Galactomannan-PEI based non-viral vectors for targeted delivery of plasmid to macrophages and hepatocytes

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 3, 2014, Pages 461-471

  Bansal, Ruby ^b,d   Singh, A K ^a   Gandhi, R P ^c   Pant, A B ^a   Kumar, P ^b   Gupta, K C ^a,b  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^c INDIAN NATIONAL SCIENCE ACADEMY   (India)

^d ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

Author keywords

Galactomannan; Gene delivery; Hepatocytes; In vitro; In vivo; Macrophages; Polyethylenimine

Indexed keywords

BIOPOLYMER; GUAR GUM; NUCLEASE; NUCLEIC ACID; PLASMID DNA; POLYETHYLENEIMINE; DNA; DRUG CARRIER; GALACTAN; GALACTOMANNAN; MANNAN; PLANT GUM; POLYSACCHARIDE;

ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; COMPARATIVE EFFECTIVENESS; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DEPOLYMERIZATION; GENE VECTOR; GENETIC TRANSFECTION; HETEROZYGOTE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MACROPHAGE; MALE; MCF 7 CELL LINE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHYSICAL CHEMISTRY; TARGET CELL; ADMINISTRATION AND DOSAGE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GENE TRANSFER; GENETICS; HEPG2 CELL LINE; PARTICLE SIZE; PLASMID; PROCEDURES; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DNA; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GALACTANS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEP G2 CELLS; HEPATOCYTES; HUMANS; MACROPHAGES; MALE; MANNANS; MCF-7 CELLS; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; PARTICLE SIZE; PLANT GUMS; PLASMIDS; POLYSACCHARIDES; TRANSFECTION;

EID: 84904251728     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.05.001     Document Type: Article

References (63)

1. M.L. Rogers, and R.A. Rush Non-viral gene therapy for neurological diseases, with an emphasis on targeted gene delivery J. Control. Release 157 2012 183 189
2. H. Okano, M. Nakamura, K. Yoshida, Y. Okada, O. Tsuji, S. Nori, E. Ikeda, S. Yamanaka, and K. Miura Steps toward safe cell therapy using induced pluripotent stem cells Circ. Res. 112 2013 523 533
3. A.J. Perisé-Barrios, J.L. Jiménez, A. Domínguez- Soto, F. Javier de la Mata, A.L. Corbí, R. Gomez, and M.A. Muñoz-Fernandez Carbosilane dendrimers as gene delivery agents for the treatment of HIV infection J. Control. Release 184 2014 51 57
4. F. Alderuccio, Z. Nasa, J. Chung, H.J. Ko, J. Chan, and B.H. Toh Hematopoietic stem cell gene therapy as a treatment for autoimmune diseases Mol. Pharm. 8 2011 1488 1494
5. J.H. Jeong, M. Lee, W.J. Kim, J.W. Yockman, T.G. Park, Y.H. Kim, and S.W. Kim Anti-GAD antibody targeted non-viral gene delivery to islet beta cells J. Control. Release 107 2005 562 570
6. Y. Zhang, A. Satterlee, and L. Huang In vivo gene delivery by nonviral vectors: overcoming hurdles? Mol. Ther. 20 2012 1298 1304
7. H. Atkinson, and R. Chalmers Delivering the goods: viral and non-viral gene therapy systems and the inherent limits on cargo DNA and internal sequences Genetica 138 2010 485 498
8. M. Ruponena, P. Honkakoskia, S. Ronkko, J. Pelkonenb, M. Tammi, and A. Urtti Extracellular and intracellular barriers in non-viral gene delivery J. Control. Release 93 2003 213 217
9. M. Cihova, V. Altanerova, and C. Altaner Stem cell based cancer gene therapy Mol. Pharm. 8 2011 1480 1487
10. U. Lungwitz, M. Breunig, R. Liebl, T. Blunk, and A. Goepferich Methoxy poly(ethylene glycol) - low molecular weight linear polyethylenimine-derived copolymers enable polyplex shielding Eur. J. Pharm. Biopharm. 69 2008 134 148
11. K. Pollinger, R. Hennig, A. Ohlmann, R. Fuchshofer, R. Wenzel, M. Breunig, J. Tessmar, E.R. Tamm, and A. Goepferich Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application Proc. Natl. Acad. Sci. USA 110 2013 6115 6120
12. A. Pathak, P. Kumar, K. Chuttani, S. Jain, A.K. Mishra, S.P. Vyas, and K.C. Gupta Gene expression, biodistribution, and pharmacoscintigraphic evaluation of chondroitin sulfate-PEI nanoconstructs mediated tumor gene therapy ACS Nano 3 2009 1493 1505
13. J.J. Green, R. Langer, and D.G. Anderson A combinatorial polymer library approach yields insight into nonviral gene delivery Acc. Chem. Res. 41 2008 749 759
14. K. Miyata, N. Nishiyama, and K. Kataoka Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses Chem. Soc. Rev. 41 2012 2562 2574
15. H. Liu, H. Wang, W. Yang, and Y. Cheng Disulfide cross-linked low generation dendrimers with high gene transfection efficacy, low cytotoxicity and low cost J. Am. Chem. Soc. 134 2012 17680 17687
16. D. Yamanouchi, J. Wu, A.N. Lazar, K.C. Kent, C.C. Chu, and B. Liu Biodegradable arginine-based poly(ester-amide)s as non-viral gene delivery reagents Biomaterials 29 2008 3269 3277
17. S. Patnaik, M. Arif, A. Pathak, N. Singh, and K.C. Gupta PEI-alginate nanocomposites: efficient non-viral vectors for nucleic acids Int. J. Pharm. 385 2010 194 202
18. N. Kim, D. Jiang, K.A. Jacobi Lennox, S.D. Rose, M.A. Behlke, and A.K. Salem Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA Int. J. Pharm. 427 2012 123 133
19. M.A. Moretton, D.A. Chiappetta, F. Andrade, J. Neves, D. Ferreira, B. Sarmento, and A. Sosnik Hydrolyzed galactomannan-modified nanoparticles and flower-like polymeric micelles for the active targeting of rifampicin to macrophages J. Biomed. Nanotechnol. 9 2013 1076 1087
20. M. Ahmed, B.F.L. Lai, J.N. Kizhakkedathu, and R. Narain Hyperbranched glycopolymers for blood biocompatibility Bioconjugate Chem. 23 2012 1050 1058
21. T. Azzam, H. Eliyahu, L. Shapira, M. Linial, Y. Barenholz, and A.J. Domb Polysaccharide-oligoamine based conjugates for gene delivery J. Med. Chem. 45 2002 1817 1824
22. M. Chu, C. Dong, H. Zhu, C. Xiaojun, D. Haiqing, R. Tianbin, S. Jiansheng, and L. Yongyong Biocompatible polyethylenimine-graft-dextran catiomer for highly efficient gene delivery assisted by a nuclear targeting ligand Polym. Chem. 4 2013 2528 2539
23. F.C. MacLaughlin, R.J. Mumper, J. Wang, J.M. Tagliaferri, G. Inder, M. Hinchcliffe, and A.P. Rolland Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery J. Control. Release 56 1998 259 272
24. W.G. Liu, X. Zhang, S.J. Sun, G.J. Sun, and K.D. Yao N-alkylated chitosan as a potential nonviral vector for gene transfection Bioconjugate Chem. 14 2003 782 789
25. R. Goyal, S.K. Tripathi, S. Tyagi, K. Ravi Ram, K.M. Ansari, Y. Shukla, D. Kar Chowdhuri, P. Kumar, and K.C. Gupta Gellan gum blended PEI nanocomposites as gene delivery agents: evidences from in vitro and in vivo studies Eur. J. Pharm. Biopharm. 79 2011 3 14
26. L. Dong, S. Xia, Y. Luo, H. Diao, J. Zhang, J. Chen, and J. Zhang Targeting delivery oligonucleotide into macrophages by cationic polysaccharide from Bletilla striata successfully inhibited the expression of TNF-α J. Control. Release 134 2009 214 220
27. W.W. Deng, X. Cao, M. Wang, Y. Yang, W.Y. Su, Y.W. Wei, Z. Ou-Yang, J.N. Yu, and X.M. Xu Efficient gene delivery to mesenchymal stem cells by an ethylenediamine-modified polysaccharide from mulberry leaves Small 8 2012 441 451
28. Y. Xiao, H. Zhang, Z. Zhang, M. Yan, M. Lei, K. Zeng, and C. Zhao Synthesis of novel tetravalent galactosylated DTPA-DSPE and study on hepatocyte-targeting efficiency in vitro and in vivo Int. J. Nanomed. 8 2013 3033 3050
29. P. Chaubey, and B. Mishra Mannose-conjugated chitosan nanoparticles loaded with rifampicin for the treatment of visceral leishmaniasis Carbohydr. Polym. 101 2014 1101 1108
30. B. Xiao, H. Laroui, S. Ayyadurai, E. Viennois, M.A. Charania, Y. Zhang, and D. Merlin Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy Biomaterials 30 2013 7471 7482
31. I.O. Adriazola, A.E. do Amaral, J.C. Amorim, B.L. Correia, C.L. Petkowicz, A.L. Mercê, and G.R. Noleto Macrophage activation and leishmanicidal activity by galactomannan and its oxovanadium (IV/V) complex in vitro J. Inorg. Biochem. 132 2014 45 51
32. J.P. Upham, D. Pickett, T. Irimura, E.M. Anders, and P.C. Reading Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry J. Virol. 84 2010 3730 3737
33. A. Lentini, L. Falasea, F. Autuori, and L. Dini The simultaneous exposition of galactose and mannose-specific receptors on Rat Liver Macrophages is developmentally regulated Biosci. Rep. 12 1992 453 461
34. G.L. Bumgardner, S. Chen, S.P. Almond, N.L. Ascher, W.D. Payne, and A.J. Matas Role of macrophages in the immune response to hepatocytes J. Surg. Res. 48 1990 568 572
35. Z. Bian, Y. Peng, Z. You, Q. Wang, Q. Miao, Y. Liu, X. Han, D. Qiu, Z. Li, and X. Ma CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice J. Lipid Res. 54 2013 44 54
36. M. Alonso-Sande, M. Cuna, C. Remunan-Lopez, D. Teijeiro-Osorio, J.L. Alonso-Lebrero, and M.J. Alonso Formation of new glucomannan-chitosan nanoparticles and study of their ability to associate and deliver proteins Macromolecules 39 2006 4152 4158
37. S. Mahor, B.C. Dash, S. O'Connor, and A. Pandit Mannosylated polyethyleneimine-hyaluronan nanohybrids for targeted gene delivery to macrophage-like cell lines Bioconjugate Chem. 23 2012 1138 1148
38. K. Kunath, A. von Harpe, D. Fischer, and T. Kissel Galactose-PEI-DNA complexes for targeted gene delivery: degree of substitution affects complex size and transfection efficiency J. Control. Release 88 2003 159 172
39. Y.S.R. Krishnaiah, V. Satyanarayana, B.D. Kumar, and R.S. Karthikeyana In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil Eur. J. Pharm. Sci. 16 2002 185 192
40. T.T. Reddy, and S. Tammishetti Free radical degradation of guar gum Polym. Degrad. Stab. 86 2004 455 459
41. Q. Wang, P.R. Ellis, and S.B. Ross-Murphy The stability of guar gum in an aqueous system under acidic conditions Food Hydrocolloids 14 2000 129 134
42. J.M. Benns, J.S. Choi, R.I. Mahato, J.S. Park, and S.W. Kim PH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(l-histidine)-graft-poly(l- lysine) comb shaped polymer Bioconjugate Chem. 11 2000 637 645
43. S.K. Tripathi, R. Goyal, M.P. Kashyap, A.B. Pant, W. Haq, P. Kumar, and K.C. Gupta Depolymerized chitosans functionalized with bPEI as carriers of nucleic acids and tuftsin-tethered conjugate for macrophage targeting Biomaterials 33 2012 4204 4219
44. N. Kapoor, A.B. Pant, A. Dhawan, U.N. Dweivedi, Y.K. Gupta, P.K. Seth, and D. Parmar Differences in sensitivity of cultured rat brain neuronal and glial cytochrome P450 2E1 to ethanol Life Sci. 79 2006 1514 1522
45. A.K. Singh, M.P. Kashyap, S. Jahan, V. Kumar, V.K. Tripathi, M.A. Siddiqui, S. Yadav, V.K. Khanna, S.K. Jain, V. Das, and A.B. Pant Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34+ stem cell derived differentiating neuronal cells Toxicol. Sci. 129 2012 392 410
46. H. Schagger Tricine-SDS-PAGE Nat. Protoc. 1 2006 16 22
47. A. Swami, R. Goyal, S.K. Tripathi, N. Singh, N. Katiyar, A.K. Mishra, and K.C. Gupta Effect of homobifunctional crosslinkers on nucleic acids delivery ability of PEI nanoparticles Int. J. Pharm. 374 2009 125 138
48. S.E.A. Gratton, P.A. Ropp, P.D. Pohlhaus, J.C. Luft, V.J. Madden, M.E. Napier, and J.M. DeSimone The effect of particle design on cellular internalization pathways Proc. Natl. Acad. Sci. USA 105 2008 11613 11618
49. J. Hradil, A. Pisarev, M. Babic, and D. Horak Dextran modified iron oxide nanoparticles Chin. Particuol. 5 2007 162 168
50. V. Sharma, R.K. Shukla, N. Saxena, D. Parmar, M. Das, and A. Dhawan DNA damaging potential of zinc oxide nanoparticles in human epidermal cells Toxicol. Lett. 185 2009 211 218
51. R.K. Srivastava, A.B. Pant, M.P. Kashyap, V. Kumar, M. Lohani, L. Jonas, and Q. Rahman Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cancer cell line-A549 Nanotoxicology 5 2011 195 207
52. R.C. Murdock, L. Braydich-Stolle, A.M. Schrand, J.J. Schlager, and S.M. Hussain Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique Toxicol. Sci. 101 2008 239 253
53. R. Bansal, S.K. Tripathi, K.C. Gupta, and P. Kumar Lipophilic and cationic triphenylphosphonium grafted linear polyethylenimine polymers for efficient gene delivery to mammalian cells J. Mater. Chem. 22 2012 25427 25436
54. R. Goyal, R. Bansal, S. Tyagi, Y. Shukla, P. Kumar, and K.C. Gupta 1,4-Butanediol diglycidyl ether (BDE)-crosslinked PEI-g-imidazole nanoparticles as nucleic acid-carriers in vitro and in vivo Mol. BioSyst. 7 2011 2055 2065
55. K. Gescher, and K.M. Deters Typha latifolia L. fruit polysaccharides induce the differentiation and stimulate the proliferation of human keratinocytes in vitro J. Ethnopharmacol. 137 2011 352 358
56. R. Bottega, and R.M. Epand Inhibition of protein kinase C by cationic amphiphiles Biochemistry 31 1992 9025 9030
57. K. Wong, G. Sun, X. Zhang, H. Dai, Y. Liu, C. He, and K.W. Leong PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo Bioconjugate Chem. 17 2006 152 158
58. L. Wasungu, M. Scarzello, G.V.G. Molema, A. Wagenaar, J.B. Engberts, and D. Hoekstra Transfection mediated by pH-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications J. Mol. Med. 84 2006 774 784
59. K.N. Ganesh, and M. Sastry DNA-amine interactions: from monolayers to nanoparticles J. Ind. Inst. Sci. 82 2002 105 112
60. D. Lechardeur, K.J. Sohn, M. Haardt, P.B. Joshi, M. Monck, R.W. Graham, B. Beatty, J. Squire, H. O'Brodovich, and G.L. Lukacs Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer Gene Ther. 6 1999 482 497
61. S.J. Hwang, and M.E. Davis Cationic polymers for gene delivery: designs for overcoming barriers to systemic administration Curr. Opin. Mol. Ther. 3 2001 183 191
62. L. Moretti, E.S. Yang, K.W. Kim, and B. Lu Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy Drug Resist. Updat. 10 2007 135 143
63. Maximum Usage Levels Permitted-Guar gum. fda.gov-Foodadditivelist.