93
    • 80051685348 scopus 로고    scopus 로고
    • Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens
    • Wyen C, Hendra H, Siccardi M. Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens. J Antimicrob Chemother 2011;66:2092-8
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2092-2098
    • Wyen, C.1    Hendra, H.2    Siccardi, M.3
  • 94
    • 27944460707 scopus 로고    scopus 로고
    • Pharmacogenetics of long-term responses to antiretroviral regimens containing efavirenz and/or nelfinavir: An adult ACTG study
    • Haas D, Smeaton L, Shafer R, et al. Pharmacogenetics of long-term responses to antiretroviral regimens containing efavirenz and/or nelfinavir: an adult ACTG study. J Infect Dis 2005;192:1931-42
    • (2005) J Infect Dis , vol.192 , pp. 1931-1942
    • Haas, D.1    Smeaton, L.2    Shafer, R.3
  • 95
    • 33750312905 scopus 로고    scopus 로고
    • Multilocus genetic interactions and response to efavirenz-containing regimens: An adult ACTG study
    • Motsinger A, Ritchie M, Shafer R, et al. Multilocus genetic interactions and response to efavirenz-containing regimens: an adult ACTG study. Pharmacogenet Genomics 2006;16:837-45
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 837-845
    • Motsinger, A.1    Ritchie, M.2    Shafer, R.3
  • 96
    • 0037022006 scopus 로고    scopus 로고
    • Response to antiretroviral treatment in HIV-1 infected individuals with allelic variants of the multidrug resistance transporter 1: A pharmacogenetic study
    • Fellay J, Marzolini C, Meaden E, et al. Response to antiretroviral treatment in HIV-1 infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetic study. Lancet 2002;259:30-6
    • (2002) Lancet , vol.259 , pp. 30-36
    • Fellay, J.1    Marzolini, C.2    Meaden, E.3
  • 97
    • 67349205036 scopus 로고    scopus 로고
    • Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals
    • Arab-Alameddine M, Di Iulio J, Buclin T, et al. Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals. Clin Pharmacol Ther 2009;85:485-94
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 485-494
    • Arab-Alameddine, M.1    Di Iulio, J.2    Buclin, T.3
  • 98
    • 63849240305 scopus 로고    scopus 로고
    • In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function
    • Di Iulio J, Fayet A, Arab-Alameddine M, et al. In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function. Pharmacogenet Genomics 2009;19:300-9
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 300-309
    • Di Iulio, J.1    Fayet, A.2    Arab-Alameddine, M.3
  • 99
    • 1642523162 scopus 로고    scopus 로고
    • Polymorphisms in human MDR1 (Pglycoprotein): Recent advances and clinical relevance
    • Marzolini C, Paus E, Buclin T, et al. Polymorphisms in human MDR1 (Pglycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther 2004;75:13-33
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 13-33
    • Marzolini, C.1    Paus, E.2    Buclin, T.3
  • 100
    • 77957145661 scopus 로고    scopus 로고
    • Influence of host genetics factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients
    • Elens L, Vandercam B, Yombi J, et al. Influence of host genetics factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. Pharamcogenomics 2010;11:1223-34
    • (2010) Pharamcogenomics , vol.11 , pp. 1223-1234
    • Elens, L.1    Vandercam, B.2    Yombi, J.3
  • 101
    • 3142751539 scopus 로고    scopus 로고
    • No influence of the P-glycoprotein genotype (MDR1 C3435T) on plasma levels of lopinavir and efavirenz during antiretroviral treatment
    • Winzer R, Langmann P, Zilly M, et al. No influence of the P-glycoprotein genotype (MDR1 C3435T) on plasma levels of lopinavir and efavirenz during antiretroviral treatment. Eur J Med Res 2003;8:531-4
    • (2003) Eur J Med Res , vol.8 , pp. 531-534
    • Winzer, R.1    Langmann, P.2    Zilly, M.3
  • 102
    • 0037462209 scopus 로고    scopus 로고
    • Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response
    • Brumme Z, Dong W, Chan K, et al. Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response. AIDS 2003;17:201-8
    • (2003) AIDS , vol.17 , pp. 201-208
    • Brumme, Z.1    Dong, W.2    Chan, K.3
  • 103
    • 15444370017 scopus 로고    scopus 로고
    • The efavirenz-induced increase in HDL-cholesterol is influenced by the multidrug resistance gene 1 C3435T polymorphism
    • Alonso-Villaverde C, Coll B, Gomez F, et al. The efavirenz-induced increase in HDL-cholesterol is influenced by the multidrug resistance gene 1 C3435T polymorphism. AIDS 2005;19:341-2
    • (2005) AIDS , vol.19 , pp. 341-342
    • Alonso-Villaverde, C.1    Coll, B.2    Gomez, F.3
  • 104
    • 0042627777 scopus 로고    scopus 로고
    • The effects of protease inhibitors and non-nucleoside reverse transcriptase inhibitors on P-glycoprotein expression in peripheral blood mononuclear cells in vitro
    • Chandler B, Almond L, Ford J, et al. The effects of protease inhibitors and non-nucleoside reverse transcriptase inhibitors on P-glycoprotein expression in peripheral blood mononuclear cells in vitro. J Acquir Immune Defic Syndr 2003;33:551-6
    • (2003) J Acquir Immune Defic Syndr , vol.33 , pp. 551-556
    • Chandler, B.1    Almond, L.2    Ford, J.3
  • 105
    • 84871927320 scopus 로고    scopus 로고
    • Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals
    • Lubomirov R, Arab-Alameddine M, Rotger M, et al. Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals. Pharmacogenet Genomics 2013;23:9-18
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 9-18
    • Lubomirov, R.1    Arab-Alameddine, M.2    Rotger, M.3
  • 106
    • 79959435688 scopus 로고    scopus 로고
    • Nevirapine versus atazanavir/ritonavir, each combined with tenofovir disoproxil fumarate/emtricitabine, in antiretroviralna? ve HIV-1 patients: The ARTEN trial
    • Soriano V, Arasteh K, Migrone H, et al. Nevirapine versus atazanavir/ritonavir, each combined with tenofovir disoproxil fumarate/emtricitabine, in antiretroviralna? ve HIV-1 patients: the ARTEN trial. Antivir Ther 2011;16:339-48
    • (2011) Antivir Ther , vol.16 , pp. 339-348
    • Soriano, V.1    Arasteh, K.2    Migrone, H.3
  • 107
    • 33845495422 scopus 로고    scopus 로고
    • Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemia
    • Rodriguez-Novoa S, Martin-Carbonero L, Barreiro P, et al Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemia. AIDS 2007 21 41-6
    • (2007) AIDS , vol.21 , pp. 41-46
    • Rodriguez-Novoa, S.1    Martin-Carbonero, L.2    Barreiro, P.3
  • 108
    • 0033841077 scopus 로고    scopus 로고
    • Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene
    • Raijmakers M, Jansen P, Steegers E, et al. Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene. J Hepatol 2000;33:348-51
    • (2000) J Hepatol , vol.33 , pp. 348-351
    • Raijmakers, M.1    Jansen, P.2    Steegers, E.3
  • 109
    • 48949119333 scopus 로고    scopus 로고
    • Pharmacogenetics of Gilbert's syndrome
    • Strassburg C. Pharmacogenetics of Gilbert's syndrome. Pharmacogenomics 2008;9:703-15
    • (2008) Pharmacogenomics , vol.9 , pp. 703-715
    • Strassburg, C.1
  • 110
    • 33751005307 scopus 로고    scopus 로고
    • Gilbert's disease and atazanavir: From phenotype to UDPglucuronosyltransferase haplotype
    • Lankisch T, Moebius U, Wehmeier M, et al. Gilbert's disease and atazanavir: from phenotype to UDPglucuronosyltransferase haplotype. Hepatology 2006;44:1324-32
    • (2006) Hepatology , vol.44 , pp. 1324-1332
    • Lankisch, T.1    Moebius, U.2    Wehmeier, M.3
  • 111
    • 25844446183 scopus 로고    scopus 로고
    • Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia
    • Rotger M, Taffe P, Bleiber G, et al. Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. J Infect Dis 2005;192:1381-6
    • (2005) J Infect Dis , vol.192 , pp. 1381-1386
    • Rotger, M.1    Taffe, P.2    Bleiber, G.3
  • 112
    • 77953775606 scopus 로고    scopus 로고
    • Genetic factors influencing severe atazanavirassociated hyperbilirubinemia in a population with low UDPglucuronosyltransferase 1A1*28 allele frequency
    • Park W, Choe P, Song K, et al. Genetic factors influencing severe atazanavirassociated hyperbilirubinemia in a population with low UDPglucuronosyltransferase 1A1*28 allele frequency. Clin Infect Dis 2010;51:101-6
    • (2010) Clin Infect Dis , vol.51 , pp. 101-106
    • Park, W.1    Choe, P.2    Song, K.3
  • 113
    • 84865387874 scopus 로고    scopus 로고
    • Switching to unboosted atazanavir reduces bilirubin and triglycerides without compromising treatment efficacy in UGT1A1*28 polymorphism carriers
    • Ferraris L, Vigano O, Peri A, et al. Switching to unboosted atazanavir reduces bilirubin and triglycerides without compromising treatment efficacy in UGT1A1*28 polymorphism carriers. J Antimicrob Chemother 2012;67:2236-42
    • (2012) J Antimicrob Chemother , vol.67 , pp. 2236-2242
    • Ferraris, L.1    Vigano, O.2    Peri, A.3
  • 114
    • 45749127878 scopus 로고    scopus 로고
    • Switch from ritonavir boosted atazanavir to unboosted atazanavir guided by therapeutic drug monitoring
    • Rodriguez-Novoa S, Morello J, Barreiro P, et al. Switch from ritonavir boosted atazanavir to unboosted atazanavir guided by therapeutic drug monitoring. AIDS Res Hum Retroviruses 2008;24:821-5
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 821-825
    • Rodriguez-Novoa, S.1    Morello, J.2    Barreiro, P.3
  • 115
    • 57749095660 scopus 로고    scopus 로고
    • Population pharmacokinetics of atazanavir in HIV-infected patients
    • Solas C, Gagnieu M, Ravaux I, et al. Population pharmacokinetics of atazanavir in HIV-infected patients. Ther Drug Monit 2008;30:670-3
    • (2008) Ther Drug Monit , vol.30 , pp. 670-673
    • Solas, C.1    Gagnieu, M.2    Ravaux, I.3
  • 116
    • 7944228403 scopus 로고    scopus 로고
    • Predictors of virological response to atazanavir in protease inhibitor exposed patients
    • Barrios A, Rendon A, Gallego O, et al. Predictors of virological response to atazanavir in protease inhibitor exposed patients. HIV Clin Trials 2004;5:201-5
    • (2004) HIV Clin Trials , vol.5 , pp. 201-205
    • Barrios, A.1    Rendon, A.2    Gallego, O.3
  • 117
    • 80053639842 scopus 로고    scopus 로고
    • Use of serum bilirubin levels as surrogate marker of early virological response to atazanavir-based antiretroviral therapy
    • Morello J, Alvarez E, Cuenca L, et al. Use of serum bilirubin levels as surrogate marker of early virological response to atazanavir-based antiretroviral therapy. AIDS Res Hum Retroviruses 2011;27:1043-5
    • (2011) AIDS Res Hum Retroviruses , vol.27 , pp. 1043-1045
    • Morello, J.1    Alvarez, E.2    Cuenca, L.3
  • 118
    • 79951801978 scopus 로고    scopus 로고
    • Detrimental effect of atazanavir plasma concentrations on total serum bilirubin levels in the presence of UGT1A1 polymorphisms
    • Cicconi P, Bini T, Barassi A, et al. Detrimental effect of atazanavir plasma concentrations on total serum bilirubin levels in the presence of UGT1A1 polymorphisms. J Acquir Immune Defic Syndr 2011;56:96-7
    • (2011) J Acquir Immune Defic Syndr , vol.56 , pp. 96-97
    • Cicconi, P.1    Bini, T.2    Barassi, A.3
  • 119
    • 30144438738 scopus 로고    scopus 로고
    • Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by 3435C>T polymorphism at the multidrug resistant gene 1
    • Rodriguez-Novoa S, Barreiro P, Rendon A, et al. Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by 3435C>T polymorphism at the multidrug resistant gene 1. Clin Infect Dis 2006;42:291-5
    • (2006) Clin Infect Dis , vol.42 , pp. 291-295
    • Rodriguez-Novoa, S.1    Barreiro, P.2    Rendon, A.3
  • 120
    • 53349160769 scopus 로고    scopus 로고
    • Association of a single nucleotide polymorphism in the pregnane X receptor (PXR 63396 C>T) with reduced concentrations of unboosted atazanavir
    • Siccardi M, D'Avolio A, Baietto L, et al. Association of a single nucleotide polymorphism in the pregnane X receptor (PXR 63396 C>T) with reduced concentrations of unboosted atazanavir. Clin Infect Dis 2008;47:1222-5
    • (2008) Clin Infect Dis , vol.47 , pp. 1222-1225
    • Siccardi, M.1    D'Avolio, A.2    Baietto, L.3
  • 121
    • 78649673343 scopus 로고    scopus 로고
    • Population pharmacokinetic modeling of the association between 63396 C>T pregnane X receptor polymorphism and unboosted atazanavir clearance
    • Shipani A, Siccardi M, D'Avolio A, et al. Population pharmacokinetic modeling of the association between 63396 C>T pregnane X receptor polymorphism and unboosted atazanavir clearance. Antimicrob Agents Chemother 2010;54:5242-50
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 5242-5250
    • Shipani, A.1    Siccardi, M.2    D'Avolio, A.3
  • 122
    • 70349213594 scopus 로고    scopus 로고
    • Efficacy and safety of atazanavir-ritonavir plus abacavir-lamivudine or tenofoviremtricitabine in patients with hyperlipidaemia switched from a stable protease inhibitor-based regimen including one thymidine analogue
    • Calza L, Manfredi R, Colangeli V, et al. Efficacy and safety of atazanavir-ritonavir plus abacavir-lamivudine or tenofoviremtricitabine in patients with hyperlipidaemia switched from a stable protease inhibitor-based regimen including one thymidine analogue. AIDS Patient Care STD 2009;23:691-7
    • (2009) AIDS Patient Care STD , vol.23 , pp. 691-697
    • Calza, L.1    Manfredi, R.2    Colangeli, V.3
  • 123
    • 84875677476 scopus 로고    scopus 로고
    • Improved metabolic profile after switch to darunavir/ritonavir in HIV-positive patients previously on protease inhibitor therapy
    • Ucciferri C, Falasca K, Vignale F, et al. Improved metabolic profile after switch to darunavir/ritonavir in HIV-positive patients previously on protease inhibitor therapy. J Med Virol 2013;85:755-9
    • (2013) J Med Virol , vol.85 , pp. 755-759
    • Ucciferri, C.1    Falasca, K.2    Vignale, F.3
  • 124
    • 84902133793 scopus 로고    scopus 로고
    • Early lipid changes with atazanavir/ritonavir or darunavir/ritonavir
    • In press
    • Martinez E, Gonzalez-Cordon A, Ferrer E, et al. Early lipid changes with atazanavir/ritonavir or darunavir/ritonavir. HIV Med 2014;In press
    • (2014) HIV Med
    • Martinez, E.1    Gonzalez-Cordon, A.2    Ferrer, E.3
  • 125
    • 84886790685 scopus 로고    scopus 로고
    • The end of AIDS: HIV infection as a chronic disease
    • Deeks S, Lewin S, Havlir D. The end of AIDS: HIV infection as a chronic disease. Lancet 2013;382:1525-33
    • (2013) Lancet , vol.382 , pp. 1525-1533
    • Deeks, S.1    Lewin, S.2    Havlir, D.3
  • 126
    • 0024497306 scopus 로고
    • Hypertriglyceridemia in the acquired immunodeficiency syndrome
    • Grunfeld C, Kotler D, Hamadeh R, et al. Hypertriglyceridemia in the acquired immunodeficiency syndrome. Am J Med 1989;86:27-31
    • (1989) Am J Med , vol.86 , pp. 27-31
    • Grunfeld, C.1    Kotler, D.2    Hamadeh, R.3
  • 127
    • 20244375708 scopus 로고    scopus 로고
    • Modeling the influence of APOC3, APOE and TNF polymorphisms on the risk of antiretroviral therapy associated lipid disorders
    • Tarr P, Taffe P, Bleiber G, et al. Modeling the influence of APOC3, APOE and TNF polymorphisms on the risk of antiretroviral therapy associated lipid disorders. J Infect Dis 2005;191:1419-26
    • (2005) J Infect Dis , vol.191 , pp. 1419-1426
    • Tarr, P.1    Taffe, P.2    Bleiber, G.3
  • 128
    • 77950344979 scopus 로고    scopus 로고
    • Dyslipidemia in HIV-infected individuals: From pharmacogenetics to pharmacogenomics
    • Tarr P, Rotger M, Telenti A. Dyslipidemia in HIV-infected individuals: from pharmacogenetics to pharmacogenomics. Pharmacogenomics 2010;11:587-94
    • (2010) Pharmacogenomics , vol.11 , pp. 587-594
    • Tarr, P.1    Rotger, M.2    Telenti, A.3
  • 129
    • 34547917168 scopus 로고    scopus 로고
    • Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy
    • Arnedo M, Tarffe P, Sahli R, et al. Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy. Pharmacogenet Genomics 2007;17:755-64
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 755-764
    • Arnedo, M.1    Tarffe, P.2    Sahli, R.3
  • 130
    • 77449143922 scopus 로고    scopus 로고
    • Contribution of genome-wide significant single-nucleotide polymorphisms and antiretroviral therapy to dyslipidemia in HIV-infected individuals: A longitudinal study
    • Rotger M, Bayard C, Taffe P, et al. Contribution of genome-wide significant single-nucleotide polymorphisms and antiretroviral therapy to dyslipidemia in HIV-infected individuals: a longitudinal study. Circ Cardiovasc Genet 2009;2:621-8
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 621-628
    • Rotger, M.1    Bayard, C.2    Taffe, P.3
  • 131
    • 67349217885 scopus 로고    scopus 로고
    • Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms
    • Wenning L, Petry A, Kost J, et al. Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms. Clin Pharmacol Ther 2009;85:623-7
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 623-627
    • Wenning, L.1    Petry, A.2    Kost, J.3
  • 132
    • 84861168106 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIVpositive and healthy individuals
    • Arab-Alameddine M, Fayet-Mello A, Lubomirov R, et al. Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIVpositive and healthy individuals. Antimicrob Agents Chemother 2012;56:2959-66
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 2959-2966
    • Arab-Alameddine, M.1    Fayet-Mello, A.2    Lubomirov, R.3
  • 133
    • 84892621348 scopus 로고    scopus 로고
    • Genetic and non-genetic determinants of raltegravir penetration into cerebrospinal fluid: A single arm pharmacokinetic study
    • Johnson D, Sutherland D, Acosta E, et al. Genetic and non-genetic determinants of raltegravir penetration into cerebrospinal fluid: a single arm pharmacokinetic study. PLoS One 2013;8:e82672
    • (2013) PLoS One , vol.8
    • Johnson, D.1    Sutherland, D.2    Acosta, E.3
  • 134
    • 84890406686 scopus 로고    scopus 로고
    • High interpatient variability of raltegravir CSF concentrations in HIV-positive patients: A pharmacogenetic analysis
    • Calcagno A, Cusato J, Simiele M, et al. High interpatient variability of raltegravir CSF concentrations in HIV-positive patients: a pharmacogenetic analysis. J Antimicrob Chemother 2014;69:241-5
    • (2014) J Antimicrob Chemother , vol.69 , pp. 241-245
    • Calcagno, A.1    Cusato, J.2    Simiele, M.3
  • 135
    • 84872696364 scopus 로고    scopus 로고
    • In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor
    • Reese M, Savina P, Generaux G, et al. In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor. Drug Metab Dispos 2013;41:353-61
    • (2013) Drug Metab Dispos , vol.41 , pp. 353-361
    • Reese, M.1    Savina, P.2    Generaux, G.3
  • 137
    • 84884277618 scopus 로고    scopus 로고
    • Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir
    • Stray K, Bam R, Birkus G, et al. Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir. Antimicrob Agents Chemother 2013;57:4982-9
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 4982-4989
    • Stray, K.1    Bam, R.2    Birkus, G.3
  • 138
    • 84896808364 scopus 로고    scopus 로고
    • Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate): A new paradigm for HIV-1 treatment
    • Manzardo C, Gatell J. Stribild (elvitegravir/cobicistat/emtricitabine/ tenofovir disoproxil fumarate): a new paradigm for HIV-1 treatment. AIDS Rev 2014;16:35-42
    • (2014) AIDS Rev , vol.16 , pp. 35-42
    • Manzardo, C.1    Gatell, J.2
  • 139
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Dorantz B, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996;382:722-5
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Dorantz, B.3
  • 140
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiplyexposed individuals to HIV-1 infection
    • Liu R, Paxton W, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiplyexposed individuals to HIV-1 infection. Cell 1996;86:367-77
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.2    Choe, S.3
  • 141
    • 54849145400 scopus 로고    scopus 로고
    • Subgroup analysis of maraviroc in previously treated R5 HIV-1 infection
    • Fakenheuer G, Nelson M, Lazzarin A, et al. Subgroup analysis of maraviroc in previously treated R5 HIV-1 infection. N Engl J Med 2008;359:1442-55
    • (2008) N Engl J Med , vol.359 , pp. 1442-1455
    • Fakenheuer, G.1    Nelson, M.2    Lazzarin, A.3
  • 143
    • 79955768389 scopus 로고    scopus 로고
    • Pharmacogenetics, pharmacogenomics, and individualized medicine
    • Ma Q, Lu A. Pharmacogenetics, pharmacogenomics, and individualized medicine. Pharmacol Rev 2011;63:437-59
    • (2011) Pharmacol Rev , vol.63 , pp. 437-459
    • Ma, Q.1    Lu, A.2
  • 144
  • 145
    • 84860910413 scopus 로고    scopus 로고
    • The predictive capacity of personal genome sequencing
    • Roberts N, Vogelstein J, Parmigiani G, et al. The predictive capacity of personal genome sequencing. Sci Transl Med 2012;4:133-8
    • (2012) Sci Transl Med , vol.4 , pp. 133-138
    • Roberts, N.1    Vogelstein, J.2    Parmigiani, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.