LXR-α genomics programmes neuronal death observed in Alzheimer's disease

Apoptosis

Volumn 15, Issue 12, 2010, Pages 1461-1469

  Raina, Ashvinder ^a   Kaul, Deepak ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

AATF; Abeta production; LXR activation; Neuronal death; PAR 4; Toxic mediators

Indexed keywords

CHOLESTEROL; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER X RECEPTOR ALPHA; PROTEINASE ACTIVATED RECEPTOR 4; REACTIVE OXYGEN METABOLITE; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ALZHEIMER DISEASE; ARTICLE; GENE OVEREXPRESSION; GENOMICS; HUMAN; HUMAN CELL; INFLAMMATION; NERVE CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; OXIDATION; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CLONING, MOLECULAR; EPIGENOMICS; GENE EXPRESSION REGULATION; HUMANS; HYDROXYCHOLESTEROLS; NEUROBLASTOMA; NEURONS; ORPHAN NUCLEAR RECEPTORS; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; TUMOR CELLS, CULTURED; WITHANOLIDES;

EID: 78649956113     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0541-5     Document Type: Article

References (19)

1. J Hardy DJ Selkoe 2002 The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 353 356 1:CAS:528:DC%2BD38Xls1Cju7s%3D 10.1126/science.1072994 12130773 (Pubitemid 34790756)
2. L Qin Y Liu C Cooper, et al. 2002 Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species J Neurochem 83 4 973 983 1:CAS:528:DC%2BD38XovFOisbs%3D 10.1046/j.1471-4159.2002.01210.x 12421370 (Pubitemid 35316048)
3. J Xie Q Guo 2005 PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein J Biol Chem 280 14 13824 13832 1:CAS:528:DC%2BD2MXivV2kurk%3D 10.1074/jbc.M411933200 15671026 (Pubitemid 40517280)
4. Q Guo J Xie 2004 AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 J Biol Chem 279 6 4596 4603 1:CAS:528:DC%2BD2cXps12lug%3D%3D 10.1074/jbc.M309811200 14627703 (Pubitemid 38199051)
5. A Jekabsone PK Mander A Tickler, et al. 2006 Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study J Neuroinflamm 7 3 24 10.1186/1742-2094-3-24 (Pubitemid 44463616)
6. C Behl JB Davis R Lesley, et al. 1994 Hydrogen peroxide mediates amyloid beta protein toxicity Cell 77 6 817 827 1:CAS:528:DyaK2cXltVWntrY%3D 10.1016/0092-8674(94)90131-7 8004671 (Pubitemid 24187680)
7. I Björkhem D Lütjohann U Diczfalusy, et al. 1998 Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation J Lipid Res 39 8 1594 1600 9717719
8. D Lütjohann A Papassotiropoulos I Björkhem, et al. 2000 Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients J Lipid Res 41 2 195 198 10681402
9. SB Joseph A Castrillo BA Laffitte, et al. 2003 Resiprocal regulation of inflammation and lipid metabolism by liver X receptors Nat Med 9 213 219 1:CAS:528:DC%2BD3sXotlSgsw%3D%3D 10.1038/nm820 12524534 (Pubitemid 36227724)
10. VP Dave D Kaul Y Sharma, et al. 2009 Functional genomics of blood cellular LXR-alpha gene in human coronary heart disease J Mol Cell Cardiol 46 4 536 544 1:CAS:528:DC%2BD1MXivVenurk%3D 10.1016/j.yjmcc.2008.12.020 19211025
11. P Chomczynski N Sacchi 1987 Single step method of RNA isolation by acid guanidium thiocynate phenol chloroform extraction Anal Biochem 162 156 159 1:CAS:528:DyaL2sXitFSns7Y%3D 10.1016/0003-2697(87)90021-2 2440339
12. P Schönknecht D Lütjohann J Pantel, et al. 2002 Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls Neurosci Lett 324 1 83 85 10.1016/S0304-3940(02) 00164-7 11983301 (Pubitemid 34442684)
13. S Srinivasan RS Ranga R Burikhanov, et al. 2007 Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells Cancer Res 67 1 246 253 1:CAS:528:DC%2BD2sXisFSmsg%3D%3D 10.1158/0008-5472.CAN-06-2430 17185378 (Pubitemid 46142781)
14. L Puglielli AL Friedlich KD Setchell, et al. 2005 Alzheimer disease beta-amyloid activity mimics cholesterol oxidase J Clin Invest 115 9 2556 2563 1:CAS:528:DC%2BD2MXhtVSjs7%2FM 10.1172/JCI23610 16127459 (Pubitemid 41266218)
15. TJ Nelson DL Alkon 2005 Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide J Biol Chem 280 8 7377 7387 1:CAS:528:DC%2BD2MXhsFSjs7s%3D 10.1074/jbc.M409071200 15591071 (Pubitemid 40341296)
16. VD Bianca S Dusi E Bianchini, et al. 1999 beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease J Biol Chem 274 22 15493 15499 1:STN:280:DyaK1M3mvFSrsQ%3D%3D 10.1074/jbc.274.22.15493 10336441 (Pubitemid 29254916)
17. A Jana K Pahan 2004 Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease J Biol Chem 279 49 51451 51459 1:CAS:528:DC%2BD2cXhtVaqs73M 10.1074/jbc.M404635200 15452132 (Pubitemid 40017893)
18. SK Cheema SK Mishra VM Rangnekar, et al. 2003 Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter J Biol Chem 278 22 19995 20005 1:CAS:528:DC%2BD3sXktVaqtbk%3D 10.1074/jbc.M205865200 12644474 (Pubitemid 36799192)
19. JR Hascalovici W Song J Vaya, et al. 2009 Impact of heme oxygenase-1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia J Neurochem 108 1 72 81 1:CAS:528:DC%2BD1MXns1Wrtg%3D%3D 10.1111/j.1471-4159.2008.05741.x 19046352