Use of the HCP5 single nucleotide polymorphism to predict hypersensitivity reactions to abacavir: correlation with HLA-B*5701

Journal of Antimicrobial Chemotherapy

Volumn 65, Issue 8, 2010, Pages 1567-1569

  Rodríguez Nóvoa, Sonia ^a   Cuenca, Lorena ^a   Morello, Judit ^a   Córdoba, Mateo ^a   Blanco, Francisco ^a   Jiménez Nácher, Inmaculada ^a   Soriano, Vincent ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Abacavir hypersensitivity reaction; NRTIs; SNPs

Indexed keywords

ABACAVIR; HLA B57 ANTIGEN; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HCP5 PROTEIN, HUMAN; HLA B ANTIGEN; HLA-B*57:01 ANTIGEN;

ALLELE; ARTICLE; ETHNIC DIFFERENCE; FEMALE; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERSENSITIVITY REACTION; MAJOR CLINICAL STUDY; MALE; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; COMPARATIVE STUDY; DRUG HYPERSENSITIVITY; EVALUATION STUDY; GENETICS; HIV INFECTIONS; MAJOR HISTOCOMPATIBILITY COMPLEX; MIDDLE AGED; PREDICTIVE VALUE; PROSPECTIVE STUDY;

ADULT; ANTI-HIV AGENTS; DIDEOXYNUCLEOSIDES; DRUG HYPERSENSITIVITY; FEMALE; HIV INFECTIONS; HLA-B ANTIGENS; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES;

EID: 77954745358     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq204     Document Type: Article

References (7)

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7. Nolan D, Thorborn D, Shaefer M et al. Genetic factors predicting abacavir hypersensitivity and tolerance in HLA-B*5701 individuals: combined analysis from PREDICT-1, SHAPE, and a multinational study. In: Abstracts of the Fifteenth Conference on Retroviruses and Opportunistic Infections, Montreal, 2009. Abstract 982. Foundation for Retrovirology and Human Health, Alexandria, VA, USA.