mTOR inhibition by everolimus in childhood acute lymphoblastic leukemia induces caspase-independent cell death

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Baraz, Rana ^a   Cisterne, Adam ^a   Saunders, Philip O ^a   Hewson, John ^a   Thien, Marilyn ^a   Weiss, Jocelyn ^a   Basnett, Jordan ^a   Bradstock, Kenneth F ^b   Bendall, Linda J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; MTOR PROTEIN, HUMAN; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CELL DEATH; CELL STRUCTURE; CHILD; CHILDHOOD CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE CONTROL; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL PERMEABILITY; PARAPTOSIS; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CASPASES; CELL DEATH; CELL LINE, TUMOR; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84904269216     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102494     Document Type: Article

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