MiR-2909-mediated regulation of KLF4: A novel molecular mechanism for differentiating between B-cell and T-cell pediatric acute lymphoblastic leukemias

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Malik, Deepti ^a   Kaul, Deepak ^a   Chauhan, Nalini ^a   Marwaha, Ram K ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Acute lymphoblastic leukemia; Cell cycle; Homology modeling; Kruppel like factor 4; miR 2909

Indexed keywords

KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 4; MICRORNA; MIRN2909 MICRORNA, HUMAN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; CELL PROLIFERATION; CHILD; DIFFERENTIAL DIAGNOSIS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR PATHOLOGY; PATHOLOGY; PRESCHOOL CHILD; PROMOTER REGION;

ADOLESCENT; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICRORNAS; PATHOLOGY, MOLECULAR; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROMOTER REGIONS, GENETIC;

EID: 84904275134     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-175     Document Type: Article

References (46)

1. Pieters R, Carroll WL. Biology and treatment of acute lymphoblastic leukemia. Pediatr Clin North Am 2008, 55:1-20. 10.1016/j.pcl.2007.11.002, 18242313.
2. Armstrong SA, Look AT. Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol 2005, 23:6306-6315. 10.1200/JCO.2005.05.047, 16155013.
3. Passananti C, Floridi A, Fanciulli M. Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis. Biochem Cell Biol 2007, 85:477-483. 10.1139/O07-062, 17713582.
4. Kaul D, Hussain A. Cellular AATF gene encodes a novel miRNA that can contribute to HIV-1 latency. Indian J Biochem Biophys 2009, 46:237-240.
5. Kaul D, Sasikala M, Raina A. Regulatory role of miR-2909 in cell-mediated immune response. Cell Biochem Funct 2012, 30:500-504. 10.1002/cbf.2828, 22504889.
6. Sharma M, Sharma S, Arora M, Kaul D. Regulation of cellular CCND1 gene by arsenic is mediated through miR-2909. Gene 2013, 522:60-64. 10.1016/j.gene.2013.03.058, 23562784.
7. McConnell BB, Yang WV. Mammalian Kruppel-like factors in Health and Diseases. Physiol Rev 2010, 90:1337-1381. 10.1152/physrev.00058.2009, 2975554, 20959618.
8. Rowland BD, Peeper DS. KLF4, p21 and context-dependent opposing forces in cancer. Nat Rev Cancer 2006, 6:11-23. 10.1038/nrc1780, 16372018.
9. Guan H, Xie L, Leithäuser F, Flossbach L, Möller P, Wirth T, Ushmorov A. KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma. Blood 2010, 116:1469-1478. 10.1182/blood-2009-12-256446, 20519630.
10. Lutherborrow M, Bryant A, Jayaswal V, Agapiou D, Palma C, Yang YH, Ma DDF. Expression profiling of cytogenetically normal acute myeloid leukemia identifies MicroRNAs that target genes involved in monocytic differentiation. Am J Hematol 2011, 86:2-11. 10.1002/ajh.21864, 20981674.
11. Schotte D, Pieters R, Den Boer ML. MicroRNAs in acute leukemia: from biological players to clinical contributors. Leukemia 2012, 26:1-12. 10.1038/leu.2011.151, 21701489.
12. Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355. 10.1038/nature02871, 15372042.
13. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99:15524-15529. 10.1073/pnas.242606799, 137750, 12434020.
14. Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 2008, 111:3183-3189. 10.1182/blood-2007-07-098749, 2265455, 18187662.
15. de Oliveira JC, Scrideli CA, Brassesco MS, Morales AG, Pezuk JA, Queiroz RP, Yunes JA, Brandalise SR, Tone LG. Differential miRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features. Leuk Res 2012, 36:293-298. 10.1016/j.leukres.2011.10.005, 22099053.
16. Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R. Fast and effective prediction of microRNA/target duplexes. RNA 2004, 10:1507-1517. 10.1261/rna.5248604, 1370637, 15383676.
17. The UniProt Consortium The Universal Protein Resource (UniProt). Nucleic Acids Res 2009, 37:D169-D174. 2686606, 18836194, The UniProt Consortium.
18. Shields JM, Yang VW. Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor. Nucleic Acids Res 1998, 26:796-802. 10.1093/nar/26.3.796, 147321, 9443972.
19. Zhang W, Geiman DE, Shields JM, Dang DT, Mahatan CS, Kaestner KH, Biggs JR, Kraft AS, Yang VW. The gut-enriched Krüppel-like factor (Krüppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem 2000, 275:18391-18398. 10.1074/jbc.C000062200, 2231805, 10749849.
20. Rowland BD, Bernards R, Peeper DS. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 2005, 7:1074-1082. 10.1038/ncb1314, 16244670.
21. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1 phase progression. Genes Dev 1999, 13:1501-1512. 10.1101/gad.13.12.1501, 10385618.
22. Kanai M, Wei D, Li Q, Jia Z, Ajani J, Le X, Yao J, Xie K. Loss of Kruppel-like factor expression contributes to SP1 over expression and human gastric cancer development and progression. Clin Cancer Res 2006, 12:6395-6402. 10.1158/1078-0432.CCR-06-1034, 17085651.
23. Kaul D, Mehrotra A. Functional characterization of AATF transcriptome in human leukemic cells. Mol Cell Biochem 2007, 297:215-220. 10.1007/s11010-006-9317-1, 17006618.
24. Yasunaga J, Taniguchi Y, Nosaka K, Yoshida M, Satou Y, Sakai T, Mitsuya H, Matsuoka M. Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Res 2004, 64:6002-6009. 10.1158/0008-5472.CAN-04-1422, 15342380.
25. Kluiver J, Poppema S, de Jong D, Blokzijl T, Harms G, Jacobs S, Kroesen BJ, van den Berg A. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol 2005, 207:243-249. 10.1002/path.1825, 16041695.
26. Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E, Dahlberg JE. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A 2005, 102:3627-3632. 10.1073/pnas.0500613102, 552785, 15738415.
27. Mattiske S, Suetani RJ, Neilsen PM, Callen DF. The oncogenic role of miR-155 in breast cancer. Cancer Epidemiol Biomarkers Prev 2012, 21:1236-1243. 10.1158/1055-9965.EPI-12-0173, 22736789.
28. Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroRNA-145 regulates OCT4, SOX2 and KLF4 and represses pluripotencyin human embryonic stem cells. Cell 2009, 137:647-658. 10.1016/j.cell.2009.02.038, 19409607.
29. Tian Y, Luo A, Cai Y, Su Q, Ding F, Chen H, Liu Z. MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. J Biol Chem 2010, 285:7986-7994. 10.1074/jbc.M109.062877, 2832949, 20075075.
30. Schuetz A, Nana D, Rose C, Zocher G, Milanovic M, Koeniqsmann J, Blasig R, Heinemann U, Carstanjen D. The structure of the KLF4 DNA-binding domain links to self-renewal and macrophage differentiation. Cell Mol Life Sci 2011, 68:3121-3131. 10.1007/s00018-010-0618-x, 21290164.
31. Zhao W, Hisamuddin IM, Nandan MO, Babbin BA, Lamb NE, Yang VW. Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene 2004, 15:395-402.
32. Kharas MG, Yusuf I, Scarfone VM, Yang VW, Segre JA, Huettner CS, Fruman DA. KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood 2007, 109:747-755. 10.1182/blood-2006-03-011106, 1785099, 16954505.
33. Yang WT, Zheng PS. Krüppel-like factor 4 functions as a tumor suppressor in cervical carcinoma. Cancer 2012, 118:3691-3702. 10.1002/cncr.26698, 22170594.
34. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest Suppl 1968, 21:77-89.
35. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685. 10.1038/227680a0, 5432063.
36. Raina A, Kaul D. LXR-α genomics programmes neuronal death observed in Alzheimer's disease. Apoptosis 2010, 15:1461-1469. 10.1007/s10495-010-0541-5, 20927647.
37. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG. Clustal W and Clustal X version 2.0. Bioinformatics 2007, 23:2947-2948. 10.1093/bioinformatics/btm404, 17846036.
38. Sali A, Blundell TL. Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 1993, 234:779-815. 10.1006/jmbi.1993.1626, 8254673.
39. Bowie JU, Lüthy R, Eisenberg D. A method to identify protein sequences that fold into a known three-dimensional structure. Science 1991, 253:164-170. 10.1126/science.1853201, 1853201.
40. Laskowski RA, Moss DS, Thornton JM. Main-chain bond lengths and bond angles in protein structures. J Mol Biol 1993, 231:1049-1067. 10.1006/jmbi.1993.1351, 8515464.
41. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. UCSF Chimera-a visualization system for exploratory research and analysis. J Comput Chem 2004, 25:1605-1612. 10.1002/jcc.20084, 15264254.
42. DeLano WL. The PyMOL molecular graphics system 2010, San Carlos, CA, USA: DeLano Scientific.
43. Vlahovicek K, Kajan L, Pongor S. DNA analysis servers: plot.it, bend.it, model.it and IS. Nucleic Acids Res 2003, 31:3686-3687. 10.1093/nar/gkg559, 168966, 12824394.
44. De Vries SJ, van Dijk M, Bonvin AM. The HADDOCK web server for data-driven biomolecular docking. Nat Protoc 2010, 5:883-897. 10.1038/nprot.2010.32, 20431534.
45. De Vries SJ, Bonvin AMJJ. CPORT: a consensus interface predictor and its performance in prediction-driven docking with HADDOCK. PLoS One 2011, 6:e17695. 10.1371/journal.pone.0017695, 3064578, 21464987.
46. Gallivan JP, Dougherty DA. Cation-pi Interactions in Structural Biology. Proc Natl Acad Sci U S A 1999, 96:9459-9464. 10.1073/pnas.96.17.9459, 22230, 10449714.